Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases

Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progres...

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Published inAgeing research reviews Vol. 97; p. 102294
Main Authors Zeng, Qing, Gong, Yongzhen, Zhu, Neng, Shi, Yaning, Zhang, Chanjuan, Qin, Li
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.06.2024
Subjects
Age-related disease
Aging - metabolism
Animals
Cellular senescence
Cellular Senescence - physiology
Humans
Lipid metabolism
Lipid Metabolism - physiology
Lipids
Lipids - physiology
Therapy strategies
Therapy strategies
Lipids
Lipid metabolism
Age-related disease
Cellular senescence
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Abstract Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers, etc. Recent studies have shown that the disorders of lipid metabolism are not only related to age-related diseases, but also regulate the cellular senescence process. Based on existing research evidences, the changes in lipid metabolism in senescent cells are mainly concentrated in the metabolic processes of phospholipids, fatty acids and cholesterol. Obviously, the changes in lipid-metabolizing enzymes and proteins involved in these pathways play a critical role in senescence. However, the link between cellular senescence, changes in lipid metabolism and age-related disease remains to be elucidated. Herein, we summarize the lipid metabolism changes in senescent cells, especially the senescent cells that promote age-related diseases, as well as focusing on the role of lipid-related enzymes or proteins in senescence. Finally, we explore the prospect of lipids in cellular senescence and their potential as drug targets for preventing and delaying age-related diseases. •Elucidate the lipids landscape of senescent cells and their critical role in cellular senescence.•Lipid metabolism disorders in cellular senescence promote the progression of aging and age-related diseases.•Intervention of lipid metabolism processes and related enzymes or proteins are novel targets to modulate senescence.
AbstractList Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers, etc. Recent studies have shown that the disorders of lipid metabolism are not only related to age-related diseases, but also regulate the cellular senescence process. Based on existing research evidences, the changes in lipid metabolism in senescent cells are mainly concentrated in the metabolic processes of phospholipids, fatty acids and cholesterol. Obviously, the changes in lipid-metabolizing enzymes and proteins involved in these pathways play a critical role in senescence. However, the link between cellular senescence, changes in lipid metabolism and age-related disease remains to be elucidated. Herein, we summarize the lipid metabolism changes in senescent cells, especially the senescent cells that promote age-related diseases, as well as focusing on the role of lipid-related enzymes or proteins in senescence. Finally, we explore the prospect of lipids in cellular senescence and their potential as drug targets for preventing and delaying age-related diseases. •Elucidate the lipids landscape of senescent cells and their critical role in cellular senescence.•Lipid metabolism disorders in cellular senescence promote the progression of aging and age-related diseases.•Intervention of lipid metabolism processes and related enzymes or proteins are novel targets to modulate senescence.
Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers, etc. Recent studies have shown that the disorders of lipid metabolism are not only related to age-related diseases, but also regulate the cellular senescence process. Based on existing research evidences, the changes in lipid metabolism in senescent cells are mainly concentrated in the metabolic processes of phospholipids, fatty acids and cholesterol. Obviously, the changes in lipid-metabolizing enzymes and proteins involved in these pathways play a critical role in senescence. However, the link between cellular senescence, changes in lipid metabolism and age-related disease remains to be elucidated. Herein, we summarize the lipid metabolism changes in senescent cells, especially the senescent cells that promote age-related diseases, as well as focusing on the role of lipid-related enzymes or proteins in senescence. Finally, we explore the prospect of lipids in cellular senescence and their potential as drug targets for preventing and delaying age-related diseases.Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers, etc. Recent studies have shown that the disorders of lipid metabolism are not only related to age-related diseases, but also regulate the cellular senescence process. Based on existing research evidences, the changes in lipid metabolism in senescent cells are mainly concentrated in the metabolic processes of phospholipids, fatty acids and cholesterol. Obviously, the changes in lipid-metabolizing enzymes and proteins involved in these pathways play a critical role in senescence. However, the link between cellular senescence, changes in lipid metabolism and age-related disease remains to be elucidated. Herein, we summarize the lipid metabolism changes in senescent cells, especially the senescent cells that promote age-related diseases, as well as focusing on the role of lipid-related enzymes or proteins in senescence. Finally, we explore the prospect of lipids in cellular senescence and their potential as drug targets for preventing and delaying age-related diseases.
Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence-associated secretory phenotype (SASP). Once senescent cells accumulate in tissues, they may eventually accelerate the progression of age-related diseases, such as atherosclerosis, osteoarthritis, chronic lung diseases, cancers, etc. Recent studies have shown that the disorders of lipid metabolism are not only related to age-related diseases, but also regulate the cellular senescence process. Based on existing research evidences, the changes in lipid metabolism in senescent cells are mainly concentrated in the metabolic processes of phospholipids, fatty acids and cholesterol. Obviously, the changes in lipid-metabolizing enzymes and proteins involved in these pathways play a critical role in senescence. However, the link between cellular senescence, changes in lipid metabolism and age-related disease remains to be elucidated. Herein, we summarize the lipid metabolism changes in senescent cells, especially the senescent cells that promote age-related diseases, as well as focusing on the role of lipid-related enzymes or proteins in senescence. Finally, we explore the prospect of lipids in cellular senescence and their potential as drug targets for preventing and delaying age-related diseases.
ArticleNumber 102294
Author Zeng, Qing
Zhu, Neng
Gong, Yongzhen
Shi, Yaning
Zhang, Chanjuan
Qin, Li
Author_xml – sequence: 1
  givenname: Qing
  surname: Zeng
  fullname: Zeng, Qing
  organization: Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
– sequence: 2
  givenname: Yongzhen
  surname: Gong
  fullname: Gong, Yongzhen
  organization: Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
– sequence: 3
  givenname: Neng
  surname: Zhu
  fullname: Zhu, Neng
  organization: The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410021, China
– sequence: 4
  givenname: Yaning
  surname: Shi
  fullname: Shi, Yaning
  organization: Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
– sequence: 5
  givenname: Chanjuan
  surname: Zhang
  fullname: Zhang, Chanjuan
  organization: Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
– sequence: 6
  givenname: Li
  surname: Qin
  fullname: Qin, Li
  email: lqin@hnucm.edu.cn
  organization: Laboratory of Stem Cell Regulation with Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
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Cites_doi 10.1186/s12951-018-0392-8
10.1038/s42255-021-00492-7
10.1038/nm.2014
10.1016/S0891-5849(02)00959-0
10.1111/acel.13788
10.1038/ncomms15208
10.1016/j.redox.2014.08.009
10.1038/nrm2329
10.1021/jacs.3c06898
10.1126/scisignal.aaa4998
10.1111/febs.16361
10.1111/acel.12895
10.1038/s41568-022-00450-9
10.3390/cells12242836
10.1378/chest.11-2091
10.1016/j.celrep.2021.108860
10.1038/s41591-022-01923-y
10.3390/molecules22111964
10.1016/j.jid.2020.11.020
10.1016/j.trecan.2022.09.002
10.1126/scirobotics.aay6626
10.1016/j.freeradbiomed.2021.05.003
10.1172/jci.insight.130056
10.1016/j.ebiom.2018.12.052
10.1038/nrd.2017.116
10.18632/oncotarget.12432
10.1172/JCI158447
10.1016/j.bbalip.2017.06.005
10.1016/S0166-2236(02)02215-4
10.1038/ncomms14532
10.1016/j.mcna.2019.10.007
10.1016/j.ebiom.2019.06.049
10.1016/j.jpha.2020.04.004
10.1038/s43587-021-00121-8
10.1039/C8MO00099A
10.1038/s41568-019-0222-9
10.1164/rccm.201208-1361OC
10.1152/ajpheart.00038.2018
10.1038/s42255-023-00747-5
10.1038/s41593-019-0566-1
10.1038/onc.2011.302
10.1038/s41419-019-1550-0
10.1016/j.bbalip.2011.11.008
10.1172/jci.insight.146334
10.18632/aging.103034
10.1111/acel.12416
10.1016/0014-4827(61)90192-6
10.1016/j.cell.2019.10.005
10.1016/j.biocel.2022.106361
10.1172/JCI97949
10.1038/cddiscovery.2016.45
10.1016/j.cell.2022.11.001
10.1016/j.tem.2019.07.015
10.1016/j.cmet.2018.12.008
10.1038/s41569-023-00881-3
10.1016/j.joca.2004.04.005
10.1155/2022/1198607
10.1016/j.cmet.2021.03.008
10.1007/s00281-020-00812-1
10.1186/s13075-022-02859-x
10.1038/s41467-023-40975-7
10.1016/j.arr.2024.102273
10.1038/s41418-017-0013-3
10.1186/s13578-022-00828-0
10.18632/aging.101202
10.1016/j.biomaterials.2021.120677
10.1146/annurev-physiol-020518-114444
10.1038/nature16932
10.1152/physrev.00020.2018
10.1038/s41419-020-03281-4
10.1038/s41580-018-0085-z
10.15252/embr.202357265
10.1038/s41586-019-0920-1
10.3389/fphys.2022.796850
10.1002/smll.202308574
10.1038/s41514-023-00128-y
10.1016/j.cmet.2016.05.011
10.1038/s41581-022-00601-z
10.1074/jbc.M110.120386
10.1016/j.molmet.2022.101529
10.1016/j.ccell.2023.02.004
10.1161/ATVBAHA.112.248617
10.1016/j.freeradbiomed.2022.09.002
10.1111/acel.13133
10.1111/brv.12866
10.1007/s10522-017-9710-z
10.1038/s41422-020-0314-9
10.1126/scitranslmed.aaz6314
10.3390/cancers12040822
10.1111/acel.12792
10.1038/s42255-023-00786-y
10.1136/thoraxjnl-2020-215114
10.1371/journal.pone.0188840
10.1038/s41467-021-27738-y
10.1002/adma.202306552
10.1136/annrheumdis-2021-221091
10.1038/s41392-021-00765-3
10.1016/j.cmet.2013.05.017
10.1016/j.mad.2022.111688
10.1016/j.devcel.2021.03.034
10.1016/j.addr.2020.06.009
10.1038/ncomms15691
10.1016/S0014-4827(03)00343-4
10.1164/rccm.200509-1374OC
10.1183/16000617.0213-2020
10.1016/j.arr.2020.101249
10.1158/2159-8290.CD-20-0329
10.1038/s41584-020-00533-7
10.1101/cshperspect.a004754
10.1038/s41586-021-03392-8
10.1016/j.lfs.2008.11.009
10.18632/aging.103200
10.1155/2016/3565127
10.1111/acel.13128
10.1016/j.cmet.2022.03.010
10.1038/s41571-022-00668-4
10.1186/s12979-019-0169-4
10.1038/s41569-022-00739-0
10.1007/s10555-020-09875-w
10.1038/s41586-018-0543-y
10.1074/jbc.270.51.30701
10.1016/j.bbrc.2004.08.177
10.1038/nprot.2017.104
10.1016/j.arr.2018.02.001
10.1002/jcp.29906
10.1038/aps.2017.198
10.1111/febs.15105
10.1101/gad.343129.120
10.1164/rccm.201810-1975TR
10.1016/j.molcel.2021.08.027
10.1126/science.aaa8870
10.1016/j.cmet.2020.06.002
10.4161/cc.19800
10.1016/j.cell.2017.02.031
10.1038/s41419-022-04752-6
10.3390/biom11020241
10.18632/aging.203170
10.1002/art.24816
10.1152/ajplung.00351.2015
10.1016/j.biocel.2007.05.018
10.1126/science.aaf6659
10.1016/j.mehy.2007.05.025
10.1007/978-3-7091-1368-4_3
10.1038/nm.4324
10.1186/s12889-023-15583-1
10.3390/ijms19113515
10.1021/acschembio.2c00216
10.1016/j.freeradbiomed.2020.02.027
10.1007/s11010-018-3476-8
10.1136/gutjnl-2020-321112
10.1186/s40035-024-00402-3
10.1152/ajplung.00293.2015
10.1038/cddiscovery.2017.75
10.1111/joim.13141
10.1002/jat.3758
10.1016/j.freeradbiomed.2012.11.010
10.1038/s41580-019-0190-7
10.1111/j.1749-6632.1991.tb16985.x
10.15252/embr.201745274
10.1016/j.arr.2021.101413
10.1016/j.celrep.2021.108779
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Keywords Therapy strategies
Lipids
Lipid metabolism
Age-related disease
Cellular senescence
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References Ogrodnik, Zhu, Langhi, Tchkonia, Krüger, Fielder, Victorelli, Ruswhandi, Giorgadze, Pirtskhalava, Podgorni, Enikolopov, Johnson, Xu, Inman, Palmer, Schafer, Weigl, Ikeno, Burns, Passos, von Zglinicki, Kirkland, Jurk (bib106) 2019; 29
Ye, DeBose-Boyd (bib154) 2011; 3
Chen, Freinkman, Sabatini (bib28) 2017; 12
Frasca, Blomberg (bib47) 2020; 42
Ou, Zhang, Tan, Zhou, Li (bib108) 2022; 13
Zhang, Duan, Yang, Sun, Zhong, Tao, Guan, Jiang, Hammock, Hwang, Zhou, Guan (bib157) 2020; 287
Pu, Liu (bib115) 2008; 70
Lagoumtzi, Chondrogianni (bib77) 2021; 171
Childs, Gluscevic, Baker, Laberge, Marquess, Dananberg, van Deursen (bib33) 2017; 16
Kirkland, Tchkonia (bib75) 2020; 288
Minamino, Orimo, Shimizu, Kunieda, Yokoyama, Ito, Nojima, Nabetani, Oike, Matsubara, Ishikawa, Komuro (bib97) 2009; 15
Chaib, Tchkonia, Kirkland (bib26) 2022; 28
Narzt, Pils, Kremslehner, Nagelreiter, Schosserer, Bessonova, Bayer, Reifschneider, Terlecki-Zaniewicz, Waidhofer-Söllner, Mildner, Tschachler, Cavinato, Wedel, Jansen-Dürr, Nanic, Rubelj, El-Ghalbzouri, Zoratto, Marchetti-Deschmann, Grillari, Gruber, Lämmermann (bib102) 2021; 141
Roh, Noh, Kim, Jang, Kim, Choi, Lee, Ji, Kang, Kim, Paik, Chung, Kim, Kang (bib120) 2023; 5
Hamsanathan, Gurkar (bib55) 2022; 13
Buratta, Urbanelli, Sagini, Giovagnoli, Caponi, Fioretto, Mitro, Caruso, Emiliani (bib20) 2017; 12
Gong, Zhu, Chen, Feng, Zhang, Zhang, Song, Liang, Yang, Fan, Fang, Shen (bib52) 2023; 14
Guerrero, Guiho, Herranz, Uren, Withers, Martínez-Barbera, Tietze, Gil (bib54) 2020; 19
Regelson, Franson (bib117) 1991; 621
Schmitt, Wang, Demaria (bib126) 2022; 19
Singh, Brocker, Koppaka, Chen, Jackson, Matsumoto, Thompson, Vasiliou (bib129) 2013; 56
Chong, Yin, Chen, Xiang, Yuan, Ding, Pan, Tang, Alexander, Li, Wang (bib35) 2018; 19
Gorgoulis, Adams, Alimonti, Bennett, Bischof, Bishop, Campisi, Collado, Evangelou, Ferbeyre, Gil, Hara, Krizhanovsky, Jurk, Maier, Narita, Niedernhofer, Passos, Robbins, Schmitt, Sedivy, Vougas, von Zglinicki, Zhou, Serrano, Demaria (bib53) 2019; 179
Tsuji, Aoshiba, Nagai (bib136) 2006; 174
Burton, Stolzing (bib21) 2018; 43
Millner, Running, Colon-Rosa, Aga, Frasor, Atilla-Gokcumen (bib96) 2022; 17
Hayflick, Moorhead (bib58) 1961; 25
Hannun, Obeid (bib56) 2008; 9
Wu, Bagarolo, Thoröe-Boveleth, Jankowski (bib148) 2020; 159
Liu, Hartman, Li, Albert, Si, Gao, Huang, Zhao, Lin, Hsueh, Shen, Shao, Hoft, Ford, Peng (bib85) 2021; 13
Saleh, Bloukh, Carpenter, Alwohoush, Bakeer, Darwish, Azab, Gewirtz (bib124) 2020; 12
Tan, Finkel (bib131) 2023; 24
Kolodkin-Gal, Roitman, Ovadya, Azazmeh, Assouline, Schlesinger, Kalifa, Horwitz, Khalatnik, Hochner-Ger, Imam, Demma, Winter, Benyamini, Elgavish, Khatib, Meir, Atlan, Pikarsky, Parnas, Dor, Zamir, Ben-Porath, Krizhanovsky (bib76) 2022; 71
Trayssac, Clarke, Stith, Snider, Newen, Gault, Hannun, Obeid (bib134) 2021; 12
Schuldiner, Bohnert (bib127) 2017; 1862
Coryell, Diekman, Loeser (bib36) 2021; 17
Rim, You, Nahm, Kwon (bib118) 2024; 13
Nogueira-Recalde, Lorenzo-Gómez, Blanco, Loza, Grassi, Shirinsky, Shirinsky, Lotz, Robbins, Domínguez, Caramés (bib104) 2019; 45
Flor, Doshi, Kron (bib45) 2016; 2
Ziegler, Czarnecka-Herok, Vernier, Scholtes, Camprubi, Huna, Massemin, Griveau, Machon, Guitton, Rieusset, Vigneron, Giguère, Martin, Bernard (bib162) 2024; 10
Das (bib40) 2021; 11
Cheng, Xie (bib30) 2015; 350
Woldhuis, Heijink, van den Berge, Timens, Oliver, de Vries, Brandsma (bib147) 2021; 76
Zhu, Doornebal, Pirtskhalava, Giorgadze, Wentworth, Fuhrmann-Stroissnigg, Niedernhofer, Robbins, Tchkonia, Kirkland (bib161) 2017; 9
Trayssac, Hannun, Obeid (bib133) 2018; 128
Ademowo, Dias, Burton, Griffiths (bib3) 2017; 18
Choi, Lee, Song, Koh, Yang, Kwak, Kim, Kim, Son, Nam, Jin, Park, Kim, Park, Hong, Kim, Chun, Ryu, Chun (bib34) 2019; 566
Soukas, Hao, Wu (bib130) 2019; 30
Fane, Weeraratna (bib44) 2019; 20
Jiang, Xing, Peng, Shang, Wu, Xiao, Lin, Xu, Lu (bib68) 2022; 205
Huang, Lin, Shih, Au, Chang, Nakagami, Morishita, Chang, Shyu, Chen (bib63) 2012; 32
Hong, He, Jiang, Zhang, Tao, Ding, Yuan, Liu, Fan, Lin, Liang, Li, Zhang (bib62) 2020; 19
Martini, Passos (bib94) 2022; 290
Wiley, Brumwell, Davis, Jackson, Valdovinos, Calhoun, Alimirah, Castellanos, Ruan, Wei, Chapman, Ramanathan, Campisi, Jourdan Le Saux (bib145) 2019; 4
Yasuda, Koiwa, Yonemura, Miyake, Kariya, Kubota, Yokomizo-Nakano, Yasuda-Yoshihara, Uchihara, Itoyama, Bu, Fu, Arima, Izumi, Iwagami, Eto, Iwatsuki, Baba, Yoshida, Ohguchi, Okada, Matsusaki, Sashida, Takahashi, Tan, Baba, Ishimoto (bib153) 2021; 34
Zhang, Zhu, Li, Gong, Gu, Shi, Liao, Wang, Dai, Qin (bib156) 2022; 63
He, Sun, Ma, Chen, Wang, Chen, Xie, Zhang, Yuan, Liu (bib60) 2024; 36
Linge, Weinhold, Bläsche, Kasper, Barth (bib82) 2007; 39
Tian, Duan, Feng, Liao, Yang, Sun (bib132) 2023; 155
Venable, Lee, Smyth, Bielawska, Obeid (bib138) 1995; 270
Nakamura, Kondo, Shimada, Waheed, Ohno-Iwashita (bib101) 2003; 290
Xiang, Tian, Xu, Du, Zhang, Liu (bib149) 2022; 97
Bian, Jing, Yang, Shi, Chen, Xu, Wang, Jiang, Yang, Zhang, Li, Wang, Wang, Sun, Zhang (bib15) 2020; 12
Hashimoto, Sugiura, Togo, Koarai, Abe, Yamada, Ichikawa, Kikuchi, Numakura, Onodera, Tanaka, Sato, Yanagisawa, Okazaki, Tamada, Kikuchi, Hoshikawa, Okada, Ichinose (bib57) 2016; 310
Kim, Chae, Kim, Park, Sim, Lee, Park, Lee, Hong, Jana, Kim, Chung, Ryu (bib72) 2023; 145
Cheng, Geng, Pan, Wu, Zhong, Wang, Tian, Cheng, Zhang, Puduvalli, Horbinski, Mo, Han, Chakravarti, Guo (bib31) 2020; 32
Munk, Anerillas, Rossi, Tsitsipatis, Martindale, Herman, Yang, Roberts, Varma, Pandey, Thambisetty, Gorospe, Abdelmohsen (bib99) 2021; 13
Barnes, Anderson, Fagerås, Belvisi (bib12) 2021; 30
Libby (bib80) 2021; 592
Go, Jeong, Yoo, Han, Kang, Kim, Nguyen, Jin, Kim, Seo, Kang, Na, Song, Jeong, Seon, Park, Choi (bib50) 2020; 5
Currie, Schulze, Zechner, Walther, Farese (bib38) 2013; 18
Flor, Wolfgeher, Wu, Kron (bib46) 2017; 3
Brunk, Terman (bib19) 2002; 33
Liu, Ding, Meng (bib86) 2018; 39
Park, Baek, Ryu, Chun, Jin (bib112) 2022; 13
Belakova, Wedige, Awad, Hess, Oszwald, Fellner, Khan, Resch, Lipovac, Šmejkal, Uhrin, Breuss (bib14) 2023; 12
Barnes, Baker, Donnelly (bib11) 2019; 200
Zushi, Akagi, Kishimoto, Teramura, Sawamura, Hamanishi (bib163) 2009; 60
Huang, Hickson, Eirin, Kirkland, Lerman (bib64) 2022; 18
Patra, Das, Fraceto, Campos, Rodriguez-Torres, Acosta-Torres, Diaz-Torres, Grillo, Swamy, Sharma, Habtemariam, Shin (bib113) 2018; 16
Baar, Brandt, Putavet, Klein, Derks, Bourgeois, Stryeck, Rijksen, van Willigenburg, Feijtel, van der Pluijm, Essers, van Cappellen, van, Houtsmuller, Pothof, de Bruin, Madl, Hoeijmakers, Campisi, de Keizer (bib8) 2017; 169
Baker, Childs, Durik, Wijers, Sieben, Zhong, Saltness, Jeganathan, Verzosa, Pezeshki, Khazaie, Miller, van Deursen (bib9) 2016; 530
Luo, Yang, Song (bib91) 2020; 21
Wang, Chen, Guan, Zhang, Huang, Johnson, Wu, Gonzalez, Yu, Huang, Wang, Yang, Chen, Fan, Huang, Bi (bib143) 2018; 25
Rodriguez-Cuenca, Vidal-Puig (bib119) 2021; 3
Gasek, Kuchel, Kirkland, Xu (bib49) 2021; 1
Ogrodnik, Miwa, Tchkonia, Tiniakos, Wilson, Lahat, Day, Burt, Palmer, Anstee, Grellscheid, Hoeijmakers, Barnhoorn, Mann, Bird, Vermeij, Kirkland, Passos, von Zglinicki, Jurk (bib105) 2017; 8
Palikaras, Mari, Ploumi, Princz, Filippidis, Tavernarakis (bib109) 2023; 22
Gonçalves, Yin, Ito, Chan, Olan, Gough, Cassidy, Serrao, Smith, Young, Narita, Hoare (bib51) 2021; 34
Lopez-Otin, Blasco, Partridge, Serrano, Kroemer (bib89) 2023; 186
Cadenas, Vosbeck, Hein, Hellwig, Langer, Hayen, Franckenstein, Büttner, Hammad, Marchan, Hermes, Selinski, Rahnenführer, Peksel, Török, Vígh, Hengstler (bib23) 2012; 1821
Abdellatif, Rainer, Sedej, Kroemer (bib1) 2023; 20
Miwa, Kashyap, Chini, von Zglinicki (bib98) 2022; 132
Alicea, Rebecca, Goldman, Fane, Douglass, Behera, Webster, Kugel, Ecker, Caino, Kossenkov, Tang, Frederick, Flaherty, Xu, Liu, Gabrilovich, Herlyn, Blair, Schug, Speicher, Weeraratna (bib6) 2020; 10
Jung, Chae, Chang, Choi, Lee, Han (bib69) 2022; 192
Pham, Kim, Ou, Phung, Nguyen, Pham, Poudel, Gautam, Nguyen, Jeong, Yong, Park, Kim, Kim (bib114) 2021; 269
Tsui-Pierchala, Encinas, Milbrandt, Johnson (bib135) 2002; 25
Yang, Wang, Zhang, Fang, Zheng, Liu, Yu, Chen, Ying, Hua (bib152) 2022; 12
Li, Peng, Wang, Li, Leng, Chen, Yuan, Zhou, Zhang, Chen (bib79) 2018; 315
