PC3T: a signature-driven predictor of chemical compounds for cellular transition
Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and highly tunable approach to overcome these issues. Here, we presen...
Saved in:
| Published in | Communications biology Vol. 6; no. 1; pp. 989 - 11 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
27.09.2023
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and highly tunable approach to overcome these issues. Here, we present PC3T, a computational framework to enrich molecules that induce desired cellular transitions, and PC3T was able to consistently enrich small molecules that had been experimentally validated in both bulk and single-cell datasets. We then predicted small molecule reprogramming of fibroblasts into hepatic progenitor-like cells (HPLCs). The converted cells exhibited epithelial cell-like morphology and HPLC-like gene expression pattern. Hepatic functions were also observed, such as glycogen storage and lipid accumulation. Finally, we collected and manually curated a cell state transition resource containing 224 time-course gene expression datasets and 153 cell types. Our framework, together with the data resource, is freely available at
http://pc3t.idrug.net.cn/
. We believe that PC3T is a powerful tool to promote chemical-induced cell state transitions.
PC3T is an in silico chemical screening pipeline to identify small-molecule treatments that induce cell state transitions for any given initial and terminal state or any intermediate state in the cell transition trajectory. |
|---|---|
| AbstractList | Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and highly tunable approach to overcome these issues. Here, we present PC3T, a computational framework to enrich molecules that induce desired cellular transitions, and PC3T was able to consistently enrich small molecules that had been experimentally validated in both bulk and single-cell datasets. We then predicted small molecule reprogramming of fibroblasts into hepatic progenitor-like cells (HPLCs). The converted cells exhibited epithelial cell-like morphology and HPLC-like gene expression pattern. Hepatic functions were also observed, such as glycogen storage and lipid accumulation. Finally, we collected and manually curated a cell state transition resource containing 224 time-course gene expression datasets and 153 cell types. Our framework, together with the data resource, is freely available at http://pc3t.idrug.net.cn/ . We believe that PC3T is a powerful tool to promote chemical-induced cell state transitions.Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and highly tunable approach to overcome these issues. Here, we present PC3T, a computational framework to enrich molecules that induce desired cellular transitions, and PC3T was able to consistently enrich small molecules that had been experimentally validated in both bulk and single-cell datasets. We then predicted small molecule reprogramming of fibroblasts into hepatic progenitor-like cells (HPLCs). The converted cells exhibited epithelial cell-like morphology and HPLC-like gene expression pattern. Hepatic functions were also observed, such as glycogen storage and lipid accumulation. Finally, we collected and manually curated a cell state transition resource containing 224 time-course gene expression datasets and 153 cell types. Our framework, together with the data resource, is freely available at http://pc3t.idrug.net.cn/ . We believe that PC3T is a powerful tool to promote chemical-induced cell state transitions. Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and highly tunable approach to overcome these issues. Here, we present PC3T, a computational framework to enrich molecules that induce desired cellular transitions, and PC3T was able to consistently enrich small molecules that had been experimentally validated in both bulk and single-cell datasets. We then predicted small molecule reprogramming of fibroblasts into hepatic progenitor-like cells (HPLCs). The converted cells exhibited epithelial cell-like morphology and HPLC-like gene expression pattern. Hepatic functions were also observed, such as glycogen storage and lipid accumulation. Finally, we collected and manually curated a cell state transition resource containing 224 time-course gene expression datasets and 153 cell types. Our framework, together with the data resource, is freely available at http://pc3t.idrug.net.cn/. We believe that PC3T is a powerful tool to promote chemical-induced cell state transitions.PC3T is an in silico chemical screening pipeline to identify small-molecule treatments that induce cell state transitions for any given initial and terminal state or any intermediate state in the cell transition trajectory. Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and highly tunable approach to overcome these issues. Here, we present PC3T, a computational framework to enrich molecules that induce desired cellular transitions, and PC3T was able to consistently enrich small molecules that had been experimentally validated in both bulk and single-cell datasets. We then predicted small molecule reprogramming of fibroblasts into hepatic progenitor-like cells (HPLCs). The converted cells exhibited epithelial cell-like morphology and HPLC-like gene expression pattern. Hepatic functions were also observed, such as glycogen storage and lipid accumulation. Finally, we collected and manually curated a cell state transition resource containing 224 time-course gene expression datasets and 153 cell types. Our framework, together with the data resource, is freely available at http://pc3t.idrug.net.cn/ . We believe that PC3T is a powerful tool to promote chemical-induced cell state transitions. PC3T is an in silico chemical screening pipeline to identify small-molecule treatments that induce cell state transitions for any given initial and terminal state or any intermediate state in the cell transition trajectory. Abstract Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and highly tunable approach to overcome these issues. Here, we present PC3T, a computational framework to enrich molecules that induce desired cellular transitions, and PC3T was able to consistently enrich small molecules that had been experimentally validated in both bulk and single-cell datasets. We then predicted small molecule reprogramming of fibroblasts into hepatic progenitor-like cells (HPLCs). The converted cells exhibited epithelial cell-like morphology and HPLC-like gene expression pattern. Hepatic functions were also observed, such as glycogen storage and lipid accumulation. Finally, we collected and manually curated a cell state transition resource containing 224 time-course gene expression datasets and 153 cell types. Our framework, together with the data resource, is freely available at http://pc3t.idrug.net.cn/ . We believe that PC3T is a powerful tool to promote chemical-induced cell state transitions. Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety concerns of using transcription factors. Small molecules provide a temporal and highly tunable approach to overcome these issues. Here, we present PC3T, a computational framework to enrich molecules that induce desired cellular transitions, and PC3T was able to consistently enrich small molecules that had been experimentally validated in both bulk and single-cell datasets. We then predicted small molecule reprogramming of fibroblasts into hepatic progenitor-like cells (HPLCs). The converted cells exhibited epithelial cell-like morphology and HPLC-like gene expression pattern. Hepatic functions were also observed, such as glycogen storage and lipid accumulation. Finally, we collected and manually curated a cell state transition resource containing 224 time-course gene expression datasets and 153 cell types. Our framework, together with the data resource, is freely available at http://pc3t.idrug.net.cn/ . We believe that PC3T is a powerful tool to promote chemical-induced cell state transitions. |
| ArticleNumber | 989 |
| Author | Song, Bin Zhong, Zhi Cui, Xiuliang Zhang, Peilin Bo, Xiaochen Wang, Hongyang Zhou, Wenxia Han, Lu Zhang, Yongxiang Zhang, Yong |
| Author_xml | – sequence: 1 givenname: Lu surname: Han fullname: Han, Lu organization: Beijing Institute of Pharmacology and Toxicology, State Key Laboratory of Toxicology and Medical Countermeasures – sequence: 2 givenname: Bin surname: Song fullname: Song, Bin organization: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University – sequence: 3 givenname: Peilin surname: Zhang fullname: Zhang, Peilin organization: National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University – sequence: 4 givenname: Zhi surname: Zhong fullname: Zhong, Zhi organization: Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University – sequence: 5 givenname: Yongxiang surname: Zhang fullname: Zhang, Yongxiang organization: Beijing Institute of Pharmacology and Toxicology, State Key Laboratory of Toxicology and Medical Countermeasures – sequence: 6 givenname: Xiaochen orcidid: 0000-0003-1911-7922 surname: Bo fullname: Bo, Xiaochen organization: Department of Bioinformatics, Institute of Health Service and Transfusion Medicine – sequence: 7 givenname: Hongyang orcidid: 0000-0002-4709-3334 surname: Wang fullname: Wang, Hongyang organization: National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University – sequence: 8 givenname: Yong orcidid: 0000-0001-6316-2734 surname: Zhang fullname: Zhang, Yong email: yzhang@tongji.edu.cn organization: Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University – sequence: 9 givenname: Xiuliang orcidid: 0000-0002-0165-5020 surname: Cui fullname: Cui, Xiuliang email: wafyai@163.com organization: National Center for Liver Cancer, Eastern Hepatobiliary Surgery Hospital, Naval Medical University – sequence: 10 givenname: Wenxia orcidid: 0000-0002-6175-4821 surname: Zhou fullname: Zhou, Wenxia email: zhouwx@bmi.ac.cn organization: Beijing Institute of Pharmacology and Toxicology, State Key Laboratory of Toxicology and Medical Countermeasures |
