Age-related changes in human bone marrow mesenchymal stromal cells: morphology, gene expression profile, immunomodulatory activity and miRNA expression

• Published in: Frontiers in immunology Vol. 14; p. 1267550
• Main Authors: Massaro, Fulvio, Corrillon, Florent, Stamatopoulos, Basile, Dubois, Nathan, Ruer, Achille, Meuleman, Nathalie, Bron, Dominique, Lagneaux, Laurence
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.12.2023
• Subjects: Aged; aging; Animals; bone marrow; Bone Marrow - metabolism; Cytokines - metabolism; Humans; Immunology; immunomodulation; macrophage polarization; Mesenchymal Stem Cells - metabolism; mesenchymal stromal cells; Mice; MicroRNAs - genetics; MicroRNAs - metabolism; Neoplasms - metabolism; Transcriptome; Tumor Microenvironment; immunomodulation; macrophage polarization; aging; bone marrow; mesenchymal stromal cells

Mesenchymal stromal cells (MSC) are one of the main cellular components of bone marrow (BM) microenvironment. MSC play a key role in tissue regeneration, but they are also capable of immunomodulating activity. With host aging, MSC undergo age-related changes, which alter these functions, contributin...