Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder
Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality...
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| Published in | Environmental research Vol. 228; p. 115795 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
01.07.2023
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| Abstract | Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05–1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00–1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01–1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of early-life exposure to PM in ASD clinical severity.
•Integration of air pollution data with clinical information for 217 ASD-subjects.•Some ASD-subjects show PM2.5 and PM10 exposure levels above admissible thresholds.•ASD severity linked to PM2.5 exposure during first trimester and full pregnancy.•ASD severity associated with PM10 exposure during third trimester of pregnancy.•PM exposure has been linked to ASD-related neuropathological mechanisms. |
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| AbstractList | Early-life exposure to air pollutants, including ozone (O₃), particulate matter (PM₂.₅ or PM₁₀, depending on diameter of particles), nitrogen dioxide (NO₂) and sulfur dioxide (SO₂) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM₂.₅, PM₁₀ and NO₂ to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM₂.₅ and PM₁₀ above the admissible threshold. A higher clinical severity was associated with higher exposure to PM₂.₅ (p = 0.001), NO₂ (p = 0.011) and PM₁₀ (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM₂.₅ exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05–1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00–1.15) and for PM₁₀ (p = 0.02; OR = 1.07, 95%CI: 1.01–1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of early-life exposure to PM in ASD clinical severity. Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05-1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00-1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01-1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of early-life exposure to PM in ASD clinical severity.Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05-1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00-1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01-1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of early-life exposure to PM in ASD clinical severity. Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM2.5, PM10 and NO2 to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM2.5 and PM10 above the admissible threshold. A higher clinical severity was associated with higher exposure to PM2.5 (p = 0.001), NO2 (p = 0.011) and PM10 (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM2.5 exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05–1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00–1.15) and for PM10 (p = 0.02; OR = 1.07, 95%CI: 1.01–1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of early-life exposure to PM in ASD clinical severity. •Integration of air pollution data with clinical information for 217 ASD-subjects.•Some ASD-subjects show PM2.5 and PM10 exposure levels above admissible thresholds.•ASD severity linked to PM2.5 exposure during first trimester and full pregnancy.•ASD severity associated with PM10 exposure during third trimester of pregnancy.•PM exposure has been linked to ASD-related neuropathological mechanisms. Early-life exposure to air pollutants, including ozone (O ), particulate matter (PM or PM , depending on diameter of particles), nitrogen dioxide (NO ) and sulfur dioxide (SO ) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants during critical periods of pregnancy, and if higher exposure levels may lead to a higher clinical severity in their offspring. We used public data from the Portuguese Environment Agency to estimate exposure to these pollutants during the first, second and third trimesters of pregnancy, full pregnancy and first year of life of the child, for 217 subjects with ASD born between 2003 and 2016. These subjects were stratified in two subgroups according to clinical severity, as defined by the Autism Diagnostic Observational Schedule (ADOS). For all time periods, the average levels of PM , PM and NO to which the subjects were exposed were within the admissible levels defined by the European Union. However, a fraction of these subjects showed exposure to levels of PM and PM above the admissible threshold. A higher clinical severity was associated with higher exposure to PM (p = 0.001), NO (p = 0.011) and PM (p = 0.041) during the first trimester of pregnancy, when compared with milder clinical severity. After logistic regression, associations with higher clinical severity were identified for PM exposure during the first trimester (p = 0.002; OR = 1.14, 95%CI: 1.05-1.23) and full pregnancy (p = 0.04; OR = 1.07, 95%CI: 1.00-1.15) and for PM (p = 0.02; OR = 1.07, 95%CI: 1.01-1.14) exposure during the third trimester. Exposure to PM is known to elicit neuropathological mechanisms associated with ASD, including neuroinflammation, mitochondrial disruptions, oxidative stress and epigenetic changes. These results offer new insights on the impact of early-life exposure to PM in ASD clinical severity. |
| ArticleNumber | 115795 |
| Author | Santos, João Xavier Vicente, Astrid Moura Café, Cátia Faria, Clarissa Duque, Frederico Oliveira, Guiomar Sousa, Lisete Sampaio, Pedro Martiniano, Hugo Rasga, Célia Oliveira, Alexandra Nunes, Ana |
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| Cites_doi | 10.1080/17518423.2019.1645222 10.1016/j.vaccine.2017.01.049 10.5094/APR.2015.087 10.1016/j.ecoenv.2020.111281 10.1177/1362361313517053 10.1007/s12264-017-0103-8 10.1007/s13181-011-0203-1 10.1016/j.parkreldis.2020.12.013 10.1186/s13229-017-0121-4 10.1016/j.envres.2019.01.013 10.1023/A:1005592401947 10.1016/j.envres.2021.111165 10.1016/j.envpol.2020.114716 10.1038/s41572-019-0138-4 10.1016/j.envres.2015.04.021 10.1016/j.jpsychires.2021.12.007 10.2147/COPD.S270762 10.3389/fpubh.2020.575330 10.1289/ehp.1205827 10.1016/j.cyto.2018.03.034 10.1016/j.neubiorev.2021.06.043 10.1001/jamapsychiatry.2013.266 10.1007/s10654-019-00506-5 10.1289/EHP9509 10.1093/aje/kwx294 10.1001/jamapsychiatry.2019.1411 10.1289/ehp.1408133 10.1038/tp.2014.4 10.1016/j.ijdevneu.2019.05.003 10.1186/s12887-014-0308-1 10.3390/ijms21093293 10.2147/IJWH.S283216 10.1007/s10803-017-3304-0 10.1017/S0033291718002039 10.1097/EE9.0000000000000160 10.1038/nm.4071 10.1007/BF02172145 10.1371/journal.pone.0218799 10.1007/s10803-014-2081-2 10.1016/j.envres.2020.110320 10.1016/j.envint.2020.105830 10.1177/1362361320971107 10.3390/ijms21134726 10.1186/s13148-019-0726-x 10.1016/j.envres.2016.06.026 10.3390/cells10113025 10.1371/journal.pone.0075510 10.1111/jnc.13135 10.1007/s10803-008-0674-3 10.21037/atm.2019.11.53 10.1038/s41467-019-11654-3 10.1161/CIRCRESAHA.116.309279 10.1080/14767058.2017.1293032 10.1007/s10753-018-0732-8 10.1016/j.atmosenv.2014.09.017 10.1016/j.scitotenv.2006.10.014 10.3390/ijms23126487 10.1016/j.ecoenv.2022.113589 10.1001/jama.2017.12141 10.1093/eurpub/ckab190 10.1002/aur.1799 10.5772/intechopen.95758 10.3389/fnins.2022.862315 10.1093/ije/dyt282 10.1159/000513536 10.1093/humupd/dmaa010 10.1080/1354750X.2017.1339294 10.1186/s13229-020-00370-1 10.1016/j.ridd.2011.03.004 10.1186/s12302-020-00450-2 10.1136/bmjopen-2021-058286 10.1002/aur.110 10.1016/j.redox.2020.101545 10.1016/j.biopsych.2015.08.007 10.1097/EDE.0000000000000173 10.1016/j.pharmthera.2020.107523 10.1111/acps.12666 10.1038/s41370-020-0223-5 10.1016/j.envres.2022.112717 10.3389/fnint.2020.00016 10.1111/j.1469-8749.2007.00726.x 10.1007/s10803-012-1501-4 10.1097/EDE.0000000000000030 10.1176/appi.ajp.2020.20111608 |
