Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer

The prolonged contagious period after viral infection in immunocompromised patients may affect how long precautions will be necessary to reduce further transmission. Replication-competent SARS-CoV-2 was detected for up to 61 days in patients who were immunocompromised by treatment for cancer.

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Bibliographic Details
Published in	The New England journal of medicine Vol. 383; no. 26; pp. 2586 - 2588
Main Authors	Aydillo, Teresa, Gonzalez-Reiche, Ana S, Aslam, Sadaf, van de Guchte, Adriana, Khan, Zenab, Obla, Ajay, Dutta, Jayeeta, van Bakel, Harm, Aberg, Judith, García-Sastre, Adolfo, Shah, Gunjan, Hohl, Tobias, Papanicolaou, Genovefa, Perales, Miguel-Angel, Sepkowitz, Kent, Babady, N. Esther, Kamboj, Mini
Format	Journal Article
Language	English
Published	United States Massachusetts Medical Society 24.12.2020
Subjects	Adult Aged Cancer therapies Coronaviruses Correspondence COVID-19 COVID-19 - complications COVID-19 - virology Disease transmission Female Genomes Hematopoietic Stem Cell Transplantation Humans Immunocompromised hosts Immunosuppression Immunosuppressive agents Influenza Male Middle Aged Neoplasms - complications Neoplasms - therapy Patients Philanthropy Severe acute respiratory syndrome coronavirus 2 Transplants & implants Virus Shedding
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Abstract	The prolonged contagious period after viral infection in immunocompromised patients may affect how long precautions will be necessary to reduce further transmission. Replication-competent SARS-CoV-2 was detected for up to 61 days in patients who were immunocompromised by treatment for cancer.
AbstractList	The prolonged contagious period after viral infection in immunocompromised patients may affect how long precautions will be necessary to reduce further transmission. Replication-competent SARS-CoV-2 was detected for up to 61 days in patients who were immunocompromised by treatment for cancer.
Author	García-Sastre, Adolfo Hohl, Tobias Perales, Miguel-Angel Papanicolaou, Genovefa Aslam, Sadaf van de Guchte, Adriana Aberg, Judith Shah, Gunjan Kamboj, Mini Khan, Zenab Obla, Ajay Babady, N. Esther Aydillo, Teresa Dutta, Jayeeta Gonzalez-Reiche, Ana S van Bakel, Harm Sepkowitz, Kent
Author_xml	– sequence: 1 givenname: Teresa surname: Aydillo fullname: Aydillo, Teresa organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 2 givenname: Ana S surname: Gonzalez-Reiche fullname: Gonzalez-Reiche, Ana S organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 3 givenname: Sadaf surname: Aslam fullname: Aslam, Sadaf organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 4 givenname: Adriana surname: van de Guchte fullname: van de Guchte, Adriana organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 5 givenname: Zenab surname: Khan fullname: Khan, Zenab organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 6 givenname: Ajay surname: Obla fullname: Obla, Ajay organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 7 givenname: Jayeeta surname: Dutta fullname: Dutta, Jayeeta organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 8 givenname: Harm surname: van Bakel fullname: van Bakel, Harm organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 9 givenname: Judith surname: Aberg fullname: Aberg, Judith organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 10 givenname: Adolfo surname: García-Sastre fullname: García-Sastre, Adolfo organization: Icahn School of Medicine at Mount Sinai, New York, NY – sequence: 11 givenname: Gunjan surname: Shah fullname: Shah, Gunjan email: kambojm@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY – sequence: 12 givenname: Tobias surname: Hohl fullname: Hohl, Tobias email: kambojm@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY – sequence: 13 givenname: Genovefa surname: Papanicolaou fullname: Papanicolaou, Genovefa email: kambojm@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY – sequence: 14 givenname: Miguel-Angel surname: Perales fullname: Perales, Miguel-Angel email: kambojm@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY – sequence: 15 givenname: Kent surname: Sepkowitz fullname: Sepkowitz, Kent email: kambojm@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY – sequence: 16 givenname: N. Esther surname: Babady fullname: Babady, N. Esther email: kambojm@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY – sequence: 17 givenname: Mini surname: Kamboj fullname: Kamboj, Mini email: kambojm@mskcc.org organization: Memorial Sloan Kettering Cancer Center, New York, NY
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33259154$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1056/NEJMoa2008457
ContentType	Journal Article
Copyright	Copyright © 2020 Massachusetts Medical Society. All rights reserved. Copyright © 2020 Massachusetts Medical Society. All rights reserved. 2020 Massachusetts Medical Society
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License	http://www.nejmgroup.org/legal/terms-of-use.htm This article is made available via the PMC Open Access Subset for unrestricted re-use, except commercial resale, and analyses in any form or by any means with acknowledgment of the original source. These permissions are granted for the duration of the Covid-19 pandemic or until revoked in writing. Upon expiration of these permissions, PMC is granted a license to make this article available via PMC and Europe PMC, subject to existing copyright protections.
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References	Arons, MM, Hatfield, KM, Reddy, SC (r001) 2020; 382 r002 e_1_3_4_3_2 e_1_3_4_2_2 33778764 - Radiol Imaging Cancer. 2021 Jan 22;3(1):e210003
References_xml	– volume: 382 start-page: 2081 year: 2020 end-page: 2090 ident: r001 article-title: Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility. publication-title: N Engl J Med – ident: r002 article-title: Centers for Disease Control and Prevention. Discontinuation of transmission-based precautions and disposition of patients with COVID-19 in healthcare settings (interim guidance). August 10, 2020 ( https://www.cdc.gov/coronavirus/2019-ncov/hcp/disposition-hospitalized-patients.html ) – ident: e_1_3_4_3_2 – ident: e_1_3_4_2_2 doi: 10.1056/NEJMoa2008457 – reference: 33778764 - Radiol Imaging Cancer. 2021 Jan 22;3(1):e210003
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Snippet	The prolonged contagious period after viral infection in immunocompromised patients may affect how long precautions will be necessary to reduce further...
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SubjectTerms	Adult Aged Cancer therapies Coronaviruses Correspondence COVID-19 COVID-19 - complications COVID-19 - virology Disease transmission Female Genomes Hematopoietic Stem Cell Transplantation Humans Immunocompromised hosts Immunosuppression Immunosuppressive agents Influenza Male Middle Aged Neoplasms - complications Neoplasms - therapy Patients Philanthropy Severe acute respiratory syndrome coronavirus 2 Transplants & implants Virus Shedding
Title	Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer
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