Fight to the bitter end: DNA repair and aging

•Aging influences DNA repair in a tissue-type specific manner.•The impairment in DNA repair is closely related to aging and aging-related diseases.•The age-related DNA damage accumulation and the onset of aging form a vicious cycle.•Enhanced DNA repair may be the common mechanism of several rejuvena...

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Published inAgeing research reviews Vol. 64; p. 101154
Main Authors Chen, Yu, Geng, Anke, Zhang, Weina, Qian, Zhen, Wan, Xiaoping, Jiang, Ying, Mao, Zhiyong
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.12.2020
Subjects
Aging
Aging - genetics
DNA Damage
DNA repair
DNA Repair - genetics
DNA repair reporter cassette
Genomic Instability
Humans
Inflammation
Rejuvenation
Senescence
Aging
Senescence
Inflammation
DNA repair reporter cassette
DNA repair
Rejuvenation
Online AccessGet full text
ISSN1568-1637
1872-9649
1872-9649
DOI10.1016/j.arr.2020.101154

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Abstract •Aging influences DNA repair in a tissue-type specific manner.•The impairment in DNA repair is closely related to aging and aging-related diseases.•The age-related DNA damage accumulation and the onset of aging form a vicious cycle.•Enhanced DNA repair may be the common mechanism of several rejuvenation methods.•Multiple novel tools were created to study DNA repair in vitro &in vivo. DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.
AbstractList DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.
DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.
•Aging influences DNA repair in a tissue-type specific manner.•The impairment in DNA repair is closely related to aging and aging-related diseases.•The age-related DNA damage accumulation and the onset of aging form a vicious cycle.•Enhanced DNA repair may be the common mechanism of several rejuvenation methods.•Multiple novel tools were created to study DNA repair in vitro &in vivo. DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and development and for human health. DNA repair is a fundamental and conserved mechanism responsible for mending damaged DNA and restoring genomic stability, while its deficiency is closely related to multiple human disorders. In recent years, remarkable progress has been made in the field of DNA repair and aging. Here, we will extensively discuss the relationship among DNA damage, DNA repair, aging and aging-associated diseases based on the latest research. In addition, the possible role of DNA repair in several potential rejuvenation strategies will be discussed. Finally, we will also review the emerging methods that may facilitate future research on DNA repair.
ArticleNumber 101154
Author Qian, Zhen
Zhang, Weina
Jiang, Ying
Geng, Anke
Mao, Zhiyong
Chen, Yu
Wan, Xiaoping
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Keywords Aging
Senescence
Inflammation
DNA repair reporter cassette
DNA repair
Rejuvenation
Language English
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Snippet •Aging influences DNA repair in a tissue-type specific manner.•The impairment in DNA repair is closely related to aging and aging-related diseases.•The...
DNA carries the genetic information that directs complex biological processes; thus, maintaining a stable genome is critical for individual growth and...
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SubjectTerms Aging
Aging - genetics
DNA Damage
DNA repair
DNA Repair - genetics
DNA repair reporter cassette
Genomic Instability
Humans
Inflammation
Rejuvenation
Senescence
Title Fight to the bitter end: DNA repair and aging
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https://dx.doi.org/10.1016/j.arr.2020.101154
https://www.ncbi.nlm.nih.gov/pubmed/32977059
https://www.proquest.com/docview/2446669079
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