Quercetin Promotes Diabetic Wound Healing via Switching Macrophages From M1 to M2 Polarization

• Published in: The Journal of surgical research Vol. 246; pp. 213 - 223
• Main Authors: Fu, Jia, Huang, Jingjuan, Lin, Man, Xie, Tingting, You, Tianhui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2020
• Subjects: Administration, Cutaneous; Animals; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - immunology; Diabetic rats; Dose-Response Relationship, Drug; Humans; Inflammation; Inflammation - drug therapy; Inflammation - immunology; Inflammation - pathology; Macrophage; Macrophage Activation - drug effects; Macrophages - drug effects; Macrophages - immunology; Male; Quercetin; Quercetin - administration & dosage; Rats; Skin - immunology; Skin - injuries; Skin - pathology; Streptozocin - toxicity; Treatment Outcome; Wound healing; Wound Healing - drug effects; Wound Healing - immunology; Diabetic rats; Inflammation; Wound healing; Quercetin; Macrophage

For patients with diabetes mellitus, excessive and long-lasting inflammatory reactions at the wound site commonly lead to the delayed refractory wound healing. The polarization of macrophages in terms of M1 and M2 phenotypes is closely related to the production of inflammatory cytokines. Quercetin i...