Complex interactions of cellular players in chronic Graft-versus-Host Disease

Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment...

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Published inFrontiers in immunology Vol. 14; p. 1199422
Main Authors Gail, Laura Marie, Schell, Kimberly Julia, Łacina, Piotr, Strobl, Johanna, Bolton, Steven J, Steinbakk Ulriksen, Emilie, Bogunia-Kubik, Katarzyna, Greinix, Hildegard, Crossland, Rachel Emily, Inngjerdingen, Marit, Stary, Georg
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 26.06.2023
Subjects
Antigen-Presenting Cells
B-Lymphocytes
Bronchiolitis Obliterans Syndrome
Cell Communication
cell-cell communication
chronic graft-versus-host disease
Extracellular Vesicles
GvHD pathogenesis
hematopoietic stem cell transplantation
Humans
immune cell networks
Immunology
hematopoietic stem cell transplantation
immune cell networks
GvHD pathogenesis
cell-cell communication
chronic graft-versus-host disease
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Abstract Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment options are still limited. To date, we lack a global understanding of the interplay between the different cellular players involved, in the affected tissues and at different stages of disease development and progression. In this review we summarize our current knowledge on pathogenic and protective mechanisms elicited by the major involved immune subsets, being T cells, B cells, NK cells and antigen presenting cells, as well as the microbiome, with a special focus on intercellular communication of these cell types extracellular vesicles as up-and-coming fields in chronic Graft-versus-Host Disease research. Lastly, we discuss the importance of understanding systemic and local aberrant cell communication during disease for defining better biomarkers and therapeutic targets, eventually enabling the design of personalized treatment schemes.
AbstractList Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment options are still limited. To date, we lack a global understanding of the interplay between the different cellular players involved, in the affected tissues and at different stages of disease development and progression. In this review we summarize our current knowledge on pathogenic and protective mechanisms elicited by the major involved immune subsets, being T cells, B cells, NK cells and antigen presenting cells, as well as the microbiome, with a special focus on intercellular communication of these cell types via extracellular vesicles as up-and-coming fields in chronic Graft-versus-Host Disease research. Lastly, we discuss the importance of understanding systemic and local aberrant cell communication during disease for defining better biomarkers and therapeutic targets, eventually enabling the design of personalized treatment schemes.
Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment options are still limited. To date, we lack a global understanding of the interplay between the different cellular players involved, in the affected tissues and at different stages of disease development and progression. In this review we summarize our current knowledge on pathogenic and protective mechanisms elicited by the major involved immune subsets, being T cells, B cells, NK cells and antigen presenting cells, as well as the microbiome, with a special focus on intercellular communication of these cell types via extracellular vesicles as up-and-coming fields in chronic Graft-versus-Host Disease research. Lastly, we discuss the importance of understanding systemic and local aberrant cell communication during disease for defining better biomarkers and therapeutic targets, eventually enabling the design of personalized treatment schemes.
Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell transplantation. Although we have made substantial progress in understanding disease pathogenesis and the role of specific immune cell subsets, treatment options are still limited. To date, we lack a global understanding of the interplay between the different cellular players involved, in the affected tissues and at different stages of disease development and progression. In this review we summarize our current knowledge on pathogenic and protective mechanisms elicited by the major involved immune subsets, being T cells, B cells, NK cells and antigen presenting cells, as well as the microbiome, with a special focus on intercellular communication of these cell types extracellular vesicles as up-and-coming fields in chronic Graft-versus-Host Disease research. Lastly, we discuss the importance of understanding systemic and local aberrant cell communication during disease for defining better biomarkers and therapeutic targets, eventually enabling the design of personalized treatment schemes.
Author Inngjerdingen, Marit
Stary, Georg
Greinix, Hildegard
Strobl, Johanna
Steinbakk Ulriksen, Emilie
Schell, Kimberly Julia
Gail, Laura Marie
Łacina, Piotr
Bolton, Steven J
Bogunia-Kubik, Katarzyna
Crossland, Rachel Emily
AuthorAffiliation 5 Department of Pharmacology, Oslo University Hospital , Oslo , Norway
4 Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences , Wrocław , Poland
1 Department of Dermatology, Medical University of Vienna , Vienna , Austria
3 Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University , Newcastle upon Tyne , United Kingdom
6 Department of Internal Medicine, Division of Hematology, Medical University of Graz , Graz , Austria
2 CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences , Vienna , Austria
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Cites_doi 10.1172/jci.insight.97011
10.4049/jimmunol.166.12.7309
10.4049/jimmunol.0804268
10.1182/bloodadvances.2020003005
10.1182/bloodadvances.2019000362
10.1038/nm915
10.1038/s41385-022-00527-6
10.1182/blood.2019003369
10.1186/s13045-022-01287-3
10.1182/blood-2005-07-2775
10.1172/jci129965
10.1182/blood-2006-10-052720
10.1038/nature06244
10.1016/j.cell.2016.10.020
10.1182/blood-2018-03-838193
10.1084/jem.20082387
10.1038/s41467-018-03704-z
10.1002/(sici)1096-8652(199606)52:2<82::Aid-ajh3>3.0.Co;2-1
10.1182/blood-2017-05-786137
10.1172/jci41072
10.1016/j.immuni.2013.08.003
10.1182/blood-2013-02-485813
10.3389/fimmu.2020.01534
10.4049/jimmunol.173.4.2392
10.1182/blood-2007-09-077438
10.1182/bloodadvances.2019000631
10.1182/blood-2013-12-543736
10.1084/jem.190.10.1505
10.1182/blood.2021012561
10.1182/blood.2021011671
10.3892/mmr.2013.1759
10.1038/ni1138
10.1371/journal.pone.0116896
10.4049/jimmunol.0903006
10.1007/s00281-018-0679-8
10.1182/blood-2016-05-717652
10.1186/s40164-022-00286-x
10.1182/blood-2013-06-507947
10.1084/jem.20150376
10.1182/blood-2008-09-177840
10.1182/blood-2012-06-438911
10.1016/0024-3205(65)90011-1
10.1016/j.bbmt.2018.11.007
10.1155/2014/143463
10.1016/j.bbmt.2012.11.008
10.1186/s12967-020-02386-w
10.1016/j.immuni.2023.01.003
10.2307/3573066
10.1038/ni1197
10.1182/blood-2013-03-484642
10.17219/acem/155373
10.1086/515579
10.1182/blood-2011-12-401166
10.1182/blood-2005-03-1257
10.1172/jci135468
10.1111/cei.13422
10.1016/j.bbmt.2016.09.006
10.1073/pnas.1414189111
10.1126/sciimmunol.abe2634
10.1038/nature17655
10.1038/icb.2015.33
10.1084/jem.20051787
10.1038/nature04753
10.1038/s41564-021-00989-7
10.3389/fcell.2021.737880
10.1200/jco.21.01755
10.1136/bmjopen-2021-053674
10.1016/j.bbmt.2012.03.005
10.1182/blood-2015-09-668251
10.3389/fonc.2021.705568
10.1182/blood.2019003186
10.1182/blood-2014-04-571125
10.1172/jci.insight.169732
10.1038/icb.2010.78
10.1182/blood-2007-01-071043
10.1182/blood-2007-08-106286
10.18632/oncotarget.5952
10.1002/1521-4141(200109)31:9<2680::aid-immu2680>3.0.co;2-a
10.1182/blood-2014-11-613323
10.1016/j.bbmt.2012.07.009
10.1182/blood-2004-09-3660
10.1371/journal.pone.0158242
10.1126/sciimmunol.aah7152
10.1182/blood-2010-10-316125
10.1158/1078-0432.Ccr-07-1290
10.1007/s00251-021-01247-0
10.1056/NEJMoa1900623
10.3390/cells9112457
10.1182/blood-2017-05-782466
10.1182/blood-2005-04-1644
10.15252/embr.201948925
10.1182/blood-2009-05-222190
10.1182/blood-2006-08-044529
10.3390/cancers13112673
10.4049/jimmunol.177.9.6192
10.1182/blood-2006-12-022038
10.1016/j.bbmt.2016.09.023
10.1016/j.bbmt.2011.05.011
10.1182/bloodadvances.2017011478
10.1182/blood-2015-11-682377
10.3389/fimmu.2020.00422
10.1126/scitranslmed.aaa6853
10.1084/jem.189.5.787
10.1084/jem.20091777
10.1182/blood-2004-10-4113
10.1038/bmt.2016.66
10.1038/s41592-019-0667-5
10.1016/j.celrep.2014.05.011
10.1200/jco.22.00509
10.3389/fimmu.2021.761616
10.1038/s41596-020-0292-x
10.1182/blood-2006-04-019059
10.3389/fimmu.2017.01937
10.1182/blood.2020009050
10.3389/fimmu.2021.783907
10.3389/fimmu.2016.00507
10.1016/j.bbmt.2014.01.002
10.1016/j.jtct.2022.12.015
10.1182/blood-2013-10-533562
10.1182/blood-2010-07-299073
10.3389/fimmu.2019.00988
10.1182/blood-2010-07-295766
10.3390/ijms24098126
10.1182/bloodadvances.2017014977
10.1126/science.1068440
10.1182/blood-2014-09-599159
10.1126/science.285.5426.412
10.1182/blood-2014-05-573303
10.1200/jco.20.02754
10.1182/blood-2013-07-514372
10.4049/jimmunol.177.7.4414
10.3324/haematol.2022.280653
10.1111/j.1399-0039.1997.tb02804.x
10.1097/MOT.0000000000000701
10.1016/j.celrep.2022.110819
10.3324/haematol.2017.170928
10.1158/2159-8290.Cd-21-1207
10.4049/jimmunol.2100025
10.1016/j.immuni.2011.03.023
10.1056/NEJMoa1108188
10.3389/fimmu.2017.00465
10.1016/j.immuni.2019.06.003
10.1182/blood-2012-06-435008
10.1038/s41467-021-21246-9
10.1182/blood-2009-06-227587
10.1126/scitranslmed.3008941
10.1038/nm.3179
10.1182/blood-2012-11-465658
10.1007/s12079-018-0448-4
10.1016/j.immuni.2017.02.019
10.1097/00007890-199308000-00031
10.1080/20013078.2017.1294368
10.1172/JCI125797
10.1182/bloodadvances.2021005103
10.1016/j.bbmt.2015.04.016
10.1182/blood-2009-03-209635
10.1038/ni1582
10.1007/s00005-016-0438-2
10.1084/jem.20081633
10.1182/blood-2014-02-554725
10.1073/pnas.0812874106
10.1172/jci136774
10.1093/cid/cix699
10.1038/s41592-022-01657-2
10.1016/j.exphem.2005.12.011
10.1056/NEJMra1703472
10.1038/nature12726
10.4049/jimmunol.180.4.2284
10.1038/ni.3400
10.1182/blood-2011-04-347070
10.1093/intimm/dxf048
10.1172/jci.insight.92111
10.1016/j.jaci.2020.01.042
10.1182/blood-2005-01-0220
10.1002/advs.201802219
10.1038/s41598-022-17944-z
10.1038/jid.2009.176
10.1172/jci89535
10.4049/jimmunol.180.2.850
10.7554/eLife.76319
10.4049/jimmunol.161.2.571
10.1111/trf.14964
10.1038/nm0602-575
10.4049/jimmunol.175.1.207
10.1182/blood.2020007158
10.1007/s00005-011-0137-y
10.1084/jem.20202345
10.1182/blood-2003-03-0984
10.1002/ajh.23885
10.1111/iji.12523
10.1182/blood-2011-06-358747
10.1182/blood-2005-09-3623
10.1016/j.bbmt.2014.11.010
10.1016/j.immuni.2014.05.019
10.1038/nature08821
10.1056/NEJMoa2033122
10.1038/srep36479
10.3389/fimmu.2022.891925
10.1182/blood-2013-05-494278
10.1084/jem.188.5.953
10.1038/ni854
10.1182/blood-2017-01-758854
10.1002/eji.201343388
10.4049/jimmunol.170.7.3572
10.3389/fimmu.2014.00662
10.1038/s41592-022-01692-z
10.1182/blood-2015-12-688895
10.3389/fimmu.2019.01879
10.4049/jimmunol.1102243
10.1182/blood-2014-03-562231
10.3389/fimmu.2022.1045168
10.3389/fimmu.2016.00144
10.1096/fj.201800636R
10.1097/dad.0000000000000357
10.1182/blood-2011-07-364414
10.1084/jem.20010934
10.1189/jlb.0911480
10.1084/jem.20211239
10.1038/s41409-023-02001-8
10.7326/0003-4819-109-6-461
10.1126/scitranslmed.abb7028
10.1182/blood.2021013054
10.1182/blood-2005-07-2696
10.1038/nrmicro2974
10.3389/fimmu.2012.00336
10.1172/jci124218
10.4049/jimmunol.0903670
10.1182/blood-2007-08-109678
10.1084/jem.20010938
10.1016/j.immuni.2023.01.007
10.1158/1078-0432.Ccr-21-4176
10.1084/jem.20011149
10.1084/jem.20210417
10.1182/blood-2015-10-678706
10.1126/science.1240537
10.4049/jimmunol.179.6.3872
10.1182/blood-2004-03-0824
10.1172/jci75328
10.1182/blood-2010-08-300954
10.1152/ajpcell.00204.2015
10.3390/ijms17111797
10.1084/jem.20170418
10.1126/sciimmunol.aay8556
10.1016/j.jid.2020.04.018
10.1016/j.immuni.2011.11.011
10.1182/blood-2018-07-863233
10.3389/fimmu.2022.1005031
10.1182/blood-2008-12-191833
10.1182/blood.2021012021
10.1038/icb.2010.64
10.1016/j.bbmt.2007.10.009
10.3390/cells10061420
10.1038/s41467-017-00880-2
10.1182/blood-2016-02-702852
10.1172/jci.insight.162180
10.1084/jem.20030788
10.1002/sctm.20-0099
10.1038/nm1038
10.1172/jci75935
10.1016/j.immuni.2016.09.009
10.1172/jci133909
10.1074/jbc.M116.769893
10.3389/fimmu.2021.816231
10.1016/j.jtct.2021.05.004
10.1182/blood.v99.7.2586
10.1038/bmt.2013.215
10.1016/j.immuni.2019.08.011
10.1007/s10616-019-00294-6
10.1126/science.1077002
10.1186/s12934-022-01812-6
10.1126/scitranslmed.3006960
10.1073/pnas.1521230113
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Copyright © 2023 Gail, Schell, Łacina, Strobl, Bolton, Steinbakk Ulriksen, Bogunia-Kubik, Greinix, Crossland, Inngjerdingen and Stary 2023 Gail, Schell, Łacina, Strobl, Bolton, Steinbakk Ulriksen, Bogunia-Kubik, Greinix, Crossland, Inngjerdingen and Stary
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Keywords hematopoietic stem cell transplantation
immune cell networks
GvHD pathogenesis
cell-cell communication
chronic graft-versus-host disease
Language English
License Copyright © 2023 Gail, Schell, Łacina, Strobl, Bolton, Steinbakk Ulriksen, Bogunia-Kubik, Greinix, Crossland, Inngjerdingen and Stary.
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Edited by: Tomomi Toubai, Yamagata University, Japan
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PublicationTitle Frontiers in immunology
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References Haniffa (B208) 2009; 206
Fernandez-Messina (B116) 2020; 21
Zhang (B31) 2017; 2
Noren Hooten (B3) 2022; 12
Klangsinsirikul (B199) 2002; 99
Zavaro (B216) 2023; 24
Huntington (B139) 2015; 6
Dubovsky (B86) 2014; 124
Cutler (B41) 2021; 138
Zotos (B107) 2010; 207
Weber (B247) 2016; 51
Forcade (B36) 2016; 127
Nakasone (B95) 2015; 125
Greinix (B46) 2015; 21
Hakim (B63) 1997
Kim (B213) 2009; 129
Malard (B73) 2017; 130
Serpenti (B173) 2021; 11
Greco (B241) 2021; 137
Beura (B56) 2016; 532
Torri (B61) 2017; 292
He (B263) 2020; 145
Lv (B38) 2022; 11
West (B206) 2022; 39
Deniz (B153) 2008; 180
Ardolino (B150) 2011; 117
Wu (B17) 2022; 6
Bartsch (B53) 2020; 9
Zeng (B225) 2018; 40
Jasperson (B254) 2009; 114
DeFilipp (B273) 2021; 27
Brüggen (B10) 2014; 123
Flynn (B19) 2016; 127
Allen (B80) 2012; 120
Choi (B108) 2011; 34
Kennedy (B200) 2021; 137
Lu (B115) 2019; 6
Rolling (B230) 2021; 6
Jardine (B197) 2020; 130
Smallwood (B113) 2016; 128
Zelante (B252) 2013; 39
Moesta (B125) 2012; 3
Srinivasan (B103) 2012; 119
Kariminia (B178) 2017; 102
Granot (B209) 2017; 46
Khoder (B89) 2014; 124
Svegliati (B102) 2007; 110
Pérez-Cruz (B260) 2015; 10
Merad (B192) 2004; 10
Fu (B258) 2019; 51
Kuzmina (B99) 2015; 90
Collin (B194) 2006; 203
Vincent-Schneider (B224) 2002; 14
Bettelli (B15) 2006; 441
Boberg (B161) 2020; 9
Le Huu (B90) 2013; 121
Li (B13) 2018; 9
Zorn (B21) 2005; 106
McQuaid (B184) 2020; 200
Kordelas (B142) 2016; 17
Ghadially (B164) 2013; 43
Rambaldi (B182) 2021; 5
Sarantopoulos (B78) 2009; 113
Glaab (B272) 2021; 11
Qiu (B250) 2012; 36
Poe (B82) 2017; 130
Winter (B126) 1998; 161
Najar (B157) 2019; 71
Ozaki (B105) 2002; 298
Kong (B110) 2021; 131
Miklos (B93) 2005; 105
Viaud (B242) 2013; 342
Laouar (B147) 2005; 6
Jin (B270) 2021; 12
Sarantopoulos (B77) 2007; 13
Sacirbegovic (B62) 2023; 56
Ryu (B48) 2020; 18
Zhang (B92) 2006; 107
Khoder (B72) 2017; 8
Kuzmina (B79) 2013; 121
Bottino (B140) 2003; 198
Sivori (B163) 2011; 117
Forcade (B16) 2017; 2
Song (B265) 2022; 12
Foley (B172) 2011; 118
Cantoni (B131) 1999; 189
Shlomchik (B195) 1999; 285
Segura (B220) 2005; 106
Nolte-'t Hoen (B221) 2013; 93
Tao (B18) 2015; 309
Golob (B240) 2017; 65
Lia (B7) 2020; 11
Whangbo (B25) 2019; 3
Vivier (B121) 2008; 9
Teshima (B189) 2002; 8
Mezrich (B253) 2010; 185
Adams (B205) 2022; 139
Dubovsky (B85) 2013; 122
Jong (B185) 2017; 6
Zeiser (B8) 2017; 377
Fujii (B98) 2008; 111
Morelli (B223) 2004; 104
Durakovic (B193) 2006; 177
Sommer (B228) 2013; 11
Kalhs (B64) 1988; 109
Chatterjee (B156) 2014; 5
Fischer (B57) 2015; 37
Talvard-Balland (B32) 2021; 141
Shinners (B84) 2007; 179
Levine (B255) 2013; 122
Vu (B106) 2008; 180
Greinix (B69) 2008; 14
Wikoff (B249) 2009; 106
Lia (B5) 2021; 12
Okoye (B60) 2014; 41
Mushtaq (B119) 2022; 13
Matsuoka (B22) 2010; 120
Teijaro (B54) 2011; 187
Cerboni (B151) 2007; 110
Storek (B65) 1996; 52
Kariminia (B180) 2016; 127
Kolupaev (B68) 2018; 2
Rabinovich (B152) 2003; 170
Sumii (B111) 2023; 8
Kowal (B2) 2016; 113
Yoon (B14) 2016; 213
Koyama (B215) 2019; 51
Seike (B233) 2023; 56
Spoerl (B39) 2014; 123
Markey (B210) 2009; 113
Kanakry (B33) 2013; 5
Heine (B201) 2013; 122
Garg (B136) 2006; 177
Takashima (B259) 2019; 4
Deng (B109) 2017; 8
Connell (B231) 1965; 4
Gauthier (B49) 2018; 2
Łacina (B217) 2022; 32
Kakihana (B262) 2016; 128
Strobl (B55) 2021; 218
Wang (B114) 2014; 9
Wachsmuth (B34) 2019; 129
Pende (B132) 1999; 190
Minculescu (B187) 2016; 22
Lundberg (B59) 2016; 6
Podgorny (B179) 2014; 20
Nalle (B177) 2014; 6
Pegram (B122) 2011; 89
Rozmus (B74) 2019; 25
Gerosa (B146) 2002; 195
Ruggeri (B162) 2002; 295
Olson (B176) 2009; 183
Xie (B266) 2021; 12
Pessino (B133) 1998; 188
Liang (B261) 2022; 21
Malard (B11) 2014; 49
McDonald-Hyman (B96) 2015; 7
Koreth (B26) 2011; 365
Poe (B76) 2023; 8
de Masson (B71) 2015; 125
Bastian (B12) 2019; 10
Markey (B239) 2020; 136
Golob (B248) 2019; 3
Miklos (B94) 2004; 103
Fredricks (B234) 2019; 129
Du (B207) 2017; 129
Bost (B267) 2022; 20
Nguyen (B23) 2007; 109
Siemaszko (B129) 2021; 10
Zeiser (B40) 2021; 385
Peled (B237) 2020; 382
Arnon (B134) 2001; 31
Lee (B154) 2009; 206
Alawam (B9) 2022; 219
Nguyen (B170) 2005; 105
Qin (B226) 2010; 464
Pende (B144) 2006; 107
Buschow (B218) 2010; 88
Fedoriw (B66) 2012; 18
Miklos (B87) 2023; 41
Glauzy (B67) 2014; 124
Tian (B212) 2021; 131
Divito (B51) 2020; 130
Faridi (B127) 2016; 11
Taur (B238) 2014; 124
Efremova (B269) 2020; 15
Mathewson (B246) 2016; 17
Sheng (B166) 2020; 11
Lin (B83) 2023; 29
Nicholls (B29) 2021; 9
Skogberg (B58) 2015; 93
Chung (B214) 2017; 127
Chakraverty (B190) 2007; 110
Patriarca (B97) 2006; 34
Thomas (B159) 2014; 2014
van der Velden (B229) 2013; 19
Zheng (B45) 2008; 111
Warren (B138) 2005; 175
Kim (B271) 2022; 19
Ogonek (B117) 2016; 7
Schirmer (B245) 2016; 167
Rozmus (B149) 2011; 17
Zhang (B44) 2012; 18
Radojcic (B91) 2010; 184
Mavoungou (B137) 2007; 195
Brehm (B196) 2019; 33
Daenthanasanmak (B37) 2019; 133
Palaniyandi (B88) 2023
Bleakley (B47) 2022; 40
Bloushtain (B135) 2004; 173
Turnbaugh (B227) 2007; 449
Arpaia (B244) 2013; 504
Edinger (B24) 2003; 9
Najar (B158) 2018; 12
Nakamizo (B264) 2021; 218
Chen (B4) 2019; 24
Flynn (B104) 2014; 123
Jones (B232) 1971; 45
Ghadially (B165) 2014; 7
Swimm (B251) 2018; 132
McCurdy (B174) 2022; 139
Nishiwaki (B204) 2009; 114
Eriguchi (B257) 2012; 120
Xun (B168) 1993; 56
Caligiuri (B171) 2008; 112
Jansen (B235) 2022; 15
Alexander (B198) 2014; 124
Zanin-Zhorov (B20) 2014; 111
Piccioli (B145) 2002; 195
Iwaszko (B141) 2011; 59
Hayase (B256) 2017; 214
Bogunia-Kubik (B130) 2021; 48
Kuzmina (B100) 2011; 117
Przepiorka (B43) 2022; 28
Jenq (B236) 2015; 21
Wilson (B124) 1997; 49
Olson (B175) 2010; 115
Blaser (B191) 2006; 108
Allen (B81) 2014; 123
Jagasia (B42) 2021; 39
Ferlazzo (B143) 2002; 195
Gagliani (B30) 2013; 19
Théry (B219) 2001; 166
Zhao (B35) 2022; 15
Iniesta (B183) 2018; 58
Martín-Fontecha (B148) 2004; 5
Olivieri (B101) 2013; 122
Koreth (B27) 2016; 128
Dosil (B186) 2022; 11
Spaggiari (B155) 2006; 107
Cooley (B167) 2005; 106
Ullah (B169) 2016; 7
Phan (B112) 2021; 207
Rogatko-Koroś (B128) 2016; 64
Devillier (B118) 2021; 13
Downing (B123) 2022; 74
Wang (B188) 2011; 118
Li (B203) 2011; 117
Zhu (B211) 2022; 140
Cooke (B1) 2017; 23
Schultz (B75) 2020; 135
Daillère (B243) 2016; 45
Kelly (B160) 2021; 12
Lawitschka (B70) 2019; 10
Meguri (B28) 2022; 13
Santos (B202) 2018; 3
de Almeida (B50) 2022; 7
Théry (B222) 2002; 3
Browaeys (B268) 2020; 17
Strobl (B52) 2020; 12
Simonetta (B120) 2017; 8
Lauener (B181) 2022; 108
Doglio (B6) 2022; 13
References_xml – volume: 3
  year: 2018
  ident: B202
  article-title: Peripheral tissues reprogram CD8+ t cells for pathogenicity during graft-versus-host disease
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.97011
  contributor:
    fullname: Santos
– volume: 166
  year: 2001
  ident: B219
  article-title: Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles
  publication-title: J Immunol
  doi: 10.4049/jimmunol.166.12.7309
  contributor:
    fullname: Théry
– volume: 183
  year: 2009
  ident: B176
  article-title: Tissue-specific homing and expansion of donor NK cells in allogeneic bone marrow transplantation
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0804268
  contributor:
    fullname: Olson
– volume: 5
  year: 2021
  ident: B182
  article-title: Impaired t- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2020003005
  contributor:
    fullname: Rambaldi
– volume: 3
  year: 2019
  ident: B248
  article-title: Butyrogenic bacteria after acute graft-versus-host disease (GVHD) are associated with the development of steroidrefractory GVHD
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2019000362
  contributor:
    fullname: Golob
– volume: 9
  year: 2003
  ident: B24
  article-title: CD4+CD25+ regulatory t cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
  publication-title: Nat Med
  doi: 10.1038/nm915
  contributor:
    fullname: Edinger
– volume: 15
  year: 2022
  ident: B235
  article-title: Challenges and opportunities targeting mechanisms of epithelial injury and recovery in acute intestinal graft-versus-host disease
  publication-title: Mucosal Immunol
  doi: 10.1038/s41385-022-00527-6
  contributor:
    fullname: Jansen
– volume: 136
  year: 2020
  ident: B239
  article-title: The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD
  publication-title: Blood
  doi: 10.1182/blood.2019003369
  contributor:
    fullname: Markey
– volume: 15
  start-page: 64
  year: 2022
  ident: B35
  article-title: Post-transplant cyclophosphamide alters immune signatures and leads to impaired t cell reconstitution in allogeneic hematopoietic stem cell transplant
  publication-title: J Hematol Oncol
  doi: 10.1186/s13045-022-01287-3
  contributor:
    fullname: Zhao
– volume: 107
