Pinostilbene inhibits full-length and splice variant of androgen receptor in prostate cancer

• Published in: Scientific reports Vol. 13; no. 1; p. 16663
• Main Authors: Shin, Won Sik, Han, Seung Hyun, Jo, Kyung Won, Cho, Yunje, Kim, Kyong-Tai
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 631/45; 631/67; 631/80; Alternative splicing; Androgen receptors; Androgens; Castration; Cell viability; Gene expression; Humanities and Social Sciences; multidisciplinary; Prostate cancer; Science; Science (multidisciplinary); Sex hormones

Prostate cancer is the most prevalent cancer in men worldwide and is promoted by the sex hormone androgen. Expression of androgen from the testis can be significantly reduced through castration. However, as most prostate cancer patients acquire castration resistance, additional therapeutic solutions...