TGFβ signaling pathways in human health and disease

Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of d...

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Published inFrontiers in molecular biosciences Vol. 10; p. 1113061
Main Authors Chen, Pei-Yu, Qin, Lingfeng, Simons, Michael
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.06.2023
Subjects
aneurysm
cell fate
EndMT
endothelail cell
Molecular Biosciences
smooth muscle cell
TGFβ
aneurysm
RNAi
smooth muscle cell
cell fate
TGFβ
nanoparticle
EndMT
endothelail cell
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Abstract Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of different activities. TGFβs are widely expressed with almost every cell in the human body producing one or another TGFβ family member and expressing its receptors. Importantly, specific effects of this growth factor family differ in different cell types and under different physiologic and pathologic conditions. One of the more important and critical TGFβ activities is the regulation of cell fate, especially in the vasculature, that will be the focus of this review.
AbstractList Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of different activities. TGFβs are widely expressed with almost every cell in the human body producing one or another TGFβ family member and expressing its receptors. Importantly, specific effects of this growth factor family differ in different cell types and under different physiologic and pathologic conditions. One of the more important and critical TGFβ activities is the regulation of cell fate, especially in the vasculature, that will be the focus of this review.
Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of different activities. TGFβs are widely expressed with almost every cell in the human body producing one or another TGFβ family member and expressing its receptors. Importantly, specific effects of this growth factor family differ in different cell types and under different physiologic and pathologic conditions. One of the more important and critical TGFβ activities is the regulation of cell fate, especially in the vasculature, that will be the focus of this review.Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of different activities. TGFβs are widely expressed with almost every cell in the human body producing one or another TGFβ family member and expressing its receptors. Importantly, specific effects of this growth factor family differ in different cell types and under different physiologic and pathologic conditions. One of the more important and critical TGFβ activities is the regulation of cell fate, especially in the vasculature, that will be the focus of this review.
Author Qin, Lingfeng
Chen, Pei-Yu
Simons, Michael
AuthorAffiliation 2 Department of Surgery , Yale University School of Medicine , New Haven , CT , United States
3 Department of Cell Biology , Yale University School of Medicine , New Haven , CT , United States
1 Yale Cardiovascular Research Center , Department of Internal Medicine , Yale University School of Medicine , New Haven , CT , United States
AuthorAffiliation_xml – name: 3 Department of Cell Biology , Yale University School of Medicine , New Haven , CT , United States
– name: 1 Yale Cardiovascular Research Center , Department of Internal Medicine , Yale University School of Medicine , New Haven , CT , United States
– name: 2 Department of Surgery , Yale University School of Medicine , New Haven , CT , United States
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  surname: Chen
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– sequence: 2
  givenname: Lingfeng
  surname: Qin
  fullname: Qin, Lingfeng
– sequence: 3
  givenname: Michael
  surname: Simons
  fullname: Simons, Michael
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37325472$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1126/science.1124287
10.1161/CIRCULATIONAHA.118.035889
10.1038/nrm2596
10.1146/annurev-physiol-021119-034527
10.1038/ng.2007.6
10.1172/jci.insight.145651
10.1161/hh2401.101070
10.1093/emboj/21.7.1743
10.1093/eurheartj/ehs106
10.1038/35888
10.2147/DDDT.S86621
10.1016/s0021-9258(18)32345-7
10.1038/nnano.2014.84
10.12688/f1000research.9185.1
10.1083/jcb.201412052
10.1089/nat.2014.0506
10.1146/annurev.biochem.67.1.753
10.1002/0471142700.nc0412s08
10.1038/nature12207
10.1021/jacs.8b08976
10.1038/nature02382
10.1101/gad.14.2.163
10.1074/jbc.M113.480764
10.1002/ajmg.c.31552
10.1161/CIRCULATIONAHA.113.007189
10.1161/CIRCRESAHA.115.304634
10.1074/jbc.M809787200
10.1073/pnas.83.19.7311
10.1172/JCI136459
10.1128/mcb.8.10.4162
10.1038/nrm2297
10.1161/CIRCRESAHA.108.183053
10.1073/pnas.82.8.2267
10.1093/emboj/16.13.3866
10.1177/1535370219881160
10.1056/NEJM199404143301503
10.1161/CIRCRESAHA.115.301146
10.1093/cvr/cvy084
10.1016/j.ajpath.2015.03.019
10.1083/jcb.115.4.1091
10.1155/2016/9762959
10.1002/cm.21652
10.1016/j.jacl.2022.01.001
10.1038/ejhg.2015.32
10.1002/ajmg.a.36029
10.1038/ncomms13884
10.1172/JCI18607
10.1371/journal.pgen.1003652
10.1038/nm.4169
10.1111/j.1365-2141.2008.06994.x
10.1111/j.1346-8138.2009.00738.x
10.1038/nbt1402
10.1242/jcs.013169
10.1161/ATVBAHA.113.301826
10.1038/ng.2421
10.1016/j.ajhg.2018.08.001
10.1038/nrd2742
10.1038/s42255-019-0102-3
10.1038/nrcardio.2009.191
10.1016/j.jacc.2013.09.069
10.1038/ng1295-415
10.1016/S0140-6736(05)67789-6
10.1002/jcp.10170
10.1172/JCI69942
10.1161/ATVBAHA.115.306573
10.1038/ng1295-409
10.1016/j.ekir.2017.03.011
10.7554/eLife.04645
10.1161/01.cir.103.22.2745
10.1172/JCI74783
10.1016/j.jid.2018.11.007
10.1056/NEJMoa0706585
10.1093/cvr/cvac159
10.1038/s41591-019-0512-5
