Variations in Suppressor Molecule CTLA-4 Gene Are Related to Susceptibility to Multiple Myeloma in a Polish Population

• Published in: Pathology oncology research Vol. 18; no. 2; pp. 219 - 226
• Main Authors: Karabon, Lidia, Pawlak-Adamska, Edyta, Tomkiewicz, Anna, Jedynak, Anna, Kielbinski, Marek, Woszczyk, Dariusz, Potoczek, Stanisław, Jonkisz, Anna, Kuliczkowski, Kazimierz, Frydecka, Irena
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2012; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Alleles; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; CTLA-4 Antigen - genetics; DNA - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes - genetics; Humans; Immunology; Male; Middle Aged; Multiple Myeloma - epidemiology; Multiple Myeloma - genetics; Oncology; Pathology; Phenotype; Poland - epidemiology; Polymerase Chain Reaction; Polymorphism, Genetic - genetics; Prognosis; Poland; MM; Gene polymorphisms; CTLA-4

Various phenotype and functional T-cell abnormalities are observed in multiple myeloma (MM) patients. The aim of this study was to investigate the association between polymorphisms in the gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4), a negative regulator of the T-lymphocyte immune respons...