The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagy

• Published in: Autophagy Vol. 19; no. 7; pp. 1916 - 1933
• Main Authors: Zhang, Bo, Xu, Shuai, Liu, Minxuan, Wei, Yanli, Wang, Qian, Shen, Wentao, Lei, Cao-Qi, Zhu, Qiyun
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.07.2023
• Subjects: Animals; Antiviral Agents - pharmacology; Autophagy; Humans; Immunity, Innate; Influenza A virus; Influenza A Virus, H1N1 Subtype; MAVS; Mice; mitophagy; Mitophagy - genetics; nucleoprotein; Nucleoproteins - pharmacology; Research Paper; TOLLIP; nucleoprotein; MAVS; mitophagy; Influenza A virus; TOLLIP

Mitophagy is a form of autophagy that plays a key role in maintaining the homeostasis of functional mitochondria in the cell. Viruses have evolved various strategies to manipulate mitophagy to escape host immune responses and promote virus replication. In this study, the nucleoprotein (NP) of H1N1 v...