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| Keywords | Pregnancy Early-life exposure Air pollution Clinical severity Particulate matter Autism spectrum disorder |
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| References | Zhang, Wang, Zhu, Li, Zhang, Liu, Ye (bib97) 2018; 41 Manoli, State (bib56) 2021; 178 van’t Hof, Tisseur, van Berckelear-Onnes, van Nieuwenhuyzen, Daniels, Deen (bib86) 2021; 25 Frazier, Thompson, Youngstrom, Law, Hardan (bib25) 2014; 44 Familari, Nääv, Erlandsson, de Iongh, Isaxon, Strandberg, Malmqvist (bib21) 2019; 14 Guerreiro, Foltescu, De Leeuw (bib36) 2014; 98 Tapia, Vasquez, Vu, Liu, Steenland, Gonzales (bib84) 2020; 30 (bib2) 2013 Rylaarsdam, Guemez-Gamboa (bib77) 2019; 385 Bové, Bongaerts, Slenders, Bijnens, Saenen, Gyselaers, Nawrot (bib9) 2019; 10 Anderson, Thundiyil, Stolbach (bib3) 2012; 8 Glick, Kadish, Rottenstreich (bib33) 2021; 13 Calderón-Garcidueñas, Jewells, Galaz-Montoya, van Zundert, Pérez-Calatayud, Ascencio-Ferrel, D'Angiulli (bib10) 2016; 150 Lyall, Schmidt, Hertz-Picciotto (bib54) 2014; 43 Grevendonk, Janssen, Vanpoucke, Lefebvre, Hoxha, Bollati (bib35) 2016; 20 Ghazi, Naidoo, Naidoo, Chuturgoon (bib100) 2021; 10 Masi, Glozier, Dale, Guastella (bib58) 2017; 33 Chen, Guo, Huang, Liu, Huang, Zhang, Ding (bib13) 2020; 264 Giovannini, Schwartz, Cipriani, Parazzini, Baini, Signorelli, Cetin (bib32) 2018; 31 Movsas, Paneth (bib65) 2012; 42 Van Heijst, Geurts (bib85) 2015; 19 Beck, Bilenberg, Davidsen, Rasmussen, Boye, Jensen (bib6) 2022 Meter, Christiansen, Delwiche, Azari, Carpenter, Hertz‐Picciotto (bib59) 2010; 3 Monteiro, Miranda, Borrego, Vautard (bib63) 2007; 373 Cutland, Lackritz, Mallett-Moore, Bardají, Chandrasekaran, Lahariya (bib17) 2017; 35 Liu, Huang, Zhang, Chen, Wu, Rui (bib53) 2015; 134 Sparrow, Cicchetti, Saulnier (bib102) 2016 Rieske, Matson (bib76) 2020; 23 Wu, Wu, Ding, Hou, Bi, Zhang (bib94) 2017; 135 Sicard, Agathokleous, De Marco, Paoletti, Calatayud (bib81) 2021; 33 Choi, Lee, Kim, Bae (bib103) 2022; 23 Lee, Gross, Francis, Karlsson, Schendel, Sourander (bib49) 2019; 34 Fleury, Himsl, Joost, Nicastro, Bereau, Guessous, Burkhard (bib23) 2021; 83 Kim, Volk, Girirajan, Pendergrass, Hall, Verma (bib45) 2017; 10 World Health Organization (bib92) 2005 Kim, Kim, Kim, Park (bib46) 2020; 8 Desai, Chu, Guo, Myneni, Mu (bib19) 2017; 22 Gotham, Pickles, Lord (bib34) 2009; 39 Kerin, Volk, Li, Lurmann, Eckel, McConnell (bib44) 2018; 48 Rossignol, Genuis, Frye (bib75) 2014; 4 Santos, Rasga, Marques, Martiniano, Asif, Vilela (bib80) 2022; 16 Geng, Fang, Li (bib30) 2019; 75 Costa, Cole, Dao, Chang, Coburn, Garrick (bib16) 2020; 210 Frye, Vassall, Kaur, Lewis, Karim, Rossignol (bib27) 2019; 7 Kim, Sohn, Cho, Seo, Kim, Hung (bib47) 2022 Jung, Lin, Hwang (bib40) 2013; 8 Santos, Rasga, Vicente (bib79) 2021; 133 Janeczko, Hołowczuk, Orzeł, Klatka, Semczuk (bib39) 2020; 12 Pangrazzi, Balasco, Bozzi (bib68) 2020; 21 (bib60) 2001 de la Torre-Ubieta, Won, Stein, Geschwind (bib18) 2016; 22 Bilinovich, Uhl, Lewis, Soehnlen, Williams, Vogt (bib8) 2020; 42 Fossé, Hoorn, Lith, Cessie, Lashley (bib24) 2020; 26 Itzchak, Lahat, Zachor (bib38) 2011; 32 Sandin, Lichtenstein, Kuja-Halkola, Hultman, Larsson, Reichenberg (bib78) 2017; 318 Becerra, Wilhelm, Olsen, Cockburn, Ritz (bib7) 2013; 121 Ongono, S. J., Michelon, C., Béranger, R., Cadot, E., Simoncic, V., Loubersac, J. et al., 2022, Association between residential proximity to agricultural crops and adaptive behaviors in children with autism spectrum disorder from the French ELENA cohort. J. Psychiat. Res. 145:197-204. doi: 10.1016/j.jpsychires.2021.12.007. Ferrari, Carugno, Bollati (bib22) 2019; 11 Martini, Merkelbach, Begeer (bib57) 2022 Bai, Yip, Windham, Sourander, Francis, Yoffe (bib5) 2019; 76 Volk, Kerin, Lurmann, Hertz-Picciotto, McConnell (bib88) 2014; 25 Isaevska, Fiano, Asta, Stafoggia, Moirano, Popovic (bib104) 2022; 209 Pettersson, Lichtenstein, Larsson, Song, Deficit, Agrawal, Polderman (bib69) 2019; 49 Oliveira, Ataíde, Marques, Miguel, Coutinho, Mota-Vieira (bib66) 2007; 49 Yau, Lu, Lee, Guo, Chan (bib95) 2021; 128 Genovese, Butler (bib31) 2020; 21 Werder, Engel, Lawrence, Sandler (bib91) 2021; 5 Eftekharian, Ghafouri-Fard, Noroozi, Omrani, Arsang-Jang, Ganji (bib20) 2018; 108 Lord, Risi, Lambrecht, Cook, Leventhal, DiLavore (bib51) 2000; 30 Chen, Hodgson, Gulliver, Granell, Henderson, Cai (bib14) 2021; 7 Cheroni, Caporale, Testa (bib15) 2020; 11 Zou, Wang, Hong, He, Hu, Sheng, Ran (bib99) 2020; 15 Kalkbrenner, Windham, Serre, Akita, Wang, Hoffman (bib41) 2015; 26 Kaufman, Wright, Rice, Connolly, Bowers, Anixt (bib42) 2019; 171 Moore, Arefadib, Deery, West, Keyes (bib62) 2017 Gaio, Roquette, Monteiro, Ferreira, Lopes, Dias, Nunes (bib28) 2022; 32 Rahman, Shu, Chow, Lurmann, Yu, Martinez (bib72) 2022; 130 Raz, Roberts, Lyall, Hart, Just, Laden, Weisskopf (bib74) 2015; 123 Volk, Perera, Braun, Kingsley, Gray, Buckley (bib89) 2021; 196 Monteiro, Ferreira, Ribeiro, Fernandes, Martins, Gama (bib64) 2015; 6 Friedman, Dabelea, Thomas, Peel, Adgate, Magzamen (bib26) 2021; 197 Krakowiak, Goines, Tancredi, Ashwood, Hansen, Hertz-Picciotto, Van de Water (bib43) 2017; 81 Zhu, Ji, Geng, Yue, Li, Sang (bib98) 2021; 207 Volk, Lurmann, Penfold, Hertz-Picciotto, McConnell (bib87) 2013; 70 Camargo-Figuera, Barros, Santos, Matijasevich, Barros (bib11) 2014; 14 McPartland, Bernier, Jeste, Dawson, Nelson, Chawarska (bib55) 2020; 14 Pope, Bhatnagar, McCracken, Abplanalp, Conklin (bib70) 2016; 119 Modabbernia, Velthorst, Reichenberg (bib61) 2017; 8 Raz, Levine, Pinto, Broday, Weisskopf (bib73) 2018; 187 Lord, Rutter, Le Couteur (bib50) 1994; 24 Wei, Liang, Meng, Nie, Zhou, Cheng (bib90) 2016; 6 Gangwar, Bevan, Palanivel, Das, Rajagopalan (bib29) 2020; 34 Talbott, Arena, Rager, Clougherty, Michanowicz, Sharma, Stacy (bib83) 2015; 140 Lord, Brugha, Charman, Cusack, Dumas, Frazier (bib52) 2020; 6 Sotty, Kluza, De Sousa, Tardivel, Anthérieu, Alleman (bib82) 2020; 142 Yi, Wang, Qu, Niu, Oliver, Chen (bib96) 2022; 238 World Health Organization (bib93) 2021 Calderón-Garcidueñas (10.1016/j.envres.2023.115795_bib10) 2016; 150 Sparrow (10.1016/j.envres.2023.115795_bib102) 2016 Chen (10.1016/j.envres.2023.115795_bib14) 2021; 7 Pangrazzi (10.1016/j.envres.2023.115795_bib68) 2020; 21 Zhang (10.1016/j.envres.2023.115795_bib97) 2018; 41 Gotham (10.1016/j.envres.2023.115795_bib34) 2009; 39 Gaio (10.1016/j.envres.2023.115795_bib28) 2022; 32 Fleury (10.1016/j.envres.2023.115795_bib23) 2021; 83 Rahman (10.1016/j.envres.2023.115795_bib72) 2022; 130 Cheroni (10.1016/j.envres.2023.115795_bib15) 2020; 11 Bové (10.1016/j.envres.2023.115795_bib9) 2019; 10 van’t Hof (10.1016/j.envres.2023.115795_bib86) 2021; 25 Costa (10.1016/j.envres.2023.115795_bib16) 2020; 210 Bilinovich (10.1016/j.envres.2023.115795_bib8) 2020; 42 Cutland (10.1016/j.envres.2023.115795_bib17) 2017; 35 Rylaarsdam (10.1016/j.envres.2023.115795_bib77) 2019; 385 Zou (10.1016/j.envres.2023.115795_bib99) 2020; 15 Wu (10.1016/j.envres.2023.115795_bib94) 2017; 135 Becerra (10.1016/j.envres.2023.115795_bib7) 2013; 121 Yi (10.1016/j.envres.2023.115795_bib96) 2022; 238 Pettersson (10.1016/j.envres.2023.115795_bib69) 2019; 49 Volk (10.1016/j.envres.2023.115795_bib89) 2021; 196 Liu (10.1016/j.envres.2023.115795_bib53) 2015; 134 Guerreiro (10.1016/j.envres.2023.115795_bib36) 2014; 98 Camargo-Figuera (10.1016/j.envres.2023.115795_bib11) 2014; 14 (10.1016/j.envres.2023.115795_bib2) 2013 Anderson (10.1016/j.envres.2023.115795_bib3) 2012; 8 Sotty (10.1016/j.envres.2023.115795_bib82) 2020; 142 Bai (10.1016/j.envres.2023.115795_bib5) 2019; 76 Raz (10.1016/j.envres.2023.115795_bib74) 2015; 123 Isaevska (10.1016/j.envres.2023.115795_bib104) 2022; 209 Glick (10.1016/j.envres.2023.115795_bib33) 2021; 13 Lord (10.1016/j.envres.2023.115795_bib51) 2000; 30 Frye (10.1016/j.envres.2023.115795_bib27) 2019; 7 Werder (10.1016/j.envres.2023.115795_bib91) 2021; 5 Ghazi (10.1016/j.envres.2023.115795_bib100) 2021; 10 Chen (10.1016/j.envres.2023.115795_bib13) 2020; 264 Gangwar (10.1016/j.envres.2023.115795_bib29) 2020; 34 Manoli (10.1016/j.envres.2023.115795_bib56) 2021; 178 Choi (10.1016/j.envres.2023.115795_bib103) 2022; 23 Oliveira (10.1016/j.envres.2023.115795_bib66) 2007; 49 Monteiro (10.1016/j.envres.2023.115795_bib63) 2007; 373 Van Heijst (10.1016/j.envres.2023.115795_bib85) 2015; 19 Talbott (10.1016/j.envres.2023.115795_bib83) 2015; 140 World Health Organization (10.1016/j.envres.2023.115795_bib92) 2005 Kalkbrenner (10.1016/j.envres.2023.115795_bib41) 2015; 26 Lee (10.1016/j.envres.2023.115795_bib49) 2019; 34 Sicard (10.1016/j.envres.2023.115795_bib81) 2021; 33 Lord (10.1016/j.envres.2023.115795_bib50) 1994; 24 Familari (10.1016/j.envres.2023.115795_bib21) 2019; 14 Yau (10.1016/j.envres.2023.115795_bib95) 2021; 128 Giovannini (10.1016/j.envres.2023.115795_bib32) 2018; 31 Kim (10.1016/j.envres.2023.115795_bib45) 2017; 10 Volk (10.1016/j.envres.2023.115795_bib88) 2014; 25 Meter (10.1016/j.envres.2023.115795_bib59) 2010; 3 Tapia (10.1016/j.envres.2023.115795_bib84) 2020; 30 Wei (10.1016/j.envres.2023.115795_bib90) 2016; 6 Kerin (10.1016/j.envres.2023.115795_bib44) 2018; 48 McPartland (10.1016/j.envres.2023.115795_bib55) 2020; 14 Movsas (10.1016/j.envres.2023.115795_bib65) 2012; 42 Genovese (10.1016/j.envres.2023.115795_bib31) 2020; 21 Moore (10.1016/j.envres.2023.115795_bib62) 2017 Desai (10.1016/j.envres.2023.115795_bib19) 2017; 22 Rieske (10.1016/j.envres.2023.115795_bib76) 2020; 23 Sandin (10.1016/j.envres.2023.115795_bib78) 2017; 318 Martini (10.1016/j.envres.2023.115795_bib57) 2022 Itzchak (10.1016/j.envres.2023.115795_bib38) 2011; 32 Lord (10.1016/j.envres.2023.115795_bib52) 2020; 6 Santos (10.1016/j.envres.2023.115795_bib80) 2022; 16 Lyall (10.1016/j.envres.2023.115795_bib54) 2014; 43 Eftekharian (10.1016/j.envres.2023.115795_bib20) 2018; 108 Geng (10.1016/j.envres.2023.115795_bib30) 2019; 75 Masi (10.1016/j.envres.2023.115795_bib58) 2017; 33 Rossignol (10.1016/j.envres.2023.115795_bib75) 2014; 4 Janeczko (10.1016/j.envres.2023.115795_bib39) 2020; 12 de la Torre-Ubieta (10.1016/j.envres.2023.115795_bib18) 2016; 22 Kim (10.1016/j.envres.2023.115795_bib46) 2020; 8 Monteiro (10.1016/j.envres.2023.115795_bib64) 2015; 6 Modabbernia (10.1016/j.envres.2023.115795_bib61) 2017; 8 Jung (10.1016/j.envres.2023.115795_bib40) 2013; 8 10.1016/j.envres.2023.115795_bib67 Zhu (10.1016/j.envres.2023.115795_bib98) 2021; 207 Kaufman (10.1016/j.envres.2023.115795_bib42) 2019; 171 Friedman (10.1016/j.envres.2023.115795_bib26) 2021; 197 Pope (10.1016/j.envres.2023.115795_bib70) 2016; 119 Kim (10.1016/j.envres.2023.115795_bib47) 2022 Grevendonk (10.1016/j.envres.2023.115795_bib35) 2016; 20 Frazier (10.1016/j.envres.2023.115795_bib25) 2014; 44 Ferrari (10.1016/j.envres.2023.115795_bib22) 2019; 11 Fossé (10.1016/j.envres.2023.115795_bib24) 2020; 26 Beck (10.1016/j.envres.2023.115795_bib6) 2022 Santos (10.1016/j.envres.2023.115795_bib79) 2021; 133 World Health Organization (10.1016/j.envres.2023.115795_bib93) 2021 (10.1016/j.envres.2023.115795_bib60) 2001 Raz (10.1016/j.envres.2023.115795_bib73) 2018; 187 Krakowiak (10.1016/j.envres.2023.115795_bib43) 2017; 81 Volk (10.1016/j.envres.2023.115795_bib87) 2013; 70 |
| References_xml | – year: 2022 ident: bib6 article-title: Prenatal and early childhood predictors of intelligence quotient (IQ) in 7-year-old Danish children from the Odense Child Cohort publication-title: Scand. J. Publ. Health – volume: 33 start-page: 1 year: 2021 end-page: 12 ident: bib81 article-title: Urban population exposure to air pollution in Europe over the last decades publication-title: Environ. Sci. Eur. – volume: 12 start-page: 83 year: 2020 end-page: 88 ident: bib39 article-title: Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring publication-title: Biomed. Rep. – volume: 10 start-page: 3025 year: 2021 ident: bib100 article-title: Prenatal Air Pollution Exposure and Placental DNA Methylation Changes: Implications on Fetal Development and Future Disease Susceptibility publication-title: Cells – volume: 31 start-page: 651 year: 2018 end-page: 655 ident: bib32 article-title: Particulate matter (PM10) exposure, birth and fetal-placental weight and umbilical arterial pH: results from a prospective study publication-title: J. Matern. Fetal Neonat. Med. – volume: 10 start-page: 1470 year: 2017 end-page: 1480 ident: bib45 article-title: The joint effect of air pollution exposure and copy number variation on risk for autism publication-title: Autism Res. – volume: 26 start-page: 30 year: 2015 end-page: 42 ident: bib41 article-title: Particulate matter exposure, prenatal and postnatal windows of susceptibility, and autism spectrum disorders publication-title: Epidemiology – volume: 49 start-page: 1166 year: 2019 end-page: 1173 ident: bib69 article-title: Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls publication-title: Psychol. Med. – volume: 6 start-page: 788 year: 2015 end-page: 796 ident: bib64 article-title: Air quality over Portugal in 2020 publication-title: Atmos. Poll. Res. – volume: 140 start-page: 414 year: 2015 end-page: 420 ident: bib83 article-title: Fine particulate matter and the risk of autism spectrum disorder publication-title: Environ. Res. – volume: 33 start-page: 194 year: 2017 end-page: 204 ident: bib58 article-title: The immune system, cytokines, and biomarkers in autism spectrum disorder publication-title: Neurosci. Bull. – volume: 133 year: 2021 ident: bib79 article-title: Exposure to xenobiotics and gene-environment interactions in autism spectrum disorder: a systematic review publication-title: Autism Spectrum Disorder-Profile, Heterogeneity, Neurobiology and Intervention – volume: 32 start-page: 1776 year: 2011 end-page: 1781 ident: bib38 article-title: Advanced parental ages and low birth weight in autism spectrum disorders—rates and effect on functioning publication-title: Res. Dev. Disabil. – volume: 14 year: 2019 ident: bib21 article-title: Exposure of trophoblast cells to fine particulate matter air pollution leads to growth inhibition, inflammation and ER stress publication-title: PLoS One – volume: 21 start-page: 4726 year: 2020 ident: bib31 article-title: Clinical assessment, genetics, and treatment approaches in autism spectrum disorder (ASD) publication-title: Int. J. Mol. Sci. – volume: 75 start-page: 59 year: 2019 end-page: 63 ident: bib30 article-title: The association between particulate matter 2.5 exposure and children with autism spectrum disorder publication-title: Int. J. Dev. Neurosci. – volume: 49 start-page: 726 year: 2007 end-page: 733 ident: bib66 article-title: Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions publication-title: Dev. Med. Child Neurol. – volume: 16 year: 2022 ident: bib80 article-title: A role for gene-environment interactions in autism spectrum disorder is supported by variants in genes regulating the effects of exposure to xenobiotics publication-title: Front. Neurosci. – year: 2013 ident: bib2 article-title: Diagnostic and Statistical Manual of Mental Disorders – volume: 21 start-page: 3293 year: 2020 ident: bib68 article-title: Oxidative stress and immune system dysfunction in autism spectrum disorders publication-title: Int. J. Mol. Sci. – volume: 134 start-page: 315 year: 2015 end-page: 326 ident: bib53 article-title: Macrophages treated with particulate matter PM 2.5 induce selective neurotoxicity through glutaminase‐mediated glutamate generation publication-title: J. Neurochem. – volume: 373 start-page: 22 year: 2007 end-page: 31 ident: bib63 article-title: Air quality assessment for Portugal publication-title: Sci. Total Environ. – volume: 20 start-page: 15 year: 