BMP signaling during craniofacial development: new insights into pathological mechanisms leading to craniofacial anomalies

• Published in: Frontiers in physiology Vol. 14; p. 1170511
• Main Authors: Ueharu, Hiroki, Mishina, Yuji
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 18.05.2023
• Subjects: BMP; craniofacial development; craniosynostosis; orofacial cleft; Physiology; transgenic animal; orofacial cleft; craniosynostosis; craniofacial development; BMP; transgenic animal

Cranial neural crest cells (NCCs) are the origin of the anterior part of the face and the head. Cranial NCCs are multipotent cells giving rise to bones, cartilage, adipose-tissues in the face, and neural cells, melanocytes, and others. The behavior of cranial NCCs (proliferation, cell death, migrati...