Modelling esophageal adenocarcinoma and Barrett's esophagus with patient-derived organoids

• Published in: Frontiers in molecular biosciences Vol. 11; p. 1382070
• Main Authors: Milne, Julia V, Mustafa, Ebtihal H, Clemons, Nicholas J
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.04.2024
• Subjects: Barrett’s esophagus; esophageal adenocarcinoma (EAC); esophageal cancer (EC); models of cancer; Molecular Biosciences; organoids; patient-derived organoid (PDO); esophageal adenocarcinoma (EAC); Barrett’s esophagus; organoids; models of cancer; tumorigenesis; esophageal cancer (EC); patient-derived organoid (PDO)

Currently, esophageal adenocarcinoma (EAC) research is hindered by a dearth of adequate models to study this disease. Traditional cell line and genetically engineered mouse models are lacking in biological and physiological significance, whilst the inefficiency of patient-derived xenografts limit th...