Application of platelet-rich plasma in spinal surgery

With the aging of the population and changes in lifestyle, the incidence of spine-related diseases is increasing, which has become a major global public health problem; this results in a huge economic burden on the family and society. Spinal diseases and complications can lead to loss of motor, sens...

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Published inFrontiers in endocrinology (Lausanne) Vol. 14; p. 1138255
Main Authors Wang, Hengyi, Zhu, Jianshu, Xia, Yuanliang, Li, Yuehong, Fu, Changfeng
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 15.03.2023
Subjects
cytokines
Endocrinology
facilitated repair
Humans
osteogenesis
Platelet-Derived Growth Factor - metabolism
Platelet-Rich Plasma
spinal diseases
Transforming Growth Factor beta1 - metabolism
Vascular Endothelial Growth Factor A - metabolism
Wound Healing
spinal diseases
cytokines
osteogenesis
platelet-rich plasma
facilitated repair
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Abstract With the aging of the population and changes in lifestyle, the incidence of spine-related diseases is increasing, which has become a major global public health problem; this results in a huge economic burden on the family and society. Spinal diseases and complications can lead to loss of motor, sensory, and autonomic functions. Therefore, it is necessary to identify effective treatment strategies. Currently, the treatment of spine-related diseases includes conservative, surgical, and minimally invasive interventional therapies. However, these treatment methods have several drawbacks such as drug tolerance and dependence, adjacent spondylosis, secondary surgery, infection, nerve injury, dural rupture, nonunion, and pseudoarthrosis. Further, it is more challenging to promote the regeneration of the interstitial disc and restore its biomechanical properties. Therefore, clinicians urgently need to identify methods that can limit disease progression or cure diseases at the etiological level. Platelet-rich plasma (PRP), a platelet-rich form of plasma extracted from venous blood, is a blood-derived product. Alpha granules contain a large number of cytokines, such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor, platelet factor 4 (PF-4), insulin-like growth factor-1 (IGF-1), and transforming growth factor-β (TGF-β). These growth factors allow stem cell proliferation and angiogenesis, promote bone regeneration, improve the local microenvironment, and enhance tissue regeneration capacity and functional recovery. This review describes the application of PRP in the treatment of spine-related diseases and discusses the clinical application of PRP in spinal surgery.
AbstractList With the aging of the population and changes in lifestyle, the incidence of spine-related diseases is increasing, which has become a major global public health problem; this results in a huge economic burden on the family and society. Spinal diseases and complications can lead to loss of motor, sensory, and autonomic functions. Therefore, it is necessary to identify effective treatment strategies. Currently, the treatment of spine-related diseases includes conservative, surgical, and minimally invasive interventional therapies. However, these treatment methods have several drawbacks such as drug tolerance and dependence, adjacent spondylosis, secondary surgery, infection, nerve injury, dural rupture, nonunion, and pseudoarthrosis. Further, it is more challenging to promote the regeneration of the interstitial disc and restore its biomechanical properties. Therefore, clinicians urgently need to identify methods that can limit disease progression or cure diseases at the etiological level. Platelet-rich plasma (PRP), a platelet-rich form of plasma extracted from venous blood, is a blood-derived product. Alpha granules contain a large number of cytokines, such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor, platelet factor 4 (PF-4), insulin-like growth factor-1 (IGF-1), and transforming growth factor-β (TGF-β). These growth factors allow stem cell proliferation and angiogenesis, promote bone regeneration, improve the local microenvironment, and enhance tissue regeneration capacity and functional recovery. This review describes the application of PRP in the treatment of spine-related diseases and discusses the clinical application of PRP in spinal surgery.
Author Xia, Yuanliang
Zhu, Jianshu
Fu, Changfeng
Wang, Hengyi
Li, Yuehong
AuthorAffiliation Department of Spinal Surgery, The First Hospital of Jilin University , Changchun , China
AuthorAffiliation_xml – name: Department of Spinal Surgery, The First Hospital of Jilin University , Changchun , China
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  givenname: Hengyi
  surname: Wang
  fullname: Wang, Hengyi
  organization: Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, China
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  givenname: Jianshu
  surname: Zhu
  fullname: Zhu, Jianshu
  organization: Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, China
– sequence: 3
  givenname: Yuanliang
  surname: Xia
  fullname: Xia, Yuanliang
  organization: Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, China
– sequence: 4
  givenname: Yuehong
  surname: Li
  fullname: Li, Yuehong
  organization: Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, China
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  givenname: Changfeng
  surname: Fu
  fullname: Fu, Changfeng
  organization: Department of Spinal Surgery, The First Hospital of Jilin University, Changchun, China
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CitedBy_id crossref_primary_10_3389_fbioe_2023_1297357
crossref_primary_10_1111_prd_12565
crossref_primary_10_3390_ijms25031525
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Keywords spinal diseases
cytokines
osteogenesis
platelet-rich plasma
facilitated repair
Language English
License Copyright © 2023 Wang, Zhu, Xia, Li and Fu.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Reviewed by: Esther Potier, Centre National de la Recherche Scientifique (CNRS), France; Joanna K. Filipowska, City of Hope National Medical Center, United States
This article was submitted to Bone Research, a section of the journal Frontiers in Endocrinology
Edited by: Meifeng Zhu, Nankai University, China
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Snippet With the aging of the population and changes in lifestyle, the incidence of spine-related diseases is increasing, which has become a major global public health...
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SubjectTerms cytokines
Endocrinology
facilitated repair
Humans
osteogenesis
Platelet-Derived Growth Factor - metabolism
Platelet-Rich Plasma
spinal diseases
Transforming Growth Factor beta1 - metabolism
Vascular Endothelial Growth Factor A - metabolism
Wound Healing
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Title Application of platelet-rich plasma in spinal surgery
URI https://www.ncbi.nlm.nih.gov/pubmed/37008931
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