10.1681/ASN.2015111230
10.1126/science.1192149
10.3390/biom10111551
10.1126/scisignal.aav5183
10.1152/physrev.00047.2009
10.1242/dev.124.13.2659
10.1158/0008-5472.CAN-07-3127
10.1056/NEJM199901143400207
10.1242/jcs.00229
10.1038/nature04688
10.1016/j.cell.2004.12.035
10.1038/ng.784
10.1136/annrheumdis-2016-210229
10.1073/pnas.93.2.790
10.1038/ncomms14361
10.1016/s1097-2765(03)00386-1
10.1016/j.bpj.2021.03.012
10.1371/journal.pone.0001452
10.3390/ijms141123086
10.1073/pnas.0910603106
10.1016/j.celrep.2012.10.021
10.1177/0192623311416259
10.2174/138920111798808266
10.1126/science.286.5440.771
10.1074/jbc.M412862200
10.1126/science.6093254
10.1038/s44161-022-00042-8
10.1093/eurheartj/suz211
10.1016/s0021-9258(17)30535-5
10.1016/j.ymthe.2018.10.015
10.3899/jrheum.150088
10.1172/JCI82719
10.15252/embj.2020106113
10.14670/HH-18-132
10.1038/ng.3396
10.1038/381620a0
10.1007/BF03085963
10.1056/NEJM200003093421001
10.1038/cr.2008.328
10.1016/s0092-8674(00)80127-0
10.1161/CIRCRESAHA.119.315968
10.1172/JCI93182
10.1371/journal.pgen.1007681
10.1101/cshperspect.a021873
10.1056/NEJMra043430
10.1093/cvr/cvv175
10.1074/jbc.R400029200
10.1038/ki.2011.33
10.1161/ATVBAHA.117.309002
10.1002/j.1460-2075.1991.tb08049.x
10.1186/1756-0500-6-456
10.1038/srep02038
10.1038/s41569-021-00517-4
10.1091/mbc.E11-02-0103
10.1113/jphysiol.2010.194753
10.1161/01.RES.0000255691.76142.4a
10.1016/s0092-8674(00)80555-3
10.1093/nar/gkl356
10.1161/ATVBAHA.117.309180
10.1126/scitranslmed.3006927
10.1126/science.aat3470
10.1126/sciadv.aar8409
10.1101/cshperspect.a021907
10.1016/s0092-8674(00)80545-0
10.1038/onc.2010.169
10.1073/pnas.1811276115
10.1016/s0021-9258(17)32142-7
10.1073/pnas.77.6.3494
10.1038/359067a0
10.1161/CIRCULATIONAHA.113.005015
10.1086/324123
10.1172/JCI69666
10.1038/nature17178
10.4330/wjc.v11.i1.1
10.2217/nmt-2018-0033
10.1172/JCI123106
10.1253/circj.CJ-16-1003
10.1161/CIRCRESAHA.116.309799
10.1073/pnas.232551499
10.1038/nm1613
10.1161/01.RES.0000255690.03436.ae
10.1038/nature02871
10.1091/mbc.e05-10-0990
10.1016/j.cmet.2014.03.025
10.1111/cge.12436
10.1038/370341a0
10.1161/CIRCULATIONAHA.111.040352
10.1038/ng1511
10.21037/acs.2017.11.03
10.1073/pnas.1708247114
10.1016/j.jacc.2018.09.089
10.1038/352337a0
10.1073/pnas.1306529110
10.1016/s1097-2765(02)00585-3
10.1111/liv.15090
10.1038/labinvest.2011.124
10.1101/gad.13.17.2196
10.1056/NEJMoa2021712
10.1371/journal.pone.0040990
10.1056/NEJM199602013340508
10.1016/j.stem.2020.02.013
10.1161/ATVBAHA.120.314978
10.1161/CIRCULATIONAHA.114.008750
10.1073/pnas.2112625118
10.1056/NEJMoa1404731
10.1038/ncomms11853
10.1002/art.22289
10.1210/jc.2012-1349
10.1046/j.1523-1755.2001.059002579.x
10.1046/j.1523-1747.2000.00010.x
10.1016/j.gim.2021.10.002
10.1038/nature04303
10.1016/0092-8674(92)90395-s
10.1038/ng1721
10.1002/jor.22920
10.1161/ATVBAHA.116.307294
10.1093/nar/23.11.2019
10.1038/nri3908
10.1016/j.matbio.2020.05.003
10.1038/359693a0
10.1371/journal.pone.0096005
10.1038/gim.2014.11
10.1002/humu.9377
10.1124/mol.118.112946
10.3390/pharmaceutics14081698
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Keywords aneurysm
RNAi
smooth muscle cell
cell fate
TGFβ
nanoparticle
EndMT
endothelail cell
Language English
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Edited by: Shizuya Saika, Wakayama Medical University Hospital, Japan
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References Khan (B87) 2018; 4
Tucker (B178) 1984; 226
Wang (B188) 2013; 33
Whitehead (B190) 2009; 8
Nikpay (B135) 2015; 47
Aird (B1) 2007; 100
Guo (B67) 2007; 39
Frank (B55) 2015; 23
Lu (B113) 2017; 37
Dietz (B45) 1993
Lu (B114) 2021; 41
Erdmann (B49) 2018; 114
La Rosa (B95) 2020; 10
Mulligan-Kehoe (B130) 2014; 129
Gallant-Behm (B56) 2019; 139
El-Hamamsy (B48) 2009; 6
Cheng (B27) 2022; 1
Culley (B36) 2021; 131
Yu (B195) 2000; 14
Ambros (B6) 2004; 431
Miyazono (B126) 1991; 10
Uike (B180) 2013; 6
Varricchio (B181) 2021; 6
Chen (B23) 2012; 2
Kristen (B93) 2019; 9
Bao (B14) 2013; 14
Kovacic (B90) 2019; 73
Manetti (B120) 2017; 76
Dietz (B44) 1991; 352
Trachtman (B177) 2011; 79
Huse (B76) 1999; 96
Krutzfeldt (B94) 2005; 438
Rensen (B146) 2007; 15
Judge (B83) 2005; 366
Rifkin (B148) 2005; 280
Sanford (B155) 1997; 124
Sago (B153) 2018; 140
Cui (B34) 2022; 14
Fleenor (B53) 2010; 588
Pfundheller (B141) 2002; 4
Robertson (B150) 2003; 112
Inman (B77) 2002; 10
Schunkert (B159) 2011; 43
Allahverdian (B5) 2014; 129
Ivey (B78) 2016; 80
Zimmermann (B203) 2006; 441
Lacro (B96) 2014; 371
Tallquist (B173) 2020; 82
Leone (B99) 2012; 97
Simons (B165) 1992; 359
Li (B102) 2014; 124
Li (B103) 2009; 284
Habashi (B68) 2006; 312
Roberts (B149) 1980; 77
Luo (B115) 1999; 13
Zeisberg (B198) 2007; 13
Herbertz (B73) 2015; 9
Loeys (B109) 2005; 37
Munger (B131) 1999; 96
Krenning (B92) 2016; 2016
Long (B111) 2014; 19
Strutz (B171) 2001; 59
Moonen (B127) 2015; 108
Holm (B74) 2011; 332
Gentry (B59) 1988; 8
Love (B112) 2010; 107
Stroschein (B170) 1999; 286
Chen (B24) 2020; 26
Liu (B108) 2005; 280
Hansson (B72) 2005; 352
Ricard (B147) 2021; 18
Hahn (B69) 2009; 10
Hu (B75) 2015; 35
Brader (B16) 2021; 120
Lai (B97) 2014; 115
Marenberg (B121) 1994; 330
Baeyens (B13) 2015; 4
GordonAbraham Lincoln--a medical appraisal (B61) 1962; 60
Cheifetz (B21) 1990; 265
Zhang (B199) 2009; 19
Liu (B107) 1996; 381
Li (B101) 2013; 3
Anderton (B7) 2011; 39
Lievens (B105) 2013; 34
Kallend (B86) 2022; 16
Jenny Zhou (B81) 2016; 22
Schwartz (B160) 2018; 360
Shull (B163) 1992; 359
Alabi (B4) 2013; 110
Morikawa (B129) 2016; 8
Deng (B40) 2021; 118
Liao (B104) 2014; 63
Parapia (B137) 2008; 141
Dewan (B43) 2015; 33
Cordeiro (B32) 2000; 41
Yu (B194) 2016; 7
Chen (B22) 2015; 125
Akinc (B3) 2008; 26
