Using brain organoids to understand Zika virus-induced microcephaly

Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble in vivo organs are pushing the frontiers of human disease modeling and drug development. In response to the global health emergency posed by the Zika virus (ZIKV) outbreak, brain orga...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 144; no. 6; pp. 952 - 957
Main Authors Qian, Xuyu, Nguyen, Ha Nam, Jacob, Fadi, Song, Hongjun, Ming, Guo-li
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Ltd 15.03.2017
Subjects
Animals
Brain - pathology
Drug development
Fetuses
Flavivirus
Humans
Microcephaly
Microcephaly - pathology
Microcephaly - virology
Microencephaly
Organoids
Organoids - pathology
Outbreaks
Pathogenesis
Pluripotency
Spotlight
Stem cells
Zika virus
Zika Virus - physiology
Zika Virus Infection - virology
Organoids
Microcephaly
Cortex
iPSC
Zika
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Summary:Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble in vivo organs are pushing the frontiers of human disease modeling and drug development. In response to the global health emergency posed by the Zika virus (ZIKV) outbreak, brain organoids engineered to mimic the developing human fetal brain have been employed to model ZIKV-induced microcephaly. Here, we discuss the advantages of brain organoids over other model systems to study development and highlight recent advances in understanding ZIKV pathophysiology and its underlying pathogenesis mechanisms. We further discuss perspectives on overcoming limitations of current organoid systems for their future use in ZIKV research.
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ISSN:0950-1991
1477-9129
1477-9129
DOI:10.1242/dev.140707