TGFβ signaling pathways in human health and disease

Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of d...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in molecular biosciences Vol. 10; p. 1113061
Main Authors Chen, Pei-Yu, Qin, Lingfeng, Simons, Michael
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 01.06.2023
Subjects
aneurysm
cell fate
EndMT
endothelail cell
Molecular Biosciences
smooth muscle cell
TGFβ
aneurysm
RNAi
smooth muscle cell
cell fate
TGFβ
nanoparticle
EndMT
endothelail cell
Online AccessGet full text

Cover

More Information
Summary:Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ is a multifaceted molecule with a myriad of different activities. TGFβs are widely expressed with almost every cell in the human body producing one or another TGFβ family member and expressing its receptors. Importantly, specific effects of this growth factor family differ in different cell types and under different physiologic and pathologic conditions. One of the more important and critical TGFβ activities is the regulation of cell fate, especially in the vasculature, that will be the focus of this review.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
Edited by: Shizuya Saika, Wakayama Medical University Hospital, Japan
Reviewed by: Cristina Espinosa-Diez, University of Pittsburgh, United States
Rahul Kumar, University of California San Francisco, United States
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2023.1113061