Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

• Published in: Journal of Virology Vol. 84; no. 16; pp. 8098 - 8110
• Main Authors: Pancera, Marie, McLellan, Jason S., Wu, Xueling, Zhu, Jiang, Changela, Anita, Schmidt, Stephen D., Yang, Yongping, Zhou, Tongqing, Phogat, Sanjay, Mascola, John R., Kwong, Peter D.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.08.2010; American Society for Microbiology (ASM)
• Subjects: AFFINITY; Amino Acid Sequence; ANTIBODIES; Antibodies, Neutralizing - chemistry; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - metabolism; Antibody Affinity; CHAINS; Complementarity Determining Regions - chemistry; Complementarity Determining Regions - immunology; CRYSTAL STRUCTURE; Crystallography, X-Ray; FUNCTIONALS; GENES; Glycosylation; HIV Antibodies - chemistry; HIV Antibodies - immunology; HIV Antibodies - metabolism; HIV-1 - immunology; Human immunodeficiency virus 1; Humans; MATERIALS SCIENCE; Models, Molecular; Molecular Sequence Data; Neutralization Tests; ORTHORHOMBIC LATTICES; Pathogenesis and Immunity; Protein Structure, Quaternary; RESIDUES; Sequence Alignment

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