Common Sites of Retroviral Integration in Mouse Hematopoietic Tumors Identified by High-Throughput, Single Nucleotide Polymorphism-Based Mapping and Bacterial Artificial Chromosome Hybridization

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Published inJournal of Virology Vol. 77; no. 2; pp. 1584 - 1588
Main Authors Shen, Haifa, Suzuki, Takeshi, Munroe, David J, Stewart, Claudia, Rasmussen, Lynn, Gilbert, Debra J, Jenkins, Nancy A, Copeland, Neal G
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.01.2003
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AbstractList Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a powerful cancer gene discovery tool. Here, we describe a high-throughput, single nucleotide polymorphism (SNP)-based method, for mapping retroviral integration sites cloned from mouse tumors, and a bacterial artificial chromosome (BAC) hybridization method, for localizing these retroviral integration sites to common sites of retroviral integration (CISs). Several new CISs were identified, including one CIS that mapped near Notch1, a gene that has been causally associated with human T-cell tumors. This mapping method is applicable to many different species, including ones where few genetic markers and little genomic sequence information are available. It can also be used to map endogenous proviruses.
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Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a powerful cancer gene discovery tool. Here, we describe a high-throughput, single nucleotide polymorphism (SNP)-based method, for mapping retroviral integration sites cloned from mouse tumors, and a bacterial artificial chromosome (BAC) hybridization method, for localizing these retroviral integration sites to common sites of retroviral integration (CISs). Several new CISs were identified, including one CIS that mapped near Notch1 , a gene that has been causally associated with human T-cell tumors. This mapping method is applicable to many different species, including ones where few genetic markers and little genomic sequence information are available. It can also be used to map endogenous proviruses.
Author Claudia Stewart
David J. Munroe
Nancy A. Jenkins
Debra J. Gilbert
Lynn Rasmussen
Haifa Shen
Takeshi Suzuki
Neal G. Copeland
AuthorAffiliation Mouse Cancer Genetics Program, National Cancer Institute-Frederick, 1 Laboratory of Molecular Technology, SAIC-Frederick, Frederick, Maryland 21702 2
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Corresponding author. Mailing address: Mouse Cancer Genetics Program, National Cancer Institute-Frederick, Frederick, MD 21702. Phone: (301) 846-1260. Fax: (301) 846-6666. E-mail: copeland@ncifcrf.gov.
Present address: Lexicon Genetics, The Woodlands, TX 77381.
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Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a powerful cancer gene discovery tool. Here, we describe a high-throughput, single...
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StartPage 1584
SubjectTerms Animals
Chromosome Mapping
Chromosomes, Artificial, Bacterial
Hematologic Neoplasms - virology
Mice
Mutagenesis, Insertional
Pathogenesis and Immunity
Polymorphism, Single Nucleotide
Retroviridae - genetics
Retroviridae - physiology
Virus Integration
Title Common Sites of Retroviral Integration in Mouse Hematopoietic Tumors Identified by High-Throughput, Single Nucleotide Polymorphism-Based Mapping and Bacterial Artificial Chromosome Hybridization
URI http://jvi.asm.org/content/77/2/1584.abstract
https://www.ncbi.nlm.nih.gov/pubmed/12502872
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