Nishimura, Akagi, Yoshida, Hayakawa, Sawamura, Munakata, Hamanishi (bib103) 2004; 12
Jeon, Kim, Lee, Kim (bib66) 2023; 5
Del Rey, Valín, Usategui, Ergueta, Martín, Municio, Cañete, Blanco, Criado, Pablos (bib42) 2019; 16
Justice, Nambiar, Tchkonia, LeBrasseur, Pascual, Hashmi, Prata, Masternak, Kritchevsky, Musi, Kirkland (bib70) 2019; 40
Wang, Lee, Lu, Ke, Chen, Dong, Lu, Chen, Chu, Chan, Kuzan, Tsai, Hsu, Dixon, Sawamura, Chang, Chen (bib144) 2018; 17
Arivazhagan, Mizutani, Fujii, Ayusawa (bib7) 2004; 323
Heffernan-Stroud, Helke, Jenkins, De Costa, Hannun, Obeid (bib61) 2011; 31
Pararasa, Ikwuobe, Shigdar, Boukouvalas, Nabney, Brown, Devitt, Bailey, Bennett, Griffiths (bib111) 2016; 15
Childs, Baker, Wijshake, Conover, Campisi, van Deursen (bib32) 2016; 354
Lee, Kim, Jang, Han, Nahmgoong, Park, Han, Cho, Lim, Noh, Oh, Lee, Kim, Kim (bib78) 2022; 34
Jeon, Kim, Laberge, Demaria, Rathod, Vasserot, Chung, Kim, Poon, David, Baker, van Deursen, Campisi, Elisseeff (bib65) 2017; 23
Liu, Zhang, Li, Xu, Zhang (bib87) 2022; 24
Panneer Selvam, De Palma, Oaks, Oleinik, Peterson, Stahelin, Skordalakes, Ponnusamy, Garrett-Mayer, Smith, Ogretmen (bib110) 2015; 8
Wiley, Sharma, Davis, Lopez-Dominguez, Mitchell, Wiley, Alimirah, Kim, Payne, Rosko, Aimontche, Deshpande, Neri, Kuehnemann, Demaria, Ramanathan, Campisi (bib146) 2021; 33
Ali, Zhang, Zaidi, Zhou (bib5) 2024; 96
Ursini, Maiorino (bib137) 2020; 152
Calcinotto, Kohli, Zagato, Pellegrini, Demaria, Alimonti (bib25) 2019; 99
Quijano, Cao, Fergusson, Romero, Liu, Gutkind, Rovira, Mohney, Karoly, Finkel (bib116) 2012; 11
Xie, Wang, Lu, Liu, Yu, Pei (bib151) 2021; 70
Cotarelo, Schad, Kirkpatrick, Sleeman, Springer, Schmidt, Thaler (bib37) 2016; 7
Fafián-Labora, Carpintero-Fernández, Jordan, Shikh-Bahaei, Abdullah, Mahenthiran, Rodríguez-Navarro, Niklison-Chirou, O’Loghlen (bib43) 2019; 10
Lobanov
Hayflick (10.1016/j.arr.2024.102294_bib58) 1961; 25
Wiley (10.1016/j.arr.2024.102294_bib145) 2019; 4
Barzilai (10.1016/j.arr.2024.102294_bib13) 2016; 23
Del Rey (10.1016/j.arr.2024.102294_bib42) 2019; 16
Kim (10.1016/j.arr.2024.102294_bib72) 2023; 145
Cheng (10.1016/j.arr.2024.102294_bib30) 2015; 350
Gabai (10.1016/j.arr.2024.102294_bib48) 2023; 9
Roh (10.1016/j.arr.2024.102294_bib120) 2023; 5
Yoon (10.1016/j.arr.2024.102294_bib155) 2021; 81
Hannun (10.1016/j.arr.2024.102294_bib56) 2008; 9
Liu (10.1016/j.arr.2024.102294_bib87) 2022; 24
Minamino (10.1016/j.arr.2024.102294_bib97) 2009; 15
Saleh (10.1016/j.arr.2024.102294_bib124) 2020; 12
Liu (10.1016/j.arr.2024.102294_bib86) 2018; 39
Lobanov-Rostovsky (10.1016/j.arr.2024.102294_bib88) 2023; 23
Rodriguez-Cuenca (10.1016/j.arr.2024.102294_bib119) 2021; 3
Chen (10.1016/j.arr.2024.102294_bib29) 2022; 81
Dagouassat (10.1016/j.arr.2024.102294_bib39) 2013; 187
Airola (10.1016/j.arr.2024.102294_bib4) 2013
Zhang (10.1016/j.arr.2024.102294_bib157) 2020; 287
Alicea (10.1016/j.arr.2024.102294_bib6) 2020; 10
Childs (10.1016/j.arr.2024.102294_bib33) 2017; 16
Bian (10.1016/j.arr.2024.102294_bib15) 2020; 12
Birch (10.1016/j.arr.2024.102294_bib17) 2015; 309
Cotarelo (10.1016/j.arr.2024.102294_bib37) 2016; 7
Huang (10.1016/j.arr.2024.102294_bib64) 2022; 18
Olzmann (10.1016/j.arr.2024.102294_bib107) 2019; 20
Patra (10.1016/j.arr.2024.102294_bib113) 2018; 16
He (10.1016/j.arr.2024.102294_bib59) 2023
Chaib (10.1016/j.arr.2024.102294_bib26) 2022; 28
Gorgoulis (10.1016/j.arr.2024.102294_bib53) 2019; 179
Seo (10.1016/j.arr.2024.102294_bib128) 2019; 18
Buratta (10.1016/j.arr.2024.102294_bib20) 2017; 12
Trayssac (10.1016/j.arr.2024.102294_bib133) 2018; 128
Gonçalves (10.1016/j.arr.2024.102294_bib51) 2021; 34
Arivazhagan (10.1016/j.arr.2024.102294_bib7) 2004; 323
Birch (10.1016/j.arr.2024.102294_bib16) 2020; 34
Saito (10.1016/j.arr.2024.102294_bib122) 2019; 39
Millner (10.1016/j.arr.2024.102294_bib96) 2022; 17
Miwa (10.1016/j.arr.2024.102294_bib98) 2022; 132
Narzt (10.1016/j.arr.2024.102294_bib102) 2021; 141
Panneer Selvam (10.1016/j.arr.2024.102294_bib110) 2015; 8
Zhang (10.1016/j.arr.2024.102294_bib156) 2022; 63
Wang (10.1016/j.arr.2024.102294_bib143) 2018; 25
Baker (10.1016/j.arr.2024.102294_bib9) 2016; 530
Brunk (10.1016/j.arr.2024.102294_bib19) 2002; 33
Singh (10.1016/j.arr.2024.102294_bib129) 2013; 56
Wang (10.1016/j.arr.2024.102294_bib141) 2020; 12
Zhu (10.1016/j.arr.2024.102294_bib161) 2017; 9
Hong (10.1016/j.arr.2024.102294_bib62) 2020; 19
Bussian (10.1016/j.arr.2024.102294_bib22) 2018; 562
Zheng (10.1016/j.arr.2024.102294_bib160) 2021; 66
Kolodkin-Gal (10.1016/j.arr.2024.102294_bib76) 2022; 71
Kim (10.1016/j.arr.2024.102294_bib73) 2017; 8
Guerrero (10.1016/j.arr.2024.102294_bib54) 2020; 19
Regelson (10.1016/j.arr.2024.102294_bib117) 1991; 621
Liu (10.1016/j.arr.2024.102294_bib84) 2021; 49
Calcinotto (10.1016/j.arr.2024.102294_bib25) 2019; 99
Venable (10.1016/j.arr.2024.102294_bib138) 1995; 270
Wiley (10.1016/j.arr.2024.102294_bib146) 2021; 33
Zushi (10.1016/j.arr.2024.102294_bib163) 2009; 60
Heffernan-Stroud (10.1016/j.arr.2024.102294_bib61) 2011; 31
Ou (10.1016/j.arr.2024.102294_bib108) 2022; 13
Saitou (10.1016/j.arr.2024.102294_bib123) 2018; 14
Nishimura (10.1016/j.arr.2024.102294_bib103) 2004; 12
Zhang (10.1016/j.arr.2024.102294_bib158) 2019; 455
Cheng (10.1016/j.arr.2024.102294_bib31) 2020; 32
Bloom (10.1016/j.arr.2024.102294_bib18) 2023; 20
Belakova (10.1016/j.arr.2024.102294_bib14) 2023; 12
Huang (10.1016/j.arr.2024.102294_bib63) 2012; 32
Wang (10.1016/j.arr.2024.102294_bib140) 2019; 81
Wang (10.1016/j.arr.2024.102294_bib142) 2022; 22
Jiang (10.1016/j.arr.2024.102294_bib68) 2022; 205
Coryell (10.1016/j.arr.2024.102294_bib36) 2021; 17
Ademowo (10.1016/j.arr.2024.102294_bib3) 2017; 18
Luo (10.1016/j.arr.2024.102294_bib91) 2020; 21
Barnes (10.1016/j.arr.2024.102294_bib11) 2019; 200
Pham (10.1016/j.arr.2024.102294_bib114) 2021; 269
Baar (10.1016/j.arr.2024.102294_bib8) 2017; 169
Park (10.1016/j.arr.2024.102294_bib112) 2022; 13
Burton (10.1016/j.arr.2024.102294_bib21) 2018; 43
Choi (10.1016/j.arr.2024.102294_bib34) 2019; 566
Hamsanathan (10.1016/j.arr.2024.102294_bib55) 2022; 13
Flor (10.1016/j.arr.2024.102294_bib45) 2016; 2
Zhang (10.1016/j.arr.2024.102294_bib159) 2021; 11
He (10.1016/j.arr.2024.102294_bib60) 2024; 36
Kim (10.1016/j.arr.2024.102294_bib74) 2010; 285
Justice (10.1016/j.arr.2024.102294_bib70) 2019; 40
Go (10.1016/j.arr.2024.102294_bib50) 2020; 5
Das (10.1016/j.arr.2024.102294_bib40) 2021; 11
Pu (10.1016/j.arr.2024.102294_bib115) 2008; 70
Davalli (10.1016/j.arr.2024.102294_bib41) 2016; 2016
Lagoumtzi (10.1016/j.arr.2024.102294_bib77) 2021; 171
Jung (10.1016/j.arr.2024.102294_bib69) 2022; 192
Libby (10.1016/j.arr.2024.102294_bib80) 2021; 592
Wang (10.1016/j.arr.2024.102294_bib144) 2018; 17
Xiang (10.1016/j.arr.2024.102294_bib149) 2022; 97
Linhart (10.1016/j.arr.2024.102294_bib83) 2014; 3
Woldhuis (10.1016/j.arr.2024.102294_bib147) 2021; 76
Hashimoto (10.1016/j.arr.2024.102294_bib57) 2016; 310
Lee (10.1016/j.arr.2024.102294_bib78) 2022; 34
Frasca (10.1016/j.arr.2024.102294_bib47) 2020; 42
Ye (10.1016/j.arr.2024.102294_bib154) 2011; 3
Nogueira-Recalde (10.1016/j.arr.2024.102294_bib104) 2019; 45
Gong (10.1016/j.arr.2024.102294_bib52) 2023; 14
Yasuda (10.1016/j.arr.2024.102294_bib153) 2021; 34
Abramoff (10.1016/j.arr.2024.102294_bib2) 2020; 104
Wu (10.1016/j.arr.2024.102294_bib148) 2020; 159
Cadenas (10.1016/j.arr.2024.102294_bib23) 2012; 1821
Chen (10.1016/j.arr.2024.102294_bib27) 2021; 236
Liu (10.1016/j.arr.2024.102294_bib85) 2021; 13
Pararasa (10.1016/j.arr.2024.102294_bib111) 2016; 15
Lin (10.1016/j.arr.2024.102294_bib81) 2022; 2022
Marschallinger (10.1016/j.arr.2024.102294_bib93) 2020; 23
Quijano (10.1016/j.arr.2024.102294_bib116) 2012; 11
Soukas (10.1016/j.arr.2024.102294_bib130) 2019; 30
Abdellatif (10.1016/j.arr.2024.102294_bib1) 2023; 20
Flor (10.1016/j.arr.2024.102294_bib46) 2017; 3
Fafián-Labora (10.1016/j.arr.2024.102294_bib43) 2019; 10
Lordan (10.1016/j.arr.2024.102294_bib90) 2017; 22
Barnes (10.1016/j.arr.2024.102294_bib12) 2021; 30
Lopez-Otin (10.1016/j.arr.2024.102294_bib89) 2023; 186
Tsui-Pierchala (10.1016/j.arr.2024.102294_bib135) 2002; 25
Bancaro (10.1016/j.arr.2024.102294_bib10) 2023; 41
Jeon (10.1016/j.arr.2024.102294_bib65) 2017; 23
Martini (10.1016/j.arr.2024.102294_bib94) 2022; 290
Meng (10.1016/j.arr.2024.102294_bib95) 2021; 6
Ziegler (10.1016/j.arr.2024.102294_bib162) 2024; 10
Gasek (10.1016/j.arr.2024.102294_bib49) 2021; 1
Nakamura (10.1016/j.arr.2024.102294_bib101) 2003; 290
Cai (10.1016/j.arr.2024.102294_bib24) 2020; 30
Tian (10.1016/j.arr.2024.102294_bib132) 2023; 155
Volonte (10.1016/j.arr.2024.102294_bib139) 2020; 39
Schmitt (10.1016/j.arr.2024.102294_bib126) 2022; 19
Jeon (10.1016/j.arr.2024.102294_bib66) 2023; 5
Chen (10.1016/j.arr.2024.102294_bib28) 2017; 12
Trayssac (10.1016/j.arr.2024.102294_bib134) 2021; 12
Currie (10.1016/j.arr.2024.102294_bib38) 2013; 18
Kikuchi (10.1016/j.arr.2024.102294_bib71) 2012; 142
Linge (10.1016/j.arr.2024.102294_bib82) 2007; 39
Yang (10.1016/j.arr.2024.102294_bib152) 2022; 12
Xie (10.1016/j.arr.2024.102294_bib151) 2021; 70
Ji (10.1016/j.arr.2024.102294_bib67) 2024
Kirkland (10.1016/j.arr.2024.102294_bib75) 2020; 288
Ali (10.1016/j.arr.2024.102294_bib5) 2024; 96
Li (10.1016/j.arr.2024.102294_bib79) 2018; 315
Maeda (10.1016/j.arr.2024.102294_bib92) 2009; 84
Tsuji (10.1016/j.arr.2024.102294_bib136) 2006; 174
Xiao (10.1016/j.arr.2024.102294_bib150) 2021; 6
Chong (10.1016/j.arr.2024.102294_bib35) 2018; 19
Sagini (10.1016/j.arr.2024.102294_bib121) 2018; 19
Schafer (10.1016/j.arr.2024.102294_bib125) 2017; 8
Tan (10.1016/j.arr.2024.102294_bib131) 2023; 24
Ursini (10.1016/j.arr.2024.102294_bib137) 2020; 152
Palikaras (10.1016/j.arr.2024.102294_bib109) 2023; 22
Ogrodnik (10.1016/j.arr.2024.102294_bib105) 2017; 8
Munk (10.1016/j.arr.2024.102294_bib99) 2021; 13
Ogrodnik (10.1016/j.arr.2024.102294_bib106) 2019; 29
Fane (10.1016/j.arr.2024.102294_bib44) 2019; 20
Mutlu (10.1016/j.arr.2024.102294_bib100) 2021; 56
Rim (10.1016/j.arr.2024.102294_bib118) 2024; 13
Childs (10.1016/j.arr.2024.102294_bib32) 2016; 354
Schuldiner (10.1016/j.arr.2024.102294_bib127) 2017; 1862
References_xml – volume: 11
  start-page: 1383
  year: 2012
  end-page: 1392
  ident: bib116
  article-title: Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
  publication-title: Cell Cycle.
