Genomic and functional diversity of the human-derived isolates of Faecalibacterium
is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the functions of genomes from cultured strains and the distribution of different species in populations may differ among different sources. We here performed an exte...
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| Published in | Frontiers in microbiology Vol. 15; p. 1379500 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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30.05.2024
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| Abstract | is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the functions of
genomes from cultured strains and the distribution of different species in populations may differ among different sources.
We here performed an extensive analysis of pan-genomes, functions, and safety evaluation of 136
genomes collected from 10 countries.
The genomes are clustered into 11 clusters, with only five of them were characterized and validly nomenclated. Over 80% of the accessory genes and unique genes of
are found with unknown function, which reflects the importance of expanding the collection of
strains. All the genomes have the potential to produce acetic acid and butyric acid. Nine clusters of
are found significantly enriched in the healthy individuals compared with patients with type II diabetes..
This study provides a comprehensive view of genomic characteristic and functions and of culturable
bacterium from human gut, and enables clinical advances in the future. |
|---|---|
| AbstractList | Faecalibacterium is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the functions of Faecalibacterium genomes from cultured strains and the distribution of different species in populations may differ among different sources.IntroductionFaecalibacterium is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the functions of Faecalibacterium genomes from cultured strains and the distribution of different species in populations may differ among different sources.We here performed an extensive analysis of pan-genomes, functions, and safety evaluation of 136 Faecalibacterium genomes collected from 10 countries.MethodsWe here performed an extensive analysis of pan-genomes, functions, and safety evaluation of 136 Faecalibacterium genomes collected from 10 countries.The genomes are clustered into 11 clusters, with only five of them were characterized and validly nomenclated. Over 80% of the accessory genes and unique genes of Faecalibacterium are found with unknown function, which reflects the importance of expanding the collection of Faecalibacterium strains. All the genomes have the potential to produce acetic acid and butyric acid. Nine clusters of Faecalibacterium are found significantly enriched in the healthy individuals compared with patients with type II diabetes..ResultsThe genomes are clustered into 11 clusters, with only five of them were characterized and validly nomenclated. Over 80% of the accessory genes and unique genes of Faecalibacterium are found with unknown function, which reflects the importance of expanding the collection of Faecalibacterium strains. All the genomes have the potential to produce acetic acid and butyric acid. Nine clusters of Faecalibacterium are found significantly enriched in the healthy individuals compared with patients with type II diabetes..This study provides a comprehensive view of genomic characteristic and functions and of culturable Faecalibacterium bacterium from human gut, and enables clinical advances in the future.DiscussionThis study provides a comprehensive view of genomic characteristic and functions and of culturable Faecalibacterium bacterium from human gut, and enables clinical advances in the future. IntroductionFaecalibacterium is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the functions of Faecalibacterium genomes from cultured strains and the distribution of different species in populations may differ among different sources.MethodsWe here performed an extensive analysis of pan-genomes, functions, and safety evaluation of 136 Faecalibacterium genomes collected from 10 countries.ResultsThe genomes are clustered into 11 clusters, with only five of them were characterized and validly nomenclated. Over 80% of the accessory genes and unique genes of Faecalibacterium are found with unknown function, which reflects the importance of expanding the collection of Faecalibacterium strains. All the genomes have the potential to produce acetic acid and butyric acid. Nine clusters of Faecalibacterium are found significantly enriched in the healthy individuals compared with patients with type II diabetes..DiscussionThis study provides a comprehensive view of genomic characteristic and functions and of culturable Faecalibacterium bacterium from human gut, and enables clinical advances in the future. is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the functions of genomes from cultured strains and the distribution of different species in populations may differ among different sources. We here performed an extensive analysis of pan-genomes, functions, and safety evaluation of 136 genomes collected from 10 countries. The genomes are clustered into 11 clusters, with only five of them were characterized and validly nomenclated. Over 80% of the accessory genes and unique genes of are found with unknown function, which reflects the importance of expanding the collection of strains. All the genomes have the potential to produce acetic acid and butyric acid. Nine clusters of are found significantly enriched in the healthy individuals compared with patients with type II diabetes.. This study provides a comprehensive view of genomic characteristic and functions and of culturable bacterium from human gut, and enables clinical advances in the future. |
| Author | Xiao, Liang Zou, Yuanqiang Sun, Jingxi Li, Wenxi Wu, Zhinan He, Wenxin Wang, Mengmeng Hu, Tongyuan Lin, Xiaoqian Gao, Xiaowei Li, Xiaofang Liang, Hewei |
| AuthorAffiliation | 2 School of Biology and Biological Engineering, South China University of Technology , Guangzhou , China 3 BGI Research , Wuhan , China 7 Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken , Copenhagen , Denmark 6 Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI-Shenzhen , Shenzhen , China 4 College of Life Sciences, University of Chinese Academy of Sciences , Beijing , China 1 BGI-Shenzhen , Shenzhen , China 5 BGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University , Zhengzhou , China |
| AuthorAffiliation_xml | – name: 5 BGI College and Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University , Zhengzhou , China – name: 6 Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI-Shenzhen , Shenzhen , China – name: 1 BGI-Shenzhen , Shenzhen , China – name: 2 School of Biology and Biological Engineering, South China University of Technology , Guangzhou , China – name: 7 Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Universitetsparken , Copenhagen , Denmark – name: 4 College of Life Sciences, University of Chinese Academy of Sciences , Beijing , China – name: 3 BGI Research , Wuhan , China |
| Author_xml | – sequence: 1 givenname: Wenxi surname: Li fullname: Li, Wenxi – sequence: 2 givenname: Xiaoqian surname: Lin fullname: Lin, Xiaoqian – sequence: 3 givenname: Hewei surname: Liang fullname: Liang, Hewei – sequence: 4 givenname: Zhinan surname: Wu fullname: Wu, Zhinan – sequence: 5 givenname: Mengmeng surname: Wang fullname: Wang, Mengmeng – sequence: 6 givenname: Jingxi surname: Sun fullname: Sun, Jingxi – sequence: 7 givenname: Xiaofang surname: Li fullname: Li, Xiaofang – sequence: 8 givenname: Wenxin surname: He fullname: He, Wenxin – sequence: 9 givenname: Xiaowei surname: Gao fullname: Gao, Xiaowei – sequence: 10 givenname: Tongyuan surname: Hu fullname: Hu, Tongyuan – sequence: 11 givenname: Liang surname: Xiao fullname: Xiao, Liang – sequence: 12 givenname: Yuanqiang surname: Zou fullname: Zou, Yuanqiang |
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| Keywords | pan-genome gut microbiology carbohydrate enzymes Faecalibacterium probiotics |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Mingfeng Cao, Xiamen University, China Juan P. Cardenas, Major University, Chile These authors have contributed equally to this work Reviewed by: Zhangran Chen, Xiamen University, China |
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genomes... Faecalibacterium is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic. However, the... IntroductionFaecalibacterium is one of the most abundant bacteria in the gut microbiota of healthy adults, highly regarded as a next-generation probiotic.... |
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| SubjectTerms | carbohydrate enzymes Faecalibacterium gut microbiology Microbiology pan-genome probiotics |
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| Title | Genomic and functional diversity of the human-derived isolates of Faecalibacterium |
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