  year: 2006
  ident: B155
  article-title: Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation
  publication-title: Blood
  doi: 10.1182/blood-2005-07-2775
  contributor:
    fullname: Spaggiari
– volume: 130
  year: 2020
  ident: B51
  article-title: Peripheral host t cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease
  publication-title: J Clin Invest
  doi: 10.1172/jci129965
  contributor:
    fullname: Divito
– volume: 110
  year: 2007
  ident: B151
  article-title: Antigen-activated human t lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis
  publication-title: Blood
  doi: 10.1182/blood-2006-10-052720
  contributor:
    fullname: Cerboni
– volume: 449
  year: 2007
  ident: B227
  article-title: The human microbiome project
  publication-title: Nature
  doi: 10.1038/nature06244
  contributor:
    fullname: Turnbaugh
– volume: 167
  start-page: 1125
  year: 2016
  ident: B245
  article-title: Linking the human gut microbiome to inflammatory cytokine production capacity
  publication-title: Cell
  doi: 10.1016/j.cell.2016.10.020
  contributor:
    fullname: Schirmer
– volume: 132
  year: 2018
  ident: B251
  article-title: Indoles derived from intestinal microbiota act via type i interferon signaling to limit graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2018-03-838193
  contributor:
    fullname: Swimm
– volume: 206
  year: 2009
  ident: B154
  article-title: Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 t cell regulation during viral infection
  publication-title: J Exp Med
  doi: 10.1084/jem.20082387
  contributor:
    fullname: Lee
– volume: 9
  start-page: 1420
  year: 2018
  ident: B13
  article-title: Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-03704-z
  contributor:
    fullname: Li
– volume: 52
  year: 1996
  ident: B65
  article-title: Lack of b cells precursors in marrow transplant recipients with chronic graft-versus-host disease
  publication-title: Am J Hematol
  doi: 10.1002/(sici)1096-8652(199606)52:2<82::Aid-ajh3>3.0.Co;2-1
  contributor:
    fullname: Storek
– volume: 130
  year: 2017
  ident: B73
  article-title: Rituximab-based first-line treatment of cGVHD after allogeneic SCT: results of a phase 2 study
  publication-title: Blood
  doi: 10.1182/blood-2017-05-786137
  contributor:
    fullname: Malard
– volume: 120
  year: 2010
  ident: B22
  article-title: Altered regulatory t cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation
  publication-title: J Clin Invest
  doi: 10.1172/jci41072
  contributor:
    fullname: Matsuoka
– volume: 39
  year: 2013
  ident: B252
  article-title: Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22
  publication-title: Immunity
  doi: 10.1016/j.immuni.2013.08.003
  contributor:
    fullname: Zelante
– volume: 122
  year: 2013
  ident: B255
  article-title: Low paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality
  publication-title: Blood
  doi: 10.1182/blood-2013-02-485813
  contributor:
    fullname: Levine
– volume: 11
  year: 2020
  ident: B166
  article-title: Cytotoxicity of donor natural killer cells to allo- reactive t cells are related with acute graft-vs.-Host-Disease following allogeneic stem cell transplantation
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.01534
  contributor:
    fullname: Sheng
– volume: 173
  year: 2004
  ident: B135
  article-title: Membrane-associated heparan sulfate proteoglycans are involved in the recognition of cellular targets by NKp30 and NKp46
  publication-title: J Immunol
  doi: 10.4049/jimmunol.173.4.2392
  contributor:
    fullname: Bloushtain
– volume: 112
  year: 2008
  ident: B171
  article-title: Human natural killer cells
  publication-title: Blood
  doi: 10.1182/blood-2007-09-077438
  contributor:
    fullname: Caligiuri
– volume: 3
  year: 2019
  ident: B25
  article-title: Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2019000631
  contributor:
    fullname: Whangbo
– volume: 123
  year: 2014
  ident: B39
  article-title: Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2013-12-543736
  contributor:
    fullname: Spoerl
– volume: 190
  year: 1999
  ident: B132
  article-title: Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
  publication-title: J Exp Med
  doi: 10.1084/jem.190.10.1505
  contributor:
    fullname: Pende
– volume: 140
  year: 2022
  ident: B211
  article-title: Donor plasmacytoid dendritic cells limit graftversus-host disease through vasoactive intestinal polypeptide expression
  publication-title: Blood
  doi: 10.1182/blood.2021012561
  contributor:
    fullname: Zhu
– volume: 139
  year: 2022
  ident: B205
  article-title: Donor bone marrow-derived macrophage MHC II drives neuroinflammation and altered behavior during chronic GVHD in mice
  publication-title: Blood
  doi: 10.1182/blood.2021011671
  contributor:
    fullname: Adams
– volume: 9
  year: 2014
  ident: B114
  article-title: More efficient induction of antitumor t cell immunity by exosomes from CD40L gene-modified lung tumor cells
  publication-title: Mol Med Rep
  doi: 10.3892/mmr.2013.1759
  contributor:
    fullname: Wang
– volume: 5
  year: 2004
  ident: B148
  article-title: Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
  publication-title: Nat Immunol
  doi: 10.1038/ni1138
  contributor:
    fullname: Martín-Fontecha
– volume: 10
  year: 2015
  ident: B260
  article-title: Outer-inner membrane vesicles naturally secreted by gram-negative pathogenic bacteria
  publication-title: PloS One
  doi: 10.1371/journal.pone.0116896
  contributor:
    fullname: Pérez-Cruz
– volume: 184
  year: 2010
  ident: B91
  article-title: STAT3 signaling in CD4+ t cells is critical for the pathogenesis of chronic sclerodermatous graft-versus-host disease in a murine model
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0903006
  contributor:
    fullname: Radojcic
– volume: 40
  year: 2018
  ident: B225
  article-title: Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer
  publication-title: Semin Immunopathol
  doi: 10.1007/s00281-018-0679-8
  contributor:
    fullname: Zeng
– volume: 128
  year: 2016
  ident: B262
  article-title: Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut
  publication-title: Blood
  doi: 10.1182/blood-2016-05-717652
  contributor:
    fullname: Kakihana
– volume: 11
  start-page: 34
  year: 2022
  ident: B38
  article-title: IL-39 promotes chronic graft-versus-host disease by increasing t and b cell pathogenicity
  publication-title: Exp Hematol Oncol
  doi: 10.1186/s40164-022-00286-x
  contributor:
    fullname: Lv
– volume: 122
  year: 2013
  ident: B85
  article-title: Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in t lymphocytes
  publication-title: Blood
  doi: 10.1182/blood-2013-06-507947
  contributor:
    fullname: Dubovsky
– volume: 213
  year: 2016
  ident: B14
  article-title: IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization
  publication-title: J Exp Med
  doi: 10.1084/jem.20150376
  contributor:
    fullname: Yoon
– volume: 113
  year: 2009
  ident: B78
  article-title: Altered b-cell homeostasis and excess BAFF in human chronic graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2008-09-177840
  contributor:
    fullname: Sarantopoulos
– volume: 120
  year: 2012
  ident: B80
  article-title: B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways
  publication-title: Blood
  doi: 10.1182/blood-2012-06-438911
  contributor:
    fullname: Allen
– volume: 4
  year: 1965
  ident: B231
  article-title: The treatment of x-irradiated germfree CFW and C3H mice with isologous and homologous bone marrow
  publication-title: Life Sci
  doi: 10.1016/0024-3205(65)90011-1
  contributor:
    fullname: Connell
– volume: 25
  year: 2019
  ident: B74
  article-title: Comprehensive b cell phenotyping profile for chronic graft-versus-Host disease diagnosis
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2018.11.007
  contributor:
    fullname: Rozmus
– volume: 2014
  year: 2014
  ident: B159
  article-title: Interaction with mesenchymal stem cells provokes natural killer cells for enhanced IL-12/IL-18-induced interferon-gamma secretion
  publication-title: Mediators Inflammation
  doi: 10.1155/2014/143463
  contributor:
    fullname: Thomas
– volume: 19
  year: 2013
  ident: B229
  article-title: Role of the mycobiome in human acute graft-versus-host disease
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2012.11.008
  contributor:
    fullname: van der Velden
– volume: 18
  start-page: 225
  year: 2020
  ident: B48
  article-title: FTY720 ameliorates GvHD by blocking t lymphocyte migration to target organs and by skin fibrosis inhibition
  publication-title: J Transl Med
  doi: 10.1186/s12967-020-02386-w
  contributor:
    fullname: Ryu
– volume: 56
  start-page: 369
  year: 2023
  ident: B62
  article-title: Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like t cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2023.01.003
  contributor:
    fullname: Sacirbegovic
– volume: 45
  year: 1971
  ident: B232
  article-title: Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras
  publication-title: Radiat Res
  doi: 10.2307/3573066
  contributor:
    fullname: Jones
– volume: 6
  year: 2005
  ident: B147
  article-title: Transforming growth factor-beta controls t helper type 1 cell development through regulation of natural killer cell interferon-gamma
  publication-title: Nat Immunol
  doi: 10.1038/ni1197
  contributor:
    fullname: Laouar
– volume: 122
  year: 2013
  ident: B201
  article-title: The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo
  publication-title: Blood
  doi: 10.1182/blood-2013-03-484642
  contributor:
    fullname: Heine
– volume: 32
  year: 2022
  ident: B217
  article-title: Differential expression of miRNAs from extracellular vesicles in chronic graft-versus-host disease: A preliminary study
  publication-title: Adv Clin Exp Med
  doi: 10.17219/acem/155373
  contributor:
    fullname: Łacina
– volume: 195
  year: 2007
  ident: B137
  article-title: A duffy binding-like domain is involved in the NKp30-mediated recognition of plasmodium falciparum-parasitized erythrocytes by natural killer cells
  publication-title: J Infect Dis
  doi: 10.1086/515579
  contributor:
    fullname: Mavoungou
– volume: 120
  year: 2012
  ident: B257
  article-title: Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting paneth cell production of α-defensins
  publication-title: Blood
  doi: 10.1182/blood-2011-12-401166
  contributor:
    fullname: Eriguchi
– volume: 106
  year: 2005
  ident: B21
  article-title: Reduced frequency of FOXP3+ CD4+CD25+ regulatory t cells in patients with chronic graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2005-03-1257
  contributor:
    fullname: Zorn
– volume: 131
  year: 2021
  ident: B110
  article-title: Tissue-resident PSGL1loCD4+ t cells promote b cell differentiation and chronic graft-versus-host disease-associated autoimmunity
  publication-title: J Clin Invest
  doi: 10.1172/jci135468
  contributor:
    fullname: Kong
– volume: 200
  year: 2020
  ident: B184
