Using brain organoids to understand Zika virus-induced microcephaly

• Published in: Development (Cambridge) Vol. 144; no. 6; pp. 952 - 957
• Main Authors: Qian, Xuyu, Nguyen, Ha Nam, Jacob, Fadi, Song, Hongjun, Ming, Guo-li
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Ltd 15.03.2017
• Subjects: Animals; Brain - pathology; Drug development; Fetuses; Flavivirus; Humans; Microcephaly; Microcephaly - pathology; Microcephaly - virology; Microencephaly; Organoids; Organoids - pathology; Outbreaks; Pathogenesis; Pluripotency; Spotlight; Stem cells; Zika virus; Zika Virus - physiology; Zika Virus Infection - virology; Organoids; Microcephaly; Cortex; iPSC; Zika

Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble in vivo organs are pushing the frontiers of human disease modeling and drug development. In response to the global health emergency posed by the Zika virus (ZIKV) outbreak, brain orga...