Advances in biomarkers for immunotherapy in small-cell lung cancer

• Published in: Frontiers in immunology Vol. 15; p. 1490590
• Main Authors: Li, Hui, Zhao, Peiyan, Tian, Lin, Lu, Yuanhua, Wang, Xinyue, Shao, Wenjun, Cheng, Ying
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.12.2024
• Subjects: Animals; biomarker; Biomarkers, Tumor; Humans; Immune Checkpoint Inhibitors - therapeutic use; Immunology; immunotherapy; Immunotherapy - methods; Lung Neoplasms - drug therapy; Lung Neoplasms - immunology; Lung Neoplasms - therapy; predictive; Prognosis; research advances; Small Cell Lung Carcinoma - immunology; Small Cell Lung Carcinoma - therapy; small-cell lung cancer; Tumor Microenvironment - immunology; predictive; small-cell lung cancer; biomarker; prognosis; research advances; immunotherapy

Small-cell lung cancer (SCLC) is a refractory cancer with rapid growth and high aggressiveness. Extensive-stage SCLC is initially sensitive to chemotherapy; however, drug resistance and recurrence occur rapidly, resulting in a poor survival outcome due to lack of subsequently efficient therapy. The...