  article-title: Low-dose IL-2 induces CD56(bright) NK regulation of t cells via NKp44 and NKp46
  publication-title: Clin Exp Immunol
  doi: 10.1111/cei.13422
  contributor:
    fullname: McQuaid
– volume: 22
  year: 2016
  ident: B187
  article-title: Early natural killer cell reconstitution predicts overall survival in t cell-replete allogeneic hematopoietic stem cell transplantation
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2016.09.006
  contributor:
    fullname: Minculescu
– volume: 111
  year: 2014
  ident: B20
  article-title: Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human t cells via STAT3-dependent mechanism
  publication-title: Proc Natl Acad Sci U.S.A.
  doi: 10.1073/pnas.1414189111
  contributor:
    fullname: Zanin-Zhorov
– volume: 7
  year: 2022
  ident: B50
  article-title: Human skin-resident host t cells can persist long term after allogeneic stem cell transplantation and maintain recirculation potential
  publication-title: Sci Immunol
  doi: 10.1126/sciimmunol.abe2634
  contributor:
    fullname: de Almeida
– volume: 532
  year: 2016
  ident: B56
  article-title: Normalizing the environment recapitulates adult human immune traits in laboratory mice
  publication-title: Nature
  doi: 10.1038/nature17655
  contributor:
    fullname: Beura
– volume: 93
  year: 2015
  ident: B58
  article-title: Human thymic epithelial primary cells produce exosomes carrying tissue-restricted antigens
  publication-title: Immunol Cell Biol
  doi: 10.1038/icb.2015.33
  contributor:
    fullname: Skogberg
– volume: 203
  start-page: 27
  year: 2006
  ident: B194
  article-title: The fate of human langerhans cells in hematopoietic stem cell transplantation
  publication-title: J Exp Med
  doi: 10.1084/jem.20051787
  contributor:
    fullname: Collin
– volume: 441
  year: 2006
  ident: B15
  article-title: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory t cells
  publication-title: Nature
  doi: 10.1038/nature04753
  contributor:
    fullname: Bettelli
– volume: 6
  year: 2021
  ident: B230
  article-title: Haematopoietic cell transplantation outcomes are linked to intestinal mycobiota dynamics and an expansion of candida parapsilosis complex species
  publication-title: Nat Microbiol
  doi: 10.1038/s41564-021-00989-7
  contributor:
    fullname: Rolling
– volume: 9
  year: 2021
  ident: B29
  article-title: Bone marrow regulatory t cells are a unique population, supported by niche-specific cytokines and plasmacytoid dendritic cells, and required for chronic graft-Versus-Host disease control
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2021.737880
  contributor:
    fullname: Nicholls
– volume: 40
  year: 2022
  ident: B47
  article-title: Naive t-cell depletion to prevent chronic graft-Versus-Host disease
  publication-title: J Clin Oncol
  doi: 10.1200/jco.21.01755
  contributor:
    fullname: Bleakley
– volume: 11
  year: 2021
  ident: B272
  article-title: Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2021-053674
  contributor:
    fullname: Glaab
– volume: 18
  year: 2012
  ident: B66
  article-title: Bone marrow b cell precursor number after allogeneic stem cell transplantation and GVHD development
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2012.03.005
  contributor:
    fullname: Fedoriw
– volume: 127
  year: 2016
  ident: B180
  article-title: Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells
  publication-title: Blood
  doi: 10.1182/blood-2015-09-668251
  contributor:
    fullname: Kariminia
– volume: 11
  year: 2021
  ident: B173
  article-title: Immune reconstitution-based score for risk stratification of chronic graft-Versus-Host disease patients
  publication-title: Front Oncol
  doi: 10.3389/fonc.2021.705568
  contributor:
    fullname: Serpenti
– volume: 135
  year: 2020
  ident: B75
  article-title: Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies
  publication-title: Blood
  doi: 10.1182/blood.2019003186
  contributor:
    fullname: Schultz
– volume: 124
  year: 2014
  ident: B89
  article-title: Regulatory b cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD
  publication-title: Blood
  doi: 10.1182/blood-2014-04-571125
  contributor:
    fullname: Khoder
– volume: 8
  start-page: e169732
  year: 2023
  ident: B76
  article-title: Single-cell landscape analysis unravels molecular programming of the human b cell compartment in chronic GVHD
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.169732
  contributor:
    fullname: Poe
– volume: 89
  year: 2011
  ident: B122
  article-title: Activating and inhibitory receptors of natural killer cells
  publication-title: Immunol Cell Biol
  doi: 10.1038/icb.2010.78
  contributor:
    fullname: Pegram
– volume: 110
  year: 2007
  ident: B102
  article-title: Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2007-01-071043
  contributor:
    fullname: Svegliati
– volume: 111
  year: 2008
  ident: B98
  article-title: Biomarkers in newly diagnosed pediatric-extensive chronic graft-versus-host disease: a report from the children's oncology group
  publication-title: Blood
  doi: 10.1182/blood-2007-08-106286
  contributor:
    fullname: Fujii
– volume: 6
  year: 2015
  ident: B139
  article-title: DNAM-1: would the real natural killer cell please stand up
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.5952
  contributor:
    fullname: Huntington
– volume: 31
  year: 2001
  ident: B134
  article-title: Recognition of viral hemagglutinins by NKp44 but not by NKp30
  publication-title: Eur J Immunol
  doi: 10.1002/1521-4141(200109)31:9<2680::aid-immu2680>3.0.co;2-a
  contributor:
    fullname: Arnon
– volume: 125
  year: 2015
  ident: B95
  article-title: Allogeneic HY antibodies detected 3 months after female-to-male HCT predict chronic GVHD and nonrelapse mortality in humans
  publication-title: Blood
  doi: 10.1182/blood-2014-11-613323
  contributor:
    fullname: Nakasone
– volume: 18
  year: 2012
  ident: B44
  article-title: Allospecific CD4(+) effector memory t cells do not induce graft-versus-host disease in mice
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2012.07.009
  contributor:
    fullname: Zhang
– volume: 105
  year: 2005
  ident: B93
  article-title: Antibody responses to h-y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission
  publication-title: Blood
  doi: 10.1182/blood-2004-09-3660
  contributor:
    fullname: Miklos
– volume: 11
  year: 2016
  ident: B127
  article-title: Donor-recipient matching for KIR genotypes reduces chronic GVHD and missing inhibitory KIR ligands protect against relapse after myeloablative, HLA matched hematopoietic cell transplantation
  publication-title: PloS One
  doi: 10.1371/journal.pone.0158242
  contributor:
    fullname: Faridi
– volume: 2
  year: 2017
  ident: B31
  article-title: Eomesodermin promotes the development of type 1 regulatory t (T(R)1) cells
  publication-title: Sci Immunol
  doi: 10.1126/sciimmunol.aah7152
  contributor:
    fullname: Zhang
– volume: 117
  year: 2011
  ident: B163
  article-title: Natural killer cells expressing the KIR2DS1-activating receptor efficiently kill t-cell blasts and dendritic cells: implications in haploidentical HSCT
  publication-title: Blood
  doi: 10.1182/blood-2010-10-316125
  contributor:
    fullname: Sivori
– volume: 13
  year: 2007
  ident: B77
  article-title: High levels of b-cell activating factor in patients with active chronic graft-versus-host disease
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.Ccr-07-1290
  contributor:
    fullname: Sarantopoulos
– volume: 74
  year: 2022
  ident: B123
  article-title: High-resolution human KIR genotyping
  publication-title: Immunogenetics
  doi: 10.1007/s00251-021-01247-0
  contributor:
    fullname: Downing
– volume: 382
  year: 2020
  ident: B237
  article-title: Microbiota as predictor of mortality in allogeneic hematopoietic-cell transplantation
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1900623
  contributor:
    fullname: Peled
– volume: 9
  year: 2020
  ident: B53
  article-title: Tissue-resident memory t cells in the liver-unique characteristics of local specialists
  publication-title: Cells
  doi: 10.3390/cells9112457
  contributor:
    fullname: Bartsch
– volume: 130
  year: 2017
  ident: B82
  article-title: An aberrant NOTCH2-BCR signaling axis in b cells from patients with chronic GVHD
  publication-title: Blood
  doi: 10.1182/blood-2017-05-782466
  contributor:
    fullname: Poe
– volume: 106
  year: 2005
  ident: B167
  article-title: KIR reconstitution is altered by t cells in the graft and correlates with clinical outcomes after unrelated donor transplantation
  publication-title: Blood
  doi: 10.1182/blood-2005-04-1644
  contributor:
    fullname: Cooley
– volume: 21
  year: 2020
  ident: B116
  article-title: Transfer of extracellular vesicle-microRNA controls germinal center reaction and antibody production
  publication-title: EMBO Rep
  doi: 10.15252/embr.201948925
  contributor:
    fullname: Fernandez-Messina
– volume: 115
  year: 2010
  ident: B175
  article-title: NK cells mediate reduction of GVHD by inhibiting activated, alloreactive t cells while retaining GVT effects
  publication-title: Blood
  doi: 10.1182/blood-2009-05-222190
  contributor:
    fullname: Olson
– volume: 109
  year: 2007
  ident: B23
  article-title: In vivo dynamics of regulatory t-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
  publication-title: Blood
  doi: 10.1182/blood-2006-08-044529
  contributor:
    fullname: Nguyen
– volume: 13
  year: 2021
  ident: B118
  article-title: Phase i trial of prophylactic donor-derived IL-2-Activated NK cell infusion after allogeneic hematopoietic stem cell transplantation from a matched sibling donor
  publication-title: Cancers
  doi: 10.3390/cancers13112673
  contributor:
    fullname: Devillier
– volume: 177
  year: 2006
  ident: B136
  article-title: Vimentin expressed on mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor
  publication-title: J Immunol
  doi: 10.4049/jimmunol.177.9.6192
  contributor:
    fullname: Garg
– volume: 110
  start-page: 9
  year: 2007
  ident: B190
  article-title: The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia
  publication-title: Blood
  doi: 10.1182/blood-2006-12-022038
  contributor:
    fullname: Chakraverty
– volume: 23
  year: 2017
  ident: B1
  article-title: The biology of chronic graft-versus-Host disease: A task force report from the national institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-Host disease
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2016.09.023
  contributor:
    fullname: Cooke
– volume-title: Graft-vs.-Host disease
  year: 1997
  ident: B63
  article-title: The immune system: effector and target of graft-versus-host-disease
  contributor:
    fullname: Hakim
– volume: 17
  year: 2011
  ident: B149
  article-title: Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the children's oncology group study ASCT0031
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2011.05.011
  contributor:
    fullname: Rozmus
– volume: 2
  year: 2018
  ident: B49
