Worldwide interethnic variability and geographical distribution of CYP2C9 genotypes and phenotypes

• Published in: Expert opinion on drug metabolism & toxicology Vol. 11; no. 12; p. 1893
• Main Authors: Céspedes-Garro, Carolina, Fricke-Galindo, Ingrid, Naranjo, María Eugenia G, Rodrigues-Soares, Fernanda, Fariñas, Humberto, de Andrés, Fernando, López-López, Marisol, Peñas-Lledó, Eva M, LLerena, Adrián
• Format: Journal Article
• Language: English
• Published: England 02.12.2015
• Subjects: Continental Population Groups - genetics; Cytochrome P-450 CYP2C9 - genetics; Gene Frequency; Genotype; Humans; Phenotype; phenotype; CYP2C9; ethnicity; genotype

Notably differences in CYP2C9 allele frequencies among worldwide populations have been reported, with an interesting low frequency of the CYP2C9*2 allele in Amerindians compared with Admixed and European populations. Literature was searched using the PubMed database and was focused on worldwide orig...