SARS-CoV-2 Gamma and Delta Variants of Concern Might Undermine Neutralizing Activity Generated in Response to BNT162b2 mRNA Vaccination

• Published in: Viruses Vol. 14; no. 4; p. 814
• Main Authors: Trabace, Luigia, Pace, Lorenzo, Morgese, Maria Grazia, Santo, Isabel Bianca, Galante, Domenico, Schiavone, Stefania, Cipolletta, Dora, Rosa, Anna Maria, Reveglia, Pierluigi, Parisi, Antonio, Tucci, Paolo, Pepe, Giovanni, Sacco, Rodolfo, Foschino Barbaro, Maria Pia, Corso, Gaetano, Fasanella, Antonio
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.04.2022; MDPI
• Subjects: Age; Antibodies; Antibodies, Neutralizing; Antibodies, Viral; BNT162 Vaccine; BNT162b2 mRNA; Coronaviruses; COVID-19 - prevention & control; COVID-19 Vaccines; Disease transmission; Females; Humans; Immunization; Immunoglobulin G; Males; Medical personnel; mRNA; neutralizing antibodies; RNA, Messenger - genetics; SARS-CoV-2 - genetics; SARS-CoV-2 VOCs; Severe acute respiratory syndrome coronavirus 2; Statistical analysis; Vaccination; Vaccines; England; Italy; South Africa; United Kingdom > UK; India; BNT162b2 mRNA; neutralizing antibodies; SARS-CoV-2 VOCs

The Delta variant raised concern regarding its ability to evade SARS-CoV-2 vaccines. We evaluated a serum neutralizing response of 172 Italian healthcare workers, three months after complete Comirnaty (BNT162b2 mRNA, BioNTech-Pfizer) vaccination, testing their sera against viral isolates of Alpha, G...