2016 ident: bib35 article-title: Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs publication-title: Environ. Health. – volume: 8 year: 2013 ident: bib40 article-title: Air pollution and newly diagnostic autism spectrum disorders: a population-based cohort study in Taiwan publication-title: PLoS One – volume: 209 year: 2022 ident: bib104 article-title: Prenatal exposure to PM publication-title: Environ. Res. – volume: 39 start-page: 693 year: 2009 end-page: 705 ident: bib34 article-title: Standardizing ADOS scores for a measure of severity in autism spectrum disorders publication-title: J. Autism Dev. Disord. – volume: 22 start-page: 489 year: 2017 end-page: 501 ident: bib19 article-title: Biomarkers used in studying air pollution exposure during pregnancy and perinatal outcomes: a review publication-title: Biomarkers – volume: 25 start-page: 862 year: 2021 end-page: 873 ident: bib86 article-title: Age at autism spectrum disorder diagnosis: a systematic review and meta-analysis from 2012 to 2019 publication-title: Autism – volume: 196 year: 2021 ident: bib89 article-title: Prenatal air pollution exposure and neurodevelopment: a review and blueprint for a harmonized approach within ECHO publication-title: Environ. Res. – volume: 150 start-page: 411 year: 2016 end-page: 422 ident: bib10 article-title: Interactive and additive influences of Gender, BMI and Apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2. 5 and ozone. APOE 4 females are at highest risk in Mexico City publication-title: Environ. Res. – volume: 128 start-page: 534 year: 2021 end-page: 548 ident: bib95 article-title: PM2. 5 as a potential risk factor for autism spectrum disorder: its possible link to neuroinflammation, oxidative stress and changes in gene expression publication-title: Neurosci. Biobehav. Rev. – volume: 207 year: 2021 ident: bib98 article-title: Maternal PM2. 5 exposure and abnormal placental nutrient transport publication-title: Ecotoxicol. Environ. Saf. – volume: 123 start-page: 264 year: 2015 end-page: 270 ident: bib74 article-title: Autism spectrum disorder and particulate matter air pollution before, during, and after pregnancy: a nested case–control analysis within the Nurses' Health Study II cohort publication-title: Environ. Health Perspect. – volume: 76 start-page: 1035 year: 2019 end-page: 1043 ident: bib5 article-title: Association of genetic and environmental factors with autism in a 5-country cohort publication-title: JAMA Psychiatr. – year: 2022 ident: bib57 article-title: Gestational age in children and adolescents: prevalence and effects on autism phenotype publication-title: J. Autism Dev. Disord. – volume: 8 start-page: 13 year: 2017 ident: bib61 article-title: Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses publication-title: Mol. Autism. – year: 2016 ident: bib102 – volume: 24 start-page: 659 year: 1994 end-page: 685 ident: bib50 article-title: Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders publication-title: J. Autism Dev. Disord. – volume: 7 start-page: 20 year: 2021 ident: bib14 article-title: Trimester effects of source-specific PM10 on birth weight outcomes in the avon longitudinal study of parents and children (ALSPAC) publication-title: Environ. Health – volume: 81 start-page: 442 year: 2017 end-page: 451 ident: bib43 article-title: Neonatal cytokine profiles associated with autism spectrum disorder publication-title: Biol. Psychiatry. – volume: 19 start-page: 158 year: 2015 end-page: 167 ident: bib85 article-title: Quality of life in autism across the lifespan: a meta-analysis publication-title: Autism – volume: 130 year: 2022 ident: bib72 article-title: Prenatal exposure to air pollution and autism spectrum disorder: sensitive windows of exposure and sex differences publication-title: Environ. Health Perspect. – volume: 25 start-page: 44 year: 2014 ident: bib88 article-title: Interaction of the MET receptor tyrosine kinase gene and air pollution exposure in autism spectrum disorder publication-title: Epidemiology – volume: 8 start-page: 166 year: 2012 end-page: 175 ident: bib3 article-title: Clearing the air: a review of the effects of particulate matter air pollution on human health publication-title: J. Med. Toxicol. – volume: 135 start-page: 29 year: 2017 end-page: 41 ident: bib94 article-title: Advanced parental age and autism risk in children: a systematic review and meta‐analysis publication-title: Acta Psychiatr. Scand. – volume: 23 start-page: 265 year: 2020 end-page: 270 ident: bib76 article-title: Parental age at conception and the relationship with severity of autism symptoms publication-title: Dev. Neurorehabil. – volume: 5 year: 2021 ident: bib91 article-title: Ambient particulate matter, ozone, and neurologic symptoms in US Gulf states adults publication-title: Environ. Epidemiol. – volume: 35 start-page: 6492 year: 2017 ident: bib17 article-title: Low birth weight: case definition and guidelines for data collection, analysis, and presentation of maternal immunization safety data publication-title: Vaccine – volume: 42 start-page: 2431 year: 2012 end-page: 2439 ident: bib65 article-title: The effect of gestational age on symptom severity in children with Autism Spectrum Disorder publication-title: J. Autism Dev. Disord. – volume: 48 start-page: 137 year: 2018 end-page: 150 ident: bib44 article-title: Association between air pollution exposure, cognitive and adaptive function, and ASD severity among children with autism spectrum disorder publication-title: J. Autism Dev. Disord. – volume: 30 start-page: 689 year: 2020 end-page: 697 ident: bib84 article-title: Association between maternal exposure to particulate matter (PM2.5) and adverse pregnancy outcomes in Lima, Peru publication-title: J. Expo. Sci. Environ. Epidemiol. – volume: 30 start-page: 205 year: 2000 end-page: 223 ident: bib51 article-title: The Autism Diagnostic Observation Schedule—generic: A standard measure of social and communication deficits associated with the spectrum of autism publication-title: J. Autism Dev. Disord. – volume: 119 start-page: 1204 year: 2016 end-page: 1214 ident: bib70 article-title: Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation publication-title: Cir. Res. – volume: 264 year: 2020 ident: bib13 article-title: Urban airborne PM2. 5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb publication-title: Environ. Pollut. – volume: 3 start-page: 19 year: 2010 end-page: 29 ident: bib59 article-title: Geographic distribution of autism in California: a retrospective birth cohort analysis publication-title: Autism Res. – year: 2001 ident: bib60 article-title: Delimitação de zonas e aglomerações para avaliação da qualidade do ar em Portugal – volume: 14 start-page: 16 year: 2020 ident: bib55 article-title: The autism biomarkers consortium for clinical trials (ABC-CT): scientific context, study design, and progress toward biomarker qualification publication-title: Front. Integr. Neurosci. – volume: 11 start-page: 1 year: 2019 end-page: 14 ident: bib22 article-title: Particulate matter exposure shapes DNA methylation through the lifespan publication-title: Clin. Epigenet. – volume: 187 start-page: 717 year: 2018 end-page: 725 ident: bib73 article-title: Traffic-related air pollution and autism spectrum disorder: a population-based nested case-control study in Israel publication-title: Am. J. Epidemiol. – volume: 7 year: 2019 ident: bib27 article-title: Emerging biomarkers in autism spectrum disorder: a systematic review publication-title: Ann. Transl. Med. – volume: 142 year: 2020 ident: bib82 article-title: Mitochondrial alterations triggered by repeated exposure to fine (PM2. 5-0.18) and quasi-ultrafine (PM0. 