Impact of homologous and heterologous boosters in neutralizing antibodies titers against SARS-CoV-2 Omicron in solid-organ transplant recipients

• Published in: Frontiers in immunology Vol. 14; p. 1135478
• Main Authors: Gaete-Argel, Aracelly, Saavedra-Alarcón, Vicente, Sauré, Denis, Alonso-Palomares, Luis, Acevedo, Mónica L., Alarcón, Marion, Bueno, Susan M., Kalergis, Alexis M., Soto-Rifo, Ricardo, Valiente-Echeverría, Fernando, Cortes, Claudia P.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.03.2023
• Subjects: Antibodies, Neutralizing; BNT162 Vaccine; Cohort Studies; COVID-19; COVID-19 Vaccines; Humans; humoral response; Immunology; neutralization; organ transplantation; Organ Transplantation - adverse effects; Prospective Studies; SARS-CoV-2; vaccine; COVID-19; vaccine; organ transplantation; neutralization; humoral response

Booster doses of SARS-CoV-2 vaccines improve seroconversion rates in solid organ transplant recipients (SOTRs) but the impact of homologous and heterologous booster doses in neutralizing antibody (NAb) titers and their ability to interfere with the variant of concern Omicron are not well studied. We...