  article-title: Successful treatment with fingolimod of graft-versus-host disease of the central nervous system
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2017011478
  contributor:
    fullname: Gauthier
– volume: 128
  year: 2016
  ident: B113
  article-title: Extracellular vesicles released by CD40/IL-4-stimulated CLL cells confer altered functional properties to CD4+ t cells
  publication-title: Blood
  doi: 10.1182/blood-2015-11-682377
  contributor:
    fullname: Smallwood
– volume: 11
  year: 2020
  ident: B7
  article-title: Extracellular vesicles after allogeneic hematopoietic cell transplantation: Emerging role in post-transplant complications
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.00422
  contributor:
    fullname: Lia
– volume: 7
  start-page: 280rv282
  year: 2015
  ident: B96
  article-title: Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.aaa6853
  contributor:
    fullname: McDonald-Hyman
– volume: 189
  year: 1999
  ident: B131
  article-title: NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily
  publication-title: J Exp Med
  doi: 10.1084/jem.189.5.787
  contributor:
    fullname: Cantoni
– volume: 207
  year: 2010
  ident: B107
  article-title: IL-21 regulates germinal center b cell differentiation and proliferation through a b cell-intrinsic mechanism
  publication-title: J Exp Med
  doi: 10.1084/jem.20091777
  contributor:
    fullname: Zotos
– volume: 105
  year: 2005
  ident: B170
  article-title: NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect
  publication-title: Blood
  doi: 10.1182/blood-2004-10-4113
  contributor:
    fullname: Nguyen
– volume: 51
  year: 2016
  ident: B247
  article-title: Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation
  publication-title: Bone Marrow Transplant
  doi: 10.1038/bmt.2016.66
  contributor:
    fullname: Weber
– volume: 17
  year: 2020
  ident: B268
  article-title: NicheNet: modeling intercellular communication by linking ligands to target genes
  publication-title: Nat Methods
  doi: 10.1038/s41592-019-0667-5
  contributor:
    fullname: Browaeys
– volume: 7
  year: 2014
  ident: B165
  article-title: NK cell receptor NKp46 regulates graft-versus-host disease
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.05.011
  contributor:
    fullname: Ghadially
– volume: 41
  year: 2023
  ident: B87
  article-title: Ibrutinib for first-line treatment of chronic graft-Versus-Host disease: Results from the randomized phase III integrate study
  publication-title: J Clin Oncol
  doi: 10.1200/jco.22.00509
  contributor:
    fullname: Miklos
– volume: 12
  year: 2021
  ident: B160
  article-title: Mesenchymal stromal cells for the treatment of graft versus host disease
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.761616
  contributor:
    fullname: Kelly
– volume: 15
  year: 2020
  ident: B269
  article-title: CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes
  publication-title: Nat Protoc
  doi: 10.1038/s41596-020-0292-x
  contributor:
    fullname: Efremova
– volume: 108
  year: 2006
  ident: B191
  article-title: Trans-presentation of donor-derived interleukin 15 is necessary for the rapid onset of acute graft-versus-host disease but not for graft-versus-tumor activity
  publication-title: Blood
  doi: 10.1182/blood-2006-04-019059
  contributor:
    fullname: Blaser
– volume: 8
  year: 2017
  ident: B72
  article-title: Evidence for b cell exhaustion in chronic graft-versus-Host disease
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.01937
  contributor:
    fullname: Khoder
– volume: 137
  year: 2021
  ident: B200
  article-title: A phase 3 double-blind study of the addition of tocilizumab vs placebo to cyclosporin/methotrexate GVHD prophylaxis
  publication-title: Blood
  doi: 10.1182/blood.2020009050
  contributor:
    fullname: Kennedy
– volume: 12
  year: 2021
  ident: B266
  article-title: Single-cell sequencing analysis and weighted co-expression network analysis based on public databases identified that TNC is a novel biomarker for keloid
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.783907
  contributor:
    fullname: Xie
– volume: 7
  year: 2016
  ident: B117
  article-title: Immune reconstitution after allogeneic hematopoietic stem cell transplantation
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2016.00507
  contributor:
    fullname: Ogonek
– volume: 20
  year: 2014
  ident: B179
  article-title: Immune cell subset counts associated with graft-versus-host disease
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2014.01.002
  contributor:
    fullname: Podgorny
– volume: 29
  start-page: 179.e171
  year: 2023
  ident: B83
  article-title: A phase i trial of SYK inhibition with fostamatinib in the prevention and treatment of chronic graft-Versus-Host disease
  publication-title: Transplant Cell Ther
  doi: 10.1016/j.jtct.2022.12.015
  contributor:
    fullname: Lin
– volume: 123
  year: 2014
  ident: B81
  article-title: Increased BCR responsiveness in b cells from patients with chronic GVHD
  publication-title: Blood
  doi: 10.1182/blood-2013-10-533562
  contributor:
    fullname: Allen
– volume: 117
  start-page: 697
  year: 2011
  ident: B203
  article-title: Langerhans cells are not required for graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2010-07-299073
  contributor:
    fullname: Li
– volume: 10
  year: 2019
  ident: B12
  article-title: The IL-12 cytokine and receptor family in graft-vs.-Host disease
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.00988
  contributor:
    fullname: Bastian
– volume: 117
  year: 2011
  ident: B100
  article-title: Significant differences in bcell subpopulations characterize patients with chronic graft-versus-host disease-associated dysgammaglobulinemia
  publication-title: Blood
  doi: 10.1182/blood-2010-07-295766
  contributor:
    fullname: Kuzmina
– volume: 24
  year: 2023
  ident: B216
  article-title: The role of extracellular vesicles (EVs) in chronic graft vs. host disease, and the potential function of placental cell-derived EVs as a therapeutic tool
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms24098126
  contributor:
    fullname: Zavaro
– volume: 2
  year: 2018
  ident: B68
  article-title: Impaired bone marrow b-cell development in mice with a bronchiolitis obliterans model of cGVHD
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2017014977
  contributor:
    fullname: Kolupaev
– volume: 295
  year: 2002
  ident: B162
  article-title: Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
  publication-title: Science
  doi: 10.1126/science.1068440
  contributor:
    fullname: Ruggeri
– volume: 125
  year: 2015
  ident: B71
  article-title: CD24(hi)CD27⁺ and plasmablast-like regulatory b cells in human chronic graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2014-09-599159
  contributor:
    fullname: de Masson
– volume: 285
  year: 1999
  ident: B195
  article-title: Prevention of graft versus host disease by inactivation of host antigen-presenting cells
  publication-title: Science
  doi: 10.1126/science.285.5426.412
  contributor:
    fullname: Shlomchik
– volume: 124
  year: 2014
  ident: B67
  article-title: Impact of acute and chronic graft-versus-host disease on human b-cell generation and replication
  publication-title: Blood
  doi: 10.1182/blood-2014-05-573303
  contributor:
    fullname: Glauzy
– volume: 39
  year: 2021
  ident: B42
  article-title: ROCK2 inhibition with belumosudil (KD025) for the treatment of chronic graft-Versus-Host disease
  publication-title: J Clin Oncol
  doi: 10.1200/jco.20.02754
  contributor:
    fullname: Jagasia
– volume: 123
  year: 2014
  ident: B10
  article-title: Diverse t-cell responses characterize the different manifestations of cutaneous graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2013-07-514372
  contributor:
    fullname: Brüggen
– volume: 177
  year: 2006
  ident: B193
  article-title: Host-derived langerhans cells persist after MHC-matched allografting independent of donor t cells and critically influence the alloresponses mediated by donor lymphocyte infusions
  publication-title: J Immunol
  doi: 10.4049/jimmunol.177.7.4414
  contributor:
    fullname: Durakovic
– volume: 108
  year: 2022
  ident: B181
  article-title: CD56brightCD16- natural killer cells as an important regulatory mechanism in chronic graftversus-host disease
  publication-title: Haematologica
  doi: 10.3324/haematol.2022.280653
  contributor:
    fullname: Lauener
– volume: 49
  year: 1997
  ident: B124
  article-title: Genomic organization of a human killer cell inhibitory receptor gene
  publication-title: Tissue Antigens
  doi: 10.1111/j.1399-0039.1997.tb02804.x
  contributor:
    fullname: Wilson
– volume: 24
  year: 2019
  ident: B4
  article-title: Impact of extracellular vesicles on innate immunity
  publication-title: Curr Opin Organ Transplant
  doi: 10.1097/MOT.0000000000000701
  contributor:
    fullname: Chen
– volume: 39
  year: 2022
  ident: B206
  article-title: Loss of t cell tolerance in the skin following immunopathology is linked to failed restoration of the dermal niche by recruited macrophages
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2022.110819
  contributor:
    fullname: West
– volume: 102
  year: 2017
  ident: B178
  article-title: CD56(bright) natural killer regulatory cells in filgrastim primed donor blood or marrow products regulate chronic graft-versushost disease: the canadian blood and marrow transplant group randomized 0601 study results
  publication-title: Haematologica
  doi: 10.3324/haematol.2017.170928
  contributor:
    fullname: Kariminia
– volume: 12
  year: 2022
  ident: B265
  article-title: Genomic and single-cell landscape reveals novel drivers and therapeutic vulnerabilities of transformed cutaneous t-cell lymphoma
  publication-title: Cancer Discovery
  doi: 10.1158/2159-8290.Cd-21-1207
  contributor:
    fullname: Song
– volume: 207
  year: 2021
  ident: B112
  article-title: CD24 and IgM stimulation of b cells triggers transfer of functional b cell receptor to b cell recipients Via extracellular vesicles
  publication-title: J Immunol
  doi: 10.4049/jimmunol.2100025
  contributor:
    fullname: Phan
– volume: 34
  year: 2011
  ident: B108
  article-title: ICOS receptor instructs t follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.03.023
  contributor:
    fullname: Choi
– volume: 365
  year: 2011
  ident: B26
  article-title: Interleukin-2 and regulatory t cells in graft-versus-host disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1108188
  contributor:
    fullname: Koreth
– volume: 8
  year: 2017
  ident: B120
  article-title: Natural killer cells in graft-versus-Host-Disease after allogeneic hematopoietic cell transplantation
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00465
  contributor:
    fullname: Simonetta
– volume: 51
  start-page: 90
  year: 2019
  ident: B258
  article-title: T cell recruitment to the intestinal stem cell compartment drives immune-mediated intestinal damage after allogeneic transplantation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.06.003
