TGFβ signaling pathways in human health and disease

• Published in: Frontiers in molecular biosciences Vol. 10; p. 1113061
• Main Authors: Chen, Pei-Yu, Qin, Lingfeng, Simons, Michael
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.06.2023
• Subjects: aneurysm; cell fate; EndMT; endothelail cell; Molecular Biosciences; smooth muscle cell; TGFβ; aneurysm; RNAi; smooth muscle cell; cell fate; TGFβ; nanoparticle; EndMT; endothelail cell

Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of d...