– volume: 11
  start-page: 241
  year: 2021
  ident: bib40
  article-title: Cell Membrane Theory of Senescence" and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications
  publication-title: Biomolecules.
– volume: 97
  start-page: 1844
  year: 2022
  end-page: 1867
  ident: bib149
  article-title: New insight into dyslipidemia-induced cellular senescence in atherosclerosis
  publication-title: Biol. Rev. Camb. Philos. Soc.
– volume: 11
  start-page: 340
  year: 2021
  end-page: 350
  ident: bib159
  article-title: Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence
  publication-title: J. Pharm. Anal.
– volume: 49
  start-page: 1041
  year: 2021
  end-page: 1047
  ident: bib84
  article-title: Clearance of senescent cells: a novel treatment strategy to attenuate aging-associated cardiovascular diseases
  publication-title: Zhonghua xin xue guan Bing. za zhi
– volume: 3
  start-page: 56
  year: 2014
  end-page: 62
  ident: bib83
  article-title: The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts
  publication-title: Redox Biol.
– volume: 155
  year: 2023
  ident: bib132
  article-title: Roles of lipid metabolism and its regulatory mechanism in idiopathic pulmonary fibrosis: A review
  publication-title: Int J. Biochem Cell Biol.
– volume: 39
  start-page: 658
  year: 2019
  end-page: 671
  ident: bib122
  article-title: Comprehensive lipid profiling of bleomycin-induced lung injury
  publication-title: J. Appl. Toxicol.
– volume: 9
  start-page: 28
  year: 2023
  end-page: 41
  ident: bib48
  article-title: Senescent stromal cells: roles in the tumor microenvironment
  publication-title: Trends Cancer.
– volume: 9
  start-page: 955
  year: 2017
  end-page: 963
  ident: bib161
  article-title: New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463
  publication-title: Aging.
– volume: 13
  year: 2021
  ident: bib85
  article-title: Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy
  publication-title: Sci. Transl. Med
– volume: 8
  start-page: ra58
  year: 2015
  ident: bib110
  article-title: Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
  publication-title: Sci. Signal.
– volume: 142
  start-page: 329
  year: 2012
  end-page: 337
  ident: bib71
  article-title: Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis
  publication-title: Chest.
– volume: 30
  start-page: 574
  year: 2020
  end-page: 589
  ident: bib24
  article-title: Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
  publication-title: Cell Res.
– volume: 99
  start-page: 1047
  year: 2019
  end-page: 1078
  ident: bib25
  article-title: Cellular Senescence: Aging, Cancer, and Injury
  publication-title: Physiol. Rev.
– volume: 70
  start-page: 338
  year: 2008
  end-page: 342
  ident: bib115
  article-title: HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL
  publication-title: Med Hypotheses.
– volume: 290
  start-page: 381
  year: 2003
  end-page: 390
  ident: bib101
  article-title: Cellular aging-dependent decrease in cholesterol in membrane microdomains of human diploid fibroblasts
  publication-title: Exp. Cell Res.
– volume: 12
  start-page: 2215
  year: 2017
  end-page: 2231
  ident: bib28
  article-title: Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites
  publication-title: Nat. Protoc.
– volume: 40
  start-page: 554
  year: 2019
  end-page: 563
  ident: bib70
  article-title: Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
  publication-title: EBioMedicine
– volume: 13
  year: 2022
  ident: bib55
  article-title: Lipids as Regulators of Cellular Senescence
  publication-title: Front Physiol.
– volume: 34
  year: 2021
  ident: bib153
  article-title: Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
  publication-title: Cell Rep.
– volume: 18
  start-page: 611
  year: 2022
  end-page: 627
  ident: bib64
  article-title: Cellular senescence: the good, the bad and the unknown
  publication-title: Nat. Rev. Nephrol.
– volume: 41
  start-page: 602
  year: 2023
  end-page: 619
  ident: bib10
  article-title: Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
  publication-title: Cancer Cell.
– volume: 70
  year: 2021
  ident: bib151
  article-title: Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications
  publication-title: Ageing Res Rev.
– volume: 10
  start-page: 318
  year: 2019
  ident: bib43
  article-title: FASN activity is important for the initial stages of the induction of senescence
  publication-title: Cell Death Dis.
– volume: 179
  start-page: 813
  year: 2019
  end-page: 827
  ident: bib53
  article-title: Cellular Senescence: Defining a Path Forward
  publication-title: Cell.
– volume: 8
  start-page: 14532
  year: 2017
  ident: bib125
  article-title: Cellular senescence mediates fibrotic pulmonary disease
  publication-title: Nat. Commun.
– volume: 10
  start-page: 5
  year: 2024
  ident: bib162
  article-title: Cholesterol biosynthetic pathway induces cellular senescence through ERRα
  publication-title: NPJ Aging.
– volume: 23
  start-page: 1272
  year: 2023
  ident: bib88
  article-title: Growing old in China in socioeconomic and epidemiological context: systematic review of social care policy for older people
  publication-title: BMC Public Health.
– volume: 22
  year: 2023
  ident: bib109
  article-title: Age-dependent nuclear lipid droplet deposition is a cellular hallmark of aging in Caenorhabditis elegans
  publication-title: Aging Cell.
– volume: 84
  start-page: 119
  year: 2009
  end-page: 124
  ident: bib92
  article-title: Regulation of fatty acid synthesis and Δ9-desaturation in senescence of human fibroblasts
  publication-title: Life Sci.
– volume: 145
  start-page: 21991
  year: 2023
  end-page: 22008
  ident: bib72
  article-title: Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells
  publication-title: J. Am. Chem. Soc.
– volume: 13
  start-page: 300
  year: 2022
  ident: bib108
  article-title: Adipose tissue aging: mechanisms and therapeutic implications
  publication-title: Cell Death Dis.
– volume: 25
  start-page: 585
  year: 1961
  end-page: 621
  ident: bib58
  article-title: The serial cultivation of human diploid cell strains
  publication-title: Exp. Cell Res.
– volume: 12
  start-page: 27
  year: 2021
  ident: bib134
  article-title: Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides
  publication-title: Cell Death Dis.
– volume: 20
  start-page: 137
  year: 2019
  end-page: 155
  ident: bib107
  article-title: Dynamics and functions of lipid droplets
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 8
  start-page: 15691
  year: 2017
  ident: bib105
  article-title: Cellular senescence drives age-dependent hepatic steatosis
  publication-title: Nat. Commun.
– volume: 17
  year: 2018
  ident: bib144
  article-title: Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo
  publication-title: Aging Cell
– volume: 9
  start-page: 139
  year: 2008
  end-page: 150
  ident: bib56
  article-title: Principles of bioactive lipid signalling: lessons from sphingolipids
  publication-title: Nat. Rev. Mol. Cell Bio.
– volume: 96
  year: 2024
  ident: bib5
  article-title: Understanding the Intricacies of Cellular Senescence in Atherosclerosis: Mechanisms and Therapeutic Implications
  publication-title: Ageing Res. Rev.
– volume: 34,
  year: 2022
  ident: bib78
  article-title: SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity
  publication-title: Cell Metab.
– volume: 315,
  year: 2018
  ident: bib79
  article-title: Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
– volume: 12
  start-page: 106
  year: 2022
  ident: bib152
  article-title: Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
  publication-title: Cell Biosci.
– volume: 23
  start-page: 1060
  year: 2016
  end-page: 1065
  ident: bib13
  article-title: Metformin as a Tool to Target Aging
  publication-title: Cell Metab.
– volume: 169
  year: 2017
  ident: bib8
  article-title: Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
  publication-title: Cell.
– volume: 22
  start-page: 1964
  year: 2017
  ident: bib90
  article-title: Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties
  publication-title: Molecules.
– volume: 66
  year: 2021
  ident: bib160
  article-title: The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
  publication-title: Ageing Res Rev.
– volume: 12
  start-page: 6385
  year: 2020
  end-page: 6400
  ident: bib15
  article-title: Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis
  publication-title: Aging.
– volume: 354
  start-page: 472
  year: 2016
  end-page: 477
  ident: bib32
  article-title: Senescent intimal foam cells are deleterious at all stages of atherosclerosis
  publication-title: Science.
– volume: 323
  start-page: 739
  year: 2004
  end-page: 742
  ident: bib7
  article-title: Cardiolipin induces premature senescence in normal human fibroblasts
  publication-title: Biochem Biophys. Res Commun.
– volume: 18
  start-page: 859
  year: 2017
  end-page: 879
  ident: bib3
  article-title: Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
  publication-title: Biogerontology.
– volume: 5,
  year: 2020
  ident: bib50
  article-title: Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo
  publication-title: Sci. Robot.
– volume: 104
  start-page: 293
  year: 2020
  end-page: 311
  ident: bib2
  article-title: Osteoarthritis: Pathology, diagnosis, and treatment options
  publication-title: Med Clin. North Am.
– volume: 20
  start-page: 38
  year: 2023
  end-page: 51
  ident: bib18
  article-title: Mechanisms and consequences of endothelial cell senescence
  publication-title: Nat. Rev. Cardiol.
– volume: 1
  start-page: 870
  year: 2021
  end-page: 879
  ident: bib49
  article-title: Strategies for Targeting Senescent Cells in Human Disease
  publication-title: Nat. Aging.
– volume: 25
  start-page: 735
  year: 2018
  end-page: 748
  ident: bib143
  article-title: Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming
  publication-title: Cell Death Differ.