  contributor:
    fullname: Fu
– volume: 121
  year: 2013
  ident: B79
  article-title: CD19(+)CD21(low) b cells and patients at risk for NIH-defined chronic graft-versus-host disease with bronchiolitis obliterans syndrome
  publication-title: Blood
  doi: 10.1182/blood-2012-06-435008
  contributor:
    fullname: Kuzmina
– volume: 12
  start-page: 1088
  year: 2021
  ident: B270
  article-title: Inference and analysis of cellcell communication using CellChat
  publication-title: Nat Commun
  doi: 10.1038/s41467-021-21246-9
  contributor:
    fullname: Jin
– volume: 114
  year: 2009
  ident: B254
  article-title: Inducing the tryptophan catabolic pathway, indoleamine 2, 3-dioxygenase (IDO), for suppression of graft-versushost disease (GVHD) lethality
  publication-title: Blood
  doi: 10.1182/blood-2009-06-227587
  contributor:
    fullname: Jasperson
– volume: 6
  start-page: 243ra287
  year: 2014
  ident: B177
  article-title: Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3008941
  contributor:
    fullname: Nalle
– volume: 19
  year: 2013
  ident: B30
  article-title: Coexpression of CD49b and LAG-3 identifies human and mouse t regulatory type 1 cells
  publication-title: Nat Med
  doi: 10.1038/nm.3179
  contributor:
    fullname: Gagliani
– volume: 121
  year: 2013
  ident: B90
  article-title: Donor-derived regulatory b cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2012-11-465658
  contributor:
    fullname: Le Huu
– volume: 12
  year: 2018
  ident: B158
  article-title: Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation
  publication-title: J Cell Commun Signal
  doi: 10.1007/s12079-018-0448-4
  contributor:
    fullname: Najar
– volume: 46
  year: 2017
  ident: B209
  article-title: Dendritic cells display subset and tissue-specific maturation dynamics over human life
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.02.019
  contributor:
    fullname: Granot
– volume: 56
  year: 1993
  ident: B168
  article-title: Acute graft-versus-host-like disease induced by transplantation of human activated natural killer cells into SCID mice
  publication-title: Transplantation
  doi: 10.1097/00007890-199308000-00031
  contributor:
    fullname: Xun
– volume: 6
  year: 2017
  ident: B185
  article-title: Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells
  publication-title: J Extracell Vesicles
  doi: 10.1080/20013078.2017.1294368
  contributor:
    fullname: Jong
– volume: 129
  year: 2019
  ident: B234
  article-title: The gut microbiota and graft-versus-host disease
  publication-title: J Clin Invest
  doi: 10.1172/JCI125797
  contributor:
    fullname: Fredricks
– volume: 6
  year: 2022
  ident: B17
  article-title: MicroRNA-31 regulates t-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice
  publication-title: Blood Adv
  doi: 10.1182/bloodadvances.2021005103
  contributor:
    fullname: Wu
– volume: 21
  year: 2015
  ident: B236
  article-title: Intestinal blautia is associated with reduced death from graft-versus-host disease
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2015.04.016
  contributor:
    fullname: Jenq
– volume: 114
  year: 2009
  ident: B204
  article-title: Impact of macrophage infiltration of skin lesions on survival after allogeneic stem cell transplantation: a clue to refractory graft-versushost disease
  publication-title: Blood
  doi: 10.1182/blood-2009-03-209635
  contributor:
    fullname: Nishiwaki
– volume: 9
  year: 2008
  ident: B121
  article-title: Functions of natural killer cells
  publication-title: Nat Immunol
  doi: 10.1038/ni1582
  contributor:
    fullname: Vivier
– volume: 64
  start-page: 63
  year: 2016
  ident: B128
  article-title: Prediction of NK cell licensing level in selection of hematopoietic stem cell donor, initial results
  publication-title: Arch Immunol Ther Exp (Warsz)
  doi: 10.1007/s00005-016-0438-2
  contributor:
    fullname: Rogatko-Koroś
– volume: 206
  year: 2009
  ident: B208
  article-title: Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation
  publication-title: J Exp Med
  doi: 10.1084/jem.20081633
  contributor:
    fullname: Haniffa
– volume: 124
  year: 2014
  ident: B238
  article-title: The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation
  publication-title: Blood
  doi: 10.1182/blood-2014-02-554725
  contributor:
    fullname: Taur
– volume: 106
  year: 2009
  ident: B249
  article-title: Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0812874106
  contributor:
    fullname: Wikoff
– volume: 131
  year: 2021
  ident: B212
  article-title: Graft-versus-host disease depletes plasmacytoid dendritic cell progenitors to impair tolerance induction
  publication-title: J Clin Invest
  doi: 10.1172/jci136774
  contributor:
    fullname: Tian
– volume: 65
  year: 2017
  ident: B240
  article-title: Stool microbiota at neutrophil recovery is predictive for severe acute graft vs host disease after hematopoietic cell transplantation
  publication-title: Clin Infect Dis
  doi: 10.1093/cid/cix699
  contributor:
    fullname: Golob
– volume: 19
  year: 2022
  ident: B271
  article-title: Unsupervised discovery of tissue architecture in multiplexed imaging
  publication-title: Nat Methods
  doi: 10.1038/s41592-022-01657-2
  contributor:
    fullname: Kim
– volume: 34
  year: 2006
  ident: B97
  article-title: The development of autoantibodies after allogeneic stem cell transplantation is related with chronic graft-vs-host disease and immune recovery
  publication-title: Exp Hematol
  doi: 10.1016/j.exphem.2005.12.011
  contributor:
    fullname: Patriarca
– volume: 377
  year: 2017
  ident: B8
  article-title: Pathophysiology of chronic graft-versus-Host disease and therapeutic targets
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1703472
  contributor:
    fullname: Zeiser
– volume: 504
  year: 2013
  ident: B244
  article-title: Metabolites produced by commensal bacteria promote peripheral regulatory t-cell generation
  publication-title: Nature
  doi: 10.1038/nature12726
  contributor:
    fullname: Arpaia
– volume: 180
  year: 2008
  ident: B106
  article-title: ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.4.2284
  contributor:
    fullname: Vu
– volume: 17
  year: 2016
  ident: B246
  article-title: Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versushost disease
  publication-title: Nat Immunol
  doi: 10.1038/ni.3400
  contributor:
    fullname: Mathewson
– volume: 118
  year: 2011
  ident: B172
  article-title: NK cell education after allogeneic transplantation: dissociation between recovery of cytokine-producing and cytotoxic functions
  publication-title: Blood
  doi: 10.1182/blood-2011-04-347070
  contributor:
    fullname: Foley
– volume: 14
  year: 2002
  ident: B224
  article-title: Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific t cells
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxf048
  contributor:
    fullname: Vincent-Schneider
– volume: 2
  start-page: e92111
  year: 2017
  ident: B16
  article-title: An activated Th17-prone t cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.92111
  contributor:
    fullname: Forcade
– volume: 145
  year: 2020
  ident: B263
  article-title: Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2020.01.042
  contributor:
    fullname: He
– volume: 106
  year: 2005
  ident: B220
  article-title: ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive t-cell priming
  publication-title: Blood
  doi: 10.1182/blood-2005-01-0220
  contributor:
    fullname: Segura
– volume: 6
  year: 2019
  ident: B115
  article-title: CD4(+) t cell-released extracellular vesicles potentiate the efficacy of the HBsAg vaccine by enhancing b cell responses
  publication-title: Adv Sci
  doi: 10.1002/advs.201802219
  contributor:
    fullname: Lu
– volume: 12
  start-page: 14049
  year: 2022
  ident: B3
  article-title: Association of extracellular vesicle inflammatory proteins and mortality
  publication-title: Sci Rep
  doi: 10.1038/s41598-022-17944-z
  contributor:
    fullname: Noren Hooten
– volume: 129
  year: 2009
  ident: B213
  article-title: Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis
  publication-title: J Invest Dermatol
  doi: 10.1038/jid.2009.176
  contributor:
    fullname: Kim
– volume: 127
  year: 2017
  ident: B214
  article-title: Fibroblastic niches prime t cell alloimmunity through delta-like notch ligands
  publication-title: J Clin Invest
  doi: 10.1172/jci89535
  contributor:
    fullname: Chung
– volume: 180
  year: 2008
  ident: B153
  article-title: Regulatory NK cells suppress antigen-specific t cell responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.180.2.850
  contributor:
    fullname: Deniz
– volume: 11
  year: 2022
  ident: B186
  article-title: Natural killer (NK) cell-derived extracellular-vesicle shuttled microRNAs control t cell responses
  publication-title: Elife
  doi: 10.7554/eLife.76319
  contributor:
    fullname: Dosil
– volume: 161
  year: 1998
  ident: B126
  article-title: Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-c allotype recognition
  publication-title: J Immunol
  doi: 10.4049/jimmunol.161.2.571
  contributor:
    fullname: Winter
– volume: 58
  year: 2018
  ident: B183
  article-title: An early increase of CD56(bright) natural killer subset as dominant effect and predictor of response to extracorporeal photopheresis for graft-versus-host disease
  publication-title: Transfusion
  doi: 10.1111/trf.14964
  contributor:
    fullname: Iniesta
– volume: 8
  year: 2002
  ident: B189
  article-title: Acute graft-versus-host disease does not require alloantigen expression on host epithelium
  publication-title: Nat Med
  doi: 10.1038/nm0602-575
  contributor:
    fullname: Teshima
– volume: 175
  year: 2005
  ident: B138
  article-title: Evidence that the cellular ligand for the human NK cell activation receptor NKp30 is not a heparan sulfate glycosaminoglycan
  publication-title: J Immunol
  doi: 10.4049/jimmunol.175.1.207
  contributor:
    fullname: Warren
– volume: 137
  year: 2021
  ident: B241
  article-title: Microbiome markers are early predictors of acute GVHD in allogeneic hematopoietic stem cell transplant recipients
  publication-title: Blood
  doi: 10.1182/blood.2020007158
  contributor:
    fullname: Greco
– volume: 59
  year: 2011
  ident: B141
  article-title: Clinical significance of the HLA-e and CD94/NKG2 interaction
  publication-title: Arch Immunol Ther Exp
  doi: 10.1007/s00005-011-0137-y
  contributor:
    fullname: Iwaszko
– volume: 218
  year: 2021
  ident: B264
  article-title: Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis
  publication-title: J Exp Med
  doi: 10.1084/jem.20202345
  contributor:
    fullname: Nakamizo
– volume: 103
  year: 2004
  ident: B94
  article-title: Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors
  publication-title: Blood
  doi: 10.1182/blood-2003-03-0984
  contributor:
    fullname: Miklos
– volume: 90
  year: 2015
  ident: B99
  article-title: Clinical significance of autoantibodies in a large cohort of patients with chronic graft-versus-host disease defined by NIH criteria
