Association between systemic immune-inflammation index and psoriasis: a population-based study

• Published in: Frontiers in immunology Vol. 15; p. 1305701
• Main Authors: Zhao, Xiya, Li, Junqin, Li, Xinhua
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.03.2024
• Subjects: Cross-Sectional Studies; Female; Humans; Immunology; Inflammation; NHANES; Nutrition Surveys; PASI; psoriasis; Psoriasis - epidemiology; stroke; systemic immune-inflammation index; systemic immune-inflammation index; PASI; NHANES; stroke; psoriasis
• ISSN: 1664-3224; 1664-3224
• DOI: 10.3389/fimmu.2024.1305701

The systemic immune-inflammation index (SII),as measured by lymphocyte, neutrophil and platelet counts in peripheral blood, is regarded as a favorable indicator of both inflammatory state and immune response. Psoriasis is an immune-mediated disease notable for its chronic inflammation of the entire system. Our research sought to explore the latent link between psoriasis and SII. We performed a cross-sectional investigation utilizing data extracted from the National Health and Nutrition Examination Survey (NHANES, 2009-2014). Employing multivariate linear regression models and subgroup analysis, we sought to uncover the association between SII and psoriasis. This study enrolled a total of 17,913 participants as part of its research cohort. Our multivariate linear regression analysis revealed a notable and positive correlation between SII and psoriasis [1.013 (1.000, 1.026)]. As SII tertiles increased, the risk of psoriasis demonstrated an upward trend. The significant dependence on this positive association were maintained in women, BMI(≥ 30 kg/m2),non-stroke and non-cancer subjects in subgroup analysis and interaction tests. Furthermore, we identified a significant association between SII and psoriasis, characterized by two consecutive inverted U-shaped patterns. Notably, the analysis revealed the most prominent inflection point at a specific value of 797.067. The results indicate a significant correlation between elevated SII levels and the presence of psoriasis. However, to corroborate and strengthen these results, additional large-scale prospective studies are required.