Comprehensive characterization of a transgene insertion in a highly repetitive, centromeric region of Anopheles mosquitoes

• Published in: Pathogens and global health Vol. 117; no. 3; pp. 273 - 283
• Main Authors: Vitale, Matteo, Leo, Chiara, Courty, Thomas, Kranjc, Nace, Connolly, John B., Morselli, Giulia, Bamikole, Christopher, Haghighat-Khah, Roya Elaine, Bernardini, Federica, Fuchs, Silke
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2023
• Subjects: Animals; Anopheles - genetics; centromere; fluorescence in situ hybridization; Malaria - parasitology; Malaria - prevention & control; Male; Mosquito Vectors - genetics; Phenotype; PiggyBac; repetitive region; Transgene; Transgenes; whole genome sequencing; fluorescence in situ hybridization; whole genome sequencing; centromere; Transgene; repetitive region; PiggyBac

The availability of the genomic sequence of the malaria mosquito Anopheles gambiae has in recent years sparked the development of transgenic technologies with the potential to be used as novel vector control tools. These technologies rely on genome editing that confer traits able to affect vectorial...