Jaschinski (B80) 2011; 12
Meester (B124) 2017; 6
Massague (B122) 1998; 67
Malfait (B119) 2017; 175
Proetzel (B143) 1995; 11
Braun (B17) 2010; 29
Arbustini (B9) 2005; 26
Doyle (B46) 2012; 44
Iyer (B79) 2018; 14
Hall (B70) 2013; 288
Ota (B136) 2002; 193
Chiu (B28) 2011; 91
Feil (B51) 2014; 115
Denton (B41) 2007; 56
Brooke (B18) 2008; 358
Guerrerio (B66) 2022; 24
Wang (B189) 2004; 428
Voelker (B185) 2017; 28
Schmierer (B157) 2007; 8
Goumans (B64) 2002; 21
Chen (B26) 1997; 16
McCann (B123) 2019; 129
Koeppen (B89) 2020; 35
Cui (B35) 1996; 86
Jinnin (B82) 2010; 37
Nguyen (B134) 2011; 91
Wrana (B192) 1994; 370
Zeisberg (B197) 2007; 67
Savage (B156) 1996; 93
Turner (B179) 2016; 36
Spender (B168) 2019; 95
Askari (B11) 1996; 334
Derynck (B42) 2019; 12
Soliman (B166) 2020
Yamashita (B193) 1994; 269
Cook (B30) 2015; 87
Dejana (B39) 2017; 8
Loeys (B110) 2013; 10
Pelton (B139) 1991; 115
Cipriani (B29) 2015; 42
Pepin (B140) 2000; 342
Zhu (B202) 2006; 38
Ross (B152) 1999; 340
Yu (B196) 2019; 139
Fire (B52) 1998; 391
Crowe (B33) 2000; 115
Gregory (B65) 2011; 22
Annes (B8) 2003; 116
Speer (B167) 2009; 104
Kim (B88) 2019; 244
Miller (B125) 2013; 9
Seyedin (B162) 1985; 82
Kaartinen (B85) 1995; 11
Neese (B133) 2002; 99
Liu (B106) 2018; 103
Gallo (B57) 2014; 124
Sago (B154) 2018; 115
Maejima (B118) 2014; 9
Dahlman (B38) 2014; 9
Pieterse (B142) 2017; 37
Moore-Morris (B128) 2014; 124
Steitz (B169) 2001; 89
Kovacic (B91) 2012; 125
Schreiber (B158) 2017; 114
Tan (B174) 2013
Bartram (B15) 2001; 103
Hanson (B71) 2019; 11
Arif (B10) 2021; 40
Jung (B84) 2017; 127
Maddaluno (B117) 2013; 498
Evrard (B50) 2016; 7
Tabas (B172) 2015; 209
Good (B60) 2015; 185
Vincenti (B184) 2017; 2
Ventura (B182) 2022; 42
Walker (B187) 1986; 83
Nagao (B132) 2020; 126
Chen (B25) 2019; 1
Park (B138) 2019; 27
Reifenberg (B145) 2012; 7
Wrana (B186) 1992; 71
Eckstein (B47) 2014; 24
MacCarrick (B116) 2014; 16
Aird (B2) 2007; 100
Vestweber (B183) 2015; 15
Tanaka (B175) 2021; 78
Zhao (B200) 2006; 17
Assoian (B12) 1983; 258
Goumans (B63) 2003; 12
Robertson (B151) 2016; 8
Chappell (B20) 2016; 119
Cummins (B37) 1995; 23
Cooley (B31) 2014; 6
Wirka (B191) 2019; 25
Ranchoux (B144) 2015; 131
Lewis (B100) 2005; 120
Zhou (B201) 2016; 532
Fleming (B54) 2008; 3
Garrelfs (B58) 2021; 384
Simonneau (B164) 2019; 21
Lee (B98) 2022
Schwarze (B161) 2001; 69
Carvalho (B19) 2007; 120
Goswami (B62) 2016; 5
Tjaden (B176) 2006; 34
References_xml – volume: 312
  start-page: 117
  year: 2006
  ident: B68
  article-title: Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
  publication-title: Science
  doi: 10.1126/science.1124287
– volume: 139
  start-page: 2238
  year: 2019
  ident: B196
  article-title: BOLA (BolA family member 3) deficiency controls endothelial metabolism and Glycine homeostasis in pulmonary hypertension
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.118.035889
– volume: 10
  start-page: 53
  year: 2009
  ident: B69
  article-title: Mechanotransduction in vascular physiology and atherogenesis
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2596
– volume: 82
  start-page: 63
  year: 2020
  ident: B173
  article-title: Cardiac fibroblast diversity
  publication-title: Annu. Rev. Physiol.
  doi: 10.1146/annurev-physiol-021119-034527
– volume: 39
  start-page: 1488
  year: 2007
  ident: B67
  article-title: Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2007.6
– volume: 6
  start-page: e145651
  year: 2021
  ident: B181
  article-title: TGF-β1 protein trap AVID200 beneficially affects hematopoiesis and bone marrow fibrosis in myelofibrosis
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.145651
– volume: 89
  start-page: 1147
  year: 2001
  ident: B169
  article-title: Smooth muscle cell phenotypic transition associated with calcification: Upregulation of Cbfa1 and downregulation of smooth muscle lineage markers
  publication-title: Circ. Res.
  doi: 10.1161/hh2401.101070
– volume: 21
  start-page: 1743
  year: 2002
  ident: B64
  article-title: Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
  publication-title: EMBO J.
  doi: 10.1093/emboj/21.7.1743
– volume: 34
  start-page: 3717
  year: 2013
  ident: B105
  article-title: Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehs106
– volume: 391
  start-page: 806
  year: 1998
  ident: B52
  article-title: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
  publication-title: Nature
  doi: 10.1038/35888
– volume: 9
  start-page: 4479
  year: 2015
  ident: B73
  article-title: Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway
  publication-title: Drug Des. Devel Ther.
  doi: 10.2147/DDDT.S86621
– volume: 258
  start-page: 7155
  year: 1983
  ident: B12
  article-title: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization
  publication-title: J. Biol. Chem.
  doi: 10.1016/s0021-9258(18)32345-7
– volume: 9
  start-page: 648
  year: 2014
  ident: B38
  article-title: In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
  publication-title: Nat. Nanotechnol.
  doi: 10.1038/nnano.2014.84
– volume: 5
  start-page: F1000 Faculty Rev-2321
  year: 2016
  ident: B62
  article-title: How leukocytes trigger opening and sealing of gaps in the endothelial barrier
  publication-title: F1000Res
  doi: 10.12688/f1000research.9185.1
– volume: 209
  start-page: 13
  year: 2015
  ident: B172
  article-title: Recent insights into the cellular biology of atherosclerosis
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.201412052
– volume: 24
  start-page: 374
  year: 2014
  ident: B47
  article-title: Phosphorothioates, essential components of therapeutic oligonucleotides
  publication-title: Nucleic Acid. Ther.
  doi: 10.1089/nat.2014.0506
– volume: 67
  start-page: 753
  year: 1998
  ident: B122
  article-title: TGF-beta signal transduction
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.biochem.67.1.753
– volume: 4
  start-page: Unit 4.12
  year: 2002
  ident: B141
  article-title: Locked nucleic acids: Synthesis and characterization of LNA-T diol
  publication-title: Curr. Protoc. Nucleic Acid. Chem
  doi: 10.1002/0471142700.nc0412s08
– volume: 498
  start-page: 492
  year: 2013
  ident: B117
  article-title: EndMT contributes to the onset and progression of cerebral cavernous malformations
  publication-title: Nature
  doi: 10.1038/nature12207
– volume: 140
  start-page: 17095
  year: 2018
  ident: B153
  article-title: Nanoparticles that deliver RNA to bone marrow identified by in vivo directed evolution
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.8b08976
– volume: 428
  start-page: 185
  year: 2004
  ident: B189
  article-title: Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression
  publication-title: Nature
  doi: 10.1038/nature02382
– volume: 14
  start-page: 163
  year: 2000
  ident: B195
  article-title: Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
  publication-title: Genes Dev.
  doi: 10.1101/gad.14.2.163
– volume: 288
  start-page: 32074
  year: 2013
  ident: B70
  article-title: Transforming growth factor-β3 (TGF-β3) knock-in ameliorates inflammation due to TGF-β1 deficiency while promoting glucose tolerance
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.480764
– volume: 175
  start-page: 8
  year: 2017
  ident: B119
  article-title: The 2017 international classification of the Ehlers-Danlos syndromes
  publication-title: Am. J. Med. Genet. C Semin. Med. Genet.
  doi: 10.1002/ajmg.c.31552
– volume: 129
  start-page: 2557
  year: 2014
  ident: B130
  article-title: Vasa vasorum in normal and diseased arteries
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.007189
– volume: 115
  start-page: 662
  year: 2014
  ident: B51
  article-title: Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.115.304634
– volume: 284
  start-page: 15676
  year: 2009
  ident: B103
  article-title: Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M809787200
– volume: 83
  start-page: 7311
  year: 1986
  ident: B187
  article-title: Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.83.19.7311
– volume: 131
  start-page: e136459
  year: 2021
  ident: B36
  article-title: Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI136459
– volume: 8
  start-page: 4162
  year: 1988
  ident: B59
  article-title: Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide
  publication-title: Mol. Cell Biol.
  doi: 10.1128/mcb.8.10.4162
– volume: 8
  start-page: 970
  year: 2007
  ident: B157
  article-title: TGFbeta-SMAD signal transduction: Molecular specificity and functional flexibility
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2297
– volume: 41
  start-page: 756
  year: 2000
  ident: B32
  article-title: TGF-beta1, -beta2, and -beta3 in vitro: Biphasic effects on tenon's fibroblast contraction, proliferation, and migration
  publication-title: Invest. Ophthalmol. Vis. Sci.
– volume: 104
  start-page: 733
  year: 2009
  ident: B167
  article-title: Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.108.183053
– volume: 82
  start-page: 2267
  year: 1985
  ident: B162
  article-title: Purification and characterization of two cartilage-inducing factors from bovine demineralized bone
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.82.8.2267
– volume: 16
  start-page: 3866
  year: 1997
  ident: B26
  article-title: Mechanism of TGFbeta receptor inhibition by FKBP12
  publication-title: EMBO J.
  doi: 10.1093/emboj/16.13.3866
– volume: 244
  start-page: 1547
  year: 2019
  ident: B88
  article-title: Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family
  publication-title: Exp. Biol. Med. (Maywood)
  doi: 10.1177/1535370219881160
– volume: 330
  start-page: 1041
  year: 1994
  ident: B121
  article-title: Genetic susceptibility to death from coronary heart disease in a study of twins
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199404143301503
– volume: 115
  start-page: 115
  year: 2014
  ident: B97
  article-title: Pulmonary arterial hypertension: The clinical syndrome
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.115.301146
– volume: 114
  start-page: 1241
  year: 2018
  ident: B49
  article-title: A decade of genome-wide association studies for coronary artery disease: The challenges ahead
  publication-title: Cardiovasc Res.
  doi: 10.1093/cvr/cvy084
– volume: 185
  start-page: 1850
  year: 2015
  ident: B60
  article-title: Endothelial to mesenchymal transition contributes to endothelial dysfunction in pulmonary arterial hypertension
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2015.03.019
– volume: 115
  start-page: 1091
  year: 1991
  ident: B139
  article-title: Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.115.4.1091
– volume: 2016
  start-page: 9762959
  year: 2016
  ident: B92
  article-title: Endothelial plasticity: Shifting phenotypes through force feedback
  publication-title: Stem Cells Int.
  doi: 10.1155/2016/9762959
– volume: 78
  start-page: 217
  year: 2021
  ident: B175
  article-title: Early events in endothelial flow sensing
  publication-title: Cytoskelet. Hob.
  doi: 10.1002/cm.21652
– volume: 16
  start-page: 208
  year: 2022
  ident: B86
  article-title: Pharmacokinetics and pharmacodynamics of inclisiran, a small interfering RNA therapy, in patients with hepatic impairment
  publication-title: J. Clin. Lipidol.
  doi: 10.1016/j.jacl.2022.01.001
– volume: 23
  start-page: 1657
  year: 2015
  ident: B55
  article-title: The type of variants at the COL3A1 gene associates with the phenotype and severity of vascular Ehlers-Danlos syndrome
  publication-title: Eur. J. Hum. Genet.
  doi: 10.1038/ejhg.2015.32
– start-page: 1910
  year: 2013
  ident: B174
  article-title: Increased fracture risk and low bone mineral density in patients with loeys-dietz syndrome
  publication-title: Am. J. Med. Genet. A
  doi: 10.1002/ajmg.a.36029
– volume: 7
  start-page: 13884
  year: 2016
  ident: B194
  article-title: MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13884
– volume: 112
  start-page: 1342
  year: 2003
  ident: B150
  article-title: Disruption of TGF-beta signaling in T cells accelerates atherosclerosis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI18607
– volume: 9
  start-page: e1003652
  year: 2013
  ident: B125
  article-title: Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1003652
– volume: 22
  start-page: 1033
  year: 2016
  ident: B81
  article-title: Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation
  publication-title: Nat. Med.
  doi: 10.1038/nm.4169
– volume: 141
  start-page: 32
  year: 2008
  ident: B137
  article-title: Ehlers-Danlos syndrome-a historical review
  publication-title: Br. J. Haematol.