– volume: 18
  start-page: 153
  year: 2013
  end-page: 161
  ident: bib38
  article-title: Cellular fatty acid metabolism and cancer
  publication-title: Cell Metab.
– volume: 30
  year: 2021
  ident: bib12
  article-title: Chronic lung diseases: prospects for regeneration and repair
  publication-title: Eur. Respir. Rev.
– volume: 3
  start-page: 17075
  year: 2017
  ident: bib46
  article-title: A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence
  publication-title: Cell Death Discov.
– volume: 290
  start-page: 1186
  year: 2022
  end-page: 1202
  ident: bib94
  article-title: Cellular senescence: all roads lead to mitochondria
  publication-title: FEBS J.
– volume: 81
  start-page: 165
  year: 2019
  end-page: 188
  ident: bib140
  article-title: Phospholipid Remodeling in Physiology and Disease
  publication-title: Annu Rev. Physiol.
– volume: 19
  year: 2018
  ident: bib35
  article-title: CD36 initiates the secretory phenotype during the establishment of cellular senescence
  publication-title: EMBO Rep.
– volume: 14
  start-page: 5242
  year: 2023
  ident: bib52
  article-title: CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications
  publication-title: Nat. Commun.
– volume: 25
  start-page: 412
  year: 2002
  end-page: 417
  ident: bib135
  article-title: Lipid rafts in neuronal signaling and function
  publication-title: Trends Neurosci.
– volume: 32
  start-page: 229
  year: 2020
  end-page: 242
  ident: bib31
  article-title: Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress
  publication-title: Cell Metab.
– volume: 287
  start-page: 1666
  year: 2020
  end-page: 1680
  ident: bib157
  article-title: COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence
  publication-title: FEBS J.
– volume: 15
  start-page: 128
  year: 2016
  end-page: 139
  ident: bib111
  article-title: Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ
  publication-title: Aging Cell.
– volume: 152
  start-page: 175
  year: 2020
  end-page: 185
  ident: bib137
  article-title: Lipid peroxidation and ferroptosis: The role of GSH and GPx4
  publication-title: Free Radic. Biol. Med.
– volume: 186
  start-page: 243
  year: 2023
  end-page: 278
  ident: bib89
  article-title: Hallmarks of aging: An expanding universe
  publication-title: Cell.
– volume: 13
  start-page: 3
  year: 2022
  ident: bib112
  article-title: PPARα-ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
  publication-title: Nat. Commun.
– volume: 566
  start-page: 254
  year: 2019
  end-page: 258
  ident: bib34
  article-title: The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis
  publication-title: Nature.
– volume: 309
  start-page: L1124
  year: 2015
  end-page: L1137
  ident: bib17
  article-title: DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease
  publication-title: Am. J. Physiol. Lung Cell Mol. Physiol.
– volume: 285
  start-page: 29069
  year: 2010
  end-page: 29077
  ident: bib74
  article-title: Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence
  publication-title: J. Biol. Chem.
– volume: 1862
  start-page: 1188
  year: 2017
  end-page: 1196
  ident: bib127
  article-title: A different kind of love - lipid droplet contact sites
  publication-title: Biochim Biophys. Acta Mol. Cell Biol. Lipids.
– volume: 34
  start-page: 1565
  year: 2020
  end-page: 1576
  ident: bib16
  article-title: Senescence and the SASP: many therapeutic avenues
  publication-title: Genes Dev.
– volume: 8
  start-page: 15208
  year: 2017
  ident: bib73
  article-title: Senescent tumor cells lead the collective invasion in thyroid cancer
  publication-title: Nat. Commun.
– volume: 71
  start-page: 345
  year: 2022
  end-page: 355
  ident: bib76
  article-title: Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions
  publication-title: Gut.
– volume: 23
  start-page: 194
  year: 2020
  end-page: 208
  ident: bib93
  article-title: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
  publication-title: Nat. Neurosci.
– volume: 24
  start-page: 174
  year: 2022
  ident: bib87
  article-title: Senescence in osteoarthritis: from mechanism to potential treatment
  publication-title: Arthritis Res Ther.
– volume: 21
  start-page: 225
  year: 2020
  end-page: 245
  ident: bib91
  article-title: Mechanisms and regulation of cholesterol homeostasis
  publication-title: Nat. Rev. Mol. Cell Bio.
– volume: 12
  start-page: 9240
  year: 2020
  end-page: 9259
  ident: bib141
  article-title: BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake
  publication-title: Aging.
– volume: 171
  start-page: 169
  year: 2021
  end-page: 190
  ident: bib77
  article-title: Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases
  publication-title: Free Radic. Bio Med.
– volume: 236
  start-page: 958
  year: 2021
  end-page: 970
  ident: bib27
  article-title: Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function
  publication-title: J. Cell Physiol.
– volume: 2022
  start-page: 1198607
  year: 2022
  ident: bib81
  article-title: Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell Senescence via Acetyl-CoA-Induced Protein Acetylation Modification
  publication-title: Oxid. Med Cell Longev.
– volume: 23
  start-page: 775
  year: 2017
  end-page: 781
  ident: bib65
  article-title: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
  publication-title: Nat. Med.
– volume: 269
  year: 2021
  ident: bib114
  article-title: Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis
  publication-title: Biomaterials.
– volume: 310
  start-page: L1028
  year: 2016
  end-page: L1041
  ident: bib57
  article-title: 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells
  publication-title: Am. J. Physiol. Lung Cell Mol. Physiol.
– volume: 5
  start-page: 735
  year: 2023
  end-page: 759
  ident: bib66
  article-title: Physiological and pathological roles of lipogenesis
  publication-title: Nat. Metab.
– volume: 60
  start-page: 3007
  year: 2009
  end-page: 3016
  ident: bib163
  article-title: Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1. Semin
  publication-title: Arthritis Rheu.
– volume: 43
  start-page: 17
  year: 2018
  end-page: 25
  ident: bib21
  article-title: Cellular senescence: Immunosurveillance and future immunotherapy
  publication-title: Ageing Res. Rev.
– volume: 42
  start-page: 573
  year: 2020
  end-page: 587
  ident: bib47
  article-title: Adipose tissue, immune aging, and cellular senescence
  publication-title: Semin Immunopathol.
– volume: 17
  start-page: 47
  year: 2021
  end-page: 57
  ident: bib36
  article-title: Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
  publication-title: Nat. Rev. Rheuma.
– volume: 19
  year: 2020
  ident: bib54
  article-title: Galactose-modified duocarmycin prodrugs as senolytics.
  publication-title: Aging Cell.
– volume: 39
  start-page: 1964
  year: 2007
  end-page: 1974
  ident: bib82
  article-title: Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells
  publication-title: Int J. Biochem Cell Biol.
– volume: 31
  start-page: 1166
  year: 2011
  end-page: 1175
  ident: bib61
  article-title: Defining a role for sphingosine kinase 1 in p53-dependent tumors
  publication-title: Oncogene.
– year: 2024
  ident: bib67
  article-title: SSK1-Loaded Neurotransmitter-Derived Nanoparticles for Alzheimer’s Disease Therapy via Clearance of Senescent Cells
  publication-title: Small.
– volume: 39
  start-page: 1553
  year: 2018
  end-page: 1558
  ident: bib86
  article-title: Oncogene-induced senescence: a double edged sword in cancer
  publication-title: Acta Pharm. Sin.
– volume: 17
  start-page: 822
  year: 2022
  end-page: 828
  ident: bib96
  article-title: Ceramide-1-Phosphate Is Involved in Therapy-Induced Senescence
  publication-title: Acs Chem. Biol.
– volume: 3
  year: 2011
  ident: bib154
  article-title: Regulation of cholesterol and fatty acid synthesis
  publication-title: Cold Spring Harb. Perspect. Biol.
– volume: 270
  start-page: 30701
  year: 1995
  end-page: 30708
  ident: bib138
  article-title: Role of Ceramide in Cellular Senescence
  publication-title: J. Biol. Chem.
– volume: 530
  start-page: 184
  year: 2016
  end-page: 189
  ident: bib9
  article-title: Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
  publication-title: Nature.
– volume: 200
  start-page: 556
  year: 2019
  end-page: 564
  ident: bib11
  article-title: Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases
  publication-title: Am J Respir Crit Care Med.
– volume: 30
  start-page: 745
  year: 2019
  end-page: 755
  ident: bib130
  article-title: Metformin as Anti-Aging Therapy: Is It for Everyone?
  publication-title: Trends Endocrinol. Metab.
– volume: 81
  start-page: 3708
  year: 2021
  end-page: 3730
  ident: bib155
  article-title: Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity
  publication-title: Mol. Cell.
– volume: 288
  start-page: 518
  year: 2020
  end-page: 536
  ident: bib75
  article-title: Senolytic drugs: from discovery to translation
  publication-title: J. Intern Med.
– volume: 33
  start-page: 611
  year: 2002
  end-page: 619
  ident: bib19
  article-title: Lipofuscin: mechanisms of age-related accumulation and influence on cell function
  publication-title: Free Radic. Biol. Med.
– year: 2023
  ident: bib59
  article-title: Elimination of Senescent Osteocytes by Bone-Targeting Delivery of β-Galactose-Modified Maytansinoid Prevents Age-Related Bone Loss
  publication-title: Adv. Health Mater.
– volume: 16
  start-page: 718
  year: 2017
  end-page: 735
  ident: bib33
  article-title: Senescent cells: an emerging target for diseases of ageing
  publication-title: Nat. Rev. Drug Discov.
– volume: 19
  year: 2020
  ident: bib62
  article-title: miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction
  publication-title: Aging Cell.
– volume: 18
  year: 2019
  ident: bib128
  article-title: Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging
  publication-title: Aging Cell.
– volume: 350
  year: 2015
  ident: bib30
  article-title: Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine
  publication-title: Science.
– volume: 36
  year: 2024
  ident: bib60
  article-title: Rejuvenating Aged Bone Repair through Multihierarchy Reactive Oxygen Species-Regulated Hydrogel
  publication-title: Adv. Mater.
– volume: 29
  start-page: 1061
  year: 2019
  end-page: 1077
  ident: bib106
  article-title: Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
  publication-title: Cell Metab.
– volume: 12
  start-page: 2836
  year: 2023
  ident: bib14
  article-title: Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death
  publication-title: Cells.
– volume: 12
  start-page: 822
  year: 2020
  ident: bib124
  article-title: Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy
  publication-title: Cancers.
– volume: 81
  start-page: 87
  year: 2022
  end-page: 99
  ident: bib29
  article-title: METTL3-mediated m(6)A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression
  publication-title: Ann. Rheum. Dis.
– volume: 192
  start-page: 1
  year: 2022
  end-page: 12
  ident: bib69
  article-title: Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF-α by reduction of fatty acid β-oxidation and anti-oxidation
  publication-title: Free Radic. Biol. Med.
– volume: 34
  year: 2021
  ident: bib51
  article-title: COX2 regulates senescence secretome composition and senescence surveillance through PGE(2)
  publication-title: Cell Rep.
– volume: 205
  year: 2022
  ident: bib68
  article-title: Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy
  publication-title: Mech. Ageing Dev.
– volume: 19
  start-page: 3515
  year: 2018
  ident: bib121
  article-title: Oncogenic H-Ras Expression Induces Fatty Acid Profile Changes in Human Fibroblasts and Extracellular Vesicles
  publication-title: Int J. Mol. Sci.
– volume: 12
  year: 2017
  ident: bib20
  article-title: Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile
  publication-title: PloS One.
– volume: 56
  start-page: 89
  year: 2013
  end-page: 101
  ident: bib129
  article-title: Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress
  publication-title: Free Radic. Biol. Med.
– volume: 19
  start-page: 619
  year: 2022
  end-page: 636
  ident: bib126
  article-title: Senescence and cancer — role and therapeutic opportunities
  publication-title: Nat. Rev. Clin. Oncol.
– volume: 24
  year: 2023
  ident: bib131
  article-title: Lysosomes in senescence and aging
  publication-title: EMBO Rep.
– volume: 45
  start-page: 588
  year: 2019
  end-page: 605
  ident: bib104
  article-title: Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
  publication-title: EBioMedicine.
– volume: 5
  start-page: 398
  year: 2023
  end-page: 413
  ident: bib120
  article-title: Lysosomal control of senescence and inflammation through cholesterol partitioning
  publication-title: Nat. Metab.
– volume: 1821
  start-page: 1256
  year: 2012
  end-page: 1268
  ident: bib23
  article-title: Glycerophospholipid profile in oncogene-induced senescence
  publication-title: Biochim Biophys Acta.
