The first extracellular domain of claudin-7 affects paracellular Cl− permeability

• Published in: Biochemical and biophysical research communications Vol. 357; no. 1; pp. 87 - 91
• Main Authors: Alexandre, Michele D., Jeansonne, Beverly G., Renegar, Randall H., Tatum, Rodney, Chen, Yan-Hua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 25.05.2007
• Subjects: Animals; Cell Line; Cell Membrane Permeability - physiology; Chlorine - metabolism; Claudin-7; Claudins; Cl− permeability; Dilution potentials; Epithelial Cells - metabolism; Extracellular Fluid - chemistry; Extracellular Fluid - metabolism; LLC-PK1 cells; Membrane Proteins - chemistry; Membrane Proteins - metabolism; Paracellular charge selectivity; Protein Structure, Tertiary; Static Electricity; Structure-Activity Relationship; Swine; Tight junctions; Tight Junctions - metabolism; Claudin-7; Tight junctions; Dilution potentials; Cl− permeability; Paracellular charge selectivity; LLC-PK1 cells

Tight junctions (TJ) constitute paracellular diffusion channels regulating the passage of ions and solutes across epithelia. We recently demonstrated that overexpression of the TJ membrane protein claudin-7 in LLC-PK1 cells decreases paracellular permeability to Cl− and increases paracellular permea...