| BookMark | eNp9kktr3DAUhUVJaB7NH-jK0E03TmVdWY9uShn6CASSRbIWGvl6osGWppIdmH9fTRzaposshITOuR_S4ZyRoxADEvK-oZcNBfUpc0Yp1JSV1TLW1vs35JSB1jUIzo7-OZ-Qi5y3lNJGay2AvyUnIGWrlOSn5PZ2BXefK1tlvwl2mhPWXfKPGKpdws67KaYq9pV7wNE7O1Qujrs4hy5XfVEcDsM82FRNyYbsJx_DO3Lc2yHjxfN-Tu6_f7tb_ayvb35crb5e144LPdUCoaNtD0IqKzpHRYeImiOz8iBxXdQGlW1RrREEgG0dSKSyYaxhqoNzcrVwu2i3Zpf8aNPeROvN00VMG2PT5N2ARq2p1LpVgrkSx9pqoK3oJRPcodOgCuvLwtrN6xE7h6H8Z3gBfakE_2A28dE0tAXg-kD4-ExI8deMeTKjz4d0bMA4Z8OUpA0XkrFi_fCfdRvnFEpWxSU0p4wCFBdbXC7FnBP2f17TUHMogFkKYEoBzFMBzL4MwTKUizlsMP1FvzL1G9g3syA |
| Cites_doi | 10.1016/j.molcel.2019.01.042 10.1016/j.stem.2014.01.003 10.1038/s41587-021-00946-z 10.1161/CIRCULATIONAHA.116.024692 10.1016/j.stem.2010.03.018 10.1016/j.stemcr.2021.03.028 10.1016/j.cell.2014.02.041 10.1093/bioinformatics/bti525 10.1038/nature10648 10.1038/nmeth.4150 10.1016/j.stem.2015.06.003 10.1073/pnas.0506580102 10.1126/science.1132939 10.1093/bioinformatics/bts635 10.1126/sciadv.aba1190 10.1016/j.cell.2021.04.048 10.7554/eLife.29518 10.1016/j.mcn.2009.10.008 10.1016/j.cell.2017.10.049 10.1089/omi.2011.0118 10.1126/science.1239278 10.1016/j.celrep.2017.07.071 10.1126/science.1151526 10.1038/nbt.2859 10.1038/s41586-018-0744-4 10.1038/nbt1326 10.1016/j.cell.2006.07.024 10.1038/s41586-022-04593-5 10.1016/j.cell.2007.11.019 10.1016/j.stem.2009.09.012 10.1016/j.exer.2014.04.006 10.1093/nar/gkac862 10.1038/s41422-019-0196-x 10.1016/j.stem.2015.01.013 10.1038/nature06534 10.3390/ijms21207695 10.1126/science.aaz3090 10.1007/s00259-005-1891-z 10.1093/nar/gkx402 10.1016/j.cell.2015.11.017 10.1016/j.stem.2019.05.020 10.1371/journal.pone.0040301 10.1016/j.stem.2018.05.025 10.1038/nature10116 10.1016/j.stem.2012.11.008 10.1126/science.aax6234 10.1007/978-1-59745-019-5_13 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2023 The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2023. Springer Nature Limited. Springer Nature Limited 2023 |
| Copyright_xml | – notice: The Author(s) 2023 – notice: The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2023. Springer Nature Limited. – notice: Springer Nature Limited 2023 |
| DBID | C6C AAYXX CITATION 3V. 7XB 88I 8FE 8FH 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO GNUQQ HCIFZ LK8 M2P M7P PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI Q9U 7X8 5PM DOA |
| DOI | 10.1038/s42003-023-05225-y |
| DatabaseName | Springer Nature OA Free Journals CrossRef ProQuest Central (Corporate) ProQuest Central (purchase pre-March 2016) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea ProQuest Central Student SciTech Premium Collection Biological Sciences Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central ProQuest One Applied & Life Sciences Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition Biological Science Database ProQuest SciTech Collection ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Publicly Available Content Database CrossRef |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2399-3642 |
| EndPage | 11 |
| ExternalDocumentID | oai_doaj_org_article_8b07995862c642ba93056f7264cec938 PMC10533498 10_1038_s42003_023_05225_y |
| GrantInformation_xml | – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 82172877 funderid: https://doi.org/10.13039/501100001809 – fundername: ; grantid: 82172877 |
| GroupedDBID | 0R~ 53G 88I AAJSJ ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV AFKRA AJTQC ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BBNVY BCNDV BENPR BHPHI C6C CCPQU DWQXO EBLON EBS GNUQQ GROUPED_DOAJ HCIFZ HYE M2P M7P M~E NAO O9- OK1 PGMZT PIMPY RNT RPM SNYQT AASML AAYXX CITATION PHGZM PHGZT 3V. 7XB 8FE 8FH 8FK AARCD LK8 PKEHL PQEST PQGLB PQQKQ PQUKI Q9U 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c469t-6e3d05f3678a6dc06deee94e2a76e3d49d051e8a5e8be3633a5c37e07122128d3 |
| IEDL.DBID | C6C |
| ISSN | 2399-3642 |
| IngestDate | Wed Aug 27 01:28:35 EDT 2025 Thu Aug 21 18:36:21 EDT 2025 Fri Jul 11 12:43:51 EDT 2025 Wed Aug 13 07:13:44 EDT 2025 Tue Jul 01 03:01:50 EDT 2025 Fri Feb 21 02:38:37 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c469t-6e3d05f3678a6dc06deee94e2a76e3d49d051e8a5e8be3633a5c37e07122128d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-0165-5020 0000-0002-4709-3334 0000-0002-6175-4821 0000-0003-1911-7922 0000-0001-6316-2734 |
| OpenAccessLink | https://www.nature.com/articles/s42003-023-05225-y |
| PMID | 37758874 |
| PQID | 2869402033 |
| PQPubID | 4669726 |
| PageCount | 11 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8b07995862c642ba93056f7264cec938 pubmedcentral_primary_oai_pubmedcentral_nih_gov_10533498 proquest_miscellaneous_2870146722 proquest_journals_2869402033 crossref_primary_10_1038_s42003_023_05225_y springer_journals_10_1038_s42003_023_05225_y |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-09-27 |
| PublicationDateYYYYMMDD | 2023-09-27 |
| PublicationDate_xml | – month: 09 year: 2023 text: 2023-09-27 day: 27 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London |
| PublicationTitle | Communications biology |
| PublicationTitleAbbrev | Commun Biol |
| PublicationYear | 2023 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Hawkins (CR18) 2010; 6 Napolitano (CR36) 2021; 16 Azuma (CR29) 2007; 25 Xie (CR32) 2019; 29 Zhou (CR22) 2019; 25 Subramanian (CR10) 2017; 171 Yu, Wang, Han, He (CR47) 2012; 16 Srivatsan (CR43) 2020; 367 Golipour (CR16) 2012; 11 Xing (CR25) 2020; 6 Sanchez Alvarado, Yamanaka (CR1) 2014; 157 Takahashi, Yamanaka (CR3) 2006; 126 Lamb (CR34) 2006; 313 Ye (CR42) 2018; 9 Mohamed (CR9) 2017; 135 Biddy (CR24) 2018; 564 Zhu (CR44) 2021; 39 Qiu (CR46) 2017; 14 Zhao (CR6) 2015; 163 Hou (CR5) 2013; 341 Ma (CR26) 2021; 7 Park (CR13) 2008; 451 Wang (CR35) 2020; 21 Orlefors (CR41) 2006; 33 Hao (CR48) 2021; 184 Xu (CR38) 2012; 7 Ichida (CR8) 2009; 5 Dobin (CR51) 2013; 29 Zhu (CR33) 2017; 45 Yuan, Zhu, Liu, Huang, Han (CR37) 2020; 2020 Guo (CR23) 2019; 73 Yu (CR14) 2007; 318 Li (CR27) 2015; 17 CR11 Durinck (CR49) 2005; 21 Takahashi (CR2) 2007; 131 Huang (CR31) 2014; 14 Kriks (CR28) 2011; 480 Huang (CR30) 2011; 475 Subramanian (CR12) 2005; 102 Wang (CR20) 2018; 7 Zhao (CR21) 2018; 23 Kimura-Kuroda (CR40) 2010; 43 Nassar (CR39) 2014; 123 Takahashi (CR17) 2014; 5 Li, Ralphs, Tosh (CR50) 2010; 633 Xu, Du, Deng (CR7) 2015; 16 Trapnell (CR45) 2014; 32 Wang (CR19) 2020; 369 Narayan, Bryant, Shah, Berrozpe, Ptashne (CR15) 2017; 20 Guan (CR4) 2022; 605 X Li (5225_CR27) 2015; 17 A Golipour (5225_CR16) 2012; 11 SR Srivatsan (5225_CR43) 2020; 367 X Qiu (5225_CR46) 2017; 14 TM Mohamed (5225_CR9) 2017; 135 J Yu (5225_CR14) 2007; 318 H Azuma (5225_CR29) 2007; 25 P Huang (5225_CR30) 2011; 475 K Takahashi (5225_CR3) 2006; 126 A Subramanian (5225_CR12) 2005; 102 L Guo (5225_CR23) 2019; 73 Y Zhao (5225_CR6) 2015; 163 Y Wang (5225_CR20) 2018; 7 IH Park (5225_CR13) 2008; 451 K Takahashi (5225_CR17) 2014; 5 QR Xing (5225_CR25) 2020; 6 T Zhao (5225_CR21) 2018; 23 YT Ma (5225_CR26) 2021; 7 G Zhu (5225_CR33) 2017; 45 J Zhu (5225_CR44) 2021; 39 ZD Yuan (5225_CR37) 2020; 2020 A Sanchez Alvarado (5225_CR1) 2014; 157 WC Li (5225_CR50) 2010; 633 P Huang (5225_CR31) 2014; 14 Y Hao (5225_CR48) 2021; 184 YM Wang (5225_CR35) 2020; 21 S Durinck (5225_CR49) 2005; 21 W Wang (5225_CR19) 2020; 369 RD Hawkins (5225_CR18) 2010; 6 J Xu (5225_CR7) 2015; 16 A Subramanian (5225_CR10) 2017; 171 F Napolitano (5225_CR36) 2021; 16 GC Yu (5225_CR47) 2012; 16 A Dobin (5225_CR51) 2013; 29 H Orlefors (5225_CR41) 2006; 33 J Kimura-Kuroda (5225_CR40) 2010; 43 J Guan (5225_CR4) 2022; 605 C Trapnell (5225_CR45) 2014; 32 5225_CR11 H Xu (5225_CR38) 2012; 7 S Kriks (5225_CR28) 2011; 480 K Nassar (5225_CR39) 2014; 123 B Xie (5225_CR32) 2019; 29 J Lamb (5225_CR34) 2006; 313 K Takahashi (5225_CR2) 2007; 131 S Narayan (5225_CR15) 2017; 20 JK Ichida (5225_CR8) 2009; 5 C Ye (5225_CR42) 2018; 9 P Hou (5225_CR5) 2013; 341 Y Zhou (5225_CR22) 2019; 25 BA Biddy (5225_CR24) 2018; 564 |
| References_xml | – volume: 135 start-page: 978 year: 2017 end-page: 995 ident: CR9 article-title: Chemical enhancement of in vitro and in vivo direct cardiac reprogramming publication-title: Circulation – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: CR51 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics – volume: 633 start-page: 185 year: 2010 end-page: 196 ident: CR50 article-title: Isolation and culture of adult mouse hepatocytes publication-title: Methods Mol. Biol. – volume: 6 start-page: 479 year: 2010 end-page: 491 ident: CR18 article-title: Distinct epigenomic landscapes of pluripotent and lineage-committed human cells publication-title: Cell Stem Cell – volume: 131 start-page: 861 year: 2007 end-page: 872 ident: CR2 article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors publication-title: Cell – volume: 16 start-page: 119 year: 2015 end-page: 134 ident: CR7 article-title: Direct lineage reprogramming: strategies, mechanisms, and applications publication-title: Cell Stem Cell – volume: 341 start-page: 651 year: 2013 end-page: 654 ident: CR5 article-title: Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds publication-title: Science – volume: 480 start-page: 547 year: 2011 end-page: U177 ident: CR28 article-title: Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease publication-title: Nature – volume: 32 start-page: 381 year: 2014 end-page: 386 ident: CR45 article-title: The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells publication-title: Nat. Biotechnol. – volume: 6 start-page: eaba1190 year: 2020 ident: CR25 article-title: Diversification of reprogramming trajectories revealed by parallel single-cell transcriptome and chromatin accessibility sequencing publication-title: Sci. Adv. – volume: 318 start-page: 1917 year: 2007 end-page: 1920 ident: CR14 article-title: Induced pluripotent stem cell lines derived from human somatic cells publication-title: Science – volume: 313 start-page: 1929 year: 2006 end-page: 1935 ident: CR34 article-title: The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease publication-title: Science – volume: 171 start-page: 1437 year: 2017 end-page: 1452.e1417 ident: CR10 article-title: A next generation Connectivity Map: L1000 platform and the first 1,000,000 profiles publication-title: Cell – volume: 157 start-page: 110 year: 2014 end-page: 119 ident: CR1 article-title: Rethinking differentiation: stem cells, regeneration, and plasticity publication-title: Cell – volume: 102 start-page: 15545 year: 2005 end-page: 15550 ident: CR12 article-title: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles publication-title: Proc. Natl Acad. Sci. USA – volume: 163 start-page: 1678 year: 2015 end-page: 1691 ident: CR6 article-title: A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming publication-title: Cell – volume: 17 start-page: 195 year: 2015 end-page: 203 ident: CR27 article-title: Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons publication-title: Cell Stem Cell – volume: 14 start-page: 370 year: 2014 end-page: 384 ident: CR31 article-title: Direct reprogramming of human fibroblasts to functional and expandable hepatocytes publication-title: Cell Stem Cell – volume: 7 start-page: e40301 year: 2012 ident: CR38 article-title: A new antifibrotic target of Ac-SDKP: inhibition of myofibroblast differentiation in rat lung with silicosis publication-title: PLoS ONE – volume: 126 start-page: 663 year: 2006 end-page: 676 ident: CR3 article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors publication-title: Cell – volume: 20 start-page: 1585 year: 2017 end-page: 1596 ident: CR15 article-title: OCT4 and SOX2 Work as transcriptional activators in reprogramming human fibroblasts publication-title: Cell Rep. – volume: 369 start-page: eaaz3090 year: 2020 ident: CR19 article-title: Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates publication-title: Science – volume: 367 start-page: 45 year: 2020 end-page: 51 ident: CR43 article-title: Massively multiplex chemical transcriptomics at single-cell resolution publication-title: Science – volume: 25 start-page: 903 year: 2007 end-page: 910 ident: CR29 article-title: Robust expansion of human hepatocytes in / / mice publication-title: Nat. Biotechnol. – ident: CR11 – volume: 43 start-page: 177 year: 2010 end-page: 187 ident: CR40 article-title: An in vitro model of the inhibition of axon growth in the lesion scar formed after central nervous system injury publication-title: Mol. Cell Neurosci. – volume: 21 start-page: 3439 year: 2005 end-page: 3440 ident: CR49 article-title: BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis publication-title: Bioinformatics – volume: 9 year: 2018 ident: CR42 article-title: DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery publication-title: Nat. Commun. – volume: 16 start-page: 284 year: 2012 end-page: 287 ident: CR47 article-title: clusterProfiler: an R package for comparing biological themes among gene clusters publication-title: Omics – volume: 475 start-page: 386 year: 2011 end-page: 389 ident: CR30 article-title: Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors publication-title: Nature – volume: 564 start-page: 219 year: 2018 end-page: 224 ident: CR24 article-title: Single-cell mapping of lineage and identity in direct reprogramming publication-title: Nature – volume: 16 start-page: 1381 year: 2021 end-page: 1390 ident: CR36 article-title: Automatic identification of small molecules that promote cell conversion and reprogramming publication-title: Stem Cell Rep. – volume: 33 start-page: 60 year: 2006 end-page: 65 ident: CR41 article-title: Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography publication-title: Eur. J. Nucl. Med. Mol. Imaging – volume: 7 start-page: e29518 year: 2018 ident: CR20 article-title: Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naive state publication-title: Elife – volume: 605 start-page: 325 year: 2022 end-page: 331 ident: CR4 article-title: Chemical reprogramming of human somatic cells to pluripotent stem cells publication-title: Nature – volume: 451 start-page: 141 year: 2008 end-page: 146 ident: CR13 article-title: Reprogramming of human somatic cells to pluripotency with defined factors publication-title: Nature – volume: 7 start-page: 12 year: 2021 ident: CR26 article-title: In vivo chemical reprogramming of astrocytes into neurons publication-title: Cell Discov. – volume: 39 start-page: 1444 year: 2021 end-page: 1452 ident: CR44 article-title: Prediction of drug efficacy from transcriptional profiles with deep learning publication-title: Nat. Biotechnol. – volume: 184 start-page: 3573 year: 2021 end-page: 3587.e3529 ident: CR48 article-title: Integrated analysis of multimodal single-cell data publication-title: Cell – volume: 23 start-page: 31 year: 2018 end-page: 45.e37 ident: CR21 article-title: Single-cell RNA-Seq reveals dynamic early embryonic-like programs during chemical reprogramming publication-title: Cell Stem Cell – volume: 11 start-page: 769 year: 2012 end-page: 782 ident: CR16 article-title: A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network publication-title: Cell Stem Cell – volume: 25 start-page: 149 year: 2019 end-page: 164.e149 ident: CR22 article-title: Single-cell transcriptomic analyses of cell fate transitions during human cardiac reprogramming publication-title: Cell Stem Cell – volume: 73 start-page: 815 year: 2019 end-page: 829.e817 ident: CR23 article-title: Resolving cell fate decisions during somatic cell reprogramming by single-cell RNA-Seq publication-title: Mol. Cell – volume: 123 start-page: 72 year: 2014 end-page: 86 ident: CR39 article-title: A TGF-beta receptor 1 inhibitor for prevention of proliferative vitreoretinopathy publication-title: Exp. Eye Res. – volume: 14 start-page: 309 year: 2017 end-page: 315 ident: CR46 article-title: Single-cell mRNA quantification and differential analysis with Census publication-title: Nat. Methods – volume: 21 start-page: 7695 year: 2020 ident: CR35 article-title: Multiple-purpose connectivity map analysis reveals the benefits of esculetin to hyperuricemia and renal fibrosis publication-title: Int. J. Mol. Sci. – volume: 5 start-page: 491 year: 2009 end-page: 503 ident: CR8 article-title: A small-molecule inhibitor of Tgf-Beta signaling replaces Sox2 in reprogramming by inducing nanog publication-title: Cell Stem Cell – volume: 5 year: 2014 ident: CR17 article-title: Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm publication-title: Nat. Commun. – volume: 29 start-page: 696 year: 2019 end-page: 710 ident: CR32 article-title: A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts publication-title: Cell Res. – volume: 45 start-page: W103 year: 2017 end-page: W108 ident: CR33 article-title: CSTEA: a webserver for the Cell State Transition Expression Atlas publication-title: Nucleic Acids Res. – volume: 2020 start-page: 8890917 year: 2020 ident: CR37 article-title: Small molecule epigenetic modulators in pure chemical cell fate conversion publication-title: Stem Cells Int. – volume: 73 start-page: 815 year: 2019 ident: 5225_CR23 publication-title: Mol. Cell doi: 10.1016/j.molcel.2019.01.042 – volume: 14 start-page: 370 year: 2014 ident: 5225_CR31 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2014.01.003 – volume: 39 start-page: 1444 year: 2021 ident: 5225_CR44 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-021-00946-z – volume: 135 start-page: 978 year: 2017 ident: 5225_CR9 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.116.024692 – volume: 6 start-page: 479 year: 2010 ident: 5225_CR18 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2010.03.018 – volume: 16 start-page: 1381 year: 2021 ident: 5225_CR36 publication-title: Stem Cell Rep. doi: 10.1016/j.stemcr.2021.03.028 – volume: 157 start-page: 110 year: 2014 ident: 5225_CR1 publication-title: Cell doi: 10.1016/j.cell.2014.02.041 – volume: 21 start-page: 3439 year: 2005 ident: 5225_CR49 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti525 – volume: 480 start-page: 547 year: 2011 ident: 5225_CR28 publication-title: Nature doi: 10.1038/nature10648 – volume: 14 start-page: 309 year: 2017 ident: 5225_CR46 publication-title: Nat. Methods doi: 10.1038/nmeth.4150 – volume: 17 start-page: 195 year: 2015 ident: 5225_CR27 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.06.003 – volume: 102 start-page: 15545 year: 2005 ident: 5225_CR12 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0506580102 – volume: 313 start-page: 1929 year: 2006 ident: 5225_CR34 publication-title: Science doi: 10.1126/science.1132939 – volume: 29 start-page: 15 year: 2013 ident: 5225_CR51 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 6 start-page: eaba1190 year: 2020 ident: 5225_CR25 publication-title: Sci. Adv. doi: 10.1126/sciadv.aba1190 – volume: 184 start-page: 3573 year: 2021 ident: 5225_CR48 publication-title: Cell doi: 10.1016/j.cell.2021.04.048 – volume: 7 start-page: e29518 year: 2018 ident: 5225_CR20 publication-title: Elife doi: 10.7554/eLife.29518 – volume: 7 start-page: 12 year: 2021 ident: 5225_CR26 publication-title: Cell Discov. – volume: 43 start-page: 177 year: 2010 ident: 5225_CR40 publication-title: Mol. Cell Neurosci. doi: 10.1016/j.mcn.2009.10.008 – volume: 171 start-page: 1437 year: 2017 ident: 5225_CR10 publication-title: Cell doi: 10.1016/j.cell.2017.10.049 – volume: 16 start-page: 284 year: 2012 ident: 5225_CR47 publication-title: Omics doi: 10.1089/omi.2011.0118 – volume: 341 start-page: 651 year: 2013 ident: 5225_CR5 publication-title: Science doi: 10.1126/science.1239278 – volume: 20 start-page: 1585 year: 2017 ident: 5225_CR15 publication-title: Cell Rep. doi: 10.1016/j.celrep.2017.07.071 – volume: 5 year: 2014 ident: 5225_CR17 publication-title: Nat. Commun. – volume: 318 start-page: 1917 year: 2007 ident: 5225_CR14 publication-title: Science doi: 10.1126/science.1151526 – volume: 32 start-page: 381 year: 2014 ident: 5225_CR45 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2859 – volume: 564 start-page: 219 year: 2018 ident: 5225_CR24 publication-title: Nature doi: 10.1038/s41586-018-0744-4 – volume: 25 start-page: 903 year: 2007 ident: 5225_CR29 publication-title: Nat. Biotechnol. doi: 10.1038/nbt1326 – volume: 126 start-page: 663 year: 2006 ident: 5225_CR3 publication-title: Cell doi: 10.1016/j.cell.2006.07.024 – volume: 605 start-page: 325 year: 2022 ident: 5225_CR4 publication-title: Nature doi: 10.1038/s41586-022-04593-5 – volume: 131 start-page: 861 year: 2007 ident: 5225_CR2 publication-title: Cell doi: 10.1016/j.cell.2007.11.019 – volume: 5 start-page: 491 year: 2009 ident: 5225_CR8 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.09.012 – volume: 123 start-page: 72 year: 2014 ident: 5225_CR39 publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2014.04.006 – ident: 5225_CR11 doi: 10.1093/nar/gkac862 – volume: 29 start-page: 696 year: 2019 ident: 5225_CR32 publication-title: Cell Res. doi: 10.1038/s41422-019-0196-x – volume: 16 start-page: 119 year: 2015 ident: 5225_CR7 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2015.01.013 – volume: 451 start-page: 141 year: 2008 ident: 5225_CR13 publication-title: Nature doi: 10.1038/nature06534 – volume: 21 start-page: 7695 year: 2020 ident: 5225_CR35 publication-title: Int. J. Mol. Sci. doi: 10.3390/ijms21207695 – volume: 369 start-page: eaaz3090 year: 2020 ident: 5225_CR19 publication-title: Science doi: 10.1126/science.aaz3090 – volume: 33 start-page: 60 year: 2006 ident: 5225_CR41 publication-title: Eur. J. Nucl. Med. Mol. Imaging doi: 10.1007/s00259-005-1891-z – volume: 45 start-page: W103 year: 2017 ident: 5225_CR33 publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkx402 – volume: 163 start-page: 1678 year: 2015 ident: 5225_CR6 publication-title: Cell doi: 10.1016/j.cell.2015.11.017 – volume: 25 start-page: 149 year: 2019 ident: 5225_CR22 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2019.05.020 – volume: 7 start-page: e40301 year: 2012 ident: 5225_CR38 publication-title: PLoS ONE doi: 10.1371/journal.pone.0040301 – volume: 9 year: 2018 ident: 5225_CR42 publication-title: Nat. Commun. – volume: 2020 start-page: 8890917 year: 2020 ident: 5225_CR37 publication-title: Stem Cells Int. – volume: 23 start-page: 31 year: 2018 ident: 5225_CR21 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2018.05.025 – volume: 475 start-page: 386 year: 2011 ident: 5225_CR30 publication-title: Nature doi: 10.1038/nature10116 – volume: 11 start-page: 769 year: 2012 ident: 5225_CR16 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2012.11.008 – volume: 367 start-page: 45 year: 2020 ident: 5225_CR43 publication-title: Science doi: 10.1126/science.aax6234 – volume: 633 start-page: 185 year: 2010 ident: 5225_CR50 publication-title: Methods Mol. Biol. doi: 10.1007/978-1-59745-019-5_13 |
| SSID | ssj0001999634 |
| Score | 2.2408803 |
| Snippet | Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and safety... Abstract Cellular transitions hold great promise in translational medicine research. However, therapeutic applications are limited by the low efficiency and... |
| SourceID | doaj pubmedcentral proquest crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 989 |