– volume: 20
  start-page: 89
  year: 2019
  end-page: 106
  ident: bib44
  article-title: How the ageing microenvironment influences tumour progression
  publication-title: Nat. Rev. Cancer.
– volume: 33
  start-page: 1124
  year: 2021
  end-page: 1136
  ident: bib146
  article-title: Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis
  publication-title: Cell Metab.
– volume: 10
  start-page: 1282
  year: 2020
  end-page: 1295
  ident: bib6
  article-title: Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2
  publication-title: Cancer Discov.
– volume: 132
  year: 2022
  ident: bib98
  article-title: Mitochondrial dysfunction in cell senescence and aging
  publication-title: J. Clin. Invest.
– volume: 141
  year: 2021
  ident: bib102
  article-title: Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors
  publication-title: J. Invest Dermatol.
– volume: 187
  start-page: 703
  year: 2013
  end-page: 714
  ident: bib39
  article-title: The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 592
  start-page: 524
  year: 2021
  end-page: 533
  ident: bib80
  article-title: The changing landscape of atherosclerosis
  publication-title: Nature.
– volume: 76
  start-page: 508
  year: 2021
  end-page: 511
  ident: bib147
  article-title: COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins
  publication-title: Thorax.
– volume: 6
  start-page: 354
  year: 2021
  ident: bib150
  article-title: Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src
  publication-title: Signal Transduct. Target Ther.
– volume: 159
  start-page: 294
  year: 2020
  end-page: 307
  ident: bib148
  article-title: Lipidomics": Mass spectrometric and chemometric analyses of lipids
  publication-title: Adv. Drug Deliv. Rev.
– volume: 39
  start-page: 397
  year: 2020
  end-page: 414
  ident: bib139
  article-title: Caveolin-1, a master regulator of cellular senescence
  publication-title: Cancer Metast Rev.
– volume: 621
  start-page: 262
  year: 1991
  end-page: 276
  ident: bib117
  article-title: Phospholipase A2 as a "death trigger" in the aging process. The use of PLA2 inhibitors as antiaging substances
  publication-title: Ann. Ny. Acad. Sci.
– volume: 14
  start-page: 237
  year: 2018
  end-page: 246
  ident: bib123
  article-title: An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence
  publication-title: Mol. Omics.
– volume: 3
  start-page: 1443
  year: 2021
  end-page: 1444
  ident: bib119
  article-title: Insulin and the last gasp of failing adipocytes
  publication-title: Nat. Metab.
– start-page: 57
  year: 2013
  end-page: 76
  ident: bib4
  article-title: Sphingolipid metabolism and neutral sphingomyelinases
  publication-title: Handb. Exp. Pharm.
– volume: 174
  start-page: 886
  year: 2006
  end-page: 893
  ident: bib136
  article-title: Alveolar cell senescence in patients with pulmonary emphysema
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 20
  start-page: 754
  year: 2023
  end-page: 777
  ident: bib1
  article-title: Hallmarks of cardiovascular ageing
  publication-title: Nat. Rev. Cardiol.
– volume: 2
  year: 2016
  ident: bib45
  article-title: Modulation of therapy-induced senescence by reactive lipid aldehydes
  publication-title: Cell Death Discov.
– volume: 13
  start-page: 10
  year: 2024
  ident: bib118
  article-title: Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
  publication-title: Transl. Neurodegener.
– volume: 562
  start-page: 578
  year: 2018
  end-page: 582
  ident: bib22
  article-title: Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
  publication-title: Nature.
– volume: 16
  start-page: 71
  year: 2018
  ident: bib113
  article-title: Nano based drug delivery systems: recent developments and future prospects
  publication-title: J. Nanobiotechnol
– volume: 28
  start-page: 1556
  year: 2022
  end-page: 1568
  ident: bib26
  article-title: Cellular senescence and senolytics: the path to the clinic
  publication-title: Nat. Med.
– volume: 16
  start-page: 29
  year: 2019
  ident: bib42
  article-title: Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
  publication-title: Immun Ageing.
– volume: 56
  start-page: 1394
  year: 2021
  end-page: 1407
  ident: bib100
  article-title: Lipid metabolism and lipid signals in aging and longevity
  publication-title: Dev. Cell.
– volume: 455
  start-page: 127
  year: 2019
  end-page: 134
  ident: bib158
  article-title: Genistein protects against ox-LDL-induced senescence through enhancing SIRT1/LKB1/AMPK-mediated autophagy flux in HUVECs
  publication-title: Mol. Cell Biochem.
– volume: 4
  year: 2019
  ident: bib145
  article-title: Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis
  publication-title: JCI Insight.
– volume: 7
  start-page: 74846
  year: 2016
  end-page: 74859
  ident: bib37
  article-title: Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes
  publication-title: Oncotarget.
– volume: 32
  start-page: 2405
  year: 2012
  end-page: 2417
  ident: bib63
  article-title: Moderate to high concentrations of high-density lipoprotein from healthy subjects paradoxically impair human endothelial progenitor cells and related angiogenesis by activating Rho-associated kinase pathways
  publication-title: Arterioscler. Thromb. Vasc. Biol.
– volume: 13
  start-page: 15750
  year: 2021
  end-page: 15769
  ident: bib99
  article-title: Acid ceramidase promotes senescent cell survival
  publication-title: Aging.
– volume: 6
  year: 2021
  ident: bib95
  article-title: Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis.
  publication-title: JCI Insight.
– volume: 12
  start-page: 568
  year: 2004
  end-page: 576
  ident: bib103
  article-title: Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB
  publication-title: Osteoarthr. Cartil.
– volume: 22
  start-page: 340
  year: 2022
  end-page: 355
  ident: bib142
  article-title: Exploiting senescence for the treatment of cancer
  publication-title: Nat. Rev. Cancer.
– volume: 128
  start-page: 2702
  year: 2018
  end-page: 2712
  ident: bib133
  article-title: Role of sphingolipids in senescence: implication in aging and age-related diseases
  publication-title: J. Clin. Invest.
– volume: 15
  start-page: 1082
  year: 2009
  end-page: 1087
  ident: bib97
  article-title: A crucial role for adipose tissue p53 in the regulation of insulin resistance
  publication-title: Nat. Med.
– volume: 2016
  start-page: 3565127
  year: 2016
  ident: bib41
  article-title: ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
  publication-title: Med Cell Longev.
– volume: 63
  year: 2022
  ident: bib156
  article-title: New dawn for cancer cell death: Emerging role of lipid metabolism
  publication-title: Mol. Metab.
– volume: 16
  start-page: 71
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib113
  article-title: Nano based drug delivery systems: recent developments and future prospects
  publication-title: J. Nanobiotechnol
  doi: 10.1186/s12951-018-0392-8
– volume: 3
  start-page: 1443
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib119
  article-title: Insulin and the last gasp of failing adipocytes
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-021-00492-7
– volume: 15
  start-page: 1082
  year: 2009
  ident: 10.1016/j.arr.2024.102294_bib97
  article-title: A crucial role for adipose tissue p53 in the regulation of insulin resistance
  publication-title: Nat. Med.
  doi: 10.1038/nm.2014
– volume: 33
  start-page: 611
  year: 2002
  ident: 10.1016/j.arr.2024.102294_bib19
  article-title: Lipofuscin: mechanisms of age-related accumulation and influence on cell function
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/S0891-5849(02)00959-0
– volume: 22
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib109
  article-title: Age-dependent nuclear lipid droplet deposition is a cellular hallmark of aging in Caenorhabditis elegans
  publication-title: Aging Cell.
  doi: 10.1111/acel.13788
– volume: 8
  start-page: 15208
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib73
  article-title: Senescent tumor cells lead the collective invasion in thyroid cancer
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15208
– volume: 3
  start-page: 56
  year: 2014
  ident: 10.1016/j.arr.2024.102294_bib83
  article-title: The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2014.08.009
– volume: 9
  start-page: 139
  year: 2008
  ident: 10.1016/j.arr.2024.102294_bib56
  article-title: Principles of bioactive lipid signalling: lessons from sphingolipids
  publication-title: Nat. Rev. Mol. Cell Bio.
  doi: 10.1038/nrm2329
– volume: 145
  start-page: 21991
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib72
  article-title: Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.3c06898
– volume: 8
  start-page: ra58
  year: 2015
  ident: 10.1016/j.arr.2024.102294_bib110
  article-title: Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.aaa4998
– volume: 290
  start-page: 1186
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib94
  article-title: Cellular senescence: all roads lead to mitochondria
  publication-title: FEBS J.
  doi: 10.1111/febs.16361
– volume: 18
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib128
  article-title: Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging
  publication-title: Aging Cell.
  doi: 10.1111/acel.12895
– volume: 22
  start-page: 340
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib142
  article-title: Exploiting senescence for the treatment of cancer
  publication-title: Nat. Rev. Cancer.
  doi: 10.1038/s41568-022-00450-9
– volume: 12
  start-page: 2836
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib14
  article-title: Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death
  publication-title: Cells.
  doi: 10.3390/cells12242836
– volume: 142
  start-page: 329
  year: 2012
  ident: 10.1016/j.arr.2024.102294_bib71
  article-title: Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis
  publication-title: Chest.
  doi: 10.1378/chest.11-2091
– volume: 49
  start-page: 1041
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib84
  article-title: Clearance of senescent cells: a novel treatment strategy to attenuate aging-associated cardiovascular diseases
  publication-title: Zhonghua xin xue guan Bing. za zhi
– volume: 34
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib51
  article-title: COX2 regulates senescence secretome composition and senescence surveillance through PGE(2)
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.108860
– volume: 28
  start-page: 1556
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib26
  article-title: Cellular senescence and senolytics: the path to the clinic
  publication-title: Nat. Med.
  doi: 10.1038/s41591-022-01923-y
– volume: 22
  start-page: 1964
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib90
  article-title: Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties
  publication-title: Molecules.
  doi: 10.3390/molecules22111964
– volume: 141
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib102
  article-title: Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors
  publication-title: J. Invest Dermatol.
  doi: 10.1016/j.jid.2020.11.020
– volume: 9
  start-page: 28
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib48
  article-title: Senescent stromal cells: roles in the tumor microenvironment
  publication-title: Trends Cancer.
  doi: 10.1016/j.trecan.2022.09.002
– volume: 5,
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib50
  article-title: Human adipose-derived mesenchymal stem cell-based medical microrobot system for knee cartilage regeneration in vivo
  publication-title: Sci. Robot.
  doi: 10.1126/scirobotics.aay6626
– volume: 171
  start-page: 169
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib77
  article-title: Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases
  publication-title: Free Radic. Bio Med.
  doi: 10.1016/j.freeradbiomed.2021.05.003
– volume: 4
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib145
  article-title: Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis
  publication-title: JCI Insight.
  doi: 10.1172/jci.insight.130056
– volume: 40
  start-page: 554
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib70
  article-title: Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2018.12.052
– volume: 16
  start-page: 718
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib33
  article-title: Senescent cells: an emerging target for diseases of ageing
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd.2017.116
– volume: 7
  start-page: 74846
  year: 2016
  ident: 10.1016/j.arr.2024.102294_bib37
  article-title: Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes
  publication-title: Oncotarget.
  doi: 10.18632/oncotarget.12432
– volume: 132
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib98
  article-title: Mitochondrial dysfunction in cell senescence and aging
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI158447
– volume: 1862
  start-page: 1188
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib127
  article-title: A different kind of love - lipid droplet contact sites
  publication-title: Biochim Biophys. Acta Mol. Cell Biol. Lipids.
  doi: 10.1016/j.bbalip.2017.06.005
– volume: 25
  start-page: 412
  year: 2002
  ident: 10.1016/j.arr.2024.102294_bib135
  article-title: Lipid rafts in neuronal signaling and function
  publication-title: Trends Neurosci.
  doi: 10.1016/S0166-2236(02)02215-4
– volume: 8
  start-page: 14532
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib125
  article-title: Cellular senescence mediates fibrotic pulmonary disease
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14532
– volume: 104
  start-page: 293
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib2
  article-title: Osteoarthritis: Pathology, diagnosis, and treatment options
  publication-title: Med Clin. North Am.
  doi: 10.1016/j.mcna.2019.10.007
– volume: 45
  start-page: 588
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib104
  article-title: Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
  publication-title: EBioMedicine.
  doi: 10.1016/j.ebiom.2019.06.049
– volume: 11
  start-page: 340
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib159
  article-title: Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence
  publication-title: J. Pharm. Anal.
  doi: 10.1016/j.jpha.2020.04.004
– volume: 1
  start-page: 870
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib49
  article-title: Strategies for Targeting Senescent Cells in Human Disease
  publication-title: Nat. Aging.