18) fractions of ambient particulate matter publication-title: Environ. Int. – year: 2022 ident: bib47 article-title: Effects of short-term exposure to air pollution on hospital admissions for autism spectrum disorder in Korean school-aged children: a nationwide time-series study publication-title: BMJ Open – volume: 238 year: 2022 ident: bib96 article-title: In-utero exposure to air pollution and early-life neural development and cognition publication-title: Ecotoxicol. Environ. Saf. – volume: 34 start-page: 785 year: 2019 end-page: 792 ident: bib49 article-title: Birth seasonality and risk of autism spectrum disorder publication-title: Eur. J. Epidemiol. – volume: 171 start-page: 218 year: 2019 end-page: 227 ident: bib42 article-title: Ambient ozone and fine particulate matter exposures and autism spectrum disorder in metropolitan Cincinnati, Ohio publication-title: Environ. Res. – volume: 121 start-page: 380 year: 2013 end-page: 386 ident: bib7 article-title: Ambient air pollution and autism in los angeles county, California publication-title: Environ. Health Perspect. – volume: 32 start-page: 281 year: 2022 end-page: 288 ident: bib28 article-title: PM10 exposure interacts with abdominal obesity to increase blood triglycerides: a cross-sectional linkage study publication-title: Eur. J. Public Health. – volume: 10 start-page: 1 year: 2019 end-page: 7 ident: bib9 article-title: Ambient black carbon particles reach the fetal side of human placenta publication-title: Nat. Commun. – volume: 318 start-page: 1182 year: 2017 end-page: 1184 ident: bib78 article-title: The heritability of autism spectrum disorder publication-title: JAMA – volume: 15 start-page: 2653 year: 2020 ident: bib99 article-title: PM2. 5 induces the expression of inflammatory cytokines via the Wnt5a/Ror2 pathway in human bronchial epithelial cells publication-title: Int. J. Chronic Obstr. Pulm. Dis. – volume: 13 start-page: 751 year: 2021 ident: bib33 article-title: Management of pregnancy in women of advanced maternal age: improving outcomes for mother and baby publication-title: Int. J. Womens Health – volume: 8 year: 2020 ident: bib46 article-title: Air pollution and central nervous system disease: a review of the impact of fine particulate matter on neurological disorders publication-title: Front. Public Health – volume: 22 start-page: 345 year: 2016 end-page: 361 ident: bib18 article-title: Advancing the understanding of autism disease mechanisms through genetics publication-title: Nat. Med. – volume: 26 start-page: 650 year: 2020 end-page: 669 ident: bib24 article-title: Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis publication-title: Hum. Reprod. Update – reference: Ongono, S. J., Michelon, C., Béranger, R., Cadot, E., Simoncic, V., Loubersac, J. et al., 2022, Association between residential proximity to agricultural crops and adaptive behaviors in children with autism spectrum disorder from the French ELENA cohort. J. Psychiat. Res. 145:197-204. doi: 10.1016/j.jpsychires.2021.12.007. – year: 2017 ident: bib62 article-title: The First Thousand Days: an Evidence Paper-Summary – volume: 108 start-page: 120 year: 2018 end-page: 126 ident: bib20 article-title: Cytokine profile in autistic patients publication-title: Cytokine – year: 2021 ident: bib93 article-title: Air Pollution and Child Health: Prescribing Clean Air – volume: 197 year: 2021 ident: bib26 article-title: Exposure to ambient air pollution during pregnancy and inflammatory biomarkers in maternal and umbilical cord blood: the Healthy Start study publication-title: Environ. Res. – volume: 41 start-page: 784 year: 2018 end-page: 794 ident: bib97 article-title: Effect of atmospheric PM2. 5 on expression levels of NF-κB genes and inflammatory cytokines regulated by NF-κB in human macrophage publication-title: Inflammation – volume: 210 year: 2020 ident: bib16 article-title: Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders publication-title: Pharmacol. Ther. – volume: 6 start-page: 1 year: 2020 end-page: 23 ident: bib52 article-title: Autism spectrum disorder publication-title: Nat. Rev. Dis. Primers. – volume: 178 start-page: 30 year: 2021 end-page: 38 ident: bib56 article-title: Autism spectrum disorder genetics and the search for pathological mechanisms publication-title: Am. J. Psychiatry. – volume: 42 start-page: 195 year: 2020 end-page: 207 ident: bib8 article-title: Integrated RNA sequencing reveals epigenetic impacts of diesel particulate matter exposure in human cerebral organoids publication-title: Dev. Neurosci. – volume: 4 year: 2014 ident: bib75 article-title: Environmental toxicants and autism spectrum disorders: a systematic review publication-title: Transl. Psychiatry – volume: 23 start-page: 6487 year: 2022 ident: bib103 article-title: Particulate Matter Exacerbates the Death of Dopaminergic Neurons in Parkinson's Disease through an Inflammatory Response publication-title: Int. J. Mol. Sci. 10 – volume: 385 year: 2019 ident: bib77 article-title: Genetic causes and modifiers of autism spectrum disorder publication-title: Front. Cell. Neurosci. – volume: 6 start-page: 1 year: 2016 end-page: 13 ident: bib90 article-title: Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells publication-title: Sci. Rep. – volume: 14 start-page: 1 year: 2014 end-page: 12 ident: bib11 article-title: Early life determinants of low IQ at age 6 in children from the 2004 Pelotas Birth Cohort: a predictive approach publication-title: BMC Pediatr. – volume: 70 start-page: 71 year: 2013 end-page: 77 ident: bib87 article-title: Traffic-related air pollution, particulate matter, and autism publication-title: JAMA Psychiatr. – volume: 11 start-page: 1 year: 2020 end-page: 18 ident: bib15 article-title: Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology publication-title: Mol. Autism. – volume: 44 start-page: 2013 year: 2014 end-page: 2025 ident: bib25 article-title: A twin study of heritable and shared environmental contributions to autism publication-title: J. Autism Dev. Disord. – year: 2005 ident: bib92 article-title: Air Quality Guidelines, Global Update – volume: 43 start-page: 443 year: 2014 end-page: 464 ident: bib54 article-title: Maternal lifestyle and environmental risk factors for autism spectrum disorders publication-title: Int. J. Epidemiol. – volume: 34 year: 2020 ident: bib29 article-title: Oxidative stress pathways of air pollution mediated toxicity: recent insights publication-title: Redox Biol. – volume: 83 start-page: 41 year: 2021 end-page: 48 ident: bib23 article-title: Geospatial analysis of individual-based Parkinson's disease data supports a link with air pollution: a case-control study publication-title: Parkinsonism Relat. Disord. – volume: 98 start-page: 376 year: 2014 end-page: 384 ident: bib36 article-title: Air quality status and trends in Europe publication-title: Atmos. Environ. – volume: 23 start-page: 265 issue: 5 year: 2020 ident: 10.1016/j.envres.2023.115795_bib76 article-title: Parental age at conception and the relationship with severity of autism symptoms publication-title: Dev. Neurorehabil. doi: 10.1080/17518423.2019.1645222 – volume: 35 start-page: 6492 issue: 48 year: 2017 ident: 10.1016/j.envres.2023.115795_bib17 article-title: Low birth weight: case definition and guidelines for data collection, analysis, and presentation of maternal immunization safety data publication-title: Vaccine doi: 10.1016/j.vaccine.2017.01.049 – volume: 6 start-page: 788 issue: 5 year: 2015 ident: 10.1016/j.envres.2023.115795_bib64 article-title: Air quality over Portugal in 2020 publication-title: Atmos. Poll. Res. doi: 10.5094/APR.2015.087 – volume: 207 year: 2021 ident: 10.1016/j.envres.2023.115795_bib98 article-title: Maternal PM2. 