| SubjectTerms | 38/39 38/91 631/114/2413 631/532/2435 631/553/1833 96/100 Biology Biomedical and Life Sciences Cytology Epithelial cells Fibroblasts Gene expression Glycogen Life Sciences Liver Progenitor cells Therapeutic applications Transcription factors |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3PS-wwEA4iCF7En1j1SQRvGuxm2jR9t_dEEUHxoOAtpOkUvXRldz3sf-9M2lUriBevTSDJTNLvSzL5RohjwlwDaIOqDHIKs3qkrAZUOWjMva8LNPw4-ebWXD1k14_546dUXxwT1skDd4Y7s1XKmmVEvANR5cqXzHmbgnA8YCghPvMlzPu0mYqnK8zjIetfyaRgz6ZZDMMiiFIpcY5czQdIFAX7Byzza4zkl4vSiD-X62KtJ47yX9fhDbGE7aZY6VJJzrfE3d053P-VXnJARhTrVPWE_2TyZcJ3MbS1luNGhl4fQHIoOWdUmkpirZKP7zkeVc4YumIU17Z4uLy4P79SfbYEFWiLO1MGoU7zBgh9vKlDampELDPUvuAicgOtP7Q-R1shGACfByiQKIYm-LI17IjldtzirpAjj8FWJd-INllFFK4pC0I1JKwHCFWdiJOF5dxLJ4rh4mU2WNfZ2ZGdXbSzmyfiPxv3vSYLWscP5GbXu9n95OZEHCxc4_pVNnXampL3vwCJOHovpvXBVvMtjl-5TsH6OIXWibADlw46NCxpn5-i0vYovlQuqfXThfc_Wv9-xHu_MeJ9sarjbC2VLg7E8mzyin-IAM2qwzjX3wDtoQB5 priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LaxwxDDZtQqGXkvRBp0mDC721JrPWPDy5hCYkhELDUhLIzXhsTZvLzHZ3c9h_X8nrzTKB9jo22CNZ0idLloT4TDa3AjRetRVyC7MwUUYDqhI0ls6FGit-nPzjurq6Lb7flXfpwm2R0io3OjEq6jB4viM_1qZq2NcBOJ39Udw1iqOrqYXGc7FLKtiQ87V7dnE9_bm9ZWE8D0V6LZODOV4UMR2LTJXKCXuUajWySLFw_whtPs2VfBIwjXbock-8SgBSfltzfF88w_61eLFuKbl6I6bTc7g5kU5yYkYs2qnCnDWanM05JkMuthw66VOdAMkp5dxZaSEJvUq-xue8VLlkExazud6K28uLm_MrlbomKE-u7lJVCCEvOyAr5Krg8yogYlOgdjUPETtIDtG4Ek2LUAG40kONBDU00zDAO7HTDz2-F3Li0Ju24choV7QE5bqmJuuGZPMBfBsy8WVDOTtbF8ewMagNxq7pbInONtLZrjJxxsR9nMmFreOHYf7LJjmxps25RB35WZ48o9Y17OJ0NcE2j74Bk4nDDWtskraF3Z6NTHx6HCY5Yaq5HocHnlNznZxa60yYEUtHGxqP9Pe_Y8XtSXyx3NDqXzfc367-7z_-8P_NHoiXOp7DRun6UOws5w_4kSDOsj1K5_gvsj76fw priority: 102 providerName: ProQuest |
| Title | PC3T: a signature-driven predictor of chemical compounds for cellular transition |
| URI | https://link.springer.com/article/10.1038/s42003-023-05225-y https://www.proquest.com/docview/2869402033 https://www.proquest.com/docview/2870146722 https://pubmed.ncbi.nlm.nih.gov/PMC10533498 https://doaj.org/article/8b07995862c642ba93056f7264cec938 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Na9wwEB3ShEIvpZ_Ubbqo0Fsr6tXYstzbZkkICw1Lm0BuRpbHbS_esLs57L_vjNZOcGgPPRksGVszkt8bafQE8JEx1yK5oGtLcoRZM9XOIOkcDeXeNwVZ2Zz87cKeX2WL6_z6AMywFyYm7UdJy_ibHrLDvmyymEXFCKNTpgy53j2CI5Ful149t_P7eRVh8Jj1-2NSdH95dIRBUap_xC8fZkc-WCKNyHP2DJ72lFHN9h_5HA6oewGP94dI7l7CcjnHy6_KK0nFiG3SzVr-YepmLaswHFSrVatCrwygJIlczlLaKOarSibuJRNVbQW0Yv7WK7g6O72cn-v-nAQdOLjdakvYpHmLjDveNiG1DRGVGRlfSBE7gEceOZ-Tqwktos8DFsTkwjBwuQZfw2G36ugNqKmn4OpS1kLbrGby1pYF4xkxyiOGukng02C56mYvh1HFZWx01d7OFdu5inaudgmciHHvaoqUdbyxWv-setdWrk5FlI4jq8CxUO1LCWragolaoFCiS-B4cE3Vj69NZZwtJfJFTODDXTGPDLGa72h1K3UKUcYpjEnAjVw6-qBxSff7V9TYnsY9yiW__fPg_fu3_7vFb_-v-jt4YmK_LLUpjuFwu76l90xytvUEjmazxY8FX09OL5bfJ7GXT-KUwR9hAfts |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9QwDLfGTQheEJ-iMCBI8ATRekk_UiSE2Nh0Y9vphG7S3rI2dYGX63F3E7p_ir8RO2136iR422tTNant2P7Fjg3whmxuotE4WSTILczKoTRKo4y1wjjPyxQTvpx8Ok5GZ9HX8_h8C_50d2E4rbLTiV5Rl7XjM_JdZZKMsY7Wn-a_JHeN4uhq10KjEYtjXP8myLb8ePSF-PtWqcOD6f5Itl0FpCMouJIJ6jKMK01aOk9KFyYlImYRqjzlIVouySmaPEZToE60zmOnUyRTrEjNm1LTd2_BdqQJygxge-9gPPm2OdVh_KCj9nZOqM3uMvLpX2QaZUi-TizXPQvoGwX0vNvruZnXArTe7h3eh3utwyo-NxL2ALZw9hBuNy0s149gMtnX0w8iF5wI4ouEynLBGlTMFxwDIkgv6kq4ti6B4BR27uS0FOQtCw4bcB6sWLHJ9Nljj-HsRuj5BAazeoZPQQxzdKbIOBJbRQW5jlWWkjVF8jG0dkUZwLuOcnbeFOOwPoiujW3obInO1tPZrgPYY-JevcmFtP2DevHdtvvSmiLkkniE6xwhsSLPGFJVKbmJDl2mTQA7HWtsu7uXdiOLAby-GqZ9yVTLZ1hf8jsp1-VJlQrA9FjaW1B_ZPbzh6_wPfQ3pDOa_X3H_c3s__7jZ_9f7Cu4M5qentiTo_Hxc7irvExmUqU7MFgtLvEFuVer4mUr0wIubnob_QVZgTdJ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwEB6VIhAXxFOkFDASNzBkM4njcIOFVXlVe2il3izHmRQu2dXu9rD_vjPepFUqOHCNHdmesf194xmPAd4w5hokG3RtSJ4waybaZki6wIwK75uSjFxO_nVsjk7z72fF2R6Y4S5MDNqPKS3jNj1Eh31Y5zGKihFGp0wZCr19v2zaW3Cb-XYqRtfUTK_PVoTFY97fkUnR_uX3EQ7FdP0jjnkzQvKGmzSiz-wB3O9po_q06-hD2KPuEdzZPSS5fQzz-RRPPiqvJBwjjks3K9nH1HIlnhg2rNWiVaHPDqAkkFzeU1or5qxKDu8lGlVtBLhiDNcTOJ19PZke6f6tBB3YwN1oQ9ikRYuMPd40ITUNEVU5Zb6UIlYCrz6yviBbExpEXwQsiQlGxuBlG3wK-92io2egJp6CrSvxh7Z5zQSurUrGNGKkRwx1k8DbQXJuuUuJ4aIrG63bydmxnF2Us9sm8FmEe1VT0lnHD4vVuevV62ydSmI6tq4C20O1r8SwaUsma4FChTaBw0E1rl9ja5dZU4n1i5jA66tiXh0iNd_R4kLqlJIdp8yyBOxIpaMOjUu6P79jnu1JvKdccevvBu1ft_7vER_8X_VXcHf-ZeZ-fjv-8RzuZXGKVjorD2F_s7qgF8x5NvXLOMEvAUWu-0k |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=PC3T%3A+a+signature-driven+predictor+of+chemical+compounds+for+cellular+transition&rft.jtitle=Communications+biology&rft.au=Han%2C+Lu&rft.au=Song%2C+Bin&rft.au=Zhang%2C+Peilin&rft.au=Zhong%2C+Zhi&rft.date=2023-09-27&rft.issn=2399-3642&rft.eissn=2399-3642&rft.volume=6&rft.issue=1&rft_id=info:doi/10.1038%2Fs42003-023-05225-y&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s42003_023_05225_y |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2399-3642&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2399-3642&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2399-3642&client=summon |