Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria

• Published in: Molecular biology of the cell Vol. 20; no. 10; pp. 2530 - 2539
• Main Authors: Milenkovic, Dusanka, Ramming, Thomas, Müller, Judith M, Wenz, Lena-Sophie, Gebert, Natalia, Schulze-Specking, Agnes, Stojanovski, Diana, Rospert, Sabine, Chacinska, Agnieszka
• Format: Journal Article
• Language: English
• Published: United States The American Society for Cell Biology 15.05.2009
• Subjects: Amino Acid Sequence; Leucine - metabolism; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Mitochondria - metabolism; Mitochondrial Membrane Transport Proteins - chemistry; Mitochondrial Membrane Transport Proteins - metabolism; Mitochondrial Membranes - metabolism; Molecular Sequence Data; Protein Binding; Protein Precursors - metabolism; Protein Sorting Signals; Protein Transport; Recombinant Fusion Proteins - metabolism; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - chemistry; Saccharomyces cerevisiae Proteins - metabolism

The intermembrane space of mitochondria contains the specific mitochondrial intermembrane space assembly (MIA) machinery that operates in the biogenesis pathway of precursor proteins destined to this compartment. The Mia40 component of the MIA pathway functions as a receptor and binds incoming precu...