5 exposure and abnormal placental nutrient transport publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2020.111281 – volume: 19 start-page: 158 issue: 2 year: 2015 ident: 10.1016/j.envres.2023.115795_bib85 article-title: Quality of life in autism across the lifespan: a meta-analysis publication-title: Autism doi: 10.1177/1362361313517053 – volume: 33 start-page: 194 issue: 2 year: 2017 ident: 10.1016/j.envres.2023.115795_bib58 article-title: The immune system, cytokines, and biomarkers in autism spectrum disorder publication-title: Neurosci. Bull. doi: 10.1007/s12264-017-0103-8 – volume: 8 start-page: 166 issue: 2 year: 2012 ident: 10.1016/j.envres.2023.115795_bib3 article-title: Clearing the air: a review of the effects of particulate matter air pollution on human health publication-title: J. Med. Toxicol. doi: 10.1007/s13181-011-0203-1 – volume: 83 start-page: 41 year: 2021 ident: 10.1016/j.envres.2023.115795_bib23 article-title: Geospatial analysis of individual-based Parkinson's disease data supports a link with air pollution: a case-control study publication-title: Parkinsonism Relat. Disord. doi: 10.1016/j.parkreldis.2020.12.013 – volume: 8 start-page: 13 issue: 1 year: 2017 ident: 10.1016/j.envres.2023.115795_bib61 article-title: Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses publication-title: Mol. Autism. doi: 10.1186/s13229-017-0121-4 – volume: 20 start-page: 15 year: 2016 ident: 10.1016/j.envres.2023.115795_bib35 article-title: Mitochondrial oxidative DNA damage and exposure to particulate air pollution in mother-newborn pairs publication-title: Environ. Health. – volume: 171 start-page: 218 year: 2019 ident: 10.1016/j.envres.2023.115795_bib42 article-title: Ambient ozone and fine particulate matter exposures and autism spectrum disorder in metropolitan Cincinnati, Ohio publication-title: Environ. Res. doi: 10.1016/j.envres.2019.01.013 – volume: 30 start-page: 205 issue: 3 year: 2000 ident: 10.1016/j.envres.2023.115795_bib51 article-title: The Autism Diagnostic Observation Schedule—generic: A standard measure of social and communication deficits associated with the spectrum of autism publication-title: J. Autism Dev. Disord. doi: 10.1023/A:1005592401947 – volume: 197 year: 2021 ident: 10.1016/j.envres.2023.115795_bib26 article-title: Exposure to ambient air pollution during pregnancy and inflammatory biomarkers in maternal and umbilical cord blood: the Healthy Start study publication-title: Environ. Res. doi: 10.1016/j.envres.2021.111165 – volume: 264 year: 2020 ident: 10.1016/j.envres.2023.115795_bib13 article-title: Urban airborne PM2. 5-activated microglia mediate neurotoxicity through glutaminase-containing extracellular vesicles in olfactory bulb publication-title: Environ. Pollut. doi: 10.1016/j.envpol.2020.114716 – volume: 6 start-page: 1 issue: 1 year: 2016 ident: 10.1016/j.envres.2023.115795_bib90 article-title: Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells publication-title: Sci. Rep. – year: 2021 ident: 10.1016/j.envres.2023.115795_bib93 – volume: 6 start-page: 1 issue: 1 year: 2020 ident: 10.1016/j.envres.2023.115795_bib52 article-title: Autism spectrum disorder publication-title: Nat. Rev. Dis. Primers. doi: 10.1038/s41572-019-0138-4 – volume: 140 start-page: 414 year: 2015 ident: 10.1016/j.envres.2023.115795_bib83 article-title: Fine particulate matter and the risk of autism spectrum disorder publication-title: Environ. Res. doi: 10.1016/j.envres.2015.04.021 – ident: 10.1016/j.envres.2023.115795_bib67 doi: 10.1016/j.jpsychires.2021.12.007 – volume: 15 start-page: 2653 year: 2020 ident: 10.1016/j.envres.2023.115795_bib99 article-title: PM2. 5 induces the expression of inflammatory cytokines via the Wnt5a/Ror2 pathway in human bronchial epithelial cells publication-title: Int. J. Chronic Obstr. Pulm. Dis. doi: 10.2147/COPD.S270762 – year: 2001 ident: 10.1016/j.envres.2023.115795_bib60 – volume: 8 year: 2020 ident: 10.1016/j.envres.2023.115795_bib46 article-title: Air pollution and central nervous system disease: a review of the impact of fine particulate matter on neurological disorders publication-title: Front. Public Health doi: 10.3389/fpubh.2020.575330 – volume: 121 start-page: 380 issue: 3 year: 2013 ident: 10.1016/j.envres.2023.115795_bib7 article-title: Ambient air pollution and autism in los angeles county, California publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1205827 – volume: 108 start-page: 120 year: 2018 ident: 10.1016/j.envres.2023.115795_bib20 article-title: Cytokine profile in autistic patients publication-title: Cytokine doi: 10.1016/j.cyto.2018.03.034 – volume: 128 start-page: 534 year: 2021 ident: 10.1016/j.envres.2023.115795_bib95 article-title: PM2. 5 as a potential risk factor for autism spectrum disorder: its possible link to neuroinflammation, oxidative stress and changes in gene expression publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2021.06.043 – volume: 70 start-page: 71 issue: 1 year: 2013 ident: 10.1016/j.envres.2023.115795_bib87 article-title: Traffic-related air pollution, particulate matter, and autism publication-title: JAMA Psychiatr. doi: 10.1001/jamapsychiatry.2013.266 – volume: 34 start-page: 785 issue: 8 year: 2019 ident: 10.1016/j.envres.2023.115795_bib49 article-title: Birth seasonality and risk of autism spectrum disorder publication-title: Eur. J. Epidemiol. doi: 10.1007/s10654-019-00506-5 – volume: 130 issue: 1 year: 2022 ident: 10.1016/j.envres.2023.115795_bib72 article-title: Prenatal exposure to air pollution and autism spectrum disorder: sensitive windows of exposure and sex differences publication-title: Environ. Health Perspect. doi: 10.1289/EHP9509 – volume: 187 start-page: 717 issue: 4 year: 2018 ident: 10.1016/j.envres.2023.115795_bib73 article-title: Traffic-related air pollution and autism spectrum disorder: a population-based nested case-control study in Israel publication-title: Am. J. Epidemiol. doi: 10.1093/aje/kwx294 – volume: 76 start-page: 1035 issue: 10 year: 2019 ident: 10.1016/j.envres.2023.115795_bib5 article-title: Association of genetic and environmental factors with autism in a 5-country cohort publication-title: JAMA Psychiatr. doi: 10.1001/jamapsychiatry.2019.1411 – volume: 123 start-page: 264 issue: 3 year: 2015 ident: 10.1016/j.envres.2023.115795_bib74 article-title: Autism spectrum disorder and particulate matter air pollution before, during, and after pregnancy: a nested case–control analysis within the Nurses' Health Study II cohort publication-title: Environ. Health Perspect. doi: 10.1289/ehp.1408133 – volume: 4 issue: 2 year: 2014 ident: 10.1016/j.envres.2023.115795_bib75 article-title: Environmental toxicants and autism spectrum disorders: a systematic review publication-title: Transl. Psychiatry doi: 10.1038/tp.2014.4 – volume: 75 start-page: 59 year: 2019 ident: 10.1016/j.envres.2023.115795_bib30 article-title: The association between particulate matter 2.5 exposure and children with autism spectrum disorder publication-title: Int. J. Dev. Neurosci. doi: 10.1016/j.ijdevneu.2019.05.003 – volume: 14 start-page: 1 issue: 1 year: 2014 ident: 10.1016/j.envres.2023.115795_bib11 article-title: Early life determinants of low IQ at age 6 in children from the 2004 Pelotas Birth Cohort: a predictive approach publication-title: BMC Pediatr. doi: 10.1186/s12887-014-0308-1 – volume: 21 start-page: 3293 issue: 9 year: 2020 ident: 10.1016/j.envres.2023.115795_bib68 article-title: Oxidative stress and immune system dysfunction in autism spectrum disorders publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21093293 – year: 2005 ident: 10.1016/j.envres.2023.115795_bib92 – volume: 13 start-page: 751 year: 2021 ident: 10.1016/j.envres.2023.115795_bib33 article-title: Management of pregnancy in women of advanced maternal age: improving outcomes for mother and baby publication-title: Int. J. Womens Health doi: 10.2147/IJWH.S283216 – volume: 48 start-page: 137 issue: 1 year: 2018 ident: 10.1016/j.envres.2023.115795_bib44 article-title: Association between