  publication-title: Am J Hematol
  doi: 10.1002/ajh.23885
  contributor:
    fullname: Kuzmina
– volume: 48
  year: 2021
  ident: B130
  article-title: Non-KIR NK cell receptors: Role in transplantation of allogeneic haematopoietic stem cells
  publication-title: Int J Immunogenet
  doi: 10.1111/iji.12523
  contributor:
    fullname: Bogunia-Kubik
– volume: 118
  year: 2011
  ident: B188
  article-title: Mechanisms of antigen presentation to t cells in murine graft-versus-host disease: cross-presentation and the appearance of crosspresentation
  publication-title: Blood
  doi: 10.1182/blood-2011-06-358747
  contributor:
    fullname: Wang
– volume: 107
  start-page: 2993
  year: 2006
  ident: B92
  article-title: Donor CD4+ t and b cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations
  publication-title: Blood
  doi: 10.1182/blood-2005-09-3623
  contributor:
    fullname: Zhang
– volume: 21
  year: 2015
  ident: B46
  article-title: CD19+CD21low b cells and CD4+CD45RA+CD31+ t cells correlate with first diagnosis of chronic graft-versus-host disease
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2014.11.010
  contributor:
    fullname: Greinix
– volume: 41
  start-page: 89
  year: 2014
  ident: B60
  article-title: MicroRNAcontaining t-regulatory-cell-derived exosomes suppress pathogenic t helper 1 cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2014.05.019
  contributor:
    fullname: Okoye
– volume: 464
  start-page: 59
  year: 2010
  ident: B226
  article-title: A human gut microbial gene catalogue established by metagenomic sequencing
  publication-title: Nature
  doi: 10.1038/nature08821
  contributor:
    fullname: Qin
– volume: 385
  year: 2021
  ident: B40
  article-title: Ruxolitinib for glucocorticoid-refractory chronic graft-versus-Host disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa2033122
  contributor:
    fullname: Zeiser
– volume: 6
  year: 2016
  ident: B59
  article-title: Thymic exosomes promote the final maturation of thymocytes
  publication-title: Sci Rep
  doi: 10.1038/srep36479
  contributor:
    fullname: Lundberg
– volume: 13
  year: 2022
  ident: B28
  article-title: Responses of regulatory and effector t-cells to low-dose interleukin-2 differ depending on the immune environment after allogeneic stem cell transplantation
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.891925
  contributor:
    fullname: Meguri
– volume: 122
  year: 2013
  ident: B101
  article-title: Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD
  publication-title: Blood
  doi: 10.1182/blood-2013-05-494278
  contributor:
    fullname: Olivieri
– volume: 188
  year: 1998
  ident: B133
  article-title: Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity
  publication-title: J Exp Med
  doi: 10.1084/jem.188.5.953
  contributor:
    fullname: Pessino
– volume: 3
  year: 2002
  ident: B222
  article-title: Indirect activation of naïve CD4+ t cells by dendritic cell-derived exosomes
  publication-title: Nat Immunol
  doi: 10.1038/ni854
  contributor:
    fullname: Théry
– volume: 129
  year: 2017
  ident: B207
  article-title: Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production
  publication-title: Blood
  doi: 10.1182/blood-2017-01-758854
  contributor:
    fullname: Du
– volume: 43
  year: 2013
  ident: B164
  article-title: NKp46 regulates allergic responses
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201343388
  contributor:
    fullname: Ghadially
– volume: 170
  year: 2003
  ident: B152
  article-title: Activated, but not resting, t cells can be recognized and killed by syngeneic NK cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.170.7.3572
  contributor:
    fullname: Rabinovich
– volume: 5
  year: 2014
  ident: B156
  article-title: Human umbilical cord- derived mesenchymal stem cells utilize activin-a to suppress interferon-γ production by natural killer cells
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2014.00662
  contributor:
    fullname: Chatterjee
– volume: 20
  year: 2022
  ident: B267
  article-title: Optimizing multiplexed imaging experimental design through tissue spatial segregation estimation
  publication-title: Nat Methods
  doi: 10.1038/s41592-022-01692-z
  contributor:
    fullname: Bost
– volume: 127
  year: 2016
  ident: B36
  article-title: Circulating t follicular helper cells with increased function during chronic graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2015-12-688895
  contributor:
    fullname: Forcade
– volume: 10
  year: 2019
  ident: B70
  article-title: National institutes of health-defined chronic graft-vs.-Host disease in pediatric hematopoietic stem cell transplantation patients correlates with parameters of long-term immune reconstitution
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.01879
  contributor:
    fullname: Lawitschka
– volume: 187
  year: 2011
  ident: B54
  article-title: Cutting edge: Tissue-retentive lung memory CD4 t cells mediate optimal protection to respiratory virus infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1102243
  contributor:
    fullname: Teijaro
– volume: 123
  year: 2014
  ident: B104
  article-title: Increased t follicular helper cells and germinal center b cells are required for cGVHD and bronchiolitis obliterans
  publication-title: Blood
  doi: 10.1182/blood-2014-03-562231
  contributor:
    fullname: Flynn
– volume: 13
  year: 2022
  ident: B6
  article-title: Cell-based therapy in prophylaxis and treatment of chronic graft-versus-host disease
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.1045168
  contributor:
    fullname: Doglio
– volume: 7
  year: 2016
  ident: B169
  article-title: Functional reconstitution of natural killer cells in allogeneic hematopoietic stem cell transplantation
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2016.00144
  contributor:
    fullname: Ullah
– volume: 33
  year: 2019
  ident: B196
  article-title: Lack of acute xenogeneic graft- versus-host disease, but retention of t-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class i and II expression
  publication-title: FASEB J
  doi: 10.1096/fj.201800636R
  contributor:
    fullname: Brehm
– volume: 37
  year: 2015
  ident: B57
  article-title: Histopathologic features of cutaneous acute graft-Versus-Host disease in t-Cell-Depleted peripheral blood stem cell transplant recipients
  publication-title: Am J Dermatopathol
  doi: 10.1097/dad.0000000000000357
  contributor:
    fullname: Fischer
– volume: 119
  year: 2012
  ident: B103
  article-title: Donor b-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
  publication-title: Blood
  doi: 10.1182/blood-2011-07-364414
  contributor:
    fullname: Srinivasan
– volume: 195
  year: 2002
  ident: B145
  article-title: Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells
  publication-title: J Exp Med
  doi: 10.1084/jem.20010934
  contributor:
    fullname: Piccioli
– volume: 93
  start-page: 395
  year: 2013
  ident: B221
  article-title: Dynamics of dendritic cell-derived vesicles: high-resolution flow cytometric analysis of extracellular vesicle quantity and quality
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0911480
  contributor:
    fullname: Nolte-'t Hoen
– volume: 219
  start-page: e20211239
  year: 2022
  ident: B9
  article-title: Failures in thymus medulla regeneration during immune recovery cause tolerance loss and prime recipients for auto-GVHD
  publication-title: J Exp Med
  doi: 10.1084/jem.20211239
  contributor:
    fullname: Alawam
– year: 2023
  ident: B88
  article-title: Combinatorial inhibition of tec kinases BTK and ITK is beneficial in ameliorating murine sclerodermatous chronic graft versus host disease
  publication-title: Bone Marrow Transplant
  doi: 10.1038/s41409-023-02001-8
  contributor:
    fullname: Palaniyandi
– volume: 109
  year: 1988
  ident: B64
  article-title: Functional asplenia after bone marrow transplantation. a late complication related to extensive chronic graft-versus-host disease
  publication-title: Ann Intern Med
  doi: 10.7326/0003-4819-109-6-461
  contributor:
    fullname: Kalhs
– volume: 12
  year: 2020
  ident: B52
  article-title: Long-term skin-resident memory t cells proliferate in situ and are involved in human graft-versus-host disease
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.abb7028
  contributor:
    fullname: Strobl
– volume: 139
  year: 2022
  ident: B174
  article-title: Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning
  publication-title: Blood
  doi: 10.1182/blood.2021013054
  contributor:
    fullname: McCurdy
– volume: 107
  year: 2006
  ident: B144
  article-title: Expression of the DNAM-1 ligands, nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
  publication-title: Blood
  doi: 10.1182/blood-2005-07-2696
  contributor:
    fullname: Pende
– volume: 11
  year: 2013
  ident: B228
  article-title: The gut microbiota — masters of host development and physiology
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2974
  contributor:
    fullname: Sommer
– volume: 3
  year: 2012
  ident: B125
  article-title: Diverse functionality among human NK cell receptors for the C1 epitope of HLA-c: KIR2DS2, KIR2DL2, and KIR2DL3
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2012.00336
  contributor:
    fullname: Moesta
– volume: 129
  year: 2019
  ident: B34
  article-title: Posttransplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive t cell dysfunction and suppression
  publication-title: J Clin Invest
  doi: 10.1172/jci124218
  contributor:
    fullname: Wachsmuth
– volume: 185
  year: 2010
  ident: B253
  article-title: An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory t cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0903670
  contributor:
    fullname: Mezrich
– volume: 111
  year: 2008
  ident: B45
  article-title: Effector memory CD4+ t cells mediate graft-versus-leukemia without inducing graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2007-08-109678
  contributor:
    fullname: Zheng
– volume: 195
  year: 2002
  ident: B146
  article-title: Reciprocal activating interaction between natural killer cells and dendritic cells
  publication-title: J Exp Med
  doi: 10.1084/jem.20010938
  contributor:
    fullname: Gerosa
– volume: 56
  start-page: 353
  year: 2023
  ident: B233
  article-title: Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2023.01.007
  contributor:
    fullname: Seike
– volume: 28
  year: 2022
  ident: B43
  article-title: FDA approval summary: Belumosudil for adult and pediatric patients 12 years and older with chronic GvHD after two or more prior lines of systemic therapy
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.Ccr-21-4176
  contributor:
    fullname: Przepiorka
– volume: 195
  year: 2002
  ident: B143
  article-title: Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
  publication-title: J Exp Med
  doi: 10.1084/jem.20011149
  contributor:
    fullname: Ferlazzo
– volume: 218
  year: 2021
  ident: B55
  article-title: Human resident memory t cells exit the skin and mediate systemic Th2-driven inflammation
