Immunogenicity and Efficacy of a Novel Multi-Antigenic Peptide Vaccine Based on Cross-Reactivity between Feline and Human Immunodeficiency Viruses

• Published in: Viruses Vol. 11; no. 2; p. 136
• Main Authors: Sahay, Bikash, Aranyos, Alek M., Mishra, Meerambika, McAvoy, Andrew C., Martin, Marcus M., Pu, Riuyu, Shiomitsu, Sayaka, Shiomitsu, Keijiro, Dark, Michael J., Sanou, Missa P., Roff, Shannon R., Rathore, Mobeen H., Yamamoto, Janet K.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.02.2019; MDPI
• Subjects: Acquired immune deficiency syndrome; AIDS; Algorithms; Animals; Antibodies, Viral - blood; Cats; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; Cell growth; Cross Reactions; Cross-reactivity; cytotoxic T lymphocyte; Cytotoxicity; Disease prevention; Epitopes; Epitopes, T-Lymphocyte - immunology; Feline Acquired Immunodeficiency Syndrome - immunology; Feline Acquired Immunodeficiency Syndrome - prevention & control; FIV vaccine; Genomes; HIV; HIV Infections - immunology; HIV Infections - prevention & control; HIV-1; Human immunodeficiency virus; Human subjects; Humans; Immunity, Cellular; Immunodeficiency; Immunodeficiency Virus, Feline; Immunogenicity; Immunogenicity, Vaccine; Infections; Leukocytes (mononuclear); Lymphocyte Activation; Lymphocytes; Lymphocytes T; Pathogens; Peptides; Peptides - immunology; Peripheral blood mononuclear cells; polyfunctional T cells; RNA-directed DNA polymerase; Specific Pathogen-Free Organisms; T cell epitopes; Vaccination; Vaccination - veterinary; Vaccines; Vaccines, Subunit - immunology; Viral infections; Viral Vaccines - immunology; United States > US; HIV-1; polyfunctional T cells; T cell epitopes; cytotoxic T lymphocyte; FIV vaccine

For the development of an effective HIV-1 vaccine, evolutionarily conserved epitopes between feline and human immunodeficiency viruses (FIV and HIV-1) were determined by analyzing overlapping peptides from retroviral genomes that induced both anti-FIV/HIV T cell-immunity in the peripheral blood mono...