Intervertebral disc degeneration-Current therapeutic options and challenges

Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status. Most of the intervertebral disc degeneration (IVDD) therapies today focu...

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Published inFrontiers in public health Vol. 11; p. 1156749
Main Authors Samanta, Ankita, Lufkin, Thomas, Kraus, Petra
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 06.07.2023
Subjects
Aging
exosome
Humans
Intervertebral Disc
intervertebral disc degeneration
Intervertebral Disc Degeneration - surgery
Low Back Pain - etiology
Low Back Pain - therapy
Public Health
Quality of Life
small molecule
stem cell
therapy
intervertebral disc degeneration
small molecule
stem cell
exosome
therapy
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Summary:Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status. Most of the intervertebral disc degeneration (IVDD) therapies today focus on the symptoms of low back pain rather than the underlying etiology or mechanical function of the disc. The deteriorated disc is typically not restored by conservative or surgical therapies that largely focus on correcting symptoms and structural abnormalities. To enhance the clinical outcome and the quality of life of a patient, several therapeutic modalities have been created. In this review, we discuss genetic and environmental causes of IVDD and describe promising modern endogenous and exogenous therapeutic approaches including their applicability and relevance to the degeneration process.
Bibliography:ObjectType-Article-1
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ObjectType-Review-2
Reviewed by: Min Lu, Shanghai Jiao Tong University, China; Danny Chan, The University of Hong Kong, Hong Kong SAR, China
Edited by: Qiling Yuan, Xi'an Jiaotong University, China
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2023.1156749