Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis

• Published in: BMJ. British medical journal (Clinical research ed.) Vol. 363; p. k4226
• Main Authors: Xu, Cheng, Chen, Yu-Pei, Du, Xiao-Jing, Liu, Jin-Qi, Huang, Cheng-Long, Chen, Lei, Zhou, Guan-Qun, Li, Wen-Fei, Mao, Yan-Ping, Hsu, Chiun, Liu, Qing, Lin, Ai-Hua, Tang, Ling-Long, Sun, Ying, Ma, Jun
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 08.11.2018; BMJ Publishing Group Ltd
• Subjects: Antibodies, Monoclonal - adverse effects; Antibodies, Monoclonal - therapeutic use; Antibodies, Monoclonal, Humanized - adverse effects; Antibodies, Monoclonal, Humanized - therapeutic use; Antigens; Antineoplastic Agents, Immunological - adverse effects; Antineoplastic Agents, Immunological - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Apoptosis; Arthralgia; Cancer therapies; Chemotherapy; Clinical trials; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cytotoxicity; Drug development; Drug dosages; Drug-Related Side Effects and Adverse Reactions - etiology; Evidence-based medicine; Humans; Hypothyroidism; Immune checkpoint inhibitors; Immunosuppressive agents; Immunotherapy; Ipilimumab - adverse effects; Ipilimumab - therapeutic use; Lung cancer; Lymphocytes; Medical prognosis; Medical research; Melanoma; Meta-analysis; Metastasis; Monoclonal antibodies; Nausea; Neoplasms - drug therapy; Neoplasms - immunology; Nivolumab - adverse effects; Nivolumab - therapeutic use; Pembrolizumab; Pharmaceutical industry; Pneumonitis; Prospero protein; Randomized Controlled Trials as Topic; Sensitivity analysis; Systematic review; Targeted cancer therapy; Toxicity; Vomiting

To provide a complete toxicity profile, toxicity spectrum, and a safety ranking of immune checkpoint inhibitor (ICI) drugs for treatment of cancer. Systematic review and network meta-analysis. Electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) were systematically searched to...