The E3 Ubiquitin Ligase Pellino3 Protects against Obesity-Induced Inflammation and Insulin Resistance

• Published in: Immunity (Cambridge, Mass.) Vol. 41; no. 6; pp. 973 - 987
• Main Authors: Yang, Shuo, Wang, Bingwei, Humphries, Fiachra, Hogan, Andrew E., O’Shea, Donal, Moynagh, Paul N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.12.2014; Elsevier Limited
• Subjects: Abdominal Fat - metabolism; Abdominal Fat - pathology; Adult; Aged; Animals; Cell Differentiation - genetics; Cells, Cultured; Diabetes; Diet, High-Fat; Female; Gene expression; Glucose; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Inflammation - etiology; Inflammation - immunology; Insulin; Insulin resistance; Insulin Resistance - genetics; Interleukin-1beta - metabolism; Kinases; Macrophages - physiology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Obesity; Obesity - complications; Obesity - immunology; Phosphorylation; Proteins; Rodents; Software; TNF Receptor-Associated Factor 6 - metabolism; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination - genetics; Young Adult

Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here...