  doi: 10.1038/s43587-021-00121-8
– volume: 14
  start-page: 237
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib123
  article-title: An evolutionary transcriptomics approach links CD36 to membrane remodeling in replicative senescence
  publication-title: Mol. Omics.
  doi: 10.1039/C8MO00099A
– volume: 20
  start-page: 89
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib44
  article-title: How the ageing microenvironment influences tumour progression
  publication-title: Nat. Rev. Cancer.
  doi: 10.1038/s41568-019-0222-9
– volume: 187
  start-page: 703
  year: 2013
  ident: 10.1016/j.arr.2024.102294_bib39
  article-title: The cyclooxygenase-2-prostaglandin E2 pathway maintains senescence of chronic obstructive pulmonary disease fibroblasts
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.201208-1361OC
– volume: 315,
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib79
  article-title: Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence
  publication-title: Am. J. Physiol. Heart Circ. Physiol.
  doi: 10.1152/ajpheart.00038.2018
– volume: 5
  start-page: 398
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib120
  article-title: Lysosomal control of senescence and inflammation through cholesterol partitioning
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-023-00747-5
– volume: 23
  start-page: 194
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib93
  article-title: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-019-0566-1
– volume: 31
  start-page: 1166
  year: 2011
  ident: 10.1016/j.arr.2024.102294_bib61
  article-title: Defining a role for sphingosine kinase 1 in p53-dependent tumors
  publication-title: Oncogene.
  doi: 10.1038/onc.2011.302
– volume: 10
  start-page: 318
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib43
  article-title: FASN activity is important for the initial stages of the induction of senescence
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-019-1550-0
– volume: 1821
  start-page: 1256
  year: 2012
  ident: 10.1016/j.arr.2024.102294_bib23
  article-title: Glycerophospholipid profile in oncogene-induced senescence
  publication-title: Biochim Biophys Acta.
  doi: 10.1016/j.bbalip.2011.11.008
– volume: 6
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib95
  article-title: Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis.
  publication-title: JCI Insight.
  doi: 10.1172/jci.insight.146334
– volume: 12
  start-page: 6385
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib15
  article-title: Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis
  publication-title: Aging.
  doi: 10.18632/aging.103034
– volume: 15
  start-page: 128
  year: 2016
  ident: 10.1016/j.arr.2024.102294_bib111
  article-title: Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ
  publication-title: Aging Cell.
  doi: 10.1111/acel.12416
– volume: 25
  start-page: 585
  year: 1961
  ident: 10.1016/j.arr.2024.102294_bib58
  article-title: The serial cultivation of human diploid cell strains
  publication-title: Exp. Cell Res.
  doi: 10.1016/0014-4827(61)90192-6
– volume: 179
  start-page: 813
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib53
  article-title: Cellular Senescence: Defining a Path Forward
  publication-title: Cell.
  doi: 10.1016/j.cell.2019.10.005
– volume: 155
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib132
  article-title: Roles of lipid metabolism and its regulatory mechanism in idiopathic pulmonary fibrosis: A review
  publication-title: Int J. Biochem Cell Biol.
  doi: 10.1016/j.biocel.2022.106361
– volume: 128
  start-page: 2702
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib133
  article-title: Role of sphingolipids in senescence: implication in aging and age-related diseases
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI97949
– volume: 2
  year: 2016
  ident: 10.1016/j.arr.2024.102294_bib45
  article-title: Modulation of therapy-induced senescence by reactive lipid aldehydes
  publication-title: Cell Death Discov.
  doi: 10.1038/cddiscovery.2016.45
– volume: 186
  start-page: 243
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib89
  article-title: Hallmarks of aging: An expanding universe
  publication-title: Cell.
  doi: 10.1016/j.cell.2022.11.001
– volume: 30
  start-page: 745
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib130
  article-title: Metformin as Anti-Aging Therapy: Is It for Everyone?
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2019.07.015
– volume: 29
  start-page: 1061
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib106
  article-title: Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2018.12.008
– volume: 20
  start-page: 754
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib1
  article-title: Hallmarks of cardiovascular ageing
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-023-00881-3
– volume: 12
  start-page: 568
  year: 2004
  ident: 10.1016/j.arr.2024.102294_bib103
  article-title: Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB
  publication-title: Osteoarthr. Cartil.
  doi: 10.1016/j.joca.2004.04.005
– volume: 2022
  start-page: 1198607
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib81
  article-title: Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell Senescence via Acetyl-CoA-Induced Protein Acetylation Modification
  publication-title: Oxid. Med Cell Longev.
  doi: 10.1155/2022/1198607
– volume: 33
  start-page: 1124
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib146
  article-title: Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2021.03.008
– volume: 42
  start-page: 573
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib47
  article-title: Adipose tissue, immune aging, and cellular senescence
  publication-title: Semin Immunopathol.
  doi: 10.1007/s00281-020-00812-1
– volume: 24
  start-page: 174
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib87
  article-title: Senescence in osteoarthritis: from mechanism to potential treatment
  publication-title: Arthritis Res Ther.
  doi: 10.1186/s13075-022-02859-x
– volume: 14
  start-page: 5242
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib52
  article-title: CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-023-40975-7
– volume: 96
  year: 2024
  ident: 10.1016/j.arr.2024.102294_bib5
  article-title: Understanding the Intricacies of Cellular Senescence in Atherosclerosis: Mechanisms and Therapeutic Implications
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2024.102273
– volume: 25
  start-page: 735
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib143
  article-title: Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming
  publication-title: Cell Death Differ.
  doi: 10.1038/s41418-017-0013-3
– volume: 12
  start-page: 106
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib152
  article-title: Lipid metabolism and storage in neuroglia: role in brain development and neurodegenerative diseases
  publication-title: Cell Biosci.
  doi: 10.1186/s13578-022-00828-0
– volume: 9
  start-page: 955
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib161
  article-title: New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463
  publication-title: Aging.
  doi: 10.18632/aging.101202
– volume: 269
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib114
  article-title: Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis
  publication-title: Biomaterials.
  doi: 10.1016/j.biomaterials.2021.120677
– volume: 81
  start-page: 165
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib140
  article-title: Phospholipid Remodeling in Physiology and Disease
  publication-title: Annu Rev. Physiol.
  doi: 10.1146/annurev-physiol-020518-114444
– volume: 530
  start-page: 184
  year: 2016
  ident: 10.1016/j.arr.2024.102294_bib9
  article-title: Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
  publication-title: Nature.
  doi: 10.1038/nature16932
– volume: 99
  start-page: 1047
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib25
  article-title: Cellular Senescence: Aging, Cancer, and Injury
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00020.2018
– volume: 12
  start-page: 27
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib134
  article-title: Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-020-03281-4
– volume: 20
  start-page: 137
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib107
  article-title: Dynamics and functions of lipid droplets
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-018-0085-z
– volume: 24
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib131
  article-title: Lysosomes in senescence and aging
  publication-title: EMBO Rep.
  doi: 10.15252/embr.202357265
– volume: 566
  start-page: 254
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib34
  article-title: The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis
  publication-title: Nature.
  doi: 10.1038/s41586-019-0920-1
– volume: 13
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib55
  article-title: Lipids as Regulators of Cellular Senescence
  publication-title: Front Physiol.
  doi: 10.3389/fphys.2022.796850
– year: 2024
  ident: 10.1016/j.arr.2024.102294_bib67
  article-title: SSK1-Loaded Neurotransmitter-Derived Nanoparticles for Alzheimer’s Disease Therapy via Clearance of Senescent Cells
  publication-title: Small.
  doi: 10.1002/smll.202308574
– volume: 10
  start-page: 5
  year: 2024
  ident: 10.1016/j.arr.2024.102294_bib162
  article-title: Cholesterol biosynthetic pathway induces cellular senescence through ERRα
  publication-title: NPJ Aging.
  doi: 10.1038/s41514-023-00128-y
– volume: 23
  start-page: 1060
  year: 2016
  ident: 10.1016/j.arr.2024.102294_bib13
  article-title: Metformin as a Tool to Target Aging
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.05.011
– volume: 18
  start-page: 611
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib64
  article-title: Cellular senescence: the good, the bad and the unknown
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/s41581-022-00601-z
– volume: 285
  start-page: 29069
  year: 2010
  ident: 10.1016/j.arr.2024.102294_bib74
  article-title: Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M110.120386
– volume: 63
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib156
  article-title: New dawn for cancer cell death: Emerging role of lipid metabolism
  publication-title: Mol. Metab.
  doi: 10.1016/j.molmet.2022.101529
– volume: 41
  start-page: 602
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib10
  article-title: Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
  publication-title: Cancer Cell.
  doi: 10.1016/j.ccell.2023.02.004
– volume: 32
  start-page: 2405
  year: 2012
  ident: 10.1016/j.arr.2024.102294_bib63
  article-title: Moderate to high concentrations of high-density lipoprotein from healthy subjects paradoxically impair human endothelial progenitor cells and related angiogenesis by activating Rho-associated kinase pathways
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.112.248617
– volume: 192
  start-page: 1
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib69
  article-title: Silencing SIRT5 induces the senescence of UCB-MSCs exposed to TNF-α by reduction of fatty acid β-oxidation and anti-oxidation
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2022.09.002
– volume: 19
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib54
  article-title: Galactose-modified duocarmycin prodrugs as senolytics.
  publication-title: Aging Cell.
  doi: 10.1111/acel.13133
– volume: 97
  start-page: 1844
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib149
  article-title: New insight into dyslipidemia-induced cellular senescence in atherosclerosis
  publication-title: Biol. Rev. Camb. Philos. Soc.
  doi: 10.1111/brv.12866
– volume: 18
  start-page: 859
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib3
  article-title: Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
  publication-title: Biogerontology.
  doi: 10.1007/s10522-017-9710-z
– volume: 30
  start-page: 574
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib24
  article-title: Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice
  publication-title: Cell Res.
  doi: 10.1038/s41422-020-0314-9
– volume: 13
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib85
  article-title: Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy
  publication-title: Sci. Transl. Med
  doi: 10.1126/scitranslmed.aaz6314
– volume: 12
  start-page: 822
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib124
  article-title: Therapy-Induced Senescence: An “Old” Friend Becomes the Enemy
  publication-title: Cancers.
  doi: 10.3390/cancers12040822
– volume: 17
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib144
  article-title: Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo
  publication-title: Aging Cell
  doi: 10.1111/acel.12792
– volume: 5
  start-page: 735
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib66
  article-title: Physiological and pathological roles of lipogenesis
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-023-00786-y
– volume: 76
  start-page: 508
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib147
  article-title: COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins
  publication-title: Thorax.
  doi: 10.1136/thoraxjnl-2020-215114
– volume: 12
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib20
  article-title: Extracellular vesicles released by fibroblasts undergoing H-Ras induced senescence show changes in lipid profile
  publication-title: PloS One.
  doi: 10.1371/journal.pone.0188840
– volume: 13
  start-page: 3
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib112
  article-title: PPARα-ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-27738-y
– volume: 36
  year: 2024
  ident: 10.1016/j.arr.2024.102294_bib60
  article-title: Rejuvenating Aged Bone Repair through Multihierarchy Reactive Oxygen Species-Regulated Hydrogel
  publication-title: Adv. Mater.
  doi: 10.1002/adma.202306552
– volume: 81
  start-page: 87
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib29
  article-title: METTL3-mediated m(6)A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2021-221091
– volume: 6
  start-page: 354
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib150
  article-title: Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src
  publication-title: Signal Transduct. Target Ther.
  doi: 10.1038/s41392-021-00765-3
– volume: 18
  start-page: 153
  year: 2013
  ident: 10.1016/j.arr.2024.102294_bib38
  article-title: Cellular fatty acid metabolism and cancer
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.05.017
– volume: 205
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib68
  article-title: Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy
  publication-title: Mech. Ageing Dev.
  doi: 10.1016/j.mad.2022.111688
– volume: 56
  start-page: 1394
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib100
  article-title: Lipid metabolism and lipid signals in aging and longevity
  publication-title: Dev. Cell.
  doi: 10.1016/j.devcel.2021.03.034
– volume: 159
  start-page: 294
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib148
  article-title: Lipidomics": Mass spectrometric and chemometric analyses of lipids
  publication-title: Adv. Drug Deliv. Rev.
  doi: 10.1016/j.addr.2020.06.009
– volume: 8
  start-page: 15691
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib105
  article-title: Cellular senescence drives age-dependent hepatic steatosis
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms15691
– volume: 290
  start-page: 381
  year: 2003
  ident: 10.1016/j.arr.2024.102294_bib101
  article-title: Cellular aging-dependent decrease in cholesterol in membrane microdomains of human diploid fibroblasts
  publication-title: Exp. Cell Res.
