Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study

• Published in: Diabetes care Vol. 39; no. 9; pp. 1543 - 1549
• Main Authors: Hirabayashi, Naoki, Hata, Jun, Ohara, Tomoyuki, Mukai, Naoko, Nagata, Masaharu, Shibata, Mao, Gotoh, Seiji, Furuta, Yoshihiko, Yamashita, Fumio, Yoshihara, Kazufumi, Kitazono, Takanari, Sudo, Nobuyuki, Kiyohara, Yutaka, Ninomiya, Toshiharu
• Format: Journal Article
• Language: English
• Published: United States American Diabetes Association 01.09.2016
• Subjects: Aged; Aged, 80 and over; Atrophy - diagnostic imaging; Atrophy - pathology; Blood Glucose - analysis; Brain - diagnostic imaging; Brain - pathology; Brain damage; Diabetes; Diabetes Mellitus - blood; Diabetes Mellitus - diagnostic imaging; Diabetes Mellitus - pathology; Female; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Hyperglycemia; Independent Living; Japan; Magnetic Resonance Imaging - methods; Male; Multivariate Analysis; NMR; Nuclear magnetic resonance; Older people; Prospective Studies; Risk Factors; Time Factors; Japan

To investigate the association between diabetes and brain or hippocampal atrophy in an elderly population. A total of 1,238 community-dwelling Japanese subjects aged ≥65 years underwent brain MRI scans and a comprehensive health examination in 2012. Total brain volume (TBV), intracranial volume (ICV...