Cytokine-Targeted Therapeutics for KSHV-Associated Disease

Kaposi's sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and recently KSHV inflammatory cytokine syndrome (KICS)....

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Published inViruses Vol. 12; no. 10; p. 1097
Main Authors Alomari, Nedaa, Totonchy, Jennifer
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.09.2020
MDPI
Subjects
Acquired immune deficiency syndrome
AIDS
Animals
Antibodies
Antiviral agents
Castleman Disease
Cell growth
Chemokines
Clinical trials
cytokine signaling
cytokine targeted therapy
cytokine therapeutics
Cytokines
Cytokines - metabolism
Cytomegalovirus
Disease
Effusion
FDA approval
Growth factors
Herpesviridae Infections - immunology
Herpesvirus 8, Human - drug effects
Herpesvirus 8, Human - immunology
HIV
Host-Pathogen Interactions
Human immunodeficiency virus
Humans
Immune system
Immunomodulation
immunomodulatory therapeutics
Infections
Inflammation
Interferon
Interleukins
Kaposi's sarcoma
KSHV
Lymphoma, Primary Effusion
Pathogenesis
Primary effusion lymphoma
Proteins
Remission (Medicine)
Review
Sarcoma
Sarcoma, Kaposi - drug therapy
Sarcoma, Kaposi - virology
Signal Transduction
Therapeutic applications
Transgenic animals
Tumorigenesis
cytokine signaling
cytokine therapeutics
pathogenesis
immunomodulatory therapeutics
cytokine targeted therapy
KSHV
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Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and recently KSHV inflammatory cytokine syndrome (KICS). As with other diseases that have a significant inflammatory component, current therapy for KSHV-associated disease is associated with significant off-target effects. However, recent advances in our understanding of the pathogenesis of KSHV have produced new insight into the use of cytokines as potential therapeutic targets. Better understanding of the role of cytokines during KSHV infection and tumorigenesis may lead to new preventive or therapeutic strategies to limit KSHV spread and improve clinical outcomes. The cytokines that appear to be promising candidates as KSHV antiviral therapies include interleukins 6, 10, and 12 as well as interferons and tumor necrosis factor-family cytokines. This review explores our current understanding of the roles that cytokines play in promoting KSHV infection and tumorigenesis, and summarizes the current use of cytokines as therapeutic targets in KSHV-associated diseases.
AbstractList Kaposi's sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and recently KSHV inflammatory cytokine syndrome (KICS). As with other diseases that have a significant inflammatory component, current therapy for KSHV-associated disease is associated with significant off-target effects. However, recent advances in our understanding of the pathogenesis of KSHV have produced new insight into the use of cytokines as potential therapeutic targets. Better understanding of the role of cytokines during KSHV infection and tumorigenesis may lead to new preventive or therapeutic strategies to limit KSHV spread and improve clinical outcomes. The cytokines that appear to be promising candidates as KSHV antiviral therapies include interleukins 6, 10, and 12 as well as interferons and tumor necrosis factor-family cytokines. This review explores our current understanding of the roles that cytokines play in promoting KSHV infection and tumorigenesis, and summarizes the current use of cytokines as therapeutic targets in KSHV-associated diseases.Kaposi's sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman's disease (MCD) and recently KSHV inflammatory cytokine syndrome (KICS). As with other diseases that have a significant inflammatory component, current therapy for KSHV-associated disease is associated with significant off-target effects. However, recent advances in our understanding of the pathogenesis of KSHV have produced new insight into the use of cytokines as potential therapeutic targets. Better understanding of the role of cytokines during KSHV infection and tumorigenesis may lead to new preventive or therapeutic strategies to limit KSHV spread and improve clinical outcomes. The cytokines that appear to be promising candidates as KSHV antiviral therapies include interleukins 6, 10, and 12 as well as interferons and tumor necrosis factor-family cytokines. This review explores our current understanding of the roles that cytokines play in promoting KSHV infection and tumorigenesis, and summarizes the current use of cytokines as therapeutic targets in KSHV-associated diseases.
Kaposi’s sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma (KS), primary effusion lymphoma (PEL), multicentric Castleman’s disease (MCD) and recently KSHV inflammatory cytokine syndrome (KICS). As with other diseases that have a significant inflammatory component, current therapy for KSHV-associated disease is associated with significant off-target effects. However, recent advances in our understanding of the pathogenesis of KSHV have produced new insight into the use of cytokines as potential therapeutic targets. Better understanding of the role of cytokines during KSHV infection and tumorigenesis may lead to new preventive or therapeutic strategies to limit KSHV spread and improve clinical outcomes. The cytokines that appear to be promising candidates as KSHV antiviral therapies include interleukins 6, 10, and 12 as well as interferons and tumor necrosis factor-family cytokines. This review explores our current understanding of the roles that cytokines play in promoting KSHV infection and tumorigenesis, and summarizes the current use of cytokines as therapeutic targets in KSHV-associated diseases.
Author Alomari, Nedaa
Totonchy, Jennifer
AuthorAffiliation Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA 92618, USA; aloma112@mail.chapman.edu
AuthorAffiliation_xml – name: Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA 92618, USA; aloma112@mail.chapman.edu
Author_xml – sequence: 1
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  surname: Alomari
  fullname: Alomari, Nedaa
  organization: Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA 92618, USA
– sequence: 2
  givenname: Jennifer
  surname: Totonchy
  fullname: Totonchy, Jennifer
  organization: Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA 92618, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32998419$$D View this record in MEDLINE/PubMed
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Keywords cytokine signaling
cytokine therapeutics
pathogenesis
immunomodulatory therapeutics
cytokine targeted therapy
KSHV
Language English
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Snippet Kaposi's sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma...
Kaposi’s sarcoma-associated herpesvirus (KSHV) also known as human herpesvirus 8 (HHV-8), is linked to several human malignancies including Kaposi sarcoma...
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StartPage 1097
SubjectTerms Acquired immune deficiency syndrome
AIDS
Animals
Antibodies
Antiviral agents
Castleman Disease
Cell growth
Chemokines
Clinical trials
cytokine signaling
cytokine targeted therapy
cytokine therapeutics
Cytokines
Cytokines - metabolism
Cytomegalovirus
Disease
Effusion
FDA approval
Growth factors
Herpesviridae Infections - immunology
Herpesvirus 8, Human - drug effects
Herpesvirus 8, Human - immunology
HIV
Host-Pathogen Interactions
Human immunodeficiency virus
Humans
Immune system
Immunomodulation
immunomodulatory therapeutics
Infections
Inflammation
Interferon
Interleukins
Kaposi's sarcoma
KSHV
Lymphoma, Primary Effusion
Pathogenesis
Primary effusion lymphoma
Proteins
Remission (Medicine)
Review
Sarcoma
Sarcoma, Kaposi - drug therapy
Sarcoma, Kaposi - virology
Signal Transduction
Therapeutic applications
Transgenic animals
Tumorigenesis
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Title Cytokine-Targeted Therapeutics for KSHV-Associated Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/32998419
https://www.proquest.com/docview/2550299291
https://www.proquest.com/docview/2447841600/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC7600567
https://doaj.org/article/6456251c14204cb582c0fab1b038b9da
Volume 12
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