  doi: 10.1016/S0014-4827(03)00343-4
– volume: 174
  start-page: 886
  year: 2006
  ident: 10.1016/j.arr.2024.102294_bib136
  article-title: Alveolar cell senescence in patients with pulmonary emphysema
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200509-1374OC
– volume: 30
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib12
  article-title: Chronic lung diseases: prospects for regeneration and repair
  publication-title: Eur. Respir. Rev.
  doi: 10.1183/16000617.0213-2020
– volume: 66
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib160
  article-title: The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis
  publication-title: Ageing Res Rev.
  doi: 10.1016/j.arr.2020.101249
– volume: 10
  start-page: 1282
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib6
  article-title: Changes in Aged Fibroblast Lipid Metabolism Induce Age-Dependent Melanoma Cell Resistance to Targeted Therapy via the Fatty Acid Transporter FATP2
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-20-0329
– volume: 17
  start-page: 47
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib36
  article-title: Mechanisms and therapeutic implications of cellular senescence in osteoarthritis
  publication-title: Nat. Rev. Rheuma.
  doi: 10.1038/s41584-020-00533-7
– volume: 3
  year: 2011
  ident: 10.1016/j.arr.2024.102294_bib154
  article-title: Regulation of cholesterol and fatty acid synthesis
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a004754
– volume: 592
  start-page: 524
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib80
  article-title: The changing landscape of atherosclerosis
  publication-title: Nature.
  doi: 10.1038/s41586-021-03392-8
– volume: 84
  start-page: 119
  year: 2009
  ident: 10.1016/j.arr.2024.102294_bib92
  article-title: Regulation of fatty acid synthesis and Δ9-desaturation in senescence of human fibroblasts
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2008.11.009
– volume: 12
  start-page: 9240
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib141
  article-title: BRD4 contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake
  publication-title: Aging.
  doi: 10.18632/aging.103200
– volume: 2016
  start-page: 3565127
  year: 2016
  ident: 10.1016/j.arr.2024.102294_bib41
  article-title: ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
  publication-title: Oxid. Med Cell Longev.
  doi: 10.1155/2016/3565127
– volume: 19
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib62
  article-title: miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction
  publication-title: Aging Cell.
  doi: 10.1111/acel.13128
– volume: 34,
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib78
  article-title: SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2022.03.010
– volume: 19
  start-page: 619
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib126
  article-title: Senescence and cancer — role and therapeutic opportunities
  publication-title: Nat. Rev. Clin. Oncol.
  doi: 10.1038/s41571-022-00668-4
– volume: 16
  start-page: 29
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib42
  article-title: Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype
  publication-title: Immun Ageing.
  doi: 10.1186/s12979-019-0169-4
– year: 2023
  ident: 10.1016/j.arr.2024.102294_bib59
  article-title: Elimination of Senescent Osteocytes by Bone-Targeting Delivery of β-Galactose-Modified Maytansinoid Prevents Age-Related Bone Loss
  publication-title: Adv. Health Mater.
– volume: 20
  start-page: 38
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib18
  article-title: Mechanisms and consequences of endothelial cell senescence
  publication-title: Nat. Rev. Cardiol.
  doi: 10.1038/s41569-022-00739-0
– volume: 39
  start-page: 397
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib139
  article-title: Caveolin-1, a master regulator of cellular senescence
  publication-title: Cancer Metast Rev.
  doi: 10.1007/s10555-020-09875-w
– volume: 562
  start-page: 578
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib22
  article-title: Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
  publication-title: Nature.
  doi: 10.1038/s41586-018-0543-y
– volume: 270
  start-page: 30701
  year: 1995
  ident: 10.1016/j.arr.2024.102294_bib138
  article-title: Role of Ceramide in Cellular Senescence
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.270.51.30701
– volume: 323
  start-page: 739
  year: 2004
  ident: 10.1016/j.arr.2024.102294_bib7
  article-title: Cardiolipin induces premature senescence in normal human fibroblasts
  publication-title: Biochem Biophys. Res Commun.
  doi: 10.1016/j.bbrc.2004.08.177
– volume: 12
  start-page: 2215
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib28
  article-title: Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2017.104
– volume: 43
  start-page: 17
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib21
  article-title: Cellular senescence: Immunosurveillance and future immunotherapy
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2018.02.001
– volume: 236
  start-page: 958
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib27
  article-title: Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function
  publication-title: J. Cell Physiol.
  doi: 10.1002/jcp.29906
– volume: 39
  start-page: 1553
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib86
  article-title: Oncogene-induced senescence: a double edged sword in cancer
  publication-title: Acta Pharm. Sin.
  doi: 10.1038/aps.2017.198
– volume: 287
  start-page: 1666
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib157
  article-title: COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence
  publication-title: FEBS J.
  doi: 10.1111/febs.15105
– volume: 34
  start-page: 1565
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib16
  article-title: Senescence and the SASP: many therapeutic avenues
  publication-title: Genes Dev.
  doi: 10.1101/gad.343129.120
– volume: 200
  start-page: 556
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib11
  article-title: Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases
  publication-title: Am J Respir Crit Care Med.
  doi: 10.1164/rccm.201810-1975TR
– volume: 81
  start-page: 3708
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib155
  article-title: Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity
  publication-title: Mol. Cell.
  doi: 10.1016/j.molcel.2021.08.027
– volume: 350
  year: 2015
  ident: 10.1016/j.arr.2024.102294_bib30
  article-title: Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine
  publication-title: Science.
  doi: 10.1126/science.aaa8870
– volume: 32
  start-page: 229
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib31
  article-title: Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2020.06.002
– volume: 11
  start-page: 1383
  year: 2012
  ident: 10.1016/j.arr.2024.102294_bib116
  article-title: Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
  publication-title: Cell Cycle.
  doi: 10.4161/cc.19800
– volume: 169
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib8
  article-title: Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
  publication-title: Cell.
  doi: 10.1016/j.cell.2017.02.031
– volume: 13
  start-page: 300
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib108
  article-title: Adipose tissue aging: mechanisms and therapeutic implications
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-022-04752-6
– volume: 11
  start-page: 241
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib40
  article-title: Cell Membrane Theory of Senescence" and the Role of Bioactive Lipids in Aging, and Aging Associated Diseases and Their Therapeutic Implications
  publication-title: Biomolecules.
  doi: 10.3390/biom11020241
– volume: 13
  start-page: 15750
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib99
  article-title: Acid ceramidase promotes senescent cell survival
  publication-title: Aging.
  doi: 10.18632/aging.203170
– volume: 60
  start-page: 3007
  year: 2009
  ident: 10.1016/j.arr.2024.102294_bib163
  article-title: Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1. Semin
  publication-title: Arthritis Rheu.
  doi: 10.1002/art.24816
– volume: 310
  start-page: L1028
  year: 2016
  ident: 10.1016/j.arr.2024.102294_bib57
  article-title: 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells
  publication-title: Am. J. Physiol. Lung Cell Mol. Physiol.
  doi: 10.1152/ajplung.00351.2015
– volume: 39
  start-page: 1964
  year: 2007
  ident: 10.1016/j.arr.2024.102294_bib82
  article-title: Downregulation of caveolin-1 affects bleomycin-induced growth arrest and cellular senescence in A549 cells
  publication-title: Int J. Biochem Cell Biol.
  doi: 10.1016/j.biocel.2007.05.018
– volume: 354
  start-page: 472
  year: 2016
  ident: 10.1016/j.arr.2024.102294_bib32
  article-title: Senescent intimal foam cells are deleterious at all stages of atherosclerosis
  publication-title: Science.
  doi: 10.1126/science.aaf6659
– volume: 70
  start-page: 338
  year: 2008
  ident: 10.1016/j.arr.2024.102294_bib115
  article-title: HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL
  publication-title: Med Hypotheses.
  doi: 10.1016/j.mehy.2007.05.025
– start-page: 57
  year: 2013
  ident: 10.1016/j.arr.2024.102294_bib4
  article-title: Sphingolipid metabolism and neutral sphingomyelinases
  publication-title: Handb. Exp. Pharm.
  doi: 10.1007/978-3-7091-1368-4_3
– volume: 23
  start-page: 775
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib65
  article-title: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
  publication-title: Nat. Med.
  doi: 10.1038/nm.4324
– volume: 23
  start-page: 1272
  year: 2023
  ident: 10.1016/j.arr.2024.102294_bib88
  article-title: Growing old in China in socioeconomic and epidemiological context: systematic review of social care policy for older people
  publication-title: BMC Public Health.
  doi: 10.1186/s12889-023-15583-1
– volume: 19
  start-page: 3515
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib121
  article-title: Oncogenic H-Ras Expression Induces Fatty Acid Profile Changes in Human Fibroblasts and Extracellular Vesicles
  publication-title: Int J. Mol. Sci.
  doi: 10.3390/ijms19113515
– volume: 17
  start-page: 822
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib96
  article-title: Ceramide-1-Phosphate Is Involved in Therapy-Induced Senescence
  publication-title: Acs Chem. Biol.
  doi: 10.1021/acschembio.2c00216
– volume: 152
  start-page: 175
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib137
  article-title: Lipid peroxidation and ferroptosis: The role of GSH and GPx4
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2020.02.027
– volume: 455
  start-page: 127
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib158
  article-title: Genistein protects against ox-LDL-induced senescence through enhancing SIRT1/LKB1/AMPK-mediated autophagy flux in HUVECs
  publication-title: Mol. Cell Biochem.
  doi: 10.1007/s11010-018-3476-8
– volume: 71
  start-page: 345
  year: 2022
  ident: 10.1016/j.arr.2024.102294_bib76
  article-title: Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions
  publication-title: Gut.
  doi: 10.1136/gutjnl-2020-321112
– volume: 13
  start-page: 10
  year: 2024
  ident: 10.1016/j.arr.2024.102294_bib118
  article-title: Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
  publication-title: Transl. Neurodegener.
  doi: 10.1186/s40035-024-00402-3
– volume: 309
  start-page: L1124
  year: 2015
  ident: 10.1016/j.arr.2024.102294_bib17
  article-title: DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease
  publication-title: Am. J. Physiol. Lung Cell Mol. Physiol.
  doi: 10.1152/ajplung.00293.2015
– volume: 3
  start-page: 17075
  year: 2017
  ident: 10.1016/j.arr.2024.102294_bib46
  article-title: A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence
  publication-title: Cell Death Discov.
  doi: 10.1038/cddiscovery.2017.75
– volume: 288
  start-page: 518
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib75
  article-title: Senolytic drugs: from discovery to translation
  publication-title: J. Intern Med.
  doi: 10.1111/joim.13141
– volume: 39
  start-page: 658
  year: 2019
  ident: 10.1016/j.arr.2024.102294_bib122
  article-title: Comprehensive lipid profiling of bleomycin-induced lung injury
  publication-title: J. Appl. Toxicol.
  doi: 10.1002/jat.3758
– volume: 56
  start-page: 89
  year: 2013
  ident: 10.1016/j.arr.2024.102294_bib129
  article-title: Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2012.11.010
– volume: 21
  start-page: 225
  year: 2020
  ident: 10.1016/j.arr.2024.102294_bib91
  article-title: Mechanisms and regulation of cholesterol homeostasis
  publication-title: Nat. Rev. Mol. Cell Bio.
  doi: 10.1038/s41580-019-0190-7
– volume: 621
  start-page: 262
  year: 1991
  ident: 10.1016/j.arr.2024.102294_bib117
  article-title: Phospholipase A2 as a "death trigger" in the aging process. The use of PLA2 inhibitors as antiaging substances
  publication-title: Ann. Ny. Acad. Sci.
  doi: 10.1111/j.1749-6632.1991.tb16985.x
– volume: 19
  year: 2018
  ident: 10.1016/j.arr.2024.102294_bib35
  article-title: CD36 initiates the secretory phenotype during the establishment of cellular senescence
  publication-title: EMBO Rep.
  doi: 10.15252/embr.201745274
– volume: 70
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib151
  article-title: Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implications
  publication-title: Ageing Res Rev.
  doi: 10.1016/j.arr.2021.101413
– volume: 34
  year: 2021
  ident: 10.1016/j.arr.2024.102294_bib153
  article-title: Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2021.108779
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Snippet Cellular senescence is a kind of cellular state triggered by endogenous or exogenous stimuli, which is mainly characterized by stable cell cycle arrest and...
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SubjectTerms Age-related disease
Aging - metabolism
Animals
Cellular senescence
Cellular Senescence - physiology
Humans
Lipid metabolism
Lipid Metabolism - physiology
Lipids
Lipids - physiology
Therapy strategies
Title Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases
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https://dx.doi.org/10.1016/j.arr.2024.102294
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