Lymphopenia Caused by Virus Infections and the Mechanisms Beyond

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia...

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Published inViruses Vol. 13; no. 9; p. 1876
Main Authors Guo, Zijing, Zhang, Zhidong, Prajapati, Meera, Li, Yanmin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.09.2021
MDPI
Subjects
Adaptive immunity
Animals
Apoptosis
Cell Death
Coronaviruses
cytokines
Cytokines - immunology
Cytokines - metabolism
Glucocorticoids - blood
Humans
Immune response
Lymphocytes
Lymphocytes - physiology
Lymphopenia
Lymphopenia - etiology
Lymphopoiesis
Metabolic Diseases - complications
Review
Severity of Illness Index
Therapeutic targets
Viral infections
Virus Diseases - complications
Virus Diseases - immunology
Virus Diseases - metabolism
Viruses
apoptosis
viruses
cytokines
immune response
lymphopenia
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Summary:Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune responses and impact the clinical course of acute viral infections. Detailed knowledge on how viruses induce lymphopenia would provide valuable information into the pathogenesis of viral infections and potential therapeutic targeting. In this review, the current progress of viruses-induced lymphopenia is summarized and the potential mechanisms and factors involved are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1999-4915
1999-4915
DOI:10.3390/v13091876