The kynurenine pathway in HIV, frailty and inflammaging

• Published in: Frontiers in immunology Vol. 14; p. 1244622
• Main Authors: Sultana, Shabiha, Elengickal, Anthony, Bensreti, Husam, de Chantemèle, Eric Belin, McGee-Lawrence, Meghan E., Hamrick, Mark W.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.09.2023
• Subjects: Aged; aryl hydrocarbon receptor; Cytokines; Frailty; HIV Infections - drug therapy; Humans; IDO1; Immunology; inflammation; Kynurenine; osteoporosis; sarcopenia; Tryptophan; osteoporosis; inflammation; IDO1; aryl hydrocarbon receptor; sarcopenia

Kynurenine (Kyn) is a circulating tryptophan (Trp) catabolite generated by enzymes including IDO1 that are induced by inflammatory cytokines such as interferon-gamma. Kyn levels in circulation increase with age and Kyn is implicated in several age-related disorders including neurodegeneration, osteo...