Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

• Published in: Viruses Vol. 13; no. 9; p. 1876
• Main Authors: Guo, Zijing, Zhang, Zhidong, Prajapati, Meera, Li, Yanmin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.09.2021; MDPI
• Subjects: Adaptive immunity; Animals; Apoptosis; Cell Death; Coronaviruses; cytokines; Cytokines - immunology; Cytokines - metabolism; Glucocorticoids - blood; Humans; Immune response; Lymphocytes; Lymphocytes - physiology; Lymphopenia; Lymphopenia - etiology; Lymphopoiesis; Metabolic Diseases - complications; Review; Severity of Illness Index; Therapeutic targets; Viral infections; Virus Diseases - complications; Virus Diseases - immunology; Virus Diseases - metabolism; Viruses; apoptosis; viruses; cytokines; immune response; lymphopenia

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia...