Sam68 is a regulator of Toll-like receptor signaling

• Published in: Cellular & molecular immunology Vol. 14; no. 1; pp. 107 - 117
• Main Authors: Tomalka, Jeffrey A, de Jesus, Tristan J, Ramakrishnan, Parameswaran
• Format: Journal Article
• Language: English
• Published: China Nature Publishing Group 01.01.2017
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Enzyme Activation - drug effects; Fibroblasts - drug effects; Fibroblasts - metabolism; Gene Expression Regulation - drug effects; Interleukin-1 - pharmacology; Lipopeptides - pharmacology; Macrophages - drug effects; Macrophages - metabolism; MAP Kinase Signaling System - drug effects; MAPK信号通路; Mice; Mice, Knockout; Models, Biological; NF-kappa B - metabolism; NF-κB; RAW 264.7 Cells; RNA-Binding Proteins - metabolism; Signal Transduction - drug effects; TLR4; Toll-Like Receptors - metabolism; Toll样受体; 丝裂原活化蛋白激酶; 信号调节器; 细胞外信号调节激酶; 诱导表达

Recognition of pathogens by Toll-like receptors （TLR） activate multiple signaling cascades and expression of genes tailored to mount a primary immune response, inflammation, cell survival and apoptosis. Although TLR-induced activation of pathways, such as nuclear factor kappaB （NF-κB） and mitogen-ac...