The mTOR inhibitor rapamycin suppresses trigeminal neuropathic pain and p-MKK4/p-p38 mitogen-activated protein kinase-mediated microglial activation in the trigeminal nucleus caudalis of mice with infraorbital nerve injury

• Published in: Frontiers in molecular neuroscience Vol. 16; p. 1172366
• Main Authors: Yeo, Ji-Hee, Roh, Dae-Hyun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 14.04.2023
• Subjects: microglia; Molecular Neuroscience; mTOR – mammalian target of rapamycin; p38 MAPK; rapamycin (CID: 5284616); trigeminal neuropathic pain; trigeminal neuropathic pain; rapamycin (CID: 5284616); microglia; p38 MAPK; mTOR – mammalian target of rapamycin

Neuropathic pain caused by trigeminal nerve injury is a typical refractory orofacial chronic pain accompanied by the development of hyperalgesia and allodynia. We previously demonstrated that the mammalian target of rapamycin (mTOR) inhibitor rapamycin suppressed orofacial formalin injection-induced...