Differential effects of fish-oil and cocoa-butter based high-fat/high-sucrose diets on endocrine pancreas morphology and function in mice

• Published in: Frontiers in endocrinology (Lausanne) Vol. 15; p. 1265799
• Main Authors: Albeloushi, Shaima, Hasan, Amal, Arefanian, Hossein, Sindhu, Sardar, Al-Rashed, Fatema, Kochumon, Shihab, Abukhalaf, Nermeen, Jacob, Texy, Shenouda, Steve, Al Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.02.2024
• Subjects: Animals; C-Peptide; cocoa butter; Dietary Fats; Endocrinology; fish oil; Fish Oils - pharmacology; Glucagon; Glucagon-Like Peptide 1 - metabolism; Glucose; high-fat/sucrose diet; Insulin; Islets of Langerhans - metabolism; Leptin; Male; Mice; Mice, Inbred C57BL; Sucrose - adverse effects; α-cell; α-cell; insulin; fish oil; glucagon; high-fat/sucrose diet; β-cell; cocoa butter

A high-fat/high-sucrose diet leads to adverse metabolic changes that affect insulin sensitivity, function, and secretion. The source of fat in the diet might inhibit or increase this adverse effect. Fish oil and cocoa butter are a significant part of our diets. Yet comparisons of these commonly used...