Ex vivo infection model for Francisella using human lung tissue

• Published in: Frontiers in cellular and infection microbiology Vol. 13; p. 1224356
• Main Authors: Köppen, Kristin, Fatykhova, Diana, Holland, Gudrun, Rauch, Jessica, Tappe, Dennis, Graff, Mareike, Rydzewski, Kerstin, Hocke, Andreas C., Hippenstiel, Stefan, Heuner, Klaus
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.07.2023
• Subjects: Cellular and Infection Microbiology; ex vivo; Francisella; human lung; intracellular bacteria; Tularemia; virulence; intracellular bacteria; human lung; virulence; ex vivo; Francisella; Tularemia

Tularemia is mainly caused by ( ) subsp. ( ) and subsp. ( ) in humans and in more than 200 animal species including rabbits and hares. Human clinical manifestations depend on the route of infection and range from flu-like symptoms to severe pneumonia with a mortality rate up to 60% without treatment...