Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age

• Published in: Environmental research Vol. 164; pp. 475 - 487
• Main Authors: Calderón-Garcidueñas, Lilian, Gónzalez-Maciel, Angélica, Reynoso-Robles, Rafael, Delgado-Chávez, Ricardo, Mukherjee, Partha S., Kulesza, Randy J., Torres-Jardón, Ricardo, Ávila-Ramírez, José, Villarreal-Ríos, Rodolfo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2018
• Subjects: Adult; air pollution; AIR POLLUTION CONTROL; alleles; Alzheimer; Alzheimer disease; Alzheimer Disease - physiopathology; amyloid; Amyloid beta-Peptides - metabolism; Amyloid plaques; APOE4; apolipoprotein E; Apolipoprotein E4 - metabolism; APOLIPOPROTEINS; brain stem; Brainstem; Child; Child, Preschool; childhood; Children; Cities; COMBUSTION; Combustion-derived nanoparticles; death; ENVIRONMENTAL SCIENCES; HEALTH HAZARDS; Humans; Hyperphosphorilated tau; immunohistochemistry; Infant; INFANTS; Mexico; Mexico City; NANOPARTICLES; NERVOUS SYSTEM DISEASES; Neurofibrillary Tangles - metabolism; Neurofibrillary Tangles - pathology; ozone; PARTICULATES; PATHOGENESIS; PATHOLOGY; PM2.5; pollution control; protein aggregates; risk factors; Suicide; Tauopathies; United States Environmental Protection Agency; URBAN AREAS; Young Adult; Young adults; Mexico; Cities; Tauopathies; Hyperphosphorilated tau; Young adults; APOE4; Brainstem; PM2.5; Combustion-derived nanoparticles; Children; Suicide; Alzheimer; Amyloid plaques; Mexico City; PM(2.5)

Exposures to fine particulate matter (PM2.5) and ozone (O3) above USEPA standards are associated with Alzheimer's disease (AD) risk. Metropolitan Mexico City (MMC) residents have life time exposures to PM2.5 and O3 above USEPA standards. We investigated AD intra and extracellular protein aggreg...