  doi: 10.1111/j.1365-2141.2008.06994.x
– volume: 37
  start-page: 11
  year: 2010
  ident: B82
  article-title: Mechanisms of skin fibrosis in systemic sclerosis
  publication-title: J. Dermatol
  doi: 10.1111/j.1346-8138.2009.00738.x
– volume: 26
  start-page: 561
  year: 2008
  ident: B3
  article-title: A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1402
– volume: 120
  start-page: 4269
  year: 2007
  ident: B19
  article-title: Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.013169
– volume: 33
  start-page: 2130
  year: 2013
  ident: B188
  article-title: Endothelial cell sensing of flow direction
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.113.301826
– volume: 44
  start-page: 1249
  year: 2012
  ident: B46
  article-title: Mutations in the TGF-beta repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2421
– volume: 103
  start-page: 377
  year: 2018
  ident: B106
  article-title: Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2018.08.001
– volume: 8
  start-page: 129
  year: 2009
  ident: B190
  article-title: Knocking down barriers: Advances in siRNA delivery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd2742
– volume: 1
  start-page: 912
  year: 2019
  ident: B25
  article-title: Endothelial TGF-beta signalling drives vascular inflammation and atherosclerosis
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-019-0102-3
– volume: 6
  start-page: 771
  year: 2009
  ident: B48
  article-title: Cellular and molecular mechanisms of thoracic aortic aneurysms
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/nrcardio.2009.191
– volume: 63
  start-page: 1685
  year: 2014
  ident: B104
  article-title: Let-7g improves multiple endothelial functions through targeting transforming growth factor-beta and SIRT-1 signaling
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2013.09.069
– volume: 11
  start-page: 415
  year: 1995
  ident: B85
  article-title: Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
  publication-title: Nat. Genet.
  doi: 10.1038/ng1295-415
– volume: 366
  start-page: 1965
  year: 2005
  ident: B83
  article-title: Marfan's syndrome
  publication-title: Lancet
  doi: 10.1016/S0140-6736(05)67789-6
– volume: 193
  start-page: 299
  year: 2002
  ident: B136
  article-title: Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells
  publication-title: J. Cell Physiol.
  doi: 10.1002/jcp.10170
– volume: 124
  start-page: 755
  year: 2014
  ident: B102
  article-title: Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI69942
– volume: 35
  start-page: 2647
  year: 2015
  ident: B75
  article-title: Postnatal deletion of the type II transforming growth factor-beta receptor in smooth muscle cells causes severe aortopathy in mice
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.115.306573
– volume: 11
  start-page: 409
  year: 1995
  ident: B143
  article-title: Transforming growth factor-beta 3 is required for secondary palate fusion
  publication-title: Nat. Genet.
  doi: 10.1038/ng1295-409
– volume: 2
  start-page: 800
  year: 2017
  ident: B184
  article-title: A phase 2, double-blind, placebo-controlled, randomized study of fresolimumab in patients with steroid-resistant primary focal segmental glomerulosclerosis
  publication-title: Kidney Int. Rep.
  doi: 10.1016/j.ekir.2017.03.011
– volume: 4
  start-page: e04645
  year: 2015
  ident: B13
  article-title: Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
  publication-title: Elife
  doi: 10.7554/eLife.04645
– volume: 103
  start-page: 2745
  year: 2001
  ident: B15
  article-title: Double-outlet right ventricle and overriding tricuspid valve reflect disturbances of looping, myocardialization, endocardial cushion differentiation, and apoptosis in TGF-beta(2)-knockout mice
  publication-title: Circulation
  doi: 10.1161/01.cir.103.22.2745
– volume: 124
  start-page: 2921
  year: 2014
  ident: B128
  article-title: Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI74783
– volume: 139
  start-page: 1073
  year: 2019
  ident: B56
  article-title: A MicroRNA-29 mimic (remlarsen) represses extracellular matrix expression and fibroplasia in the skin
  publication-title: J. Invest. Dermatol
  doi: 10.1016/j.jid.2018.11.007
– volume: 358
  start-page: 2787
  year: 2008
  ident: B18
  article-title: Angiotensin II blockade and aortic-root dilation in Marfan's syndrome
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0706585
– start-page: cvac159
  year: 2022
  ident: B98
  article-title: BMPR1A promotes ID2-ZEB1 interaction to suppress excessive endothelial to mesenchymal transition
  publication-title: Cardiovasc Res.
  doi: 10.1093/cvr/cvac159
– volume: 25
  start-page: 1280
  year: 2019
  ident: B191
  article-title: Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis
  publication-title: Nat. Med.
  doi: 10.1038/s41591-019-0512-5
– volume: 28
  start-page: 953
  year: 2017
  ident: B185
  article-title: Anti-TGF-β1 antibody therapy in patients with diabetic nephropathy
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2015111230
– volume: 332
  start-page: 358
  year: 2011
  ident: B74
  article-title: Noncanonical TGFβ signaling contributes to aortic aneurysm progression in Marfan syndrome mice
  publication-title: Science
  doi: 10.1126/science.1192149
– volume: 10
  start-page: 1551
  year: 2020
  ident: B95
  article-title: Ferroptosis in Friedreich's ataxia: A metal-induced neurodegenerative disease
  publication-title: Biomolecules
  doi: 10.3390/biom10111551
– volume: 12
  start-page: eaav5183
  year: 2019
  ident: B42
  article-title: Specificity, versatility, and control of TGF-beta family signaling
  publication-title: Sci. Signal
  doi: 10.1126/scisignal.aav5183
– volume: 91
  start-page: 327
  year: 2011
  ident: B28
  article-title: Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00047.2009
– volume: 124
  start-page: 2659
  year: 1997
  ident: B155
  article-title: TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes
  publication-title: Development
  doi: 10.1242/dev.124.13.2659
– volume: 67
  start-page: 10123
  year: 2007
  ident: B197
  article-title: Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-3127
– volume: 340
  start-page: 115
  year: 1999
  ident: B152
  article-title: Atherosclerosis-an inflammatory disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199901143400207
– volume: 116
  start-page: 217
  year: 2003
  ident: B8
  article-title: Making sense of latent TGFbeta activation
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.00229
– volume: 441
  start-page: 111
  year: 2006
  ident: B203
  article-title: RNAi-mediated gene silencing in non-human primates
  publication-title: Nature
  doi: 10.1038/nature04688
– volume: 120
  start-page: 15
  year: 2005
  ident: B100
  article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
  publication-title: Cell
  doi: 10.1016/j.cell.2004.12.035
– volume: 43
  start-page: 333
  year: 2011
  ident: B159
  article-title: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
  publication-title: Nat. Genet.
  doi: 10.1038/ng.784
– volume: 76
  start-page: 924
  year: 2017
  ident: B120
  article-title: Endothelial-to-mesenchymal transition contributes to endothelial dysfunction and dermal fibrosis in systemic sclerosis
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2016-210229
– volume: 93
  start-page: 790
  year: 1996
  ident: B156
  article-title: Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.93.2.790
– volume: 8
  start-page: 14361
  year: 2017
  ident: B39
  article-title: The molecular basis of endothelial cell plasticity
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14361
– volume: 12
  start-page: 817
  year: 2003
  ident: B63
  article-title: Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
  publication-title: Mol. Cell
  doi: 10.1016/s1097-2765(03)00386-1
– volume: 120
  start-page: 2766
  year: 2021
  ident: B16
  article-title: Encapsulation state of messenger RNA inside lipid nanoparticles
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2021.03.012
– volume: 3
  start-page: e1452
  year: 2008
  ident: B54
  article-title: Capillary regeneration in scleroderma: Stem cell therapy reverses phenotype?
