Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder

• Published in: Environmental research Vol. 228; p. 115795
• Main Authors: Santos, João Xavier, Sampaio, Pedro, Rasga, Célia, Martiniano, Hugo, Faria, Clarissa, Café, Cátia, Oliveira, Alexandra, Duque, Frederico, Oliveira, Guiomar, Sousa, Lisete, Nunes, Ana, Vicente, Astrid Moura
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.07.2023
• Subjects: air; Air Pollutants - analysis; Air Pollutants - toxicity; Air pollution; Air Pollution - adverse effects; Air Pollution - analysis; air quality; autism; Autism spectrum disorder; Autism Spectrum Disorder - chemically induced; Autism Spectrum Disorder - epidemiology; Child; children; Clinical severity; Early-life exposure; Environmental Exposure - analysis; epigenetics; etiology; European Union; Female; Humans; maternal exposure; mitochondria; nitrogen dioxide; Nitrogen Dioxide - analysis; Nitrogen Dioxide - toxicity; oxidative stress; ozone; Particulate matter; Particulate Matter - analysis; Particulate Matter - toxicity; particulates; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - epidemiology; regression analysis; sulfur dioxide; Pregnancy; Early-life exposure; Air pollution; Clinical severity; Particulate matter; Autism spectrum disorder

Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality...