Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection

• Published in: Frontiers in immunology Vol. 15; p. 1484143
• Main Authors: Farroni, Chiara, Altera, Anna Maria Gerarda, Salmi, Andrea, Vanini, Valentina, Cuzzi, Gilda, Lindestam Arlehamn, Cecilia S., Sette, Alessandro, Delogu, Giovanni, Palucci, Ivana, Sbarra, Settimia, Aiello, Alessandra, Picchianti-Diamanti, Andrea, Gualano, Gina, Palmieri, Fabrizio, Goletti, Delia, Petruccioli, Elisa
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.01.2025
• Subjects: Adult; AIM assay, IFN-γ; antigen-specific response; Arthritis, Rheumatoid - immunology; CD4-Positive T-Lymphocytes - immunology; Cytokines - metabolism; Female; Humans; Immunologic Memory; Immunology; Lymphocyte Activation; Male; MGIA; Middle Aged; Mycobacterium tuberculosis - growth & development; Mycobacterium tuberculosis - immunology; rheumatoid arthritis; Th1; tuberculosis; Tuberculosis - immunology; Tuberculosis - microbiology; tuberculosis infection; MGIA; tuberculosis; Th1; rheumatoid arthritis; antigen-specific response; AIM assay, IFN-γ

Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, with tuberculosis infection (TBI), have a high probability of progressing to tuberculosis disease (TB). We aim to characterize the impact of IMID on the immune response to (Mtb) in patients with TBI and TB dise...