Itaconate-producing neutrophils regulate local and systemic inflammation following trauma

• Published in: JCI insight Vol. 8; no. 20
• Main Authors: Crossley, Janna L, Ostashevskaya-Gohstand, Sonya, Comazzetto, Stefano, Hook, Jessica S, Guo, Lei, Vishlaghi, Neda, Juan, Conan, Xu, Lin, Horswill, Alexander R, Hoxhaj, Gerta, Moreland, Jessica G, Tower, Robert J, Levi, Benjamin
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 23.10.2023; American Society for Clinical investigation
• Subjects: Humans; Immunology; Inflammation; Inflammation - metabolism; Macrophages - metabolism; Neutrophils - metabolism; Succinates - metabolism; Succinates - pharmacology; Succinates - therapeutic use; Inflammation; Immunology; Neutrophils

Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injuries that undergo normal and aberrant repair were evaluated by m...