  publication-title: J Exp Med
  doi: 10.1084/jem.20210417
  contributor:
    fullname: Strobl
– volume: 127
  year: 2016
  ident: B19
  article-title: Targeted rhoassociated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism
  publication-title: Blood
  doi: 10.1182/blood-2015-10-678706
  contributor:
    fullname: Flynn
– volume: 342
  year: 2013
  ident: B242
  article-title: The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
  publication-title: Science
  doi: 10.1126/science.1240537
  contributor:
    fullname: Viaud
– volume: 179
  year: 2007
  ident: B84
  article-title: Bruton's tyrosine kinase mediates NF-kappa b activation and b cell survival by b cell-activating factor receptor of the TNF-r family
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.6.3872
  contributor:
    fullname: Shinners
– volume: 104
  year: 2004
  ident: B223
  article-title: Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells
  publication-title: Blood
  doi: 10.1182/blood-2004-03-0824
  contributor:
    fullname: Morelli
– volume: 124
  year: 2014
  ident: B86
  article-title: Ibrutinib treatment ameliorates murine chronic graft-versus-host disease
  publication-title: J Clin Invest
  doi: 10.1172/jci75328
  contributor:
    fullname: Dubovsky
– volume: 117
  year: 2011
  ident: B150
  article-title: DNAM-1 ligand expression on ag-stimulated t lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-t cell interaction
  publication-title: Blood
  doi: 10.1182/blood-2010-08-300954
  contributor:
    fullname: Ardolino
– volume: 309
  year: 2015
  ident: B18
  article-title: Hypoxia-inducible factors in t lymphocyte differentiation and function. a review in the theme: Cellular responses to hypoxia
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00204.2015
  contributor:
    fullname: Tao
– volume: 17
  year: 2016
  ident: B142
  article-title: The activating NKG2C receptor is significantly reduced in NK cells after allogeneic stem cell transplantation in patients with severe graft-versus-Host disease
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms17111797
  contributor:
    fullname: Kordelas
– volume: 214
  year: 2017
  ident: B256
  article-title: R-Spondin1 expands paneth cells and prevents dysbiosis induced by graft-versus-host disease
  publication-title: J Exp Med
  doi: 10.1084/jem.20170418
  contributor:
    fullname: Hayase
– volume: 4
  year: 2019
  ident: B259
  article-title: T cell-derived interferon-γ programs stem cell death in immune-mediated intestinal damage
  publication-title: Sci Immunol
  doi: 10.1126/sciimmunol.aay8556
  contributor:
    fullname: Takashima
– volume: 141
  start-page: 193
  year: 2021
  ident: B32
  article-title: Expansion of circulating CD49b(+)LAG3(+) type 1 regulatory t cells in human chronic graft-versus- host disease
  publication-title: J Invest Dermatol
  doi: 10.1016/j.jid.2020.04.018
  contributor:
    fullname: Talvard-Balland
– volume: 36
  start-page: 92
  year: 2012
  ident: B250
  article-title: The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.11.011
  contributor:
    fullname: Qiu
– volume: 133
  year: 2019
  ident: B37
  article-title: Targeting sirt-1 controls GVHD by inhibiting t-cell allo-response and promoting treg stability in mice
  publication-title: Blood
  doi: 10.1182/blood-2018-07-863233
  contributor:
    fullname: Daenthanasanmak
– volume: 13
  year: 2022
  ident: B119
  article-title: Impact of natural killer cells on outcomes after allogeneic hematopoietic stem cell transplantation: A systematic review and meta-analysis
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2022.1005031
  contributor:
    fullname: Mushtaq
– volume: 113
  year: 2009
  ident: B210
  article-title: Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation
  publication-title: Blood
  doi: 10.1182/blood-2008-12-191833
  contributor:
    fullname: Markey
– volume: 138
  year: 2021
  ident: B41
  article-title: Belumosudil for chronic graft-versushost disease after 2 or more prior lines of therapy: the ROCKstar study
  publication-title: Blood
  doi: 10.1182/blood.2021012021
  contributor:
    fullname: Cutler
– volume: 88
  year: 2010
  ident: B218
  article-title: MHC class iiassociated proteins in b-cell exosomes and potential functional implications for exosome biogenesis
  publication-title: Immunol Cell Biol
  doi: 10.1038/icb.2010.64
  contributor:
    fullname: Buschow
– volume: 14
  year: 2008
  ident: B69
  article-title: Elevated numbers of immature/transitional CD21- b lymphocytes and deficiency of memory CD27+ b cells identify patients with active chronic graft-versus-host disease
  publication-title: Biol Blood Marrow Transplant
  doi: 10.1016/j.bbmt.2007.10.009
  contributor:
    fullname: Greinix
– volume: 10
  year: 2021
  ident: B129
  article-title: NKG2D natural killer cell receptor-a short description and potential clinical applications
  publication-title: Cells
  doi: 10.3390/cells10061420
  contributor:
    fullname: Siemaszko
– volume: 8
  start-page: 978
  year: 2017
  ident: B109
  article-title: Extrafollicular CD4(+) t-b interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-00880-2
  contributor:
    fullname: Deng
– volume: 128
  year: 2016
  ident: B27
  article-title: Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease
  publication-title: Blood
  doi: 10.1182/blood-2016-02-702852
  contributor:
    fullname: Koreth
– volume: 8
  year: 2023
  ident: B111
  article-title: Hematopoietic stem cellderived tregs are essential for maintaining favorable b cell lymphopoiesis following posttransplant cyclophosphamide
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.162180
  contributor:
    fullname: Sumii
– volume: 198
  year: 2003
  ident: B140
  article-title: Identification of PVR (CD155) and nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
  publication-title: J Exp Med
  doi: 10.1084/jem.20030788
  contributor:
    fullname: Bottino
– volume: 9
  year: 2020
  ident: B161
  article-title: Treatment of chronic GvHD with mesenchymal stromal cells induces durable responses: A phase II study
  publication-title: Stem Cells Transl Med
  doi: 10.1002/sctm.20-0099
  contributor:
    fullname: Boberg
– volume: 10
  year: 2004
  ident: B192
  article-title: Depletion of host langerhans cells before transplantation of donor alloreactive t cells prevents skin graft-versus-host disease
  publication-title: Nat Med
  doi: 10.1038/nm1038
  contributor:
    fullname: Merad
– volume: 124
  year: 2014
  ident: B198
  article-title: CSF-1-dependant donorderived macrophages mediate chronic graft-versus-host disease
  publication-title: J Clin Invest
  doi: 10.1172/jci75935
  contributor:
    fullname: Alexander
– volume: 45
  year: 2016
  ident: B243
  article-title: Enterococcus hirae and barnesiella intestinihominis facilitate cyclophosphamide-induced therapeutic immunomodulatory effects
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.09.009
  contributor:
    fullname: Daillère
– volume: 130
  year: 2020
  ident: B197
  article-title: Donor monocyte-derived macrophages promote human acute graft-versus-host disease
  publication-title: J Clin Invest
  doi: 10.1172/jci133909
  contributor:
    fullname: Jardine
– volume: 292
  year: 2017
  ident: B61
  article-title: Extracellular MicroRNA signature of human helper t cell subsets in health and autoimmunity
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.769893
  contributor:
    fullname: Torri
– volume: 12
  year: 2021
  ident: B5
  article-title: Extracellular vesicles as biomarkers of acute graft-vs.-Host disease after haploidentical stem cell transplantation and post- transplant cyclophosphamide
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.816231
  contributor:
    fullname: Lia
– volume: 27
  year: 2021
  ident: B273
  article-title: National institutes of health consensus development project on criteria for clinical trials in chronic graft-versus-Host disease: III. the 2020 treatment of chronic GVHD report
  publication-title: Transplant Cell Ther
  doi: 10.1016/j.jtct.2021.05.004
  contributor:
    fullname: DeFilipp
– volume: 99
  year: 2002
  ident: B199
  article-title: Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution
  publication-title: Blood
  doi: 10.1182/blood.v99.7.2586
  contributor:
    fullname: Klangsinsirikul
– volume: 49
  year: 2014
  ident: B11
  article-title: Increased Th17/Treg ratio in chronic liver GVHD
  publication-title: Bone Marrow Transplant
  doi: 10.1038/bmt.2013.215
  contributor:
    fullname: Malard
– volume: 51
  start-page: 885
  year: 2019
  ident: B215
  article-title: MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-Host disease and is influenced by the microbiota
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.08.011
  contributor:
    fullname: Koyama
– volume: 71
  year: 2019
  ident: B157
  article-title: Reciprocal immuno-biological alterations occur during the co-culture of natural killer cells and adipose tissuederived mesenchymal stromal cells
  publication-title: Cytotechnology
  doi: 10.1007/s10616-019-00294-6
  contributor:
    fullname: Najar
– volume: 298
  year: 2002
  ident: B105
  article-title: A critical role for IL-21 in regulating immunoglobulin production
  publication-title: Science
  doi: 10.1126/science.1077002
  contributor:
    fullname: Ozaki
– volume: 21
  start-page: 88
  year: 2022
  ident: B261
  article-title: Commensal bacteria-derived extracellular vesicles suppress ulcerative colitis through regulating the macrophages polarization and remodeling the gut microbiota
  publication-title: Microb Cell Fact
  doi: 10.1186/s12934-022-01812-6
  contributor:
    fullname: Liang
– volume: 5
  start-page: 211ra157
  year: 2013
  ident: B33
  article-title: Aldehyde dehydrogenase expression drives human regulatory t cell resistance to posttransplantation cyclophosphamide
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3006960
  contributor:
    fullname: Kanakry
– volume: 113
  year: 2016
  ident: B2
  article-title: Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1521230113
  contributor:
    fullname: Kowal
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Snippet Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects many patients after allogeneic hematopoietic stem cell...
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StartPage 1199422
SubjectTerms Antigen-Presenting Cells
B-Lymphocytes
Bronchiolitis Obliterans Syndrome
Cell Communication
cell-cell communication
chronic graft-versus-host disease
Extracellular Vesicles
GvHD pathogenesis
hematopoietic stem cell transplantation
Humans
immune cell networks
Immunology
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Title Complex interactions of cellular players in chronic Graft-versus-Host Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/37435079
https://search.proquest.com/docview/2836293936
https://pubmed.ncbi.nlm.nih.gov/PMC10332803
https://doaj.org/article/fb995d204e5e4efd9c33469da1e33256
Volume 14
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