Modelling esophageal adenocarcinoma and Barrett's esophagus with patient-derived organoids

Currently, esophageal adenocarcinoma (EAC) research is hindered by a dearth of adequate models to study this disease. Traditional cell line and genetically engineered mouse models are lacking in biological and physiological significance, whilst the inefficiency of patient-derived xenografts limit th...

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Published inFrontiers in molecular biosciences Vol. 11; p. 1382070
Main Authors Milne, Julia V, Mustafa, Ebtihal H, Clemons, Nicholas J
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.04.2024
Subjects
Barrett’s esophagus
esophageal adenocarcinoma (EAC)
esophageal cancer (EC)
models of cancer
Molecular Biosciences
organoids
patient-derived organoid (PDO)
esophageal adenocarcinoma (EAC)
Barrett’s esophagus
organoids
models of cancer
tumorigenesis
esophageal cancer (EC)
patient-derived organoid (PDO)
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Abstract Currently, esophageal adenocarcinoma (EAC) research is hindered by a dearth of adequate models to study this disease. Traditional cell line and genetically engineered mouse models are lacking in biological and physiological significance, whilst the inefficiency of patient-derived xenografts limit their potential applications. This review describes the landscape of EAC research using patient-derived organoids (PDOs). Here, we detail the methods of establishment and optimization of EAC PDO cultures, as well as current and prospective applications of these models. We further highlight a crucial knowledge gap in the mechanisms of EAC transformation from its precursor lesion, Barrett's esophagus (BE). As such, we also describe the culture requirements of BE PDOs and attempts to model tumorigenesis using PDO models.
AbstractList Currently, esophageal adenocarcinoma (EAC) research is hindered by a dearth of adequate models to study this disease. Traditional cell line and genetically engineered mouse models are lacking in biological and physiological significance, whilst the inefficiency of patient-derived xenografts limit their potential applications. This review describes the landscape of EAC research using patient-derived organoids (PDOs). Here, we detail the methods of establishment and optimization of EAC PDO cultures, as well as current and prospective applications of these models. We further highlight a crucial knowledge gap in the mechanisms of EAC transformation from its precursor lesion, Barrett’s esophagus (BE). As such, we also describe the culture requirements of BE PDOs and attempts to model tumorigenesis using PDO models.
Author Clemons, Nicholas J
Mustafa, Ebtihal H
Milne, Julia V
AuthorAffiliation 2 Sir Peter MacCallum Department of Oncology , The University of Melbourne , Melbourne , VIC , Australia
1 Division of Cancer Research , Peter MacCallum Cancer Centre , Melbourne , VIC , Australia
AuthorAffiliation_xml – name: 2 Sir Peter MacCallum Department of Oncology , The University of Melbourne , Melbourne , VIC , Australia
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Keywords esophageal adenocarcinoma (EAC)
Barrett’s esophagus
organoids
models of cancer
tumorigenesis
esophageal cancer (EC)
patient-derived organoid (PDO)
Language English
License Copyright © 2024 Milne, Mustafa and Clemons.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Edited by: Farah Ballout, University of Miami Health System, United States
Reviewed by: Hemamylammal Sivakumar, The Ohio State University, United States
Wassim Abou-Kheir, American University of Beirut, Lebanon
Paloma Ordonez Moran, University of Nottingham, United Kingdom
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Snippet Currently, esophageal adenocarcinoma (EAC) research is hindered by a dearth of adequate models to study this disease. Traditional cell line and genetically...
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SubjectTerms Barrett’s esophagus
esophageal adenocarcinoma (EAC)
esophageal cancer (EC)
models of cancer
Molecular Biosciences
organoids
patient-derived organoid (PDO)
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Title Modelling esophageal adenocarcinoma and Barrett's esophagus with patient-derived organoids
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