Corticotropin-Releasing Factor receptor 1 (CRF1) antagonism in patients with alcohol use disorder and high anxiety levels: effect on neural response during Trier Social Stress Test video feedback

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 48; no. 5; pp. 816 - 820
• Main Authors: Lee, Mary R., Rio, Daniel, Kwako, Laura, George, David T., Heilig, Markus, Momenan, Reza
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2023; Springer International Publishing
• Subjects: Addictions; Alcohol use; Alcoholism - diagnostic imaging; Alcoholism - drug therapy; Amygdala; Anxiety; Brain mapping; Clinical trials; Corticotropin-releasing hormone; Corticotropin-Releasing Hormone - metabolism; Drinking behavior; Feedback; Female; Frontal gyrus; Functional magnetic resonance imaging; Humans; Hypothalamic-pituitary-adrenal axis; Hypothalamo-Hypophyseal System - metabolism; Hypothalamus; Male; Pituitary; Pituitary-Adrenal System - metabolism; Placebos; Psychological Tests; Receptors, Corticotropin-Releasing Hormone; Social interactions

In preclinical models of alcohol use disorder, the corticotropin-releasing factor (CRF) receptor is upregulated, particularly in the extended amygdala. This upregulation is thought to play a role in stress-induced relapse to drinking by a mechanism that is independent of the hypothalamic-pituitary-a...