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0001452
– volume: 14
  start-page: 23086
  year: 2013
  ident: B14
  article-title: Let-7 in cardiovascular diseases, heart development and cardiovascular differentiation from stem cells
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms141123086
– volume: 107
  start-page: 1864
  year: 2010
  ident: B112
  article-title: Lipid-like materials for low-dose, in vivo gene silencing
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.0910603106
– volume: 2
  start-page: 1684
  year: 2012
  ident: B23
  article-title: FGF regulates TGF-beta signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2012.10.021
– volume: 39
  start-page: 916
  year: 2011
  ident: B7
  article-title: Induction of heart valve lesions by small-molecule ALK5 inhibitors
  publication-title: Toxicol. Pathol.
  doi: 10.1177/0192623311416259
– volume: 12
  start-page: 2203
  year: 2011
  ident: B80
  article-title: The antisense oligonucleotide trabedersen (AP 12009) for the targeted inhibition of TGF-β2
  publication-title: Curr. Pharm. Biotechnol.
  doi: 10.2174/138920111798808266
– volume: 286
  start-page: 771
  year: 1999
  ident: B170
  article-title: Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein
  publication-title: Science
  doi: 10.1126/science.286.5440.771
– volume: 280
  start-page: 9719
  year: 2005
  ident: B108
  article-title: Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M412862200
– volume: 226
  start-page: 705
  year: 1984
  ident: B178
  article-title: Growth inhibitor from BSC-1 cells closely related to platelet type beta transforming growth factor
  publication-title: Science
  doi: 10.1126/science.6093254
– volume: 1
  start-page: 322
  year: 2022
  ident: B27
  article-title: Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque
  publication-title: Nat. Cardiovasc Res.
  doi: 10.1038/s44161-022-00042-8
– volume: 21
  start-page: K4
  year: 2019
  ident: B164
  article-title: The revised definition of pulmonary hypertension: Exploring the impact on patient management
  publication-title: Eur. Heart J. Suppl.
  doi: 10.1093/eurheartj/suz211
– volume: 265
  start-page: 20533
  year: 1990
  ident: B21
  article-title: Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms
  publication-title: J. Biol. Chem.
  doi: 10.1016/s0021-9258(17)30535-5
– volume: 27
  start-page: 342
  year: 2019
  ident: B138
  article-title: LDR-induced miR-30a and miR-30b target the PAI-1 pathway to control adverse effects of NSCLC radiotherapy
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2018.10.015
– volume: 42
  start-page: 1808
  year: 2015
  ident: B29
  article-title: The endothelial-mesenchymal transition in systemic sclerosis is induced by endothelin-1 and transforming growth factor-beta and may Be blocked by macitentan, a dual endothelin-1 receptor antagonist
  publication-title: J. Rheumatol.
  doi: 10.3899/jrheum.150088
– volume: 125
  start-page: 4514
  year: 2015
  ident: B22
  article-title: Endothelial-to-mesenchymal transition drives atherosclerosis progression
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI82719
– volume: 40
  start-page: e106113
  year: 2021
  ident: B10
  article-title: PECAM-1 supports leukocyte diapedesis by tension-dependent dephosphorylation of VE-cadherin
  publication-title: EMBO J.
  doi: 10.15252/embj.2020106113
– volume: 35
  start-page: 39
  year: 2020
  ident: B89
  article-title: Microvascular pathology in Friedreich cardiomyopathy
  publication-title: Histol. Histopathol.
  doi: 10.14670/HH-18-132
– volume: 47
  start-page: 1121
  year: 2015
  ident: B135
  article-title: A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3396
– volume: 381
  start-page: 620
  year: 1996
  ident: B107
  article-title: A human Mad protein acting as a BMP-regulated transcriptional activator
  publication-title: Nature
  doi: 10.1038/381620a0
– volume: 15
  start-page: 100
  year: 2007
  ident: B146
  article-title: Regulation and characteristics of vascular smooth muscle cell phenotypic diversity
  publication-title: Neth Heart J.
  doi: 10.1007/BF03085963
– volume: 342
  start-page: 673
  year: 2000
  ident: B140
  article-title: Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM200003093421001
– volume: 19
  start-page: 128
  year: 2009
  ident: B199
  article-title: Non-Smad pathways in TGF-beta signaling
  publication-title: Cell Res.
  doi: 10.1038/cr.2008.328
– volume: 86
  start-page: 531
  year: 1996
  ident: B35
  article-title: TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
  publication-title: Cell
  doi: 10.1016/s0092-8674(00)80127-0
– volume: 126
  start-page: 517
  year: 2020
  ident: B132
  article-title: Coronary disease-associated gene TCF21 inhibits smooth muscle cell differentiation by blocking the myocardin-serum response factor pathway
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.119.315968
– volume: 127
  start-page: 3039
  year: 2017
  ident: B84
  article-title: Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI93182
– volume: 14
  start-page: e1007681
  year: 2018
  ident: B79
  article-title: Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1007681
– volume: 8
  start-page: a021873
  year: 2016
  ident: B129
  article-title: TGF-Beta and the TGF-beta family: Context-dependent roles in cell and tissue physiology
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a021873
– volume: 352
  start-page: 1685
  year: 2005
  ident: B72
  article-title: Inflammation, atherosclerosis, and coronary artery disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMra043430
– volume: 108
  start-page: 377
  year: 2015
  ident: B127
  article-title: Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress
  publication-title: Cardiovasc Res.
  doi: 10.1093/cvr/cvv175
– volume: 280
  start-page: 7409
  year: 2005
  ident: B148
  article-title: Latent transforming growth factor-beta (TGF-beta) binding proteins: Orchestrators of TGF-beta availability
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R400029200
– volume: 79
  start-page: 1236
  year: 2011
  ident: B177
  article-title: A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis
  publication-title: Kidney Int.
  doi: 10.1038/ki.2011.33
– volume: 37
  start-page: 1371
  year: 2017
  ident: B142
  article-title: Neutrophil extracellular traps drive endothelial-to-mesenchymal transition
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.117.309002
– volume: 10
  start-page: 1091
  year: 1991
  ident: B126
  article-title: A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1
  publication-title: EMBO J.
  doi: 10.1002/j.1460-2075.1991.tb08049.x
– volume: 60
  start-page: 249
  year: 1962
  ident: B61
  article-title: Abraham Lincoln-a medical appraisal
  publication-title: J. Ky Med. Assoc.