air pollution exposure, cognitive and adaptive function, and ASD severity among children with autism spectrum disorder publication-title: J. Autism Dev. Disord. doi: 10.1007/s10803-017-3304-0 – volume: 49 start-page: 1166 issue: 7 year: 2019 ident: 10.1016/j.envres.2023.115795_bib69 article-title: Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls publication-title: Psychol. Med. doi: 10.1017/S0033291718002039 – volume: 5 issue: 4 year: 2021 ident: 10.1016/j.envres.2023.115795_bib91 article-title: Ambient particulate matter, ozone, and neurologic symptoms in US Gulf states adults publication-title: Environ. Epidemiol. doi: 10.1097/EE9.0000000000000160 – volume: 22 start-page: 345 issue: 4 year: 2016 ident: 10.1016/j.envres.2023.115795_bib18 article-title: Advancing the understanding of autism disease mechanisms through genetics publication-title: Nat. Med. doi: 10.1038/nm.4071 – volume: 24 start-page: 659 issue: 5 year: 1994 ident: 10.1016/j.envres.2023.115795_bib50 article-title: Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders publication-title: J. Autism Dev. Disord. doi: 10.1007/BF02172145 – volume: 14 issue: 7 year: 2019 ident: 10.1016/j.envres.2023.115795_bib21 article-title: Exposure of trophoblast cells to fine particulate matter air pollution leads to growth inhibition, inflammation and ER stress publication-title: PLoS One doi: 10.1371/journal.pone.0218799 – volume: 44 start-page: 2013 issue: 8 year: 2014 ident: 10.1016/j.envres.2023.115795_bib25 article-title: A twin study of heritable and shared environmental contributions to autism publication-title: J. Autism Dev. Disord. doi: 10.1007/s10803-014-2081-2 – volume: 196 year: 2021 ident: 10.1016/j.envres.2023.115795_bib89 article-title: Prenatal air pollution exposure and neurodevelopment: a review and blueprint for a harmonized approach within ECHO publication-title: Environ. Res. doi: 10.1016/j.envres.2020.110320 – volume: 142 year: 2020 ident: 10.1016/j.envres.2023.115795_bib82 article-title: Mitochondrial alterations triggered by repeated exposure to fine (PM2. 5-0.18) and quasi-ultrafine (PM0. 18) fractions of ambient particulate matter publication-title: Environ. Int. doi: 10.1016/j.envint.2020.105830 – volume: 25 start-page: 862 issue: 4 year: 2021 ident: 10.1016/j.envres.2023.115795_bib86 article-title: Age at autism spectrum disorder diagnosis: a systematic review and meta-analysis from 2012 to 2019 publication-title: Autism doi: 10.1177/1362361320971107 – volume: 21 start-page: 4726 issue: 13 year: 2020 ident: 10.1016/j.envres.2023.115795_bib31 article-title: Clinical assessment, genetics, and treatment approaches in autism spectrum disorder (ASD) publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21134726 – volume: 11 start-page: 1 issue: 1 year: 2019 ident: 10.1016/j.envres.2023.115795_bib22 article-title: Particulate matter exposure shapes DNA methylation through the lifespan publication-title: Clin. Epigenet. doi: 10.1186/s13148-019-0726-x – year: 2022 ident: 10.1016/j.envres.2023.115795_bib57 article-title: Gestational age in children and adolescents: prevalence and effects on autism phenotype publication-title: J. Autism Dev. Disord. – volume: 150 start-page: 411 year: 2016 ident: 10.1016/j.envres.2023.115795_bib10 article-title: Interactive and additive influences of Gender, BMI and Apolipoprotein 4 on cognition in children chronically exposed to high concentrations of PM2. 5 and ozone. APOE 4 females are at highest risk in Mexico City publication-title: Environ. Res. doi: 10.1016/j.envres.2016.06.026 – year: 2017 ident: 10.1016/j.envres.2023.115795_bib62 – volume: 10 start-page: 3025 issue: 11 year: 2021 ident: 10.1016/j.envres.2023.115795_bib100 article-title: Prenatal Air Pollution Exposure and Placental DNA Methylation Changes: Implications on Fetal Development and Future Disease Susceptibility publication-title: Cells doi: 10.3390/cells10113025 – volume: 8 issue: 9 year: 2013 ident: 10.1016/j.envres.2023.115795_bib40 article-title: Air pollution and newly diagnostic autism spectrum disorders: a population-based cohort study in Taiwan publication-title: PLoS One doi: 10.1371/journal.pone.0075510 – volume: 134 start-page: 315 issue: 2 year: 2015 ident: 10.1016/j.envres.2023.115795_bib53 article-title: Macrophages treated with particulate matter PM 2.5 induce selective neurotoxicity through glutaminase‐mediated glutamate generation publication-title: J. Neurochem. doi: 10.1111/jnc.13135 – year: 2016 ident: 10.1016/j.envres.2023.115795_bib102 – volume: 7 start-page: 20 issue: 1 year: 2021 ident: 10.1016/j.envres.2023.115795_bib14 article-title: Trimester effects of source-specific PM10 on birth weight outcomes in the avon longitudinal study of parents and children (ALSPAC) publication-title: Environ. Health – volume: 39 start-page: 693 issue: 5 year: 2009 ident: 10.1016/j.envres.2023.115795_bib34 article-title: Standardizing ADOS scores for a measure of severity in autism spectrum disorders publication-title: J. Autism Dev. Disord. doi: 10.1007/s10803-008-0674-3 – volume: 7 issue: 23 year: 2019 ident: 10.1016/j.envres.2023.115795_bib27 article-title: Emerging biomarkers in autism spectrum disorder: a systematic review publication-title: Ann. Transl. Med. doi: 10.21037/atm.2019.11.53 – volume: 10 start-page: 1 issue: 1 year: 2019 ident: 10.1016/j.envres.2023.115795_bib9 article-title: Ambient black carbon particles reach the fetal side of human placenta publication-title: Nat. Commun. doi: 10.1038/s41467-019-11654-3 – volume: 119 start-page: 1204 issue: 11 year: 2016 ident: 10.1016/j.envres.2023.115795_bib70 article-title: Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation publication-title: Cir. Res. doi: 10.1161/CIRCRESAHA.116.309279 – year: 2022 ident: 10.1016/j.envres.2023.115795_bib6 article-title: Prenatal and early childhood predictors of intelligence quotient (IQ) in 7-year-old Danish children from the Odense Child Cohort publication-title: Scand. J. Publ. Health – volume: 31 start-page: 651 issue: 5 year: 2018 ident: 10.1016/j.envres.2023.115795_bib32 article-title: Particulate matter (PM10) exposure, birth and fetal-placental weight and umbilical arterial pH: results from a prospective study publication-title: J. Matern. Fetal Neonat. Med. doi: 10.1080/14767058.2017.1293032 – volume: 41 start-page: 784 issue: 3 year: 2018 ident: 10.1016/j.envres.2023.115795_bib97 article-title: Effect of atmospheric PM2. 5 on expression levels of NF-κB genes and inflammatory cytokines regulated by NF-κB in human macrophage publication-title: Inflammation doi: 10.1007/s10753-018-0732-8 – volume: 98 start-page: 376 year: 2014 ident: 10.1016/j.envres.2023.115795_bib36 article-title: Air quality status and trends in Europe publication-title: Atmos. Environ. doi: 10.1016/j.atmosenv.2014.09.017 – volume: 373 start-page: 22 issue: 1 year: 2007 ident: 10.1016/j.envres.2023.115795_bib63 article-title: Air quality assessment for Portugal publication-title: Sci. Total Environ. doi: 10.1016/j.scitotenv.2006.10.014 – volume: 23 start-page: 6487 issue: 12 year: 2022 ident: 10.1016/j.envres.2023.115795_bib103 article-title: Particulate Matter Exacerbates the Death of Dopaminergic Neurons in Parkinson's Disease through an Inflammatory Response publication-title: Int. J. Mol. Sci. 10 doi: 10.3390/ijms23126487 – volume: 238 year: 2022 ident: 10.1016/j.envres.2023.115795_bib96 article-title: In-utero exposure to air pollution and early-life neural development and cognition publication-title: Ecotoxicol. Environ. Saf. doi: 10.1016/j.ecoenv.2022.113589 – volume: 318 start-page: 1182 issue: 12 year: 2017 ident: 10.1016/j.envres.2023.115795_bib78 article-title: The heritability of autism spectrum disorder publication-title: JAMA doi: 10.1001/jama.2017.12141 – volume: 32 start-page: 281 issue: 2 year: 2022 