Repeated Morphine Produces Sensitization to Reward and Tolerance to Antiallodynia in Male and Female Rats with Chemotherapy-Induced Neuropathy

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 365; no. 1; pp. 9 - 19
• Main Authors: Legakis, L. P, Negus, S. S
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2018; The American Society for Pharmacology and Experimental Therapeutics
• Subjects: analysis of variance; Animals; ANOVA; Antineoplastic Agents - adverse effects; Behavioral Pharmacology; chemotherapy-induced neuropathic pain; CINP; Female; Hyperalgesia - psychology; ICSS; intracranial self-stimulation; Male; maximum control rate; maximum possible effect; MCR; Morphine - pharmacology; MPE; Neuralgia - chemically induced; Neuralgia - psychology; Paclitaxel - adverse effects; Rats; Rats, Sprague-Dawley; Reward; Time Factors; ICSS; MPE; ANOVA; MCR; CINP

Paclitaxel is a cancer chemotherapy drug with adverse effects that include chemotherapy-induced neuropathic pain (CINP) as well as depression of behavior and mood. In the clinical setting, opioids are often used concurrently with or after chemotherapy to treat pain related to the cancer or CINP, but...