– volume: 6
  start-page: 456
  year: 2013
  ident: B180
  article-title: Systemic vascular phenotypes of loeys-dietz syndrome in a child carrying a de novo R381P mutation in TGFBR2: A case report
  publication-title: BMC Res. Notes
  doi: 10.1186/1756-0500-6-456
– volume: 3
  start-page: 2038
  year: 2013
  ident: B101
  article-title: MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
  publication-title: Sci. Rep.
  doi: 10.1038/srep02038
– volume: 18
  start-page: 565
  year: 2021
  ident: B147
  article-title: The quiescent endothelium: Signalling pathways regulating organ-specific endothelial normalcy
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-021-00517-4
– volume: 22
  start-page: 1686
  year: 2011
  ident: B65
  article-title: An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.E11-02-0103
– volume: 588
  start-page: 3971
  year: 2010
  ident: B53
  article-title: Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: Reversal by aerobic exercise
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2010.194753
– volume: 100
  start-page: 158
  year: 2007
  ident: B2
  article-title: Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000255691.76142.4a
– volume: 96
  start-page: 425
  year: 1999
  ident: B76
  article-title: Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12
  publication-title: Cell
  doi: 10.1016/s0092-8674(00)80555-3
– volume: 34
  start-page: 2791
  year: 2006
  ident: B176
  article-title: Target prediction for small, noncoding RNAs in bacteria
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkl356
– volume: 37
  start-page: 1380
  year: 2017
  ident: B113
  article-title: Endothelial myocyte enhancer factor 2c inhibits migration of smooth muscle cells through fenestrations in the internal elastic lamina
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.117.309180
– volume: 6
  start-page: 227ra34
  year: 2014
  ident: B31
  article-title: TGF-beta signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3006927
– volume: 360
  start-page: 270
  year: 2018
  ident: B160
  article-title: A unifying concept in vascular health and disease
  publication-title: Science
  doi: 10.1126/science.aat3470
– volume: 4
  start-page: eaar8409
  year: 2018
  ident: B87
  article-title: Endothelial siRNA delivery in nonhuman primates using ionizable low-molecular weight polymeric nanoparticles
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aar8409
– volume: 8
  start-page: a021907
  year: 2016
  ident: B151
  article-title: Regulation of the bioavailability of TGF-beta and TGF-beta-related proteins
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a021907
– volume-title: FBN1-Related marfan syndrome
  year: 1993
  ident: B45
– volume: 96
  start-page: 319
  year: 1999
  ident: B131
  article-title: The integrin alpha v beta 6 binds and activates latent TGF beta 1: A mechanism for regulating pulmonary inflammation and fibrosis
  publication-title: Cell
  doi: 10.1016/s0092-8674(00)80545-0
– volume: 29
  start-page: 4237
  year: 2010
  ident: B17
  article-title: Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
  publication-title: Oncogene
  doi: 10.1038/onc.2010.169
– volume: 10
  start-page: 417
  year: 2013
  ident: B110
  article-title: Bone lessons from marfan syndrome and related disorders: Fibrillin, TGF-B and BMP at the balance of too long and too short
  publication-title: Pediatr. Endocrinol. Rev.
– volume: 115
  start-page: E9944
  year: 2018
  ident: B154
  article-title: High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1811276115
– volume: 269
  start-page: 20172
  year: 1994
  ident: B193
  article-title: Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta
  publication-title: J. Biol. Chem.
  doi: 10.1016/s0021-9258(17)32142-7
– volume: 77
  start-page: 3494
  year: 1980
  ident: B149
  article-title: Transforming growth factors: Isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.77.6.3494
– volume: 359
  start-page: 67
  year: 1992
  ident: B165
  article-title: Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo
  publication-title: Nature
  doi: 10.1038/359067a0
– volume: 129
  start-page: 1551
  year: 2014
  ident: B5
  article-title: Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.113.005015
– volume: 69
  start-page: 989
  year: 2001
  ident: B161
  article-title: Haploinsufficiency for one COL3A1 allele of type III procollagen results in a phenotype similar to the vascular form of Ehlers-Danlos syndrome, Ehlers-Danlos syndrome type IV
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/324123
– volume: 124
  start-page: 448
  year: 2014
  ident: B57
  article-title: Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI69666
– volume: 532
  start-page: 122
  year: 2016
  ident: B201
  article-title: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling
  publication-title: Nature
  doi: 10.1038/nature17178
– volume: 11
  start-page: 1
  year: 2019
  ident: B71
  article-title: Heart disease in Friedreich's ataxia
  publication-title: World J. Cardiol.
  doi: 10.4330/wjc.v11.i1.1
– volume: 9
  start-page: 5
  year: 2019
  ident: B93
  article-title: Patisiran, an RNAi therapeutic for the treatment of hereditary transthyretin-mediated amyloidosis
  publication-title: Neurodegener. Dis. Manag.
  doi: 10.2217/nmt-2018-0033
– volume: 129
  start-page: 1654
  year: 2019
  ident: B123
  article-title: Endothelial miR-30c suppresses tumor growth via inhibition of TGF-beta-induced Serpine1
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI123106
– volume: 80
  start-page: 2269
  year: 2016
  ident: B78
  article-title: Defining the cardiac fibroblast
  publication-title: Circ. J.
  doi: 10.1253/circj.CJ-16-1003
– volume: 119
  start-page: 1313
  year: 2016
  ident: B20
  article-title: Extensive proliferation of a subset of differentiated, yet plastic, medial vascular smooth muscle cells contributes to neointimal formation in mouse injury and atherosclerosis models
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.116.309799
– volume: 99
  start-page: 15345
  year: 2002
  ident: B133
  article-title: Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.232551499
– volume: 13
  start-page: 952
  year: 2007
  ident: B198
  article-title: Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
  publication-title: Nat. Med.
  doi: 10.1038/nm1613
– volume: 100
  start-page: 174
  year: 2007
  ident: B1
  article-title: Phenotypic heterogeneity of the endothelium: II. Representative vascular beds
  publication-title: Circ. Res.
  doi: 10.1161/01.RES.0000255690.03436.ae
– volume: 431
  start-page: 350
  year: 2004
  ident: B6
  article-title: The functions of animal microRNAs
  publication-title: Nature
  doi: 10.1038/nature02871
– volume: 17
  start-page: 3819
  year: 2006
  ident: B200
  article-title: Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e05-10-0990
– volume: 19
  start-page: 810
  year: 2014
  ident: B111
  article-title: A smooth muscle-like origin for beige adipocytes
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.03.025
– volume: 87
  start-page: 11
  year: 2015
  ident: B30
  article-title: Cardiovascular manifestations in Marfan syndrome and related diseases; multiple genes causing similar phenotypes
  publication-title: Clin. Genet.
  doi: 10.1111/cge.12436
– volume: 370
  start-page: 341
  year: 1994
  ident: B192
  article-title: Mechanism of activation of the TGF-beta receptor
  publication-title: Nature
  doi: 10.1038/370341a0
– volume: 125
  start-page: 1795
  year: 2012
  ident: B91
  article-title: Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: From cardiovascular development to disease
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.111.040352
– volume: 37
  start-page: 275
  year: 2005
  ident: B109
  article-title: A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
  publication-title: Nat. Genet.
  doi: 10.1038/ng1511
– volume: 6
  start-page: 582
  year: 2017
  ident: B124
  article-title: Differences in manifestations of Marfan syndrome, Ehlers-Danlos syndrome, and Loeys-Dietz syndrome
  publication-title: Ann. Cardiothorac. Surg.
  doi: 10.21037/acs.2017.11.03
– volume: 114
  start-page: E9618
  year: 2017
  ident: B158
  article-title: Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1708247114
– volume: 73
  start-page: 190
  year: 2019
  ident: B90
  article-title: Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2018.09.089
– volume: 352
  start-page: 337
  year: 1991
  ident: B44
  article-title: Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene
  publication-title: Nature
  doi: 10.1038/352337a0
– volume: 110
  start-page: 12881
  year: 2013
  ident: B4
  article-title: Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1306529110
– volume: 10
  start-page: 283
  year: 2002
  ident: B77
  article-title: Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity
  publication-title: Mol. Cell
  doi: 10.1016/s1097-2765(02)00585-3
– volume: 42
  start-page: 161
  year: 2022
  ident: B182
  article-title: Efficacy and safety of givosiran for acute hepatic porphyria: 24-month interim analysis of the randomized phase 3 ENVISION study
  publication-title: Liver Int.
  doi: 10.1111/liv.15090
– volume: 91
  start-page: 1554
  year: 2011
  ident: B134
  article-title: TGF-beta signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development
  publication-title: Lab. Invest.
  doi: 10.1038/labinvest.2011.124
– volume: 13
  start-page: 2196
  year: 1999
  ident: B115
  article-title: The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
  publication-title: Genes Dev.
  doi: 10.1101/gad.13.17.2196
– volume: 384
  start-page: 1216
  year: 2021
  ident: B58
  article-title: Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2021712
– volume: 7
  start-page: e40990
  year: 2012
  ident: B145
  article-title: Overexpression of TGF-ß1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0040990
– volume: 334
  start-page: 316
  year: 1996
  ident: B11
  article-title: Antisense-oligonucleotide therapy
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199602013340508
– volume: 26
  start-page: 542
  year: 2020
  ident: B24
  article-title: Smooth muscle cell reprogramming in aortic aneurysms
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2020.02.013
– volume: 41
  start-page: 1105
  year: 2021
  ident: B114
  article-title: MEF2 (myocyte enhancer factor 2) is essential for endothelial homeostasis and the atheroprotective gene expression program
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.120.314978
– volume: 131
  start-page: 1006
  year: 2015
  ident: B144
  article-title: Endothelial-to-mesenchymal transition in pulmonary hypertension
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.114.008750
– volume: 118
  start-page: e2112625118
  year: 2021
  ident: B40
  article-title: MEKK3-TGFβ crosstalk regulates inward arterial remodeling
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.2112625118
– volume: 371
  start-page: 2061
  year: 2014
  ident: B96
  article-title: Atenolol versus losartan in children and young adults with Marfan's syndrome
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1404731
– volume: 7
  start-page: 11853
  year: 2016
  ident: B50
  article-title: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11853
– volume: 56
  start-page: 323
  year: 2007
  ident: B41
  article-title: Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I/II trial of CAT-192
  publication-title: Arthritis Rheum.
  doi: 10.1002/art.22289
– volume: 97
  start-page: 3292
  year: 2012
  ident: B99
  article-title: Thyrotropin regulates thyroid cell proliferation by up-regulating miR-23b and miR-29b that target SMAD3
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2012-1349
– volume: 59
  start-page: 579
  year: 2001
  ident: B171
  article-title: TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)
  publication-title: Kidney Int.
  doi: 10.1046/j.1523-1755.2001.059002579.x
– volume: 115
  start-page: 3
  year: 2000
  ident: B33
  article-title: Delayed wound healing in immunodeficient TGF-beta 1 knockout mice
  publication-title: J. Invest. Dermatol
  doi: 10.1046/j.1523-1747.2000.00010.x
– volume: 24
  start-page: 419
  year: 2022
  ident: B66
  article-title: Predictors of low bone density and fracture risk in Loeys-Dietz syndrome
  publication-title: Genet. Med.
  doi: 10.1016/j.gim.2021.10.002
– volume: 438
  start-page: 685
  year: 2005
  ident: B94
  article-title: Silencing of microRNAs in vivo with 'antagomirs
  publication-title: Nature
  doi: 10.1038/nature04303
– volume: 71
  start-page: 1003
  year: 1992
  ident: B186
  article-title: TGF beta signals through a heteromeric protein kinase receptor complex
  publication-title: Cell
  doi: 10.1016/0092-8674(92)90395-s
– volume: 38
  start-page: 343
  year: 2006
  ident: B202
  article-title: Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus
  publication-title: Nat. Genet.
  doi: 10.1038/ng1721
– volume: 33
  start-page: 1447
  year: 2015
  ident: B43
  article-title: Dysregulated TGF-beta signaling alters bone microstructure in a mouse model of Loeys-Dietz syndrome
  publication-title: J. Orthop. Res.
  doi: 10.1002/jor.22920
– volume: 36
  start-page: 972
  year: 2016
  ident: B179
  article-title: Functional analysis of a novel genome-wide association study signal in SMAD3 that confers protection from coronary artery disease
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.116.307294
– volume: 23
  start-page: 2019
  year: 1995
  ident: B37
  article-title: Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/23.11.2019
– volume: 15
  start-page: 692
  year: 2015
  ident: B183
  article-title: How leukocytes cross the vascular endothelium
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3908
– start-page: 75
  year: 2020
  ident: B166
  article-title: Cardiac fibroblast diversity in health and disease
  publication-title: Matrix Biol.
  doi: 10.1016/j.matbio.2020.05.003
– volume: 359
  start-page: 693
  year: 1992
  ident: B163
  article-title: Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
  publication-title: Nature
  doi: 10.1038/359693a0
– volume: 9
  start-page: e96005
  year: 2014
  ident: B118
  article-title: Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0096005
– volume: 16
  start-page: 576
  year: 2014
  ident: B116
  article-title: Loeys-Dietz syndrome: A primer for diagnosis and management
  publication-title: Genet. Med.
  doi: 10.1038/gim.2014.11
– volume: 26
  start-page: 494
  year: 2005
  ident: B9
  article-title: Identification of sixty-two novel and twelve known FBN1 mutations in eighty-one unrelated probands with Marfan syndrome and other fibrillinopathies
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.9377
– volume: 95
  start-page: 222
  year: 2019
  ident: B168
  article-title: Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor beta superfamily type 1 receptors
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.118.112946
– volume: 14
  start-page: 1698
  year: 2022
  ident: B34
  article-title: Efficient delivery of DNA using lipid nanoparticles
  publication-title: Pharmaceutics
  doi: 10.3390/pharmaceutics14081698
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SubjectTerms aneurysm
cell fate
EndMT
endothelail cell
Molecular Biosciences
smooth muscle cell
TGFβ
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Title TGFβ signaling pathways in human health and disease
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