ident: 10.1016/j.envres.2023.115795_bib28 article-title: PM10 exposure interacts with abdominal obesity to increase blood triglycerides: a cross-sectional linkage study publication-title: Eur. J. Public Health. doi: 10.1093/eurpub/ckab190 – volume: 385 year: 2019 ident: 10.1016/j.envres.2023.115795_bib77 article-title: Genetic causes and modifiers of autism spectrum disorder publication-title: Front. Cell. Neurosci. – volume: 10 start-page: 1470 issue: 9 year: 2017 ident: 10.1016/j.envres.2023.115795_bib45 article-title: The joint effect of air pollution exposure and copy number variation on risk for autism publication-title: Autism Res. doi: 10.1002/aur.1799 – volume: 133 year: 2021 ident: 10.1016/j.envres.2023.115795_bib79 article-title: Exposure to xenobiotics and gene-environment interactions in autism spectrum disorder: a systematic review publication-title: Autism Spectrum Disorder-Profile, Heterogeneity, Neurobiology and Intervention doi: 10.5772/intechopen.95758 – volume: 16 year: 2022 ident: 10.1016/j.envres.2023.115795_bib80 article-title: A role for gene-environment interactions in autism spectrum disorder is supported by variants in genes regulating the effects of exposure to xenobiotics publication-title: Front. Neurosci. doi: 10.3389/fnins.2022.862315 – volume: 43 start-page: 443 issue: 2 year: 2014 ident: 10.1016/j.envres.2023.115795_bib54 article-title: Maternal lifestyle and environmental risk factors for autism spectrum disorders publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyt282 – volume: 42 start-page: 195 issue: 5–6 year: 2020 ident: 10.1016/j.envres.2023.115795_bib8 article-title: Integrated RNA sequencing reveals epigenetic impacts of diesel particulate matter exposure in human cerebral organoids publication-title: Dev. Neurosci. doi: 10.1159/000513536 – volume: 26 start-page: 650 issue: 5 year: 2020 ident: 10.1016/j.envres.2023.115795_bib24 article-title: Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis publication-title: Hum. Reprod. Update doi: 10.1093/humupd/dmaa010 – volume: 22 start-page: 489 issue: 6 year: 2017 ident: 10.1016/j.envres.2023.115795_bib19 article-title: Biomarkers used in studying air pollution exposure during pregnancy and perinatal outcomes: a review publication-title: Biomarkers doi: 10.1080/1354750X.2017.1339294 – volume: 11 start-page: 1 issue: 1 year: 2020 ident: 10.1016/j.envres.2023.115795_bib15 article-title: Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology publication-title: Mol. Autism. doi: 10.1186/s13229-020-00370-1 – volume: 32 start-page: 1776 issue: 5 year: 2011 ident: 10.1016/j.envres.2023.115795_bib38 article-title: Advanced parental ages and low birth weight in autism spectrum disorders—rates and effect on functioning publication-title: Res. Dev. Disabil. doi: 10.1016/j.ridd.2011.03.004 – volume: 33 start-page: 1 issue: 1 year: 2021 ident: 10.1016/j.envres.2023.115795_bib81 article-title: Urban population exposure to air pollution in Europe over the last decades publication-title: Environ. Sci. Eur. doi: 10.1186/s12302-020-00450-2 – year: 2022 ident: 10.1016/j.envres.2023.115795_bib47 article-title: Effects of short-term exposure to air pollution on hospital admissions for autism spectrum disorder in Korean school-aged children: a nationwide time-series study publication-title: BMJ Open doi: 10.1136/bmjopen-2021-058286 – volume: 3 start-page: 19 issue: 1 year: 2010 ident: 10.1016/j.envres.2023.115795_bib59 article-title: Geographic distribution of autism in California: a retrospective birth cohort analysis publication-title: Autism Res. doi: 10.1002/aur.110 – volume: 34 year: 2020 ident: 10.1016/j.envres.2023.115795_bib29 article-title: Oxidative stress pathways of air pollution mediated toxicity: recent insights publication-title: Redox Biol. doi: 10.1016/j.redox.2020.101545 – volume: 12 start-page: 83 issue: 3 year: 2020 ident: 10.1016/j.envres.2023.115795_bib39 article-title: Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring publication-title: Biomed. Rep. – volume: 81 start-page: 442 issue: 5 year: 2017 ident: 10.1016/j.envres.2023.115795_bib43 article-title: Neonatal cytokine profiles associated with autism spectrum disorder publication-title: Biol. Psychiatry. doi: 10.1016/j.biopsych.2015.08.007 – volume: 26 start-page: 30 issue: 1 year: 2015 ident: 10.1016/j.envres.2023.115795_bib41 article-title: Particulate matter exposure, prenatal and postnatal windows of susceptibility, and autism spectrum disorders publication-title: Epidemiology doi: 10.1097/EDE.0000000000000173 – volume: 210 year: 2020 ident: 10.1016/j.envres.2023.115795_bib16 article-title: Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2020.107523 – volume: 135 start-page: 29 issue: 1 year: 2017 ident: 10.1016/j.envres.2023.115795_bib94 article-title: Advanced parental age and autism risk in children: a systematic review and meta‐analysis publication-title: Acta Psychiatr. Scand. doi: 10.1111/acps.12666 – volume: 30 start-page: 689 issue: 4 year: 2020 ident: 10.1016/j.envres.2023.115795_bib84 article-title: Association between maternal exposure to particulate matter (PM2.5) and adverse pregnancy outcomes in Lima, Peru publication-title: J. Expo. Sci. Environ. Epidemiol. doi: 10.1038/s41370-020-0223-5 – volume: 209 year: 2022 ident: 10.1016/j.envres.2023.115795_bib104 article-title: Prenatal exposure to PM10 and changes in DNA methylation and telomere length in cord blood publication-title: Environ. Res. doi: 10.1016/j.envres.2022.112717 – volume: 14 start-page: 16 year: 2020 ident: 10.1016/j.envres.2023.115795_bib55 article-title: The autism biomarkers consortium for clinical trials (ABC-CT): scientific context, study design, and progress toward biomarker qualification publication-title: Front. Integr. Neurosci. doi: 10.3389/fnint.2020.00016 – volume: 49 start-page: 726 issue: 10 year: 2007 ident: 10.1016/j.envres.2023.115795_bib66 article-title: Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions publication-title: Dev. Med. Child Neurol. doi: 10.1111/j.1469-8749.2007.00726.x – volume: 42 start-page: 2431 year: 2012 ident: 10.1016/j.envres.2023.115795_bib65 article-title: The effect of gestational age on symptom severity in children with Autism Spectrum Disorder publication-title: J. Autism Dev. Disord. doi: 10.1007/s10803-012-1501-4 – year: 2013 ident: 10.1016/j.envres.2023.115795_bib2 – volume: 25 start-page: 44 issue: 1 year: 2014 ident: 10.1016/j.envres.2023.115795_bib88 article-title: Interaction of the MET receptor tyrosine kinase gene and air pollution exposure in autism spectrum disorder publication-title: Epidemiology doi: 10.1097/EDE.0000000000000030 – volume: 178 start-page: 30 issue: 1 year: 2021 ident: 10.1016/j.envres.2023.115795_bib56 article-title: Autism spectrum disorder genetics and the search for pathological mechanisms publication-title: Am. J. Psychiatry. doi: 10.1176/appi.ajp.2020.20111608 |
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| SubjectTerms | air Air Pollutants - analysis Air Pollutants - toxicity Air pollution Air Pollution - adverse effects Air Pollution - analysis air quality autism Autism spectrum disorder Autism Spectrum Disorder - chemically induced Autism Spectrum Disorder - epidemiology Child children Clinical severity Early-life exposure Environmental Exposure - analysis epigenetics etiology European Union Female Humans maternal exposure mitochondria nitrogen dioxide Nitrogen Dioxide - analysis Nitrogen Dioxide - toxicity oxidative stress ozone Particulate matter Particulate Matter - analysis Particulate Matter - toxicity particulates Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - epidemiology regression analysis